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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for TBX21_TBR1

Z-value: 0.98

Motif logo

Transcription factors associated with TBX21_TBR1

Gene Symbol Gene ID Gene Info
ENSG00000073861.2 T-box transcription factor 21
ENSG00000136535.10 T-box brain transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX21hg19_v2_chr17_+_45810594_458106100.802.0e-01Click!
TBR1hg19_v2_chr2_+_162272605_1622727530.188.2e-01Click!

Activity profile of TBX21_TBR1 motif

Sorted Z-values of TBX21_TBR1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_69139467 1.48 ENST00000569188.1
hyaluronan synthase 3
chr17_-_1553346 0.79 ENST00000301336.6
Rab interacting lysosomal protein
chrX_-_106146547 0.77 ENST00000276173.4
ENST00000411805.1
ripply transcriptional repressor 1
chr19_-_10213335 0.73 ENST00000592641.1
ENST00000253109.4
angiopoietin-like 6
chr6_-_160166218 0.72 ENST00000537657.1
superoxide dismutase 2, mitochondrial
chr9_+_96717821 0.68 ENST00000454594.1
RP11-231K24.2
chr2_+_176972000 0.63 ENST00000249504.5
homeobox D11
chr16_-_11350036 0.60 ENST00000332029.2
suppressor of cytokine signaling 1
chr1_+_19967014 0.58 ENST00000428975.1
neuroblastoma 1, DAN family BMP antagonist
chr2_+_228736335 0.58 ENST00000440997.1
ENST00000545118.1
dynein assembly factor with WDR repeat domains 1
chr9_-_96717654 0.57 ENST00000253968.6
BARX homeobox 1
chr9_+_127023704 0.54 ENST00000373596.1
ENST00000425237.1
NIMA-related kinase 6
chr4_+_108746282 0.54 ENST00000503862.1
sphingomyelin synthase 2
chr11_-_133826852 0.54 ENST00000533871.2
ENST00000321016.8
immunoglobulin superfamily, member 9B
chr22_-_31688431 0.54 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
phosphoinositide-3-kinase interacting protein 1
chr1_-_44482979 0.52 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_-_615570 0.50 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
interferon regulatory factor 7
chr5_+_74807886 0.49 ENST00000514296.1
polymerase (DNA directed) kappa
chr11_-_33913708 0.48 ENST00000257818.2
LIM domain only 2 (rhombotin-like 1)
chr1_+_155099927 0.46 ENST00000368407.3
ephrin-A1
chr12_+_75874984 0.45 ENST00000550491.1
GLI pathogenesis-related 1
chr1_+_39456895 0.44 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
akirin 1
chr19_+_10381769 0.42 ENST00000423829.2
ENST00000588645.1
intercellular adhesion molecule 1
chr3_+_137728842 0.42 ENST00000183605.5
claudin 18
chr14_+_95078714 0.42 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr1_-_100643765 0.42 ENST00000370137.1
ENST00000370138.1
ENST00000342895.3
leucine rich repeat containing 39
chr9_+_34329493 0.42 ENST00000379158.2
ENST00000346365.4
ENST00000379155.5
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr14_-_98444386 0.42 ENST00000556462.1
ENST00000556138.1
chromosome 14 open reading frame 64
chrX_+_56259316 0.41 ENST00000468660.1
Kruppel-like factor 8
chr5_-_39270725 0.41 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr16_+_66461175 0.40 ENST00000536005.2
ENST00000299694.8
ENST00000561796.1
brain expressed, associated with NEDD4, 1
chr2_-_152146385 0.40 ENST00000414946.1
ENST00000243346.5
N-myc (and STAT) interactor
chr1_-_205290865 0.40 ENST00000367157.3
NUAK family, SNF1-like kinase, 2
chr6_-_31619742 0.39 ENST00000433828.1
ENST00000456286.1
BCL2-associated athanogene 6
chr5_+_150040403 0.39 ENST00000517768.1
ENST00000297130.4
myozenin 3
chr7_-_20826504 0.38 ENST00000418710.2
ENST00000361443.4
Sp8 transcription factor
chr7_-_87849340 0.38 ENST00000419179.1
ENST00000265729.2
sorcin
chr3_-_120170052 0.38 ENST00000295633.3
follistatin-like 1
chr1_+_144989309 0.37 ENST00000596396.1
Uncharacterized protein
chr12_-_52685312 0.36 ENST00000327741.5
keratin 81
chr22_-_31688381 0.36 ENST00000487265.2
phosphoinositide-3-kinase interacting protein 1
chr17_-_56609302 0.36 ENST00000581607.1
ENST00000317256.6
ENST00000426861.1
ENST00000580809.1
ENST00000577729.1
ENST00000583291.1
septin 4
chr11_+_18477369 0.35 ENST00000396213.3
ENST00000280706.2
lactate dehydrogenase A-like 6A
chr17_-_34122596 0.35 ENST00000250144.8
matrix metallopeptidase 28
chr11_+_120081475 0.35 ENST00000328965.4
OAF homolog (Drosophila)
chr19_-_44174330 0.35 ENST00000340093.3
plasminogen activator, urokinase receptor
chr14_-_62217779 0.34 ENST00000554254.1
HIF1A antisense RNA 2
chr8_-_61193947 0.33 ENST00000317995.4
carbonic anhydrase VIII
chr19_-_45748628 0.33 ENST00000590022.1
AC006126.4
chr19_-_44174305 0.32 ENST00000601723.1
ENST00000339082.3
plasminogen activator, urokinase receptor
chr17_-_47925379 0.32 ENST00000352793.2
ENST00000334568.4
ENST00000398154.1
ENST00000436235.1
ENST00000326219.5
tachykinin 4 (hemokinin)
chr1_-_52456352 0.32 ENST00000371655.3
RAB3B, member RAS oncogene family
chr3_+_193809263 0.31 ENST00000457815.1
RP11-135A1.3
chr7_-_27135591 0.31 ENST00000343060.4
ENST00000355633.5
homeobox A1
chr11_-_47616210 0.31 ENST00000302514.3
C1q and tumor necrosis factor related protein 4
chr6_-_31620095 0.31 ENST00000424176.1
ENST00000456622.1
BCL2-associated athanogene 6
chr12_-_52761262 0.31 ENST00000257901.3
keratin 85
chr3_-_139195350 0.31 ENST00000232217.2
retinol binding protein 2, cellular
chr12_-_26278030 0.30 ENST00000242728.4
basic helix-loop-helix family, member e41
chr17_-_76356148 0.30 ENST00000587578.1
ENST00000330871.2
suppressor of cytokine signaling 3
chr3_+_171844762 0.29 ENST00000443501.1
fibronectin type III domain containing 3B
chr16_-_67965756 0.29 ENST00000571044.1
ENST00000571605.1
chymotrypsin-like
chr8_+_1993173 0.28 ENST00000523438.1
myomesin 2
chr4_-_177116772 0.28 ENST00000280191.2
spermatogenesis associated 4
chr6_+_43603552 0.28 ENST00000372171.4
MAD2L1 binding protein
chr1_+_199996733 0.28 ENST00000236914.3
nuclear receptor subfamily 5, group A, member 2
chr1_+_89829610 0.28 ENST00000370456.4
ENST00000535065.1
guanylate binding protein family, member 6
chrX_-_19689106 0.28 ENST00000379716.1
SH3-domain kinase binding protein 1
chr5_-_119669160 0.28 ENST00000514240.1
CTC-552D5.1
chr3_+_107243204 0.27 ENST00000456817.1
ENST00000458458.1
bobby sox homolog (Drosophila)
chr3_-_107777208 0.27 ENST00000398258.3
CD47 molecule
chr12_+_22778291 0.27 ENST00000545979.1
ethanolamine kinase 1
chr4_+_160188889 0.26 ENST00000264431.4
Rap guanine nucleotide exchange factor (GEF) 2
chr6_-_31619697 0.26 ENST00000434444.1
BCL2-associated athanogene 6
chr14_-_65569244 0.26 ENST00000557277.1
ENST00000556892.1
MYC associated factor X
chr1_+_244227632 0.26 ENST00000598000.1
Uncharacterized protein; cDNA FLJ42623 fis, clone BRACE3015894
chr1_-_46598371 0.25 ENST00000372006.1
ENST00000425892.1
ENST00000420542.1
ENST00000354242.4
ENST00000340332.6
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
chr13_-_30160925 0.25 ENST00000450494.1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr6_-_26124138 0.24 ENST00000314332.5
ENST00000396984.1
histone cluster 1, H2bc
chr12_-_49351303 0.24 ENST00000256682.4
ADP-ribosylation factor 3
chr10_+_90660832 0.24 ENST00000371924.1
STAM binding protein-like 1
chr6_-_31620149 0.24 ENST00000435080.1
ENST00000375976.4
ENST00000441054.1
BCL2-associated athanogene 6
chr11_+_122709200 0.24 ENST00000227348.4
cytotoxic and regulatory T cell molecule
chr1_-_85930246 0.24 ENST00000426972.3
dimethylarginine dimethylaminohydrolase 1
chr17_-_18585131 0.24 ENST00000443457.1
ENST00000583002.1
zinc finger protein 286B
chr17_-_76713100 0.23 ENST00000585509.1
cytohesin 1
chr17_+_26662679 0.23 ENST00000578158.1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr12_-_89746264 0.23 ENST00000548755.1
dual specificity phosphatase 6
chr12_+_52695617 0.23 ENST00000293525.5
keratin 86
chr1_+_202995611 0.23 ENST00000367240.2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr19_-_44258770 0.23 ENST00000601925.1
ENST00000602222.1
ENST00000599804.1
SMG9 nonsense mediated mRNA decay factor
chr1_+_145507587 0.23 ENST00000330165.8
ENST00000369307.3
RNA binding motif protein 8A
chr3_+_177534653 0.23 ENST00000436078.1
RP11-91K9.1
chr11_-_115127611 0.23 ENST00000545094.1
cell adhesion molecule 1
chr12_-_49351228 0.23 ENST00000541959.1
ENST00000447318.2
ADP-ribosylation factor 3
chr19_+_48949087 0.23 ENST00000598711.1
glutamate-rich WD repeat containing 1
chr7_-_130597935 0.22 ENST00000447307.1
ENST00000418546.1
microRNA 29a
chr15_-_80263506 0.22 ENST00000335661.6
BCL2-related protein A1
chr2_-_40679186 0.22 ENST00000406785.2
solute carrier family 8 (sodium/calcium exchanger), member 1
chr7_+_76101379 0.22 ENST00000429179.1
deltex homolog 2 (Drosophila)
chr16_+_69221028 0.22 ENST00000336278.4
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr9_-_117267717 0.22 ENST00000374057.3
deafness, autosomal recessive 31
chr12_-_89746173 0.21 ENST00000308385.6
dual specificity phosphatase 6
chr17_-_47308128 0.21 ENST00000413580.1
ENST00000511066.1
phosphatase, orphan 1
chr19_-_50529193 0.21 ENST00000596445.1
ENST00000599538.1
vaccinia related kinase 3
chr14_+_91709279 0.21 ENST00000554096.1
HCG1816139; Uncharacterized protein
chr8_-_6914251 0.21 ENST00000330590.2
defensin, alpha 5, Paneth cell-specific
chr17_-_47308100 0.21 ENST00000503902.1
ENST00000512250.1
phosphatase, orphan 1
chrX_-_132549506 0.20 ENST00000370828.3
glypican 4
chr14_-_51411194 0.20 ENST00000544180.2
phosphorylase, glycogen, liver
chr1_-_46598284 0.20 ENST00000423209.1
ENST00000262741.5
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
chr2_+_201994042 0.20 ENST00000417748.1
CASP8 and FADD-like apoptosis regulator
chrX_+_102862834 0.19 ENST00000372627.5
ENST00000243286.3
transcription elongation factor A (SII)-like 3
chr11_+_82783097 0.19 ENST00000501011.2
ENST00000527627.1
ENST00000526795.1
ENST00000533528.1
ENST00000533708.1
ENST00000534499.1
RAB30 antisense RNA 1 (head to head)
chr2_+_201994208 0.19 ENST00000440180.1
CASP8 and FADD-like apoptosis regulator
chr6_-_31619892 0.19 ENST00000454165.1
ENST00000428326.1
ENST00000452994.1
BCL2-associated athanogene 6
chr11_-_74204692 0.18 ENST00000528085.1
lipoyl(octanoyl) transferase 2 (putative)
chr19_+_55987998 0.18 ENST00000591164.1
zinc finger protein 628
chr16_+_75690093 0.18 ENST00000564671.2
telomeric repeat binding factor 2, interacting protein
chr18_-_6928495 0.18 ENST00000580197.1
long intergenic non-protein coding RNA 668
chr17_-_42452063 0.18 ENST00000588098.1
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr17_-_37557846 0.18 ENST00000394294.3
ENST00000583610.1
ENST00000264658.6
F-box and leucine-rich repeat protein 20
chr15_+_60296421 0.18 ENST00000396057.4
forkhead box B1
chr2_+_210636697 0.18 ENST00000439458.1
ENST00000272845.6
unc-80 homolog (C. elegans)
chr19_+_1000418 0.17 ENST00000234389.3
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
chr17_+_57970469 0.17 ENST00000443572.2
ENST00000406116.3
ENST00000225577.4
ENST00000393021.3
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr3_-_126373929 0.17 ENST00000523403.1
ENST00000524230.2
thioredoxin reductase 3
chr1_+_213123976 0.17 ENST00000366965.2
ENST00000366967.2
vasohibin 2
chrX_+_47050798 0.17 ENST00000412206.1
ENST00000427561.1
ubiquitin-like modifier activating enzyme 1
chr11_+_66824346 0.17 ENST00000532559.1
ras homolog family member D
chr12_-_70004942 0.16 ENST00000361484.3
leucine rich repeat containing 10
chr11_+_107799118 0.16 ENST00000320578.2
RAB39A, member RAS oncogene family
chr19_+_36236491 0.16 ENST00000591949.1
presenilin enhancer gamma secretase subunit
chr22_+_42196666 0.16 ENST00000402061.3
ENST00000255784.5
coiled-coil domain containing 134
chr15_+_59908633 0.16 ENST00000559626.1
glucosaminyl (N-acetyl) transferase 3, mucin type
chr4_-_185303418 0.16 ENST00000610223.1
ENST00000608785.1
RP11-290F5.1
chr1_+_200993071 0.16 ENST00000446333.1
ENST00000458003.1
RP11-168O16.1
chr8_+_38965048 0.16 ENST00000399831.3
ENST00000437682.2
ENST00000519315.1
ENST00000379907.4
ENST00000522506.1
ADAM metallopeptidase domain 32
chr18_-_32957260 0.16 ENST00000587422.1
ENST00000306346.1
ENST00000589332.1
ENST00000586687.1
ENST00000585522.1
zinc finger protein 396
chr22_+_18560743 0.16 ENST00000399744.3
peroxisomal biogenesis factor 26
chr3_+_119217422 0.16 ENST00000466984.1
translocase of inner mitochondrial membrane domain containing 1
chr17_+_25958174 0.16 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
lectin, galactoside-binding, soluble, 9
chr19_+_37407212 0.16 ENST00000427117.1
ENST00000587130.1
ENST00000333987.7
ENST00000415168.1
ENST00000444991.1
zinc finger protein 568
chr1_+_40840320 0.16 ENST00000372708.1
small ArfGAP2
chr1_+_20915409 0.16 ENST00000375071.3
cytidine deaminase
chr6_+_45389893 0.16 ENST00000371432.3
runt-related transcription factor 2
chr19_-_10426663 0.16 ENST00000541276.1
ENST00000393708.3
ENST00000494368.1
ferredoxin 1-like
chr1_+_41445413 0.16 ENST00000541520.1
CTP synthase 1
chr11_-_60010556 0.16 ENST00000427611.2
membrane-spanning 4-domains, subfamily A, member 4E
chr6_+_131894284 0.15 ENST00000368087.3
ENST00000356962.2
arginase 1
chr15_+_41913690 0.15 ENST00000563576.1
MGA, MAX dimerization protein
chr19_+_48949030 0.15 ENST00000253237.5
glutamate-rich WD repeat containing 1
chr16_+_57844549 0.15 ENST00000564282.1
uncharacterized protein LOC388282
chr3_+_57741957 0.15 ENST00000295951.3
sarcolemma associated protein
chr19_-_44258733 0.15 ENST00000597586.1
ENST00000596714.1
SMG9 nonsense mediated mRNA decay factor
chr6_-_154751629 0.15 ENST00000424998.1
CNKSR family member 3
chr16_-_79634595 0.15 ENST00000326043.4
ENST00000393350.1
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chr22_-_38699003 0.15 ENST00000451964.1
casein kinase 1, epsilon
chr2_-_61697862 0.15 ENST00000398571.2
ubiquitin specific peptidase 34
chr13_+_46276441 0.15 ENST00000310521.1
ENST00000533564.1
spermatid associated
chr8_+_145218673 0.15 ENST00000326134.5
maestro heat-like repeat family member 1
chr1_+_155294342 0.15 ENST00000292254.4
RUN and SH3 domain containing 1
chr4_-_89619386 0.15 ENST00000323061.5
nucleosome assembly protein 1-like 5
chr19_-_13213662 0.15 ENST00000264824.4
lymphoblastic leukemia derived sequence 1
chr2_-_177684007 0.15 ENST00000451851.1
AC092162.1
chr17_-_79604075 0.15 ENST00000374747.5
ENST00000539314.1
ENST00000331134.6
nuclear protein localization 4 homolog (S. cerevisiae)
chr17_+_7358889 0.14 ENST00000575379.1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr20_+_30193083 0.14 ENST00000376112.3
ENST00000376105.3
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
chr2_-_228497888 0.14 ENST00000264387.4
ENST00000409066.1
chromosome 2 open reading frame 83
chr1_-_19229218 0.14 ENST00000432718.1
aldehyde dehydrogenase 4 family, member A1
chr2_-_113594279 0.14 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
interleukin 1, beta
chr8_+_145490549 0.14 ENST00000340695.2
scleraxis homolog A (mouse)
chr1_+_27648648 0.14 ENST00000374076.4
transmembrane protein 222
chr2_-_200322723 0.14 ENST00000417098.1
SATB homeobox 2
chr22_-_42915788 0.14 ENST00000323013.6
ribosomal RNA processing 7 homolog A (S. cerevisiae)
chr11_-_111649074 0.14 ENST00000534218.1
RP11-108O10.2
chr6_+_26383318 0.14 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
butyrophilin, subfamily 2, member A2
chr2_-_74776586 0.14 ENST00000420535.1
lysyl oxidase-like 3
chr7_+_150076406 0.14 ENST00000329630.5
zinc finger protein 775
chr15_-_38852251 0.14 ENST00000558432.1
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr15_-_52030293 0.14 ENST00000560491.1
ENST00000267838.3
LysM, putative peptidoglycan-binding, domain containing 2
chr20_-_1165319 0.14 ENST00000429036.1
transmembrane protein 74B
chrX_-_69509738 0.14 ENST00000374454.1
ENST00000239666.4
PDZ domain containing 11
chr3_+_121554046 0.14 ENST00000273668.2
ENST00000451944.2
ELL associated factor 2
chr14_+_23727694 0.14 ENST00000399905.1
ENST00000470456.1
chromosome 14 open reading frame 164
chr14_-_51411146 0.14 ENST00000532462.1
phosphorylase, glycogen, liver
chr21_+_30503282 0.13 ENST00000399925.1
MAP3K7 C-terminal like
chr17_-_40428359 0.13 ENST00000293328.3
signal transducer and activator of transcription 5B
chr14_-_81687575 0.13 ENST00000434192.2
general transcription factor IIA, 1, 19/37kDa
chr2_+_228678550 0.13 ENST00000409189.3
ENST00000358813.4
chemokine (C-C motif) ligand 20
chr9_-_86322516 0.13 ENST00000529923.1
ubiquilin 1
chr16_+_77233294 0.13 ENST00000378644.4
synaptonemal complex central element protein 1-like
chr9_+_22646189 0.13 ENST00000436786.1
RP11-399D6.2
chr16_+_72459838 0.13 ENST00000564508.1
AC004158.3
chr1_+_26737253 0.13 ENST00000326279.6
lin-28 homolog A (C. elegans)
chr17_+_46184911 0.13 ENST00000580219.1
ENST00000452859.2
ENST00000393405.2
ENST00000439357.2
ENST00000359238.2
sorting nexin 11
chr15_-_83316087 0.13 ENST00000568757.1
cytoplasmic polyadenylation element binding protein 1
chr3_-_196065248 0.13 ENST00000446879.1
ENST00000273695.3
transmembrane 4 L six family member 19
chr15_-_33180439 0.13 ENST00000559610.1
formin 1
chr4_-_90756769 0.13 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
synuclein, alpha (non A4 component of amyloid precursor)

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX21_TBR1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.3 0.8 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.2 0.8 GO:0001757 somite specification(GO:0001757)
0.2 0.9 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 0.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.7 GO:0001315 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.1 1.4 GO:1904327 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 0.5 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
0.1 0.6 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.1 0.5 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 0.3 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 0.2 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.1 0.2 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 0.7 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.1 0.8 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.1 0.4 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.4 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.4 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.3 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.4 GO:0045354 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.1 0.4 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 0.3 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.1 0.3 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.3 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.2 GO:0007412 axon target recognition(GO:0007412)
0.1 0.2 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 0.3 GO:0014805 smooth muscle adaptation(GO:0014805)
0.0 0.4 GO:0006880 intracellular sequestering of iron ion(GO:0006880) negative regulation of heart rate(GO:0010459) sequestering of iron ion(GO:0097577)
0.0 0.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.4 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0045362 interleukin-1 biosynthetic process(GO:0042222) regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0 0.1 GO:1901340 negative regulation of store-operated calcium channel activity(GO:1901340)
0.0 0.2 GO:1903826 arginine transmembrane transport(GO:1903826)
0.0 0.2 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.0 0.2 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.2 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.5 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.2 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.2 GO:0051621 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.5 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.1 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.0 0.4 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.2 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.2 GO:0002860 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.4 GO:0035630 bone mineralization involved in bone maturation(GO:0035630)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.2 GO:0046717 glutamate secretion(GO:0014047) acid secretion(GO:0046717)
0.0 0.1 GO:2000329 peptidyl-lysine oxidation(GO:0018057) negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
0.0 0.1 GO:0000255 allantoin metabolic process(GO:0000255)
0.0 0.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.1 GO:2000987 hormone-mediated apoptotic signaling pathway(GO:0008628) cellular response to cocaine(GO:0071314) positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0032826 natural killer cell differentiation involved in immune response(GO:0002325) regulation of natural killer cell differentiation involved in immune response(GO:0032826) regulation of cytolysis in other organism(GO:0051710)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.0 GO:0072695 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0 0.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.1 GO:0032252 secretory granule localization(GO:0032252)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.2 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093)
0.0 0.1 GO:1903026 negative regulation of endothelial cell differentiation(GO:0045602) negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.6 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.0 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:0030101 natural killer cell activation(GO:0030101)
0.0 0.1 GO:1905066 regulation of Wnt signaling pathway involved in heart development(GO:0003307) arterial endothelial cell fate commitment(GO:0060844) positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.0 GO:0032661 central nervous system myelin formation(GO:0032289) regulation of interleukin-18 production(GO:0032661) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 0.1 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.2 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.0 0.1 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.0 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.0 0.1 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.1 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.5 GO:2000772 regulation of cellular senescence(GO:2000772)
0.0 0.3 GO:0008228 opsonization(GO:0008228)
0.0 0.1 GO:0015747 urate transport(GO:0015747)
0.0 0.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.0 0.1 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.0 0.1 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.1 GO:0043622 cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660)
0.0 0.0 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.2 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 0.1 GO:0035864 response to potassium ion(GO:0035864)
0.0 0.2 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 0.3 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.0 0.3 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0036117 hyaluranon cable(GO:0036117)
0.1 1.4 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.4 GO:0044326 dendritic spine neck(GO:0044326)
0.1 0.4 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.1 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.7 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.1 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.4 GO:0097227 sperm annulus(GO:0097227)
0.0 0.4 GO:0097342 ripoptosome(GO:0097342)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 0.0 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.0 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.3 GO:0031092 platelet alpha granule membrane(GO:0031092)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 0.9 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 0.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.4 GO:0051373 FATZ binding(GO:0051373)
0.1 0.7 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.1 0.7 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.3 GO:0008184 purine nucleobase binding(GO:0002060) glycogen phosphorylase activity(GO:0008184)
0.1 0.5 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 1.4 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.2 GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.1 0.6 GO:0016015 morphogen activity(GO:0016015)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.2 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.2 GO:0048030 disaccharide binding(GO:0048030)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.2 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.3 GO:0043426 MRF binding(GO:0043426)
0.0 0.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.1 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.2 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.3 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 0.3 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.2 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.4 GO:0019841 retinol binding(GO:0019841)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.8 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.0 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.0 0.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.2 GO:1990825 G-quadruplex RNA binding(GO:0002151) sequence-specific mRNA binding(GO:1990825)
0.0 0.2 GO:0016594 glycine binding(GO:0016594)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.1 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.2 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.0 GO:0004461 lactose synthase activity(GO:0004461)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.3 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.8 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.9 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.4 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.8 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.7 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR