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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for REST

Z-value: 1.21

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 RE1 silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.991.3e-02Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_99609996 2.24 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr19_+_39759154 2.02 ENST00000331982.5
IFNL2
interferon, lambda 2
chrX_-_153141302 1.82 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1CAM
L1 cell adhesion molecule
chr19_-_51845378 1.08 ENST00000335624.4
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr12_+_52695617 1.07 ENST00000293525.5
KRT86
keratin 86
chrX_-_153141434 0.96 ENST00000407935.2
ENST00000439496.1
L1CAM
L1 cell adhesion molecule
chr6_+_43603552 0.73 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr15_+_75287861 0.70 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
SCAMP5
secretory carrier membrane protein 5
chr19_-_3971050 0.69 ENST00000545797.2
ENST00000596311.1
DAPK3
death-associated protein kinase 3
chr5_-_176037105 0.68 ENST00000303991.4
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr20_+_62327996 0.62 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr8_-_145559943 0.62 ENST00000332135.4
SCRT1
scratch family zinc finger 1
chr14_-_51562037 0.53 ENST00000338969.5
TRIM9
tripartite motif containing 9
chr19_-_45927097 0.53 ENST00000340192.7
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr16_+_3019309 0.45 ENST00000576565.1
PAQR4
progestin and adipoQ receptor family member IV
chr8_-_145752390 0.45 ENST00000529415.2
ENST00000533758.1
LRRC24
leucine rich repeat containing 24
chrX_-_49056635 0.43 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
SYP
synaptophysin
chr16_+_3019246 0.43 ENST00000318782.8
ENST00000293978.8
PAQR4
progestin and adipoQ receptor family member IV
chr12_+_113229737 0.42 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr5_+_167956121 0.40 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr19_-_45926739 0.37 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr20_-_62284766 0.37 ENST00000370053.1
STMN3
stathmin-like 3
chr16_+_335680 0.37 ENST00000435833.1
PDIA2
protein disulfide isomerase family A, member 2
chr12_+_113229543 0.35 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr9_+_140033862 0.33 ENST00000350902.5
ENST00000371550.4
ENST00000371546.4
ENST00000371555.4
ENST00000371553.3
ENST00000371559.4
ENST00000371560.3
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr3_-_48700310 0.33 ENST00000164024.4
ENST00000544264.1
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3
chr19_-_11639910 0.33 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr12_+_113796347 0.33 ENST00000545182.2
ENST00000280800.3
PLBD2
phospholipase B domain containing 2
chr14_-_51561784 0.32 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr2_+_46524537 0.32 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr10_-_79398250 0.32 ENST00000286627.5
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr10_-_50970322 0.31 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr12_+_113229452 0.30 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chrX_-_153237258 0.29 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr7_-_100808394 0.28 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr10_-_79398127 0.28 ENST00000372443.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr10_-_50970382 0.28 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr9_+_93921855 0.27 ENST00000423719.2
ENST00000609752.1
LINC00484
long intergenic non-protein coding RNA 484
chr19_-_45927622 0.27 ENST00000300853.3
ENST00000589165.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_-_55691472 0.25 ENST00000537500.1
SYT5
synaptotagmin V
chr17_+_30813576 0.23 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr2_-_47798044 0.23 ENST00000327876.4
KCNK12
potassium channel, subfamily K, member 12
chr10_+_102790980 0.22 ENST00000393459.1
ENST00000224807.5
SFXN3
sideroflexin 3
chr4_-_175750364 0.20 ENST00000340217.5
ENST00000274093.3
GLRA3
glycine receptor, alpha 3
chr15_-_83378611 0.20 ENST00000542200.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr17_-_27332931 0.18 ENST00000442608.3
ENST00000335960.6
SEZ6
seizure related 6 homolog (mouse)
chr3_+_120626919 0.17 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
STXBP5L
syntaxin binding protein 5-like
chr14_+_93389425 0.17 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr19_-_11639931 0.17 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr15_-_79576156 0.16 ENST00000560452.1
ENST00000560872.1
ENST00000560732.1
ENST00000559979.1
ENST00000560533.1
ENST00000559225.1
RP11-17L5.4
RP11-17L5.4
chr11_-_72492878 0.16 ENST00000535054.1
ENST00000545082.1
STARD10
StAR-related lipid transfer (START) domain containing 10
chrX_+_153237740 0.16 ENST00000369982.4
TMEM187
transmembrane protein 187
chr12_+_71833550 0.16 ENST00000266674.5
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr19_-_40724246 0.16 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr14_-_74892805 0.16 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr2_+_131513864 0.16 ENST00000458606.1
ENST00000423981.1
AMER3
APC membrane recruitment protein 3
chr10_-_102790852 0.15 ENST00000470414.1
ENST00000370215.3
PDZD7
PDZ domain containing 7
chr3_+_9745510 0.15 ENST00000383831.3
CPNE9
copine family member IX
chr7_-_100808843 0.15 ENST00000249330.2
VGF
VGF nerve growth factor inducible
chr1_-_175712665 0.14 ENST00000263525.2
TNR
tenascin R
chrX_-_47479246 0.13 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr15_-_83378526 0.13 ENST00000535348.1
ENST00000535359.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr12_-_99288986 0.13 ENST00000552407.1
ENST00000551613.1
ENST00000548447.1
ENST00000546364.3
ENST00000552748.1
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_+_226265364 0.12 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr17_-_7218403 0.12 ENST00000570780.1
GPS2
G protein pathway suppressor 2
chr2_-_51259528 0.11 ENST00000404971.1
NRXN1
neurexin 1
chr1_+_210111570 0.11 ENST00000367019.1
ENST00000472886.1
SYT14
synaptotagmin XIV
chr17_+_42385927 0.11 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
RUNDC3A
RUN domain containing 3A
chr9_-_139096955 0.11 ENST00000371748.5
LHX3
LIM homeobox 3
chr13_-_111214015 0.11 ENST00000267328.3
RAB20
RAB20, member RAS oncogene family
chr1_+_212606219 0.10 ENST00000366988.3
NENF
neudesin neurotrophic factor
chr11_-_66115032 0.10 ENST00000311181.4
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr4_+_96012585 0.09 ENST00000502683.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr12_-_29936731 0.08 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr19_-_55691614 0.08 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr6_+_25652501 0.08 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr12_+_71833756 0.08 ENST00000536515.1
ENST00000540815.2
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr2_-_51259641 0.07 ENST00000406316.2
ENST00000405581.1
NRXN1
neurexin 1
chr1_+_65775204 0.07 ENST00000371069.4
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr10_+_26505179 0.07 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_+_154540246 0.06 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr17_-_27333311 0.05 ENST00000317338.12
ENST00000585644.1
SEZ6
seizure related 6 homolog (mouse)
chr20_+_44657845 0.05 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr18_+_57567180 0.04 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr11_-_6677018 0.03 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chr1_+_171750776 0.02 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chr12_-_12837423 0.02 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chrX_+_153238220 0.01 ENST00000425274.1
TMEM187
transmembrane protein 187
chr12_+_119419294 0.01 ENST00000267260.4
SRRM4
serine/arginine repetitive matrix 4

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.2 1.2 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.2 2.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.4 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.1 0.6 GO:0021586 pons maturation(GO:0021586)
0.1 2.0 GO:0002385 mucosal immune response(GO:0002385)
0.1 0.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 0.3 GO:0019046 release from viral latency(GO:0019046)
0.1 0.2 GO:1900738 dense core granule biogenesis(GO:0061110) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.6 GO:0034465 response to carbon monoxide(GO:0034465)
0.0 0.3 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.0 0.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.7 GO:0031033 myosin filament organization(GO:0031033)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:0032105 regulation of response to food(GO:0032095) negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.0 0.2 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 2.8 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.4 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.2 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.7 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 1.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.7 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.1 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.1 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.6 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.4 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.0 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.1 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 2.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 2.7 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.3 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.2 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.2 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.6 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.3 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 2.3 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.2 GO:0042583 chromaffin granule(GO:0042583)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 0.4 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.1 0.6 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 1.1 GO:0008430 selenium binding(GO:0008430) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 0.6 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 2.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.3 GO:1904315 postsynaptic neurotransmitter receptor activity(GO:0098960) neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.2 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.4 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.3 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.6 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.8 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.2 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor