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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for PRDM4

Z-value: 1.07

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Transcription factors associated with PRDM4

Gene Symbol Gene ID Gene Info
PRDM4
ENSG00000110851.7 PR/SET domain 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM4hg19_v2_chr12_-_108154925_108154945-0.633.7e-01Click!

Activity profile of PRDM4 motif

Sorted Z-values of PRDM4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_49371711 1.94 ENST00000355496.5
ENST00000263265.6
PLEKHA4
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr5_-_78281775 0.98 ENST00000396151.3
ENST00000565165.1
ARSB
arylsulfatase B
chr19_+_41117770 0.81 ENST00000601032.1
LTBP4
latent transforming growth factor beta binding protein 4
chr22_-_39636914 0.76 ENST00000381551.4
PDGFB
platelet-derived growth factor beta polypeptide
chr1_+_43232913 0.73 ENST00000372525.5
ENST00000536543.1
C1orf50
chromosome 1 open reading frame 50
chr20_-_49639631 0.70 ENST00000424171.1
ENST00000439216.1
ENST00000371571.4
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr1_+_6511651 0.65 ENST00000434576.1
ESPN
espin
chr15_+_74287035 0.64 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr5_-_78281603 0.64 ENST00000264914.4
ARSB
arylsulfatase B
chr12_-_58240470 0.63 ENST00000548823.1
ENST00000398073.2
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr1_+_172502336 0.51 ENST00000263688.3
SUCO
SUN domain containing ossification factor
chr7_+_143079000 0.49 ENST00000392910.2
ZYX
zyxin
chrX_+_115567767 0.49 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr20_-_49639612 0.48 ENST00000396017.3
ENST00000433903.1
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr7_+_143078652 0.45 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr5_-_78281623 0.42 ENST00000521117.1
ARSB
arylsulfatase B
chr12_+_15475462 0.42 ENST00000543886.1
ENST00000348962.2
PTPRO
protein tyrosine phosphatase, receptor type, O
chr2_+_233734994 0.39 ENST00000331342.2
C2orf82
chromosome 2 open reading frame 82
chr7_+_90893783 0.39 ENST00000287934.2
FZD1
frizzled family receptor 1
chr10_-_105677886 0.39 ENST00000224950.3
OBFC1
oligonucleotide/oligosaccharide-binding fold containing 1
chr6_-_24721054 0.33 ENST00000378119.4
C6orf62
chromosome 6 open reading frame 62
chr14_-_74462922 0.31 ENST00000553284.1
ENTPD5
ectonucleoside triphosphate diphosphohydrolase 5
chrX_+_15808569 0.30 ENST00000380308.3
ENST00000307771.7
ZRSR2
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
chr12_+_104682667 0.30 ENST00000527335.1
TXNRD1
thioredoxin reductase 1
chr14_+_24025345 0.23 ENST00000557630.1
THTPA
thiamine triphosphatase
chr16_+_29823552 0.22 ENST00000300797.6
PRRT2
proline-rich transmembrane protein 2
chr1_+_172502244 0.22 ENST00000610051.1
SUCO
SUN domain containing ossification factor
chr17_-_9929581 0.21 ENST00000437099.2
ENST00000396115.2
GAS7
growth arrest-specific 7
chr5_+_80256453 0.21 ENST00000265080.4
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr14_+_24025194 0.20 ENST00000404535.3
ENST00000288014.6
THTPA
thiamine triphosphatase
chr14_+_32030582 0.20 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr1_+_16865561 0.20 ENST00000601199.1
AL355149.2
family with sequence similarity 231, member B
chr14_+_64565442 0.20 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr11_-_67188642 0.19 ENST00000546202.1
ENST00000542876.1
PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr12_+_15475331 0.18 ENST00000281171.4
PTPRO
protein tyrosine phosphatase, receptor type, O
chr11_+_8040739 0.16 ENST00000534099.1
TUB
tubby bipartite transcription factor
chr9_+_139560197 0.15 ENST00000371698.3
EGFL7
EGF-like-domain, multiple 7
chr1_-_43232649 0.14 ENST00000372526.2
ENST00000236040.4
ENST00000296388.5
ENST00000397054.3
LEPRE1
leucine proline-enriched proteoglycan (leprecan) 1
chr16_+_88636875 0.14 ENST00000569435.1
ZC3H18
zinc finger CCCH-type containing 18
chrX_-_73072534 0.14 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr8_-_135652051 0.14 ENST00000522257.1
ZFAT
zinc finger and AT hook domain containing
chr20_+_61569463 0.14 ENST00000266069.3
GID8
GID complex subunit 8
chr8_+_81397846 0.14 ENST00000379091.4
ZBTB10
zinc finger and BTB domain containing 10
chr5_-_61031495 0.13 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2
CTD-2170G1.2
chr11_+_58910295 0.12 ENST00000420244.1
FAM111A
family with sequence similarity 111, member A
chr4_-_83295296 0.12 ENST00000507010.1
ENST00000503822.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr4_+_667307 0.11 ENST00000506838.1
MYL5
myosin, light chain 5, regulatory
chr7_-_23571586 0.11 ENST00000538367.1
ENST00000392502.4
ENST00000297071.4
TRA2A
transformer 2 alpha homolog (Drosophila)
chr12_+_69979446 0.10 ENST00000543146.2
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr17_+_42634844 0.08 ENST00000315323.3
FZD2
frizzled family receptor 2
chr3_+_148709128 0.08 ENST00000345003.4
ENST00000296048.6
ENST00000483267.1
GYG1
glycogenin 1
chr1_+_151043070 0.07 ENST00000368918.3
ENST00000368917.1
GABPB2
GA binding protein transcription factor, beta subunit 2
chr8_+_94712752 0.07 ENST00000522324.1
ENST00000522803.1
ENST00000423990.2
FAM92A1
family with sequence similarity 92, member A1
chr19_+_50180317 0.05 ENST00000534465.1
PRMT1
protein arginine methyltransferase 1
chr7_-_38398721 0.05 ENST00000390346.2
TRGV3
T cell receptor gamma variable 3
chr1_+_27114589 0.04 ENST00000431541.1
ENST00000449950.2
ENST00000374145.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr2_+_234296792 0.04 ENST00000409813.3
DGKD
diacylglycerol kinase, delta 130kDa
chr19_-_11639910 0.04 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr12_+_104682496 0.04 ENST00000378070.4
TXNRD1
thioredoxin reductase 1
chr6_-_8064567 0.04 ENST00000543936.1
ENST00000397457.2
BLOC1S5
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr4_-_83295103 0.03 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr1_+_55107489 0.03 ENST00000395690.2
MROH7
maestro heat-like repeat family member 7
chr1_+_171750776 0.02 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chr9_-_16727978 0.02 ENST00000418777.1
ENST00000468187.2
BNC2
basonuclin 2
chr15_-_66797172 0.01 ENST00000569438.1
ENST00000569696.1
ENST00000307961.6
RPL4
ribosomal protein L4
chr1_+_54359854 0.01 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
DIO1
deiodinase, iodothyronine, type I
chr1_+_27114418 0.01 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr9_+_96338647 0.01 ENST00000359246.4
PHF2
PHD finger protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0061580 colon epithelial cell migration(GO:0061580)
0.2 0.6 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 0.8 GO:1990936 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.1 0.4 GO:0035425 autocrine signaling(GO:0035425)
0.1 0.4 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.1 0.6 GO:0030578 PML body organization(GO:0030578)
0.0 0.1 GO:1904585 response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586) hepatocyte dedifferentiation(GO:1990828)
0.0 0.6 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.0 1.2 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.2 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.0 0.1 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
0.0 0.3 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.8 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.1 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.0 0.3 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.6 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0089701 U2AF(GO:0089701)
0.0 0.4 GO:1990909 Wnt signalosome(GO:1990909)
0.0 2.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.1 0.4 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.1 0.3 GO:0098626 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.1 0.3 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.1 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.4 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.3 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.8 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 1.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.6 GO:0032183 SUMO binding(GO:0032183)
0.0 0.5 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.9 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.6 PID MYC PATHWAY C-MYC pathway
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels