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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for SIX1_SIX3_SIX2

Z-value: 1.07

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Transcription factors associated with SIX1_SIX3_SIX2

Gene Symbol Gene ID Gene Info
SIX1
ENSG00000126778.7 SIX homeobox 1
SIX3
ENSG00000138083.3 SIX homeobox 3
SIX2
ENSG00000170577.7 SIX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX1hg19_v2_chr14_-_61124977_61125037-0.742.6e-01Click!
SIX3hg19_v2_chr2_+_45168875_45168916-0.188.2e-01Click!

Activity profile of SIX1_SIX3_SIX2 motif

Sorted Z-values of SIX1_SIX3_SIX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_241695424 1.40 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr10_-_33405600 1.37 ENST00000414308.1
RP11-342D11.3
RP11-342D11.3
chr1_+_241695670 1.33 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr15_-_31521567 1.10 ENST00000560812.1
ENST00000559853.1
ENST00000558109.1
RP11-16E12.2
RP11-16E12.2
chr13_-_46679144 0.97 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr5_-_159846066 0.84 ENST00000519349.1
ENST00000520664.1
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr13_-_46679185 0.81 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr16_-_28550320 0.76 ENST00000395641.2
NUPR1
nuclear protein, transcriptional regulator, 1
chr7_+_139025875 0.65 ENST00000297534.6
C7orf55
chromosome 7 open reading frame 55
chr6_-_136847099 0.64 ENST00000438100.2
MAP7
microtubule-associated protein 7
chr6_-_136847610 0.63 ENST00000454590.1
ENST00000432797.2
MAP7
microtubule-associated protein 7
chr17_+_4675175 0.63 ENST00000270560.3
TM4SF5
transmembrane 4 L six family member 5
chr16_+_22517166 0.62 ENST00000356156.3
NPIPB5
nuclear pore complex interacting protein family, member B5
chr9_-_34662651 0.61 ENST00000259631.4
CCL27
chemokine (C-C motif) ligand 27
chr16_-_28550348 0.60 ENST00000324873.6
NUPR1
nuclear protein, transcriptional regulator, 1
chr15_+_75491203 0.59 ENST00000562637.1
C15orf39
chromosome 15 open reading frame 39
chr3_+_149191723 0.57 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr4_-_140477928 0.57 ENST00000274031.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr9_+_67977438 0.55 ENST00000456982.1
RP11-195B21.3
Protein LOC644249
chr2_-_150444300 0.54 ENST00000303319.5
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr19_+_45445524 0.51 ENST00000591600.1
APOC4
apolipoprotein C-IV
chr10_-_134331695 0.49 ENST00000455414.1
RP11-432J24.5
RP11-432J24.5
chr12_+_147052 0.48 ENST00000594563.1
AC026369.1
Uncharacterized protein
chr1_+_64014588 0.46 ENST00000371086.2
ENST00000340052.3
DLEU2L
deleted in lymphocytic leukemia 2-like
chr3_+_149192475 0.46 ENST00000465758.1
TM4SF4
transmembrane 4 L six family member 4
chr1_+_207277632 0.44 ENST00000421786.1
C4BPA
complement component 4 binding protein, alpha
chr4_+_89300158 0.43 ENST00000502870.1
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr16_+_19098178 0.43 ENST00000568032.1
RP11-626G11.4
RP11-626G11.4
chr4_-_140477910 0.42 ENST00000404104.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr1_+_214776516 0.40 ENST00000366955.3
CENPF
centromere protein F, 350/400kDa
chr12_-_10826612 0.39 ENST00000535345.1
ENST00000542562.1
STYK1
serine/threonine/tyrosine kinase 1
chr15_+_59279851 0.39 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr1_-_109618566 0.38 ENST00000338366.5
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr1_-_207119738 0.38 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr8_-_95229531 0.36 ENST00000450165.2
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr17_-_7080883 0.36 ENST00000570576.1
ASGR1
asialoglycoprotein receptor 1
chr3_-_149095652 0.36 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr4_-_467892 0.35 ENST00000506646.1
ENST00000505900.1
ZNF721
zinc finger protein 721
chr11_-_8892900 0.34 ENST00000526155.1
ENST00000524757.1
ENST00000527392.1
ENST00000534665.1
ENST00000525169.1
ENST00000527516.1
ENST00000533471.1
ST5
suppression of tumorigenicity 5
chr14_-_74296806 0.34 ENST00000555539.1
RP5-1021I20.2
RP5-1021I20.2
chr4_+_155484155 0.33 ENST00000509493.1
FGB
fibrinogen beta chain
chr7_-_48068643 0.33 ENST00000453192.2
SUN3
Sad1 and UNC84 domain containing 3
chr2_-_150444116 0.33 ENST00000428879.1
ENST00000422782.2
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr6_-_138428613 0.33 ENST00000421351.3
PERP
PERP, TP53 apoptosis effector
chr16_+_29690358 0.31 ENST00000395384.4
ENST00000562473.1
QPRT
quinolinate phosphoribosyltransferase
chr10_-_38265517 0.31 ENST00000302609.7
ZNF25
zinc finger protein 25
chr20_-_55100981 0.30 ENST00000243913.4
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr4_+_2794750 0.29 ENST00000452765.2
ENST00000389838.2
SH3BP2
SH3-domain binding protein 2
chr4_+_159131346 0.29 ENST00000508243.1
ENST00000296529.6
TMEM144
transmembrane protein 144
chr1_+_53793885 0.28 ENST00000445039.2
RP4-784A16.5
RP4-784A16.5
chr2_+_161993465 0.28 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr14_+_54863667 0.28 ENST00000335183.6
CDKN3
cyclin-dependent kinase inhibitor 3
chr1_+_150245099 0.28 ENST00000369099.3
C1orf54
chromosome 1 open reading frame 54
chr14_+_54863682 0.27 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
CDKN3
cyclin-dependent kinase inhibitor 3
chr1_+_93913665 0.27 ENST00000271234.7
ENST00000370256.4
ENST00000260506.8
FNBP1L
formin binding protein 1-like
chr11_+_327171 0.27 ENST00000534483.1
ENST00000524824.1
ENST00000531076.1
RP11-326C3.12
RP11-326C3.12
chr12_-_112614506 0.27 ENST00000548588.2
HECTD4
HECT domain containing E3 ubiquitin protein ligase 4
chr2_+_183989157 0.27 ENST00000541912.1
NUP35
nucleoporin 35kDa
chr3_+_11267691 0.26 ENST00000413416.1
HRH1
histamine receptor H1
chr10_-_103603523 0.26 ENST00000370046.1
KCNIP2
Kv channel interacting protein 2
chr12_-_53594227 0.26 ENST00000550743.2
ITGB7
integrin, beta 7
chr3_+_184529929 0.25 ENST00000287546.4
ENST00000437079.3
VPS8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr8_+_19536083 0.25 ENST00000519803.1
RP11-1105O14.1
RP11-1105O14.1
chr11_-_2924720 0.24 ENST00000455942.2
SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr3_+_172034218 0.24 ENST00000366261.2
AC092964.1
Uncharacterized protein
chr14_+_58711539 0.24 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr11_+_85339623 0.23 ENST00000358867.6
ENST00000534341.1
ENST00000393375.1
ENST00000531274.1
TMEM126B
transmembrane protein 126B
chr11_+_17298522 0.23 ENST00000529313.1
NUCB2
nucleobindin 2
chr11_+_71900572 0.23 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr4_-_14889791 0.23 ENST00000509654.1
ENST00000515031.1
ENST00000505089.2
LINC00504
long intergenic non-protein coding RNA 504
chr19_+_11750566 0.23 ENST00000344893.3
ZNF833P
zinc finger protein 833, pseudogene
chr1_-_44818599 0.22 ENST00000537474.1
ERI3
ERI1 exoribonuclease family member 3
chr1_-_169337176 0.22 ENST00000472647.1
ENST00000367811.3
NME7
NME/NM23 family member 7
chr19_+_11457232 0.22 ENST00000587531.1
CCDC159
coiled-coil domain containing 159
chr9_-_113018746 0.22 ENST00000374515.5
TXN
thioredoxin
chr6_+_96969672 0.22 ENST00000369278.4
UFL1
UFM1-specific ligase 1
chr22_+_21321531 0.21 ENST00000405089.1
ENST00000335375.5
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr1_+_150245177 0.21 ENST00000369098.3
C1orf54
chromosome 1 open reading frame 54
chr14_+_91709103 0.20 ENST00000553725.1
CTD-2547L24.3
HCG1816139; Uncharacterized protein
chr15_-_100258029 0.20 ENST00000378904.2
DKFZP779J2370
DKFZP779J2370
chr2_-_105953912 0.20 ENST00000610036.1
RP11-332H14.2
RP11-332H14.2
chr12_+_16500037 0.20 ENST00000536371.1
ENST00000010404.2
MGST1
microsomal glutathione S-transferase 1
chr2_-_128615681 0.20 ENST00000409955.1
ENST00000272645.4
POLR2D
polymerase (RNA) II (DNA directed) polypeptide D
chr14_-_94759361 0.20 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr1_+_215740709 0.20 ENST00000259154.4
KCTD3
potassium channel tetramerization domain containing 3
chr2_-_220034745 0.20 ENST00000455516.2
ENST00000396775.3
ENST00000295738.7
SLC23A3
solute carrier family 23, member 3
chrX_+_75392771 0.20 ENST00000373358.3
ENST00000373357.3
PBDC1
polysaccharide biosynthesis domain containing 1
chr7_-_141541221 0.20 ENST00000350549.3
ENST00000438520.1
PRSS37
protease, serine, 37
chr2_-_107502456 0.20 ENST00000419159.2
ST6GAL2
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
chr7_+_90012986 0.19 ENST00000416322.1
CLDN12
claudin 12
chr11_-_118134997 0.19 ENST00000278937.2
MPZL2
myelin protein zero-like 2
chr18_+_61575200 0.19 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr19_+_45445491 0.19 ENST00000592954.1
ENST00000419266.2
ENST00000589057.1
APOC4
APOC4-APOC2
apolipoprotein C-IV
APOC4-APOC2 readthrough (NMD candidate)
chr3_+_184529948 0.19 ENST00000436792.2
ENST00000446204.2
ENST00000422105.1
VPS8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr2_+_211421262 0.19 ENST00000233072.5
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr14_+_54863739 0.18 ENST00000541304.1
CDKN3
cyclin-dependent kinase inhibitor 3
chr11_+_102552041 0.18 ENST00000537079.1
RP11-817J15.3
Uncharacterized protein
chr5_-_145562147 0.18 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
LARS
leucyl-tRNA synthetase
chr4_-_156298028 0.18 ENST00000433024.1
ENST00000379248.2
MAP9
microtubule-associated protein 9
chr14_-_24729251 0.18 ENST00000559136.1
TGM1
transglutaminase 1
chr7_-_92219337 0.18 ENST00000456502.1
ENST00000427372.1
FAM133B
family with sequence similarity 133, member B
chr15_+_40331456 0.18 ENST00000504245.1
ENST00000560341.1
SRP14-AS1
SRP14 antisense RNA1 (head to head)
chr8_-_124749609 0.18 ENST00000262219.6
ENST00000419625.1
ANXA13
annexin A13
chr1_-_179457805 0.18 ENST00000600581.1
AL160286.1
Uncharacterized protein
chr12_-_89920030 0.18 ENST00000413530.1
ENST00000547474.1
GALNT4
POC1B-GALNT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chr17_-_33446735 0.18 ENST00000460118.2
ENST00000335858.7
RAD51D
RAD51 paralog D
chr17_+_73997796 0.17 ENST00000586261.1
CDK3
cyclin-dependent kinase 3
chr6_-_31846744 0.17 ENST00000414427.1
ENST00000229729.6
ENST00000375562.4
SLC44A4
solute carrier family 44, member 4
chr11_-_76155618 0.17 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr1_-_108743471 0.17 ENST00000569674.1
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr11_-_118135160 0.17 ENST00000438295.2
MPZL2
myelin protein zero-like 2
chr12_-_89919965 0.17 ENST00000548729.1
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr11_-_111794446 0.17 ENST00000527950.1
CRYAB
crystallin, alpha B
chr12_+_49717019 0.17 ENST00000549275.1
ENST00000551245.1
ENST00000380327.5
ENST00000548311.1
ENST00000550346.1
ENST00000550709.1
ENST00000549534.1
ENST00000257909.3
TROAP
trophinin associated protein
chr11_+_34654011 0.17 ENST00000531794.1
EHF
ets homologous factor
chr1_+_207277590 0.17 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr14_-_94759595 0.17 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr11_+_100862811 0.16 ENST00000303130.2
TMEM133
transmembrane protein 133
chr12_-_49523896 0.16 ENST00000549870.1
TUBA1B
tubulin, alpha 1b
chr4_+_119199904 0.16 ENST00000602483.1
ENST00000602819.1
SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr3_+_42850959 0.16 ENST00000442925.1
ENST00000422265.1
ENST00000497921.1
ENST00000426937.1
ACKR2
KRBOX1
atypical chemokine receptor 2
KRAB box domain containing 1
chr19_+_42055879 0.15 ENST00000407170.2
ENST00000601116.1
ENST00000595395.1
CEACAM21
AC006129.2
carcinoembryonic antigen-related cell adhesion molecule 21
AC006129.2
chrX_-_154060946 0.15 ENST00000369529.1
SMIM9
small integral membrane protein 9
chr5_-_133304473 0.15 ENST00000231512.3
C5orf15
chromosome 5 open reading frame 15
chr1_+_198189921 0.15 ENST00000391974.3
NEK7
NIMA-related kinase 7
chr17_-_45056606 0.15 ENST00000322329.3
RPRML
reprimo-like
chr6_+_147830362 0.15 ENST00000566741.1
SAMD5
sterile alpha motif domain containing 5
chr9_-_117568365 0.15 ENST00000374045.4
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr3_-_129147432 0.15 ENST00000503957.1
ENST00000505956.1
ENST00000326085.3
EFCAB12
EF-hand calcium binding domain 12
chr12_-_53901266 0.14 ENST00000609999.1
ENST00000267017.3
NPFF
neuropeptide FF-amide peptide precursor
chr7_-_92219698 0.14 ENST00000438306.1
ENST00000445716.1
FAM133B
family with sequence similarity 133, member B
chr9_-_27005686 0.14 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chr2_-_55496344 0.14 ENST00000403721.1
ENST00000263629.4
MTIF2
mitochondrial translational initiation factor 2
chr8_+_76452097 0.14 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr4_-_156297919 0.14 ENST00000450097.1
MAP9
microtubule-associated protein 9
chr4_+_159131596 0.14 ENST00000512481.1
TMEM144
transmembrane protein 144
chr2_-_18770812 0.13 ENST00000359846.2
ENST00000304081.4
ENST00000600945.1
ENST00000532967.1
ENST00000444297.2
NT5C1B
NT5C1B-RDH14
5'-nucleotidase, cytosolic IB
NT5C1B-RDH14 readthrough
chr17_-_4938712 0.13 ENST00000254853.5
ENST00000424747.1
SLC52A1
solute carrier family 52 (riboflavin transporter), member 1
chrX_+_101906294 0.13 ENST00000361600.5
ENST00000415986.1
ENST00000444152.1
ENST00000537097.1
GPRASP1
G protein-coupled receptor associated sorting protein 1
chr10_+_48359344 0.13 ENST00000412534.1
ENST00000444585.1
ZNF488
zinc finger protein 488
chr19_-_3600549 0.13 ENST00000589966.1
TBXA2R
thromboxane A2 receptor
chr16_+_16481306 0.13 ENST00000422673.2
NPIPA7
nuclear pore complex interacting protein family, member A7
chr16_+_84402098 0.13 ENST00000262429.4
ENST00000416219.2
ATP2C2
ATPase, Ca++ transporting, type 2C, member 2
chr7_+_141490017 0.13 ENST00000247883.4
TAS2R5
taste receptor, type 2, member 5
chr15_+_75041184 0.13 ENST00000343932.4
CYP1A2
cytochrome P450, family 1, subfamily A, polypeptide 2
chr7_+_95171457 0.13 ENST00000601424.1
AC002451.1
Protein LOC100996577
chr6_-_32160622 0.12 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr3_+_187957646 0.12 ENST00000457242.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr7_+_16685756 0.12 ENST00000415365.1
ENST00000258761.3
ENST00000433922.2
ENST00000452975.2
ENST00000405202.1
BZW2
basic leucine zipper and W2 domains 2
chr1_-_171711387 0.12 ENST00000236192.7
VAMP4
vesicle-associated membrane protein 4
chr10_+_104613980 0.12 ENST00000339834.5
C10orf32
chromosome 10 open reading frame 32
chr2_+_58134756 0.12 ENST00000435505.2
ENST00000417641.2
VRK2
vaccinia related kinase 2
chr8_+_95835438 0.11 ENST00000521860.1
ENST00000519457.1
ENST00000519053.1
ENST00000523731.1
ENST00000447247.1
INTS8
integrator complex subunit 8
chr9_+_6645887 0.11 ENST00000413145.1
RP11-390F4.6
RP11-390F4.6
chr16_+_22524379 0.11 ENST00000536620.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr11_+_58874658 0.11 ENST00000411426.1
FAM111B
family with sequence similarity 111, member B
chr16_-_15736345 0.11 ENST00000549219.1
KIAA0430
KIAA0430
chr5_+_70220768 0.11 ENST00000351205.4
ENST00000503079.2
ENST00000380707.4
ENST00000514951.1
ENST00000506163.1
SMN1
survival of motor neuron 1, telomeric
chr1_+_17531614 0.11 ENST00000375471.4
PADI1
peptidyl arginine deiminase, type I
chr5_-_141392538 0.11 ENST00000503794.1
ENST00000510194.1
ENST00000504424.1
ENST00000513454.1
ENST00000458112.2
ENST00000542860.1
ENST00000503229.1
ENST00000500692.2
ENST00000311337.6
ENST00000504139.1
ENST00000505689.1
GNPDA1
glucosamine-6-phosphate deaminase 1
chr8_-_83589388 0.11 ENST00000522776.1
RP11-653B10.1
RP11-653B10.1
chr3_-_196669298 0.11 ENST00000411704.1
ENST00000452404.2
NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr2_-_207630033 0.11 ENST00000449792.1
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr17_+_43213004 0.11 ENST00000586346.1
ENST00000398322.3
ENST00000592162.1
ENST00000376955.4
ENST00000321854.8
ACBD4
acyl-CoA binding domain containing 4
chr11_+_125365110 0.11 ENST00000527818.1
AP000708.1
AP000708.1
chr8_+_35649365 0.11 ENST00000437887.1
AC012215.1
Uncharacterized protein
chr11_-_82782952 0.11 ENST00000534141.1
RAB30
RAB30, member RAS oncogene family
chr2_-_198299726 0.11 ENST00000409915.4
ENST00000487698.1
ENST00000414963.2
ENST00000335508.6
SF3B1
splicing factor 3b, subunit 1, 155kDa
chr4_-_156298087 0.11 ENST00000311277.4
MAP9
microtubule-associated protein 9
chr2_+_161993412 0.10 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr2_-_187367356 0.10 ENST00000595956.1
AC018867.2
AC018867.2
chr2_+_207630081 0.10 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr19_+_57999101 0.10 ENST00000347466.6
ENST00000523138.1
ENST00000415379.2
ENST00000521754.1
ENST00000221735.7
ENST00000518999.1
ENST00000521137.1
ZNF419
zinc finger protein 419
chr5_-_143550241 0.10 ENST00000522203.1
YIPF5
Yip1 domain family, member 5
chr17_+_75315654 0.10 ENST00000590595.1
SEPT9
septin 9
chrX_+_72064876 0.10 ENST00000373532.3
ENST00000333826.5
DMRTC1B
DMRT-like family C1B
chr8_-_29120604 0.10 ENST00000521515.1
KIF13B
kinesin family member 13B
chr17_-_8113542 0.10 ENST00000578549.1
ENST00000535053.1
ENST00000582368.1
AURKB
aurora kinase B
chr7_+_151771377 0.10 ENST00000434507.1
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr12_-_111395610 0.10 ENST00000548329.1
ENST00000546852.1
RP1-46F2.3
RP1-46F2.3
chr19_+_56116771 0.10 ENST00000568956.1
ZNF865
zinc finger protein 865
chr19_-_43702231 0.10 ENST00000597374.1
ENST00000599371.1
PSG4
pregnancy specific beta-1-glycoprotein 4
chr6_+_28048753 0.10 ENST00000377325.1
ZNF165
zinc finger protein 165
chr12_+_70574088 0.10 ENST00000552324.1
RP11-320P7.2
RP11-320P7.2
chr1_-_220220000 0.10 ENST00000366923.3
EPRS
glutamyl-prolyl-tRNA synthetase
chr3_+_141144954 0.10 ENST00000441582.2
ENST00000321464.5
ZBTB38
zinc finger and BTB domain containing 38
chr1_+_186265399 0.09 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr8_-_66546373 0.09 ENST00000518908.1
ENST00000458464.2
ENST00000519352.1
ARMC1
armadillo repeat containing 1
chr7_-_123198284 0.09 ENST00000355749.2
NDUFA5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr7_+_139026057 0.09 ENST00000541515.3
LUC7L2
LUC7-like 2 (S. cerevisiae)
chr4_-_156297949 0.09 ENST00000515654.1
MAP9
microtubule-associated protein 9
chr10_-_43762329 0.09 ENST00000395810.1
RASGEF1A
RasGEF domain family, member 1A
chr1_-_156647189 0.09 ENST00000368223.3
NES
nestin
chr20_+_34824355 0.09 ENST00000397286.3
ENST00000320849.4
ENST00000373932.3
AAR2
AAR2 splicing factor homolog (S. cerevisiae)
chr16_+_29832634 0.09 ENST00000565164.1
ENST00000570234.1
MVP
major vault protein
chr13_-_47471155 0.09 ENST00000543956.1
ENST00000542664.1
HTR2A
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
chr6_-_35656685 0.09 ENST00000539068.1
ENST00000540787.1
FKBP5
FK506 binding protein 5
chr4_-_83719884 0.09 ENST00000282709.4
ENST00000273908.4
SCD5
stearoyl-CoA desaturase 5
chr1_-_12908578 0.09 ENST00000317869.6
HNRNPCL1
heterogeneous nuclear ribonucleoprotein C-like 1
chr10_-_6622258 0.09 ENST00000263125.5
PRKCQ
protein kinase C, theta

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX1_SIX3_SIX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.4 2.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.2 0.3 GO:0046874 quinolinate metabolic process(GO:0046874)
0.1 0.7 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.3 GO:1903717 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.1 0.2 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.1 1.4 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 0.8 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.4 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 0.4 GO:0008218 bioluminescence(GO:0008218)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.6 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.1 0.2 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.2 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.1 1.0 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.2 GO:0006429 glutaminyl-tRNA aminoacylation(GO:0006425) leucyl-tRNA aminoacylation(GO:0006429)
0.1 0.3 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.2 GO:0046833 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.5 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 0.1 GO:0006043 glucosamine catabolic process(GO:0006043)
0.0 0.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.1 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.0 0.1 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.0 0.2 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.1 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 0.9 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.3 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.2 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.0 GO:0007398 ectoderm development(GO:0007398)
0.0 0.1 GO:2000570 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.2 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.1 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.1 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 0.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.3 GO:0002934 desmosome organization(GO:0002934)
0.0 0.4 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.1 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.1 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.1 GO:1902159 regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.0 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.0 0.1 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.4 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.0 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.1 GO:0071461 cellular response to redox state(GO:0071461)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.2 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.6 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.7 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.4 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 0.8 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.4 GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.1 0.4 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.2 GO:0061714 folic acid receptor activity(GO:0061714)
0.1 0.3 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.3 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1 0.2 GO:0004823 glutamine-tRNA ligase activity(GO:0004819) leucine-tRNA ligase activity(GO:0004823)
0.1 1.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0004960 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.4 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 0.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.1 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.3 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220) azole transporter activity(GO:0045118)
0.0 0.1 GO:0004766 spermidine synthase activity(GO:0004766)
0.0 0.1 GO:0033677 DNA/RNA helicase activity(GO:0033677)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.2 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 1.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.0 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.0 0.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.0 GO:0015616 DNA translocase activity(GO:0015616)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome