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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for SRF

Z-value: 0.43

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Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
ENSG00000112658.6 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SRFhg19_v2_chr6_+_43139037_431390940.936.5e-02Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_62653903 0.23 ENST00000552075.1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr14_-_94443105 0.22 ENST00000555019.1
ankyrin repeat and SOCS box containing 2
chr12_+_75874580 0.21 ENST00000456650.3
GLI pathogenesis-related 1
chr11_-_65626753 0.19 ENST00000526975.1
ENST00000531413.1
cofilin 1 (non-muscle)
chr22_+_45714672 0.19 ENST00000424557.1
family with sequence similarity 118, member A
chr6_+_151561085 0.18 ENST00000402676.2
A kinase (PRKA) anchor protein 12
chr1_+_223889310 0.18 ENST00000434648.1
calpain 2, (m/II) large subunit
chr12_+_54426637 0.18 ENST00000312492.2
homeobox C5
chr22_+_45714361 0.17 ENST00000452238.1
family with sequence similarity 118, member A
chr6_+_151561506 0.17 ENST00000253332.1
A kinase (PRKA) anchor protein 12
chr4_+_189321881 0.17 ENST00000512839.1
ENST00000513313.1
long intergenic non-protein coding RNA 1060
chr10_+_112257596 0.17 ENST00000369583.3
dual specificity phosphatase 5
chr22_-_39150947 0.17 ENST00000411587.2
ENST00000420859.1
ENST00000452294.1
ENST00000456894.1
Sad1 and UNC84 domain containing 2
chr15_+_83776324 0.16 ENST00000379390.6
ENST00000379386.4
ENST00000565774.1
ENST00000565982.1
transmembrane 6 superfamily member 1
chr19_+_54372877 0.16 ENST00000414489.1
myeloid-associated differentiation marker
chr8_+_97597148 0.15 ENST00000521590.1
syndecan 2
chr10_-_64576105 0.15 ENST00000242480.3
ENST00000411732.1
early growth response 2
chr2_-_106054952 0.15 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
four and a half LIM domains 2
chr1_-_89531041 0.14 ENST00000370473.4
guanylate binding protein 1, interferon-inducible
chr17_-_41132010 0.13 ENST00000409103.1
ENST00000360221.4
PTGES3L-AARSD1 readthrough
chr2_+_87769459 0.13 ENST00000414030.1
ENST00000437561.1
long intergenic non-protein coding RNA 152
chr12_+_75874460 0.13 ENST00000266659.3
GLI pathogenesis-related 1
chr5_+_96077888 0.13 ENST00000509259.1
ENST00000503828.1
calpastatin
chr22_-_36357671 0.13 ENST00000408983.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr22_-_36784035 0.12 ENST00000216181.5
myosin, heavy chain 9, non-muscle
chr3_+_9834179 0.12 ENST00000498623.2
actin related protein 2/3 complex, subunit 4, 20kDa
chr17_-_41132410 0.11 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr2_-_73520667 0.11 ENST00000545030.1
ENST00000436467.2
early growth response 4
chr5_-_176923846 0.11 ENST00000506537.1
PDZ and LIM domain 7 (enigma)
chr1_-_11907829 0.11 ENST00000376480.3
natriuretic peptide A
chr8_-_101964832 0.11 ENST00000523131.1
ENST00000418997.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr19_+_54372693 0.11 ENST00000391768.2
myeloid-associated differentiation marker
chr19_-_35166604 0.11 ENST00000601241.1
secretoglobin, family 2B, member 2
chr1_+_206858328 0.10 ENST00000367103.3
mitogen-activated protein kinase-activated protein kinase 2
chr1_-_229569834 0.10 ENST00000366684.3
ENST00000366683.2
actin, alpha 1, skeletal muscle
chr2_-_106015491 0.09 ENST00000408995.1
ENST00000393353.3
ENST00000322142.8
four and a half LIM domains 2
chr2_+_56179262 0.09 ENST00000606639.1
RP11-481J13.1
chr5_-_33892118 0.09 ENST00000515401.1
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr6_+_158402860 0.09 ENST00000367122.2
ENST00000367121.3
ENST00000355585.4
ENST00000367113.4
synaptojanin 2
chr8_-_101965104 0.09 ENST00000437293.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr6_+_43139037 0.09 ENST00000265354.4
serum response factor (c-fos serum response element-binding transcription factor)
chr8_-_22550815 0.09 ENST00000317216.2
early growth response 3
chr2_-_106015527 0.08 ENST00000344213.4
ENST00000358129.4
four and a half LIM domains 2
chr2_+_191792376 0.08 ENST00000409428.1
ENST00000409215.1
glutaminase
chr8_-_22550691 0.08 ENST00000519492.1
early growth response 3
chr11_+_12108410 0.08 ENST00000527997.1
RP13-631K18.5
chr3_+_9834758 0.08 ENST00000485273.1
ENST00000433034.1
ENST00000397256.1
actin related protein 2/3 complex, subunit 4, 20kDa
ARPC4-TTLL3 readthrough
chr11_-_65667884 0.07 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOS-like antigen 1
chr6_+_27107053 0.07 ENST00000354348.2
histone cluster 1, H4i
chr17_+_30089454 0.07 ENST00000577970.1
RP11-805L22.3
chr3_-_71294304 0.07 ENST00000498215.1
forkhead box P1
chrX_-_153602991 0.07 ENST00000369850.3
ENST00000422373.1
filamin A, alpha
chr19_+_13134772 0.07 ENST00000587760.1
ENST00000585575.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr5_-_176923803 0.07 ENST00000506161.1
PDZ and LIM domain 7 (enigma)
chr17_-_4871085 0.06 ENST00000575142.1
ENST00000206020.3
sperm associated antigen 7
chr19_+_1026298 0.06 ENST00000263097.4
calponin 2
chr1_-_168106536 0.06 ENST00000537209.1
ENST00000361697.2
ENST00000546300.1
ENST00000367835.1
G protein-coupled receptor 161
chr5_-_33892204 0.06 ENST00000504830.1
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr14_-_102553371 0.06 ENST00000553585.1
ENST00000216281.8
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr12_+_59989918 0.06 ENST00000547379.1
ENST00000549465.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr19_+_54372639 0.06 ENST00000391769.2
myeloid-associated differentiation marker
chr10_+_31610064 0.06 ENST00000446923.2
ENST00000559476.1
zinc finger E-box binding homeobox 1
chr17_+_41132564 0.06 ENST00000361677.1
ENST00000589705.1
RUN domain containing 1
chr5_-_53606396 0.06 ENST00000504924.1
ENST00000507646.2
ENST00000502271.1
ADP-ribosylation factor-like 15
chr12_-_125398850 0.05 ENST00000535859.1
ENST00000546271.1
ENST00000540700.1
ENST00000546120.1
ubiquitin C
chr14_+_105266933 0.05 ENST00000555360.1
zinc finger and BTB domain containing 42
chr19_-_36247910 0.05 ENST00000587965.1
ENST00000004982.3
heat shock protein, alpha-crystallin-related, B6
chr8_+_1993152 0.05 ENST00000262113.4
myomesin 2
chr7_+_149416439 0.05 ENST00000497895.1
KRAB-A domain containing 1
chr19_+_1026566 0.05 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
calponin 2
chr2_-_161264385 0.05 ENST00000409972.1
RNA binding motif, single stranded interacting protein 1
chr18_+_54318566 0.05 ENST00000589935.1
ENST00000357574.3
WD repeat domain 7
chr3_-_52486841 0.05 ENST00000496590.1
troponin C type 1 (slow)
chr11_-_65667997 0.05 ENST00000312562.2
ENST00000534222.1
FOS-like antigen 1
chr19_+_13135386 0.04 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr17_-_79481666 0.04 ENST00000575659.1
actin, gamma 1
chr8_+_1993173 0.04 ENST00000523438.1
myomesin 2
chr10_+_75757863 0.04 ENST00000372755.3
ENST00000211998.4
ENST00000417648.2
vinculin
chr19_-_47975417 0.04 ENST00000236877.6
solute carrier family 8 (sodium/calcium exchanger), member 2
chr7_+_143078379 0.04 ENST00000449630.1
ENST00000457235.1
zyxin
chr2_-_172087824 0.04 ENST00000521943.1
tousled-like kinase 1
chr7_-_94285511 0.04 ENST00000265735.7
sarcoglycan, epsilon
chr4_-_10118573 0.04 ENST00000382452.2
ENST00000382451.2
WD repeat domain 1
chr4_-_10118469 0.04 ENST00000499869.2
WD repeat domain 1
chr7_-_107643567 0.04 ENST00000393559.1
ENST00000439976.1
ENST00000393560.1
laminin, beta 1
chr7_-_559853 0.04 ENST00000405692.2
platelet-derived growth factor alpha polypeptide
chr18_+_54318616 0.04 ENST00000254442.3
WD repeat domain 7
chr13_+_27825446 0.03 ENST00000311549.6
ribosomal protein L21
chr5_-_179050660 0.03 ENST00000519056.1
ENST00000506721.1
ENST00000503105.1
ENST00000504348.1
ENST00000508103.1
ENST00000510431.1
ENST00000515158.1
ENST00000393432.4
ENST00000442819.2
heterogeneous nuclear ribonucleoprotein H1 (H)
chr8_-_143696833 0.03 ENST00000356613.2
activity-regulated cytoskeleton-associated protein
chr17_+_3379284 0.03 ENST00000263080.2
aspartoacylase
chr7_+_143078652 0.03 ENST00000354434.4
ENST00000449423.2
zyxin
chr1_+_47881744 0.03 ENST00000335071.2
forkhead box E3
chr6_-_16761678 0.03 ENST00000244769.4
ENST00000436367.1
ataxin 1
chr17_-_27949911 0.03 ENST00000492276.2
ENST00000345068.5
ENST00000584602.1
coronin 6
chr5_-_130868688 0.03 ENST00000504575.1
ENST00000513227.1
Rap guanine nucleotide exchange factor (GEF) 6
chr1_+_11994715 0.03 ENST00000449038.1
ENST00000376369.3
ENST00000429000.2
ENST00000196061.4
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr17_-_79479789 0.03 ENST00000571691.1
ENST00000571721.1
ENST00000573283.1
ENST00000575842.1
ENST00000575087.1
ENST00000570382.1
ENST00000331925.2
actin, gamma 1
chr19_+_13135439 0.03 ENST00000586873.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr8_-_101964738 0.03 ENST00000523938.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr3_+_9834227 0.03 ENST00000287613.7
ENST00000397261.3
actin related protein 2/3 complex, subunit 4, 20kDa
chr5_+_150404904 0.03 ENST00000521632.1
glutathione peroxidase 3 (plasma)
chr4_-_83934078 0.03 ENST00000505397.1
lin-54 homolog (C. elegans)
chr2_-_208031943 0.03 ENST00000421199.1
ENST00000457962.1
Kruppel-like factor 7 (ubiquitous)
chr17_-_27277615 0.02 ENST00000583747.1
ENST00000584236.1
PHD finger protein 12
chr9_+_140772226 0.02 ENST00000277551.2
ENST00000371372.1
ENST00000277549.5
ENST00000371363.1
ENST00000371357.1
ENST00000371355.4
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr15_+_33603147 0.02 ENST00000415757.3
ENST00000389232.4
ryanodine receptor 3
chr11_-_47374246 0.02 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
myosin binding protein C, cardiac
chr5_-_58295712 0.02 ENST00000317118.8
phosphodiesterase 4D, cAMP-specific
chr16_+_71879861 0.02 ENST00000427980.2
ENST00000568581.1
ataxin 1-like
increased sodium tolerance 1 homolog (yeast)
chr13_+_27825706 0.02 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
ribosomal protein L21
chr12_-_50616122 0.02 ENST00000552823.1
ENST00000552909.1
LIM domain and actin binding 1
chr4_-_83933999 0.02 ENST00000510557.1
lin-54 homolog (C. elegans)
chr1_-_91487806 0.02 ENST00000361321.5
zinc finger protein 644
chr7_-_94285402 0.02 ENST00000428696.2
ENST00000445866.2
sarcoglycan, epsilon
chr3_-_99595037 0.02 ENST00000383694.2
filamin A interacting protein 1-like
chr13_+_42614176 0.02 ENST00000540693.1
diacylglycerol kinase, eta
chr7_-_107643674 0.02 ENST00000222399.6
laminin, beta 1
chr17_+_50939459 0.02 ENST00000412360.1
Uncharacterized protein
chr7_-_94285472 0.02 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
sarcoglycan, epsilon
chr1_+_223889285 0.02 ENST00000433674.2
calpain 2, (m/II) large subunit
chr10_-_16859442 0.02 ENST00000602389.1
ENST00000345264.5
Ras suppressor protein 1
chr1_+_16085244 0.02 ENST00000400773.1
filamin binding LIM protein 1
chr14_+_74034310 0.02 ENST00000538782.1
acyl-CoA thioesterase 2
chr8_-_125827922 0.02 ENST00000533516.1
RP11-1082L8.4
chr6_-_99797522 0.02 ENST00000389677.5
failed axon connections homolog (Drosophila)
chr10_-_16859361 0.02 ENST00000377921.3
Ras suppressor protein 1
chr7_+_107531580 0.02 ENST00000537148.1
ENST00000440410.1
ENST00000437604.2
dihydrolipoamide dehydrogenase
chr12_-_50616382 0.02 ENST00000552783.1
LIM domain and actin binding 1
chr11_-_65626797 0.02 ENST00000525451.2
cofilin 1 (non-muscle)
chr17_+_73452695 0.02 ENST00000582186.1
ENST00000582455.1
ENST00000581252.1
ENST00000579208.1
KIAA0195
chr16_+_4666475 0.01 ENST00000591895.1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr15_+_74218787 0.01 ENST00000261921.7
lysyl oxidase-like 1
chr6_-_111804905 0.01 ENST00000358835.3
ENST00000435970.1
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr10_-_29923893 0.01 ENST00000355867.4
supervillin
chr19_+_57901208 0.01 ENST00000366197.5
ENST00000596282.1
ENST00000597400.1
ENST00000598895.1
ENST00000336128.7
ENST00000596617.1
zinc finger protein 548
Uncharacterized protein
chr5_+_137774706 0.01 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
receptor accessory protein 2
chr17_-_10560619 0.01 ENST00000583535.1
myosin, heavy chain 3, skeletal muscle, embryonic
chr3_-_123339418 0.01 ENST00000583087.1
myosin light chain kinase
chr4_-_54930790 0.01 ENST00000263921.3
cysteine-rich hydrophobic domain 2
chr5_-_33892046 0.01 ENST00000352040.3
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr19_-_47975106 0.01 ENST00000539381.1
ENST00000594353.1
ENST00000542837.1
solute carrier family 8 (sodium/calcium exchanger), member 2
chr5_-_124080203 0.01 ENST00000504926.1
zinc finger protein 608
chr3_-_9834375 0.01 ENST00000343450.2
ENST00000301964.2
transcriptional adaptor 3
chr19_+_48958766 0.01 ENST00000342291.2
potassium inwardly-rectifying channel, subfamily J, member 14
chr11_-_2162468 0.01 ENST00000434045.2
insulin-like growth factor 2 (somatomedin A)
chr19_+_16178317 0.01 ENST00000344824.6
ENST00000538887.1
tropomyosin 4
chr1_-_89591749 0.01 ENST00000370466.3
guanylate binding protein 2, interferon-inducible
chr4_-_87028478 0.01 ENST00000515400.1
ENST00000395157.3
mitogen-activated protein kinase 10
chr16_+_30077098 0.01 ENST00000395240.3
ENST00000566846.1
aldolase A, fructose-bisphosphate
chr12_+_4382917 0.01 ENST00000261254.3
cyclin D2
chr9_+_131644781 0.01 ENST00000259324.5
leucine rich repeat containing 8 family, member A
chr2_-_209118974 0.00 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
isocitrate dehydrogenase 1 (NADP+), soluble
chr12_-_6772303 0.00 ENST00000396807.4
ENST00000446105.2
ENST00000341550.4
inhibitor of growth family, member 4
chr10_-_17659357 0.00 ENST00000326961.6
ENST00000361271.3
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr10_+_123922941 0.00 ENST00000360561.3
transforming, acidic coiled-coil containing protein 2
chr1_-_91487770 0.00 ENST00000337393.5
zinc finger protein 644
chr12_+_59989791 0.00 ENST00000552432.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr11_+_117070037 0.00 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
transgelin

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:2001113 negative regulation of hepatocyte growth factor receptor signaling pathway(GO:1902203) regulation of cellular response to hepatocyte growth factor stimulus(GO:2001112) negative regulation of cellular response to hepatocyte growth factor stimulus(GO:2001113)
0.0 0.1 GO:0021569 rhombomere 3 development(GO:0021569) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.3 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.3 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.2 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.1 GO:0060532 bronchus cartilage development(GO:0060532) lung smooth muscle development(GO:0061145)
0.0 0.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.0 0.1 GO:0032796 uropod organization(GO:0032796)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.1 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.0 0.1 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.0 0.1 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.0 0.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.2 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.0 0.2 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.1 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.1 GO:0043335 protein unfolding(GO:0043335)
0.0 0.0 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.0 GO:0006533 aspartate catabolic process(GO:0006533)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.1 GO:0097513 actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513)
0.0 0.1 GO:0043257 laminin-8 complex(GO:0043257)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0010736 serum response element binding(GO:0010736)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.0 0.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.1 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression