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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for ZFHX3

Z-value: 0.48

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Transcription factors associated with ZFHX3

Gene Symbol Gene ID Gene Info
ZFHX3
ENSG00000140836.10 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZFHX3hg19_v2_chr16_-_73082274_73082274-0.495.1e-01Click!

Activity profile of ZFHX3 motif

Sorted Z-values of ZFHX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_111649015 0.21 ENST00000529841.1
RP11-108O10.2
RP11-108O10.2
chr16_-_28192360 0.19 ENST00000570033.1
XPO6
exportin 6
chr19_-_36304201 0.19 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr17_-_64225508 0.16 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chrM_+_14741 0.15 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b
chr12_-_91546926 0.14 ENST00000550758.1
DCN
decorin
chr6_+_161123270 0.13 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chrM_+_10053 0.13 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr9_+_44868935 0.13 ENST00000448436.2
RP11-160N1.10
RP11-160N1.10
chr11_-_125366089 0.12 ENST00000366139.3
ENST00000278919.3
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr16_-_69385681 0.11 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr14_+_95027772 0.11 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr16_-_75284758 0.10 ENST00000561970.1
BCAR1
breast cancer anti-estrogen resistance 1
chr11_-_61687739 0.10 ENST00000531922.1
ENST00000301773.5
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr14_-_83262540 0.09 ENST00000554451.1
RP11-11K13.1
RP11-11K13.1
chr5_+_60933634 0.09 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr3_-_161089289 0.09 ENST00000497137.1
SPTSSB
serine palmitoyltransferase, small subunit B
chr16_+_87636474 0.09 ENST00000284262.2
JPH3
junctophilin 3
chr1_+_76540386 0.08 ENST00000328299.3
ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr15_-_42343388 0.08 ENST00000399518.3
PLA2G4E
phospholipase A2, group IVE
chr16_-_15474904 0.08 ENST00000534094.1
NPIPA5
nuclear pore complex interacting protein family, member A5
chrY_-_20935572 0.08 ENST00000382852.1
ENST00000344884.4
ENST00000304790.3
HSFY2
heat shock transcription factor, Y linked 2
chrX_-_18690210 0.08 ENST00000379984.3
RS1
retinoschisin 1
chr12_+_54410664 0.08 ENST00000303406.4
HOXC4
homeobox C4
chrY_+_20708557 0.08 ENST00000307393.2
ENST00000309834.4
ENST00000382856.2
HSFY1
heat shock transcription factor, Y-linked 1
chrX_+_1710484 0.07 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr11_+_71934962 0.07 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase-like 1
chrM_+_8527 0.07 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase 6
chr4_-_155511887 0.07 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr7_-_86595190 0.07 ENST00000398276.2
ENST00000416314.1
ENST00000425689.1
KIAA1324L
KIAA1324-like
chr13_-_30881134 0.07 ENST00000380617.3
ENST00000441394.1
KATNAL1
katanin p60 subunit A-like 1
chrM_-_14670 0.07 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chrX_-_110655306 0.06 ENST00000371993.2
DCX
doublecortin
chr19_-_58864848 0.06 ENST00000263100.3
A1BG
alpha-1-B glycoprotein
chr15_-_76352069 0.06 ENST00000305435.10
ENST00000563910.1
NRG4
neuregulin 4
chr9_-_95298314 0.06 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr6_+_126070726 0.06 ENST00000368364.3
HEY2
hes-related family bHLH transcription factor with YRPW motif 2
chr4_-_149365827 0.06 ENST00000344721.4
NR3C2
nuclear receptor subfamily 3, group C, member 2
chr21_+_40824003 0.06 ENST00000452550.1
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr22_-_30970560 0.06 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr5_-_125930929 0.05 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chrM_+_9207 0.05 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr14_-_54425475 0.05 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr11_+_22696314 0.05 ENST00000532398.1
ENST00000433790.1
GAS2
growth arrest-specific 2
chr1_-_247921982 0.05 ENST00000408896.2
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr12_+_65996599 0.04 ENST00000539116.1
ENST00000541391.1
RP11-221N13.3
RP11-221N13.3
chr11_-_111649074 0.04 ENST00000534218.1
RP11-108O10.2
RP11-108O10.2
chr13_-_30880979 0.04 ENST00000414289.1
KATNAL1
katanin p60 subunit A-like 1
chr22_-_22337204 0.04 ENST00000430142.1
ENST00000357179.5
TOP3B
topoisomerase (DNA) III beta
chr12_+_131438443 0.04 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chrX_+_84258832 0.04 ENST00000373173.2
APOOL
apolipoprotein O-like
chr6_-_161085291 0.03 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr2_+_190541153 0.03 ENST00000313581.4
ENST00000438402.2
ENST00000431575.2
ENST00000281412.6
ANKAR
ankyrin and armadillo repeat containing
chr19_+_926000 0.03 ENST00000263620.3
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr4_+_3443614 0.03 ENST00000382774.3
ENST00000511533.1
HGFAC
HGF activator
chr3_+_46919235 0.03 ENST00000449590.1
PTH1R
parathyroid hormone 1 receptor
chr7_+_150725510 0.03 ENST00000461373.1
ENST00000358849.4
ENST00000297504.6
ENST00000542328.1
ENST00000498578.1
ENST00000356058.4
ENST00000477719.1
ENST00000477092.1
ABCB8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr2_+_105050794 0.03 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr17_-_26697304 0.03 ENST00000536498.1
VTN
vitronectin
chr2_-_60780702 0.03 ENST00000359629.5
BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr6_-_116447283 0.03 ENST00000452729.1
ENST00000243222.4
COL10A1
collagen, type X, alpha 1
chr2_-_60780546 0.03 ENST00000358510.4
BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr2_-_60780536 0.03 ENST00000538214.1
BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr19_-_46234119 0.03 ENST00000317683.3
FBXO46
F-box protein 46
chr1_+_63063152 0.02 ENST00000371129.3
ANGPTL3
angiopoietin-like 3
chr6_-_31681839 0.02 ENST00000409239.1
ENST00000461287.1
LY6G6E
XXbac-BPG32J3.20
lymphocyte antigen 6 complex, locus G6E (pseudogene)
Uncharacterized protein
chr1_-_159684371 0.02 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr3_-_49066811 0.02 ENST00000442157.1
ENST00000326739.4
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr10_+_45406627 0.02 ENST00000389583.4
TMEM72
transmembrane protein 72
chr6_-_152793728 0.02 ENST00000495090.2
SYNE1
spectrin repeat containing, nuclear envelope 1
chr9_-_123812542 0.02 ENST00000223642.1
C5
complement component 5
chr12_+_53835383 0.02 ENST00000429243.2
PRR13
proline rich 13
chr8_+_98900132 0.02 ENST00000520016.1
MATN2
matrilin 2
chr7_+_100026406 0.02 ENST00000414441.1
MEPCE
methylphosphate capping enzyme
chr20_-_33735070 0.02 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr2_-_60780607 0.02 ENST00000537768.1
ENST00000335712.6
ENST00000356842.4
BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr8_+_104831440 0.02 ENST00000515551.1
RIMS2
regulating synaptic membrane exocytosis 2
chr7_+_48211048 0.02 ENST00000435803.1
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr11_-_125366018 0.02 ENST00000527534.1
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr12_-_10321754 0.02 ENST00000539518.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr8_-_70745575 0.02 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr12_+_53835539 0.02 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
PRR13
proline rich 13
chr12_+_53835508 0.02 ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
ENST00000541275.1
PRR13
PCBP2
proline rich 13
poly(rC) binding protein 2
chr12_+_59989791 0.01 ENST00000552432.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr19_+_50016610 0.01 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr7_-_7575477 0.01 ENST00000399429.3
COL28A1
collagen, type XXVIII, alpha 1
chr7_-_91794590 0.01 ENST00000430130.2
ENST00000454089.2
LRRD1
leucine-rich repeats and death domain containing 1
chrX_-_32173579 0.01 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr2_+_234627424 0.01 ENST00000373409.3
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chrX_-_15619076 0.01 ENST00000252519.3
ACE2
angiotensin I converting enzyme 2
chrX_+_9431324 0.01 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr15_+_58724184 0.01 ENST00000433326.2
LIPC
lipase, hepatic
chr2_-_87248975 0.01 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr6_+_25754927 0.01 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr14_+_39703084 0.00 ENST00000553728.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr3_-_114477787 0.00 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr8_-_18541603 0.00 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.2 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:2000173 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.0 0.1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.1 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.0 0.1 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.1 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.2 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 0.1 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.1 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.0 0.1 GO:0051013 microtubule severing(GO:0051013)
0.0 0.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.1 GO:0036025 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)