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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for RORC

Z-value: 0.44

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.12 RAR related orphan receptor C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg19_v2_chr1_-_151798546_151798590-0.505.0e-01Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_39759154 0.44 ENST00000331982.5
IFNL2
interferon, lambda 2
chr16_+_1832902 0.30 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
NUBP2
nucleotide binding protein 2
chr12_+_7167980 0.28 ENST00000360817.5
ENST00000402681.3
C1S
complement component 1, s subcomponent
chr3_-_117716418 0.24 ENST00000484092.1
RP11-384F7.2
RP11-384F7.2
chr1_-_1763721 0.24 ENST00000437146.1
GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr4_-_170948361 0.22 ENST00000393702.3
MFAP3L
microfibrillar-associated protein 3-like
chr19_-_8567478 0.21 ENST00000255612.3
PRAM1
PML-RARA regulated adaptor molecule 1
chr12_+_13061894 0.20 ENST00000540125.1
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr20_-_33732952 0.20 ENST00000541621.1
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr11_-_47616210 0.19 ENST00000302514.3
C1QTNF4
C1q and tumor necrosis factor related protein 4
chr19_-_39735646 0.19 ENST00000413851.2
IFNL3
interferon, lambda 3
chr19_+_12780512 0.18 ENST00000242796.4
WDR83
WD repeat domain 83
chr12_+_93963590 0.17 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr17_-_42992856 0.15 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP
glial fibrillary acidic protein
chr12_+_93964158 0.15 ENST00000549206.1
SOCS2
suppressor of cytokine signaling 2
chr8_-_116673894 0.15 ENST00000395713.2
TRPS1
trichorhinophalangeal syndrome I
chr14_+_23025534 0.14 ENST00000557595.1
AE000662.92
Uncharacterized protein
chr19_-_46580352 0.13 ENST00000601672.1
IGFL4
IGF-like family member 4
chr22_-_32022280 0.13 ENST00000442379.1
PISD
phosphatidylserine decarboxylase
chr19_-_7697857 0.12 ENST00000598935.1
PCP2
Purkinje cell protein 2
chr1_+_67632083 0.12 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr8_+_66955648 0.12 ENST00000522619.1
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr19_+_38924316 0.10 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1
ryanodine receptor 1 (skeletal)
chrX_-_110655391 0.10 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr4_+_110749143 0.10 ENST00000317735.4
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr12_-_54652060 0.10 ENST00000552562.1
CBX5
chromobox homolog 5
chr16_+_16326352 0.09 ENST00000399336.4
ENST00000263012.6
ENST00000538468.1
NOMO3
NODAL modulator 3
chr2_+_119699864 0.09 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr3_-_164914640 0.09 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr9_-_110251836 0.09 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr2_+_20650796 0.08 ENST00000448241.1
AC023137.2
AC023137.2
chr16_-_1821496 0.08 ENST00000564628.1
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr14_+_21785693 0.08 ENST00000382933.4
ENST00000557351.1
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr6_+_138266498 0.08 ENST00000434437.1
ENST00000417800.1
RP11-240M16.1
RP11-240M16.1
chr2_+_119699742 0.08 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr4_-_120243545 0.08 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr10_-_21435488 0.08 ENST00000534331.1
ENST00000529198.1
ENST00000377118.4
C10orf113
chromosome 10 open reading frame 113
chr5_+_177557997 0.08 ENST00000313386.4
ENST00000515098.1
ENST00000542098.1
ENST00000502814.1
ENST00000507457.1
ENST00000508647.1
RMND5B
required for meiotic nuclear division 5 homolog B (S. cerevisiae)
chr1_+_205197304 0.08 ENST00000358024.3
TMCC2
transmembrane and coiled-coil domain family 2
chr15_+_31508174 0.07 ENST00000559292.2
ENST00000557928.1
RP11-16E12.1
RP11-16E12.1
chr12_+_56414795 0.07 ENST00000431367.2
IKZF4
IKAROS family zinc finger 4 (Eos)
chr12_-_82152444 0.07 ENST00000549325.1
ENST00000550584.2
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr13_+_109248500 0.07 ENST00000356711.2
MYO16
myosin XVI
chr17_-_48785216 0.07 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr6_-_46922659 0.06 ENST00000265417.7
GPR116
G protein-coupled receptor 116
chrX_-_43832711 0.06 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chrX_-_49089771 0.06 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr10_-_105845674 0.06 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr10_+_102295616 0.06 ENST00000299163.6
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr19_+_1269324 0.06 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP
cold inducible RNA binding protein
chr2_-_30144432 0.06 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chr1_+_236849754 0.05 ENST00000542672.1
ENST00000366578.4
ACTN2
actinin, alpha 2
chr1_-_153522562 0.05 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chr10_-_105845536 0.05 ENST00000393211.3
COL17A1
collagen, type XVII, alpha 1
chr11_+_65292884 0.05 ENST00000527009.1
SCYL1
SCY1-like 1 (S. cerevisiae)
chr4_+_140586922 0.04 ENST00000265498.1
ENST00000506797.1
MGST2
microsomal glutathione S-transferase 2
chr19_-_10450287 0.04 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
ICAM3
intercellular adhesion molecule 3
chr12_+_4671352 0.04 ENST00000542744.1
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr1_-_217311090 0.04 ENST00000493603.1
ENST00000366940.2
ESRRG
estrogen-related receptor gamma
chr16_-_67514982 0.04 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr3_+_45986511 0.04 ENST00000458629.1
ENST00000457814.1
CXCR6
chemokine (C-X-C motif) receptor 6
chr14_-_23755297 0.03 ENST00000357460.5
HOMEZ
homeobox and leucine zipper encoding
chr6_+_44094627 0.03 ENST00000259746.9
TMEM63B
transmembrane protein 63B
chr3_-_65583561 0.03 ENST00000460329.2
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr7_+_97736197 0.03 ENST00000297293.5
LMTK2
lemur tyrosine kinase 2
chr21_+_17553910 0.03 ENST00000428669.2
LINC00478
long intergenic non-protein coding RNA 478
chr20_-_44007014 0.03 ENST00000372726.3
ENST00000537995.1
TP53TG5
TP53 target 5
chr7_+_127527965 0.03 ENST00000486037.1
SND1
staphylococcal nuclease and tudor domain containing 1
chr4_+_169633310 0.03 ENST00000510998.1
PALLD
palladin, cytoskeletal associated protein
chr7_+_20686946 0.02 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr1_-_157069590 0.02 ENST00000454449.2
ETV3L
ets variant 3-like
chr3_+_160559931 0.01 ENST00000464260.1
ENST00000295839.9
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr16_+_30936971 0.01 ENST00000565690.1
FBXL19
F-box and leucine-rich repeat protein 19
chr7_-_128415844 0.01 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr6_+_43738444 0.01 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
VEGFA
vascular endothelial growth factor A
chr17_-_10707410 0.00 ENST00000581851.1
LINC00675
long intergenic non-protein coding RNA 675

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.1 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.4 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.0 0.1 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 0.1 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.1 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.0 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.1 REACTOME OPSINS Genes involved in Opsins