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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for SREBF2

Z-value: 0.32

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Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.7 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_422291460.366.4e-01Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_43313269 0.31 ENST00000511774.1
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr6_+_151561085 0.23 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr6_-_31926208 0.19 ENST00000454913.1
ENST00000436289.2
NELFE
negative elongation factor complex member E
chr5_+_159656437 0.19 ENST00000402432.3
FABP6
fatty acid binding protein 6, ileal
chr20_+_33464238 0.17 ENST00000360596.2
ACSS2
acyl-CoA synthetase short-chain family member 2
chr20_+_33464407 0.16 ENST00000253382.5
ACSS2
acyl-CoA synthetase short-chain family member 2
chr15_-_73075964 0.15 ENST00000563907.1
ADPGK
ADP-dependent glucokinase
chr2_+_120517717 0.14 ENST00000420482.1
ENST00000488279.2
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr18_-_21166841 0.14 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr15_-_73076030 0.13 ENST00000311669.8
ADPGK
ADP-dependent glucokinase
chr19_+_11200038 0.13 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR
low density lipoprotein receptor
chr5_-_149535190 0.12 ENST00000517488.1
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr11_-_73309112 0.12 ENST00000450446.2
FAM168A
family with sequence similarity 168, member A
chr1_+_55505184 0.12 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr1_+_39796810 0.11 ENST00000289893.4
MACF1
microtubule-actin crosslinking factor 1
chr4_+_75230853 0.11 ENST00000244869.2
EREG
epiregulin
chr12_-_91505608 0.10 ENST00000266718.4
LUM
lumican
chr6_-_32152020 0.10 ENST00000375055.2
AGER
advanced glycosylation end product-specific receptor
chr11_+_65480222 0.10 ENST00000534681.1
KAT5
K(lysine) acetyltransferase 5
chrX_-_153236620 0.10 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chr2_-_26205550 0.10 ENST00000405914.1
KIF3C
kinesin family member 3C
chr1_+_206643806 0.09 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr1_+_206643787 0.09 ENST00000367120.3
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr1_-_155232221 0.09 ENST00000355379.3
SCAMP3
secretory carrier membrane protein 3
chr16_+_50187556 0.08 ENST00000561678.1
ENST00000357464.3
PAPD5
PAP associated domain containing 5
chr2_-_26205340 0.08 ENST00000264712.3
KIF3C
kinesin family member 3C
chr17_+_73257945 0.08 ENST00000579002.1
MRPS7
mitochondrial ribosomal protein S7
chr17_+_73257742 0.08 ENST00000579761.1
ENST00000245539.6
MRPS7
mitochondrial ribosomal protein S7
chr1_-_155232047 0.08 ENST00000302631.3
SCAMP3
secretory carrier membrane protein 3
chrX_-_153236819 0.07 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr6_-_32151999 0.06 ENST00000375069.3
ENST00000538695.1
ENST00000438221.2
ENST00000375065.5
ENST00000450110.1
ENST00000375067.3
ENST00000375056.2
AGER
advanced glycosylation end product-specific receptor
chrX_-_153237258 0.06 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr17_-_73257667 0.06 ENST00000538886.1
ENST00000580799.1
ENST00000351904.7
ENST00000537686.1
GGA3
golgi-associated, gamma adaptin ear containing, ARF binding protein 3
chr11_-_73309228 0.06 ENST00000356467.4
ENST00000064778.4
FAM168A
family with sequence similarity 168, member A
chr14_-_74959978 0.05 ENST00000541064.1
NPC2
Niemann-Pick disease, type C2
chr2_-_219925189 0.05 ENST00000295731.6
IHH
indian hedgehog
chr17_-_17726907 0.05 ENST00000423161.3
SREBF1
sterol regulatory element binding transcription factor 1
chr3_+_5020801 0.04 ENST00000256495.3
BHLHE40
basic helix-loop-helix family, member e40
chr22_+_42229100 0.04 ENST00000361204.4
SREBF2
sterol regulatory element binding transcription factor 2
chr14_-_74959994 0.04 ENST00000238633.2
ENST00000434013.2
NPC2
Niemann-Pick disease, type C2
chr16_+_8736232 0.04 ENST00000562973.1
METTL22
methyltransferase like 22
chr3_-_171527560 0.04 ENST00000331659.2
PP13439
PP13439
chr9_+_126131131 0.04 ENST00000373629.2
CRB2
crumbs homolog 2 (Drosophila)
chr6_-_39902160 0.03 ENST00000340692.5
MOCS1
molybdenum cofactor synthesis 1
chr5_+_137774706 0.03 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2
receptor accessory protein 2
chr3_+_46742823 0.03 ENST00000326431.3
TMIE
transmembrane inner ear
chr19_+_55591743 0.03 ENST00000588359.1
ENST00000245618.5
EPS8L1
EPS8-like 1
chr14_-_74960030 0.02 ENST00000553490.1
ENST00000557510.1
NPC2
Niemann-Pick disease, type C2
chr8_+_104512976 0.02 ENST00000504942.2
RIMS2
regulating synaptic membrane exocytosis 2
chr1_-_6659876 0.02 ENST00000496707.1
KLHL21
kelch-like family member 21
chr19_-_55791058 0.02 ENST00000587959.1
ENST00000585927.1
ENST00000587922.1
ENST00000585698.1
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr1_+_231297798 0.02 ENST00000444294.3
TRIM67
tripartite motif containing 67
chr11_+_22688150 0.02 ENST00000454584.2
GAS2
growth arrest-specific 2
chr8_+_104513086 0.02 ENST00000406091.3
RIMS2
regulating synaptic membrane exocytosis 2
chr17_-_40075197 0.02 ENST00000590770.1
ENST00000590151.1
ACLY
ATP citrate lyase
chr17_-_40075219 0.02 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
ACLY
ATP citrate lyase
chr10_-_74856608 0.02 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr12_-_53343560 0.01 ENST00000548998.1
KRT8
keratin 8
chr19_+_38664224 0.01 ENST00000601054.1
SIPA1L3
signal-induced proliferation-associated 1 like 3
chr17_-_15168624 0.01 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
PMP22
peripheral myelin protein 22
chr20_+_58533471 0.01 ENST00000244047.5
ENST00000348616.4
CDH26
cadherin 26
chr6_+_79577189 0.01 ENST00000369940.2
IRAK1BP1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr1_+_247582097 0.00 ENST00000391827.2
NLRP3
NLR family, pyrin domain containing 3
chr13_+_24844857 0.00 ENST00000409126.1
ENST00000343003.6
SPATA13
spermatogenesis associated 13
chr2_+_27435734 0.00 ENST00000419744.1
ATRAID
all-trans retinoic acid-induced differentiation factor
chr1_-_42384343 0.00 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1905053 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.1 0.2 GO:0019046 release from viral latency(GO:0019046)
0.0 0.3 GO:0019542 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.0 0.1 GO:1904604 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.0 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.1 GO:1903979 negative regulation of microglial cell activation(GO:1903979)
0.0 0.1 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.0 0.3 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.1 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0 0.1 GO:0035441 cell migration involved in vasculogenesis(GO:0035441)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.0 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.0 0.2 GO:0032021 NELF complex(GO:0032021)
0.0 0.0 GO:0009346 citrate lyase complex(GO:0009346)
0.0 0.0 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.1 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.0 0.2 GO:0008384 IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435)
0.0 0.3 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189) very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0005019 platelet-derived growth factor beta-receptor activity(GO:0005019)
0.0 0.2 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.0 GO:0003878 ATP citrate synthase activity(GO:0003878)
0.0 0.2 GO:0032052 bile acid binding(GO:0032052)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts