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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for SOX1

Z-value: 0.92

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Transcription factors associated with SOX1

Gene Symbol Gene ID Gene Info
SOX1
ENSG00000182968.3 SRY-box transcription factor 1

Activity profile of SOX1 motif

Sorted Z-values of SOX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_139756791 2.14 ENST00000489809.1
PARP12
poly (ADP-ribose) polymerase family, member 12
chr3_+_136676707 1.01 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr5_+_135383008 0.97 ENST00000508767.1
ENST00000604555.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr12_+_75874460 0.95 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr6_+_32685782 0.86 ENST00000448198.1
ENST00000585372.1
XXbac-BPG254F23.7
XXbac-BPG254F23.7
chr3_+_136676851 0.83 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr2_-_163175133 0.79 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr19_+_3762703 0.76 ENST00000589174.1
MRPL54
mitochondrial ribosomal protein L54
chr20_-_48747662 0.67 ENST00000371656.2
TMEM189
transmembrane protein 189
chr3_-_171489085 0.48 ENST00000418087.1
PLD1
phospholipase D1, phosphatidylcholine-specific
chr5_-_150460914 0.48 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chr19_+_49588677 0.42 ENST00000598984.1
ENST00000598441.1
SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr12_+_93096619 0.42 ENST00000397833.3
C12orf74
chromosome 12 open reading frame 74
chr11_-_18062872 0.42 ENST00000250018.2
TPH1
tryptophan hydroxylase 1
chr19_+_49588690 0.40 ENST00000221448.5
SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr1_-_43638168 0.39 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr17_+_75181292 0.38 ENST00000431431.2
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr21_-_16126181 0.37 ENST00000455253.2
AF127936.3
AF127936.3
chr1_-_89641680 0.37 ENST00000294671.2
GBP7
guanylate binding protein 7
chr12_+_57810198 0.34 ENST00000598001.1
AC126614.1
HCG1818482; Uncharacterized protein
chr11_-_111649074 0.34 ENST00000534218.1
RP11-108O10.2
RP11-108O10.2
chr2_-_200320768 0.32 ENST00000428695.1
SATB2
SATB homeobox 2
chr13_+_53602894 0.32 ENST00000219022.2
OLFM4
olfactomedin 4
chr6_+_27833034 0.28 ENST00000357320.2
HIST1H2AL
histone cluster 1, H2al
chr11_-_58035732 0.28 ENST00000395079.2
OR10W1
olfactory receptor, family 10, subfamily W, member 1
chr16_-_18937072 0.27 ENST00000569122.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr22_+_32149927 0.27 ENST00000437411.1
ENST00000535622.1
ENST00000536766.1
ENST00000400242.3
ENST00000266091.3
ENST00000400249.2
ENST00000400246.1
ENST00000382105.2
DEPDC5
DEP domain containing 5
chr10_+_78078088 0.26 ENST00000496424.2
C10orf11
chromosome 10 open reading frame 11
chr5_-_54988559 0.25 ENST00000502247.1
SLC38A9
solute carrier family 38, member 9
chr11_-_76381029 0.24 ENST00000407242.2
ENST00000421973.1
LRRC32
leucine rich repeat containing 32
chr12_-_120763739 0.24 ENST00000549767.1
PLA2G1B
phospholipase A2, group IB (pancreas)
chr14_+_35514323 0.23 ENST00000555211.1
FAM177A1
family with sequence similarity 177, member A1
chr19_+_3762645 0.22 ENST00000330133.4
MRPL54
mitochondrial ribosomal protein L54
chr17_-_39646116 0.22 ENST00000328119.6
KRT36
keratin 36
chr3_+_132316081 0.22 ENST00000249887.2
ACKR4
atypical chemokine receptor 4
chr19_+_38880252 0.21 ENST00000586301.1
SPRED3
sprouty-related, EVH1 domain containing 3
chr14_+_62462541 0.21 ENST00000430451.2
SYT16
synaptotagmin XVI
chr19_+_17830051 0.21 ENST00000594625.1
ENST00000324096.4
ENST00000600186.1
ENST00000597735.1
MAP1S
microtubule-associated protein 1S
chr3_-_185655795 0.20 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr6_-_130543958 0.19 ENST00000437477.2
ENST00000439090.2
SAMD3
sterile alpha motif domain containing 3
chr2_+_171034646 0.19 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr17_-_15519008 0.18 ENST00000261644.8
CDRT1
CMT1A duplicated region transcript 1
chr4_-_48116540 0.18 ENST00000506073.1
TXK
TXK tyrosine kinase
chr17_+_19186292 0.18 ENST00000395626.1
ENST00000571254.1
EPN2
epsin 2
chr14_-_74417096 0.18 ENST00000286544.3
FAM161B
family with sequence similarity 161, member B
chr22_-_30662828 0.17 ENST00000403463.1
ENST00000215781.2
OSM
oncostatin M
chr12_-_10607084 0.17 ENST00000408006.3
ENST00000544822.1
ENST00000536188.1
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr6_+_123317116 0.17 ENST00000275162.5
CLVS2
clavesin 2
chr18_+_6834472 0.16 ENST00000581099.1
ENST00000419673.2
ENST00000531294.1
ARHGAP28
Rho GTPase activating protein 28
chr1_+_12806141 0.16 ENST00000288048.5
C1orf158
chromosome 1 open reading frame 158
chr14_-_89878369 0.16 ENST00000553840.1
ENST00000556916.1
FOXN3
forkhead box N3
chr11_-_76381781 0.16 ENST00000260061.5
ENST00000404995.1
LRRC32
leucine rich repeat containing 32
chr10_+_47894572 0.16 ENST00000355876.5
FAM21B
family with sequence similarity 21, member B
chr13_+_109248500 0.15 ENST00000356711.2
MYO16
myosin XVI
chr12_-_11150474 0.15 ENST00000538986.1
TAS2R20
taste receptor, type 2, member 20
chr10_+_15085895 0.15 ENST00000378228.3
OLAH
oleoyl-ACP hydrolase
chr18_-_67629015 0.15 ENST00000579496.1
CD226
CD226 molecule
chr1_-_13331692 0.14 ENST00000353410.5
ENST00000376173.3
PRAMEF3
PRAME family member 3
chr3_-_16524357 0.14 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chrX_+_129040094 0.13 ENST00000425117.2
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr4_-_142134031 0.13 ENST00000420921.2
RNF150
ring finger protein 150
chr10_-_73976025 0.13 ENST00000342444.4
ENST00000533958.1
ENST00000527593.1
ENST00000394915.3
ENST00000530461.1
ENST00000317168.6
ENST00000524829.1
ASCC1
activating signal cointegrator 1 complex subunit 1
chr1_+_240255166 0.13 ENST00000319653.9
FMN2
formin 2
chr7_-_76955563 0.13 ENST00000441833.2
GSAP
gamma-secretase activating protein
chr22_-_17302589 0.13 ENST00000331428.5
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr3_+_174577070 0.12 ENST00000454872.1
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chrX_+_129040122 0.12 ENST00000394422.3
ENST00000371051.5
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr2_+_102615416 0.12 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr15_+_42565393 0.12 ENST00000561871.1
GANC
glucosidase, alpha; neutral C
chr4_+_156680153 0.12 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr4_+_154622652 0.11 ENST00000260010.6
TLR2
toll-like receptor 2
chr18_-_51751132 0.11 ENST00000256429.3
MBD2
methyl-CpG binding domain protein 2
chr3_-_33686925 0.11 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr4_-_74486217 0.11 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr12_-_110434096 0.11 ENST00000320063.9
ENST00000457474.2
ENST00000547815.1
ENST00000361006.5
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr1_+_144811943 0.11 ENST00000281815.8
NBPF9
neuroblastoma breakpoint family, member 9
chr2_+_171036635 0.11 ENST00000484338.2
ENST00000334231.6
MYO3B
myosin IIIB
chr3_-_126327398 0.11 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr14_-_20801427 0.11 ENST00000557665.1
ENST00000358932.4
ENST00000353689.4
CCNB1IP1
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr11_-_56238014 0.10 ENST00000312240.2
OR5M3
olfactory receptor, family 5, subfamily M, member 3
chr14_+_74417192 0.10 ENST00000554320.1
COQ6
coenzyme Q6 monooxygenase
chr8_+_145133493 0.09 ENST00000316052.5
ENST00000525936.1
EXOSC4
exosome component 4
chr4_-_74486347 0.09 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr6_+_28249299 0.08 ENST00000405948.2
PGBD1
piggyBac transposable element derived 1
chr11_-_26593649 0.08 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr11_-_104827425 0.07 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr1_+_46805832 0.07 ENST00000474844.1
NSUN4
NOP2/Sun domain family, member 4
chr12_-_10605929 0.07 ENST00000347831.5
ENST00000359151.3
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr2_-_96926313 0.07 ENST00000435268.1
TMEM127
transmembrane protein 127
chrX_+_11129388 0.06 ENST00000321143.4
ENST00000380763.3
ENST00000380762.4
HCCS
holocytochrome c synthase
chr9_-_13165457 0.06 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr6_+_28249332 0.06 ENST00000259883.3
PGBD1
piggyBac transposable element derived 1
chr3_+_178276488 0.06 ENST00000432997.1
ENST00000455865.1
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr3_+_126113734 0.05 ENST00000352312.1
ENST00000393425.1
CCDC37
coiled-coil domain containing 37
chr2_+_87808725 0.05 ENST00000413202.1
LINC00152
long intergenic non-protein coding RNA 152
chr20_+_49575342 0.04 ENST00000244051.1
MOCS3
molybdenum cofactor synthesis 3
chr10_-_73976884 0.04 ENST00000317126.4
ENST00000545550.1
ASCC1
activating signal cointegrator 1 complex subunit 1
chr4_+_26585538 0.04 ENST00000264866.4
TBC1D19
TBC1 domain family, member 19
chr1_-_19578003 0.04 ENST00000375199.3
ENST00000375208.3
ENST00000356068.2
ENST00000477853.1
EMC1
ER membrane protein complex subunit 1
chr4_-_170924888 0.04 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibrillar-associated protein 3-like
chr11_-_113577014 0.04 ENST00000544634.1
ENST00000539732.1
ENST00000538770.1
ENST00000536856.1
ENST00000544476.1
TMPRSS5
transmembrane protease, serine 5
chr1_-_13698405 0.03 ENST00000540591.1
PRAMEF19
PRAME family member 19
chr5_+_140743859 0.03 ENST00000518069.1
PCDHGA5
protocadherin gamma subfamily A, 5
chr4_-_122686261 0.03 ENST00000337677.5
TMEM155
transmembrane protein 155
chr4_-_74486109 0.03 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr12_-_110434183 0.02 ENST00000360185.4
ENST00000354574.4
ENST00000338373.5
ENST00000343646.5
ENST00000356259.4
ENST00000553118.1
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr9_-_95166884 0.02 ENST00000375561.5
OGN
osteoglycin
chr15_+_57540230 0.02 ENST00000559703.1
TCF12
transcription factor 12
chr9_-_95166841 0.02 ENST00000262551.4
OGN
osteoglycin
chr19_-_44388116 0.02 ENST00000587539.1
ZNF404
zinc finger protein 404
chr14_+_62164340 0.01 ENST00000557538.1
ENST00000539097.1
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr1_-_86848760 0.00 ENST00000460698.2
ODF2L
outer dense fiber of sperm tails 2-like
chr19_+_21324863 0.00 ENST00000598331.1
ZNF431
zinc finger protein 431

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.2 0.8 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 0.8 GO:0061083 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.1 0.5 GO:0085032 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1 0.4 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.1 0.2 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.5 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.0 0.1 GO:0032289 central nervous system myelin formation(GO:0032289) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 0.3 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.0 0.1 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.2 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.4 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 0.2 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.0 GO:0018307 enzyme active site formation(GO:0018307)
0.0 0.1 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.1 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.2 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.1 GO:0051026 chiasma assembly(GO:0051026)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0000243 commitment complex(GO:0000243)
0.0 0.3 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.1 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0 0.3 GO:0071986 Ragulator complex(GO:0071986)
0.0 1.1 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.4 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 0.4 GO:0005549 odorant binding(GO:0005549)
0.1 0.8 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.4 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 2.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297)
0.0 0.1 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.0 0.1 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0003696 satellite DNA binding(GO:0003696)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 1.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.1 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening