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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for TFAP2E

Z-value: 0.29

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
TFAP2E
ENSG00000116819.6 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TFAP2Ehg19_v2_chr1_+_36038971_360389710.376.3e-01Click!

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_17634689 0.23 ENST00000375453.1
ENST00000375448.4
PADI4
peptidyl arginine deiminase, type IV
chr17_+_74070853 0.21 ENST00000329003.3
GALR2
galanin receptor 2
chr9_-_86432547 0.18 ENST00000376365.3
ENST00000376371.2
GKAP1
G kinase anchoring protein 1
chr12_-_15942503 0.18 ENST00000281172.5
EPS8
epidermal growth factor receptor pathway substrate 8
chr6_+_292253 0.17 ENST00000603453.1
ENST00000605315.1
ENST00000603881.1
DUSP22
dual specificity phosphatase 22
chr6_+_13272904 0.17 ENST00000379335.3
ENST00000379329.1
PHACTR1
phosphatase and actin regulator 1
chr12_-_15942309 0.16 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8
epidermal growth factor receptor pathway substrate 8
chr7_+_100464760 0.15 ENST00000200457.4
TRIP6
thyroid hormone receptor interactor 6
chr22_+_22676808 0.14 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr3_+_105086056 0.14 ENST00000472644.2
ALCAM
activated leukocyte cell adhesion molecule
chr2_-_174828892 0.13 ENST00000418194.2
SP3
Sp3 transcription factor
chr3_+_110790590 0.13 ENST00000485303.1
PVRL3
poliovirus receptor-related 3
chr11_-_82612678 0.13 ENST00000534631.1
ENST00000531801.1
PRCP
prolylcarboxypeptidase (angiotensinase C)
chr11_-_82612549 0.13 ENST00000528082.1
ENST00000533126.1
PRCP
prolylcarboxypeptidase (angiotensinase C)
chr4_+_41992489 0.12 ENST00000264451.7
SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr1_+_9005917 0.12 ENST00000549778.1
ENST00000480186.3
ENST00000377443.2
ENST00000377436.3
ENST00000377442.2
CA6
carbonic anhydrase VI
chr22_+_29601840 0.12 ENST00000334018.6
ENST00000429226.1
ENST00000404755.3
ENST00000404820.3
ENST00000430127.1
EMID1
EMI domain containing 1
chrX_+_131157322 0.11 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4
Serine/threonine-protein kinase MST4
chr15_+_27112296 0.10 ENST00000554038.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr20_-_13619550 0.10 ENST00000455532.1
ENST00000544472.1
ENST00000539805.1
ENST00000337743.4
TASP1
taspase, threonine aspartase, 1
chr19_-_10613862 0.10 ENST00000592055.1
KEAP1
kelch-like ECH-associated protein 1
chr13_-_76056250 0.09 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1D4
TBC1 domain family, member 4
chr2_+_38893047 0.08 ENST00000272252.5
GALM
galactose mutarotase (aldose 1-epimerase)
chr22_+_31608219 0.08 ENST00000406516.1
ENST00000444929.2
ENST00000331728.4
LIMK2
LIM domain kinase 2
chr1_+_211433275 0.08 ENST00000367005.4
RCOR3
REST corepressor 3
chr11_+_82612740 0.08 ENST00000524921.1
ENST00000528759.1
ENST00000525361.1
ENST00000430323.2
ENST00000533655.1
ENST00000532764.1
ENST00000532589.1
ENST00000525388.1
C11orf82
chromosome 11 open reading frame 82
chr1_+_104068562 0.07 ENST00000423855.2
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr9_+_19230433 0.07 ENST00000434457.2
ENST00000602925.1
DENND4C
DENN/MADD domain containing 4C
chr17_-_47755338 0.07 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
SPOP
speckle-type POZ protein
chr17_-_42188598 0.07 ENST00000591714.1
HDAC5
histone deacetylase 5
chr12_-_65153175 0.06 ENST00000543646.1
ENST00000542058.1
ENST00000258145.3
GNS
glucosamine (N-acetyl)-6-sulfatase
chr12_+_53443963 0.06 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr17_-_47755436 0.06 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
SPOP
speckle-type POZ protein
chr12_-_48213735 0.06 ENST00000417902.1
ENST00000417107.1
HDAC7
histone deacetylase 7
chrX_+_131157290 0.06 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chr11_-_71753188 0.06 ENST00000543009.1
NUMA1
nuclear mitotic apparatus protein 1
chr1_+_233749739 0.06 ENST00000366621.3
KCNK1
potassium channel, subfamily K, member 1
chr14_-_64010006 0.06 ENST00000555899.1
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr11_-_82612727 0.06 ENST00000531128.1
ENST00000535099.1
ENST00000527444.1
PRCP
prolylcarboxypeptidase (angiotensinase C)
chr17_+_3627185 0.06 ENST00000325418.4
GSG2
germ cell associated 2 (haspin)
chr22_+_31644388 0.06 ENST00000333611.4
ENST00000340552.4
LIMK2
LIM domain kinase 2
chr19_-_11039188 0.05 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr11_+_118478313 0.05 ENST00000356063.5
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr8_+_17780346 0.05 ENST00000325083.8
PCM1
pericentriolar material 1
chr19_+_49458107 0.05 ENST00000539787.1
ENST00000345358.7
ENST00000391871.3
ENST00000415969.2
ENST00000354470.3
ENST00000506183.1
ENST00000293288.8
BAX
BCL2-associated X protein
chr7_-_140624499 0.05 ENST00000288602.6
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr8_+_17780483 0.05 ENST00000517730.1
ENST00000518537.1
ENST00000523055.1
ENST00000519253.1
PCM1
pericentriolar material 1
chr17_+_29158962 0.05 ENST00000321990.4
ATAD5
ATPase family, AAA domain containing 5
chr7_-_23053719 0.05 ENST00000432176.2
ENST00000440481.1
FAM126A
family with sequence similarity 126, member A
chr12_-_48213568 0.05 ENST00000080059.7
ENST00000354334.3
ENST00000430670.1
ENST00000552960.1
ENST00000440293.1
HDAC7
histone deacetylase 7
chr4_-_82393009 0.04 ENST00000436139.2
RASGEF1B
RasGEF domain family, member 1B
chr3_-_136471204 0.04 ENST00000480733.1
ENST00000383202.2
ENST00000236698.5
ENST00000434713.2
STAG1
stromal antigen 1
chr6_+_150070831 0.04 ENST00000367380.5
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr11_-_66056478 0.04 ENST00000431556.2
ENST00000528575.1
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr11_-_47870019 0.04 ENST00000378460.2
NUP160
nucleoporin 160kDa
chrX_+_51636629 0.04 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
MAGED1
melanoma antigen family D, 1
chr14_-_64010046 0.04 ENST00000337537.3
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr8_+_125463048 0.04 ENST00000328599.3
TRMT12
tRNA methyltransferase 12 homolog (S. cerevisiae)
chr2_-_133429091 0.04 ENST00000345008.6
LYPD1
LY6/PLAUR domain containing 1
chr7_-_23053693 0.04 ENST00000409763.1
ENST00000409923.1
FAM126A
family with sequence similarity 126, member A
chr1_+_104068312 0.04 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr5_-_179499086 0.03 ENST00000261947.4
RNF130
ring finger protein 130
chr11_-_65625014 0.03 ENST00000534784.1
CFL1
cofilin 1 (non-muscle)
chr20_+_36888551 0.03 ENST00000418004.1
ENST00000451435.1
BPI
bactericidal/permeability-increasing protein
chr20_+_58508817 0.03 ENST00000358293.3
FAM217B
family with sequence similarity 217, member B
chr5_-_179498703 0.03 ENST00000522208.2
RNF130
ring finger protein 130
chr11_-_71752571 0.03 ENST00000544238.1
NUMA1
nuclear mitotic apparatus protein 1
chr11_+_116700600 0.03 ENST00000227667.3
APOC3
apolipoprotein C-III
chr1_-_11865351 0.03 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr11_-_47869865 0.03 ENST00000530326.1
ENST00000532747.1
NUP160
nucleoporin 160kDa
chr3_+_50192833 0.03 ENST00000426511.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr11_+_116700614 0.03 ENST00000375345.1
APOC3
apolipoprotein C-III
chrX_+_54466829 0.03 ENST00000375151.4
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr4_+_154387480 0.03 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922
KIAA0922
chr2_+_241375069 0.02 ENST00000264039.2
GPC1
glypican 1
chr22_+_38146987 0.02 ENST00000418339.1
TRIOBP
TRIO and F-actin binding protein
chr2_-_24149977 0.02 ENST00000238789.5
ATAD2B
ATPase family, AAA domain containing 2B
chr2_+_75061108 0.02 ENST00000290573.2
HK2
hexokinase 2
chr1_-_231175964 0.02 ENST00000366654.4
FAM89A
family with sequence similarity 89, member A
chr2_-_37551846 0.02 ENST00000443187.1
PRKD3
protein kinase D3
chr9_+_136501478 0.02 ENST00000393056.2
ENST00000263611.2
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr1_+_17248418 0.02 ENST00000375541.5
CROCC
ciliary rootlet coiled-coil, rootletin
chr17_+_40932610 0.02 ENST00000246914.5
WNK4
WNK lysine deficient protein kinase 4
chr5_+_133984462 0.02 ENST00000398844.2
ENST00000322887.4
SEC24A
SEC24 family member A
chr11_-_47870091 0.02 ENST00000526870.1
NUP160
nucleoporin 160kDa
chr9_+_128024067 0.02 ENST00000461379.1
ENST00000394084.1
ENST00000394105.2
ENST00000470056.1
ENST00000394104.2
ENST00000265956.4
ENST00000394083.2
ENST00000495955.1
ENST00000467750.1
ENST00000297933.6
GAPVD1
GTPase activating protein and VPS9 domains 1
chr15_+_27112058 0.02 ENST00000355395.5
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr2_+_233243233 0.02 ENST00000392027.2
ALPP
alkaline phosphatase, placental
chr19_+_11039391 0.02 ENST00000270502.6
C19orf52
chromosome 19 open reading frame 52
chr11_-_61062762 0.01 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr17_+_36584662 0.01 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr1_-_63782888 0.01 ENST00000436475.2
LINC00466
long intergenic non-protein coding RNA 466
chr16_-_28506840 0.01 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chr1_-_11866034 0.01 ENST00000376590.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chrX_+_49028265 0.01 ENST00000376322.3
ENST00000376327.5
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr6_+_150070857 0.01 ENST00000544496.1
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr22_-_39096661 0.01 ENST00000216039.5
JOSD1
Josephin domain containing 1
chr1_-_9189144 0.01 ENST00000414642.2
GPR157
G protein-coupled receptor 157
chr3_+_51428704 0.01 ENST00000323686.4
RBM15B
RNA binding motif protein 15B
chr8_+_22250334 0.01 ENST00000520832.1
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr15_+_27112251 0.00 ENST00000400081.3
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr15_+_77287426 0.00 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr14_-_25519095 0.00 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr16_-_72698834 0.00 ENST00000570152.1
ENST00000561611.2
ENST00000570035.1
AC004158.2
AC004158.2
chr10_+_99894399 0.00 ENST00000298999.3
ENST00000314594.5
R3HCC1L
R3H domain and coiled-coil containing 1-like
chr5_-_179499108 0.00 ENST00000521389.1
RNF130
ring finger protein 130
chr15_+_27112194 0.00 ENST00000555182.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr3_-_48130314 0.00 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4
microtubule-associated protein 4
chr7_-_129251459 0.00 ENST00000608694.1
RP11-448A19.1
RP11-448A19.1

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.3 GO:0002353 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.0 0.3 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.1 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.0 GO:0002352 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway