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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for SIX4

Z-value: 0.82

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
SIX4
ENSG00000100625.8 SIX homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX4hg19_v2_chr14_-_61191049_61191080-0.972.6e-02Click!

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_4488872 1.64 ENST00000237837.1
FGF23
fibroblast growth factor 23
chr2_-_42160486 0.85 ENST00000427054.1
AC104654.2
AC104654.2
chr9_+_132427883 0.72 ENST00000372469.4
PRRX2
paired related homeobox 2
chr20_-_4055812 0.69 ENST00000379526.1
RP11-352D3.2
Uncharacterized protein
chr15_+_41245160 0.68 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr6_+_53794780 0.66 ENST00000505762.1
ENST00000511369.1
ENST00000431554.2
MLIP
RP11-411K7.1
muscular LMNA-interacting protein
RP11-411K7.1
chr12_+_30948600 0.61 ENST00000550292.1
LINC00941
long intergenic non-protein coding RNA 941
chrX_+_41583408 0.55 ENST00000302548.4
GPR82
G protein-coupled receptor 82
chr12_+_30948865 0.49 ENST00000547804.1
LINC00941
long intergenic non-protein coding RNA 941
chr3_+_107602030 0.46 ENST00000494231.1
LINC00636
long intergenic non-protein coding RNA 636
chr2_-_113999260 0.40 ENST00000468980.2
PAX8
paired box 8
chr1_+_15736359 0.38 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr11_+_117947724 0.37 ENST00000534111.1
TMPRSS4
transmembrane protease, serine 4
chr1_+_8378140 0.36 ENST00000377479.2
SLC45A1
solute carrier family 45, member 1
chr11_-_64511575 0.36 ENST00000431822.1
ENST00000377486.3
ENST00000394432.3
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_-_47128294 0.35 ENST00000596260.1
ENST00000597185.1
ENST00000598865.1
ENST00000594275.1
ENST00000291294.2
PTGIR
prostaglandin I2 (prostacyclin) receptor (IP)
chr12_+_43086018 0.33 ENST00000550177.1
RP11-25I15.3
RP11-25I15.3
chr10_-_131762105 0.33 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chr7_-_99063769 0.32 ENST00000394186.3
ENST00000359832.4
ENST00000449683.1
ENST00000488775.1
ENST00000523680.1
ENST00000292475.3
ENST00000430982.1
ENST00000555673.1
ENST00000413834.1
ATP5J2
PTCD1
ATP5J2-PTCD1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
pentatricopeptide repeat domain 1
ATP5J2-PTCD1 readthrough
chr1_-_32264250 0.32 ENST00000528579.1
SPOCD1
SPOC domain containing 1
chr1_+_149239529 0.32 ENST00000457216.2
RP11-403I13.4
RP11-403I13.4
chr15_-_73661605 0.29 ENST00000261917.3
HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr22_-_30960876 0.28 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr12_-_58135903 0.28 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr19_-_58892389 0.27 ENST00000427624.2
ENST00000597582.1
ZNF837
zinc finger protein 837
chr17_-_39684550 0.26 ENST00000455635.1
ENST00000361566.3
KRT19
keratin 19
chr8_+_132916318 0.25 ENST00000254624.5
ENST00000522709.1
EFR3A
EFR3 homolog A (S. cerevisiae)
chr4_-_13546632 0.24 ENST00000382438.5
NKX3-2
NK3 homeobox 2
chr5_+_179135246 0.22 ENST00000508787.1
CANX
calnexin
chr3_+_11267691 0.22 ENST00000413416.1
HRH1
histamine receptor H1
chr1_+_26737292 0.22 ENST00000254231.4
LIN28A
lin-28 homolog A (C. elegans)
chr6_+_160693591 0.20 ENST00000419196.1
RP1-276N6.2
RP1-276N6.2
chr1_+_26737253 0.20 ENST00000326279.6
LIN28A
lin-28 homolog A (C. elegans)
chr2_-_61244308 0.20 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr1_-_38061522 0.19 ENST00000373062.3
GNL2
guanine nucleotide binding protein-like 2 (nucleolar)
chr19_+_50270219 0.17 ENST00000354293.5
ENST00000359032.5
AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr19_+_50887585 0.17 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr3_+_183967409 0.15 ENST00000324557.4
ENST00000402825.3
ECE2
endothelin converting enzyme 2
chrX_+_135388147 0.15 ENST00000394141.1
GPR112
G protein-coupled receptor 112
chr8_-_95907423 0.15 ENST00000396133.3
ENST00000308108.4
CCNE2
cyclin E2
chr1_-_32264356 0.15 ENST00000452755.2
SPOCD1
SPOC domain containing 1
chr12_-_102874102 0.14 ENST00000392905.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr17_+_7465216 0.14 ENST00000321337.7
SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr4_-_170897045 0.13 ENST00000508313.1
RP11-205M3.3
RP11-205M3.3
chr10_+_88414298 0.12 ENST00000372071.2
OPN4
opsin 4
chr4_+_2420659 0.12 ENST00000382849.2
RP11-503N18.1
RP11-503N18.1
chr19_+_11466167 0.12 ENST00000591608.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr7_+_69064300 0.11 ENST00000342771.4
AUTS2
autism susceptibility candidate 2
chr5_+_78365536 0.11 ENST00000255192.3
BHMT2
betaine--homocysteine S-methyltransferase 2
chr19_+_35417939 0.10 ENST00000601142.1
ENST00000426813.2
ZNF30
zinc finger protein 30
chr19_+_11466062 0.10 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr4_-_2420335 0.10 ENST00000503000.1
ZFYVE28
zinc finger, FYVE domain containing 28
chr6_-_41040195 0.10 ENST00000463088.1
ENST00000469104.1
ENST00000486443.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr10_+_50507232 0.09 ENST00000374144.3
C10orf71
chromosome 10 open reading frame 71
chrX_-_110655391 0.09 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr1_-_224624730 0.09 ENST00000445239.1
WDR26
WD repeat domain 26
chr7_-_111428957 0.08 ENST00000417165.1
DOCK4
dedicator of cytokinesis 4
chr8_-_6115044 0.08 ENST00000519555.1
RP11-124B13.1
RP11-124B13.1
chr6_+_41040678 0.08 ENST00000341376.6
ENST00000353205.5
NFYA
nuclear transcription factor Y, alpha
chr20_-_43150601 0.08 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
SERINC3
serine incorporator 3
chr10_+_7860460 0.07 ENST00000344293.5
TAF3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
chr3_-_183966717 0.07 ENST00000446569.1
ENST00000418734.2
ENST00000397676.3
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr19_+_35417844 0.07 ENST00000601957.1
ZNF30
zinc finger protein 30
chr3_-_183967296 0.07 ENST00000455059.1
ENST00000445626.2
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr2_+_219135115 0.07 ENST00000248451.3
ENST00000273077.4
PNKD
paroxysmal nonkinesigenic dyskinesia
chr10_+_26505179 0.07 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_-_151778630 0.07 ENST00000368820.3
LINGO4
leucine rich repeat and Ig domain containing 4
chr14_-_94984181 0.06 ENST00000341228.2
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr1_+_38022572 0.06 ENST00000541606.1
DNALI1
dynein, axonemal, light intermediate chain 1
chr10_+_102759045 0.06 ENST00000370220.1
LZTS2
leucine zipper, putative tumor suppressor 2
chr1_+_156611704 0.06 ENST00000329117.5
BCAN
brevican
chrX_-_19504642 0.06 ENST00000469203.2
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr11_+_7273181 0.06 ENST00000318881.6
SYT9
synaptotagmin IX
chr1_+_160097462 0.06 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr7_+_69064566 0.05 ENST00000403018.2
AUTS2
autism susceptibility candidate 2
chr8_+_56014949 0.05 ENST00000327381.6
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr19_+_13135439 0.05 ENST00000586873.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_-_180427304 0.05 ENST00000336917.5
ZNF385B
zinc finger protein 385B
chr3_-_49158218 0.05 ENST00000417901.1
ENST00000306026.5
ENST00000434032.2
USP19
ubiquitin specific peptidase 19
chr1_+_17559776 0.04 ENST00000537499.1
ENST00000413717.2
ENST00000536552.1
PADI1
peptidyl arginine deiminase, type I
chr6_-_27840099 0.04 ENST00000328488.2
HIST1H3I
histone cluster 1, H3i
chr17_-_18547731 0.04 ENST00000575220.1
ENST00000405044.1
ENST00000572213.1
ENST00000573652.1
TBC1D28
TBC1 domain family, member 28
chr14_-_106692191 0.04 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr12_+_4714145 0.04 ENST00000545342.1
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr19_+_13135386 0.04 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_-_122712079 0.04 ENST00000393583.2
SEMA5B
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
chr6_-_41040268 0.04 ENST00000373154.2
ENST00000244558.9
ENST00000464633.1
ENST00000424266.2
ENST00000479950.1
ENST00000482515.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr11_+_117947782 0.03 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
TMPRSS4
transmembrane protease, serine 4
chr1_+_226250379 0.03 ENST00000366815.3
ENST00000366814.3
H3F3A
H3 histone, family 3A
chr12_+_8975061 0.03 ENST00000299698.7
A2ML1
alpha-2-macroglobulin-like 1
chr1_+_156611960 0.02 ENST00000361588.5
BCAN
brevican
chr1_-_173176452 0.02 ENST00000281834.3
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr11_+_2415061 0.02 ENST00000481687.1
CD81
CD81 molecule
chr11_+_33279850 0.02 ENST00000531504.1
ENST00000456517.1
HIPK3
homeodomain interacting protein kinase 3
chr5_-_175788758 0.02 ENST00000510164.1
ENST00000533553.1
ENST00000504688.1
ENST00000393725.2
ENST00000503082.1
ENST00000506983.1
KIAA1191
KIAA1191
chr11_+_117049854 0.01 ENST00000278951.7
SIDT2
SID1 transmembrane family, member 2
chr1_+_231473990 0.01 ENST00000008440.9
SPRTN
SprT-like N-terminal domain
chr7_-_38969150 0.01 ENST00000418457.2
VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr7_+_2687173 0.01 ENST00000403167.1
TTYH3
tweety family member 3
chr11_+_123325106 0.01 ENST00000525757.1
LINC01059
long intergenic non-protein coding RNA 1059
chr1_-_114414316 0.01 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr7_-_14880892 0.01 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr11_+_117049445 0.00 ENST00000324225.4
ENST00000532960.1
SIDT2
SID1 transmembrane family, member 2
chr12_-_10282836 0.00 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0010966 regulation of phosphate transport(GO:0010966) regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) vitamin D catabolic process(GO:0042369)
0.1 0.4 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.0 0.2 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.2 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.1 GO:1904075 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 0.4 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.7 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.3 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.2 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.1 GO:1903280 negative regulation of calcium:sodium antiporter activity(GO:1903280)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.2 GO:0048245 eosinophil chemotaxis(GO:0048245) cellular response to histamine(GO:0071420)
0.0 0.2 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.1 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.1 GO:0071267 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.3 GO:1990357 terminal web(GO:1990357)
0.0 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 1.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.4 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.1 0.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.4 GO:0002151 G-quadruplex RNA binding(GO:0002151) sequence-specific mRNA binding(GO:1990825)
0.0 0.3 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.4 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.4 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle