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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ATF4

Z-value: 0.57

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ENSG00000128272.10 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_399165790.621.9e-01Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_28550320 1.05 ENST00000395641.2
nuclear protein, transcriptional regulator, 1
chr15_+_41245160 0.68 ENST00000444189.2
ENST00000446533.3
ChaC, cation transport regulator homolog 1 (E. coli)
chr16_-_28550348 0.64 ENST00000324873.6
nuclear protein, transcriptional regulator, 1
chr17_-_77967433 0.64 ENST00000571872.1
TBC1 domain family, member 16
chr12_-_57914275 0.54 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
DNA-damage-inducible transcript 3
chr1_+_239882842 0.47 ENST00000448020.1
cholinergic receptor, muscarinic 3
chr12_+_57914481 0.46 ENST00000548887.1
methyl-CpG binding domain protein 6
chr12_+_57914742 0.42 ENST00000551351.1
methyl-CpG binding domain protein 6
chr14_-_100841794 0.40 ENST00000556295.1
ENST00000554820.1
tryptophanyl-tRNA synthetase
chr2_+_65663812 0.34 ENST00000606978.1
ENST00000377977.3
ENST00000536804.1
AC074391.1
chr16_+_56970567 0.31 ENST00000563911.1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr2_-_98280383 0.29 ENST00000289228.5
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr14_-_100841670 0.28 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
tryptophanyl-tRNA synthetase
chr19_-_47288162 0.26 ENST00000594991.1
solute carrier family 1 (neutral amino acid transporter), member 5
chr17_+_56315936 0.22 ENST00000543544.1
lactoperoxidase
chr16_-_70323422 0.22 ENST00000261772.8
alanyl-tRNA synthetase
chr14_-_100841930 0.22 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
tryptophanyl-tRNA synthetase
chr19_-_47287990 0.22 ENST00000593713.1
ENST00000598022.1
ENST00000434726.2
solute carrier family 1 (neutral amino acid transporter), member 5
chr17_-_76836963 0.21 ENST00000312010.6
ubiquitin specific peptidase 36
chr7_-_56101826 0.21 ENST00000421626.1
phosphoserine phosphatase
chr1_+_149804218 0.19 ENST00000610125.1
histone cluster 2, H4a
chr11_-_3078616 0.19 ENST00000401769.3
ENST00000278224.9
ENST00000397114.3
ENST00000380525.4
cysteinyl-tRNA synthetase
chr10_-_101190202 0.19 ENST00000543866.1
ENST00000370508.5
glutamic-oxaloacetic transaminase 1, soluble
chr17_+_73089382 0.19 ENST00000538213.2
ENST00000584118.1
solute carrier family 16 (monocarboxylate transporter), member 5
chr2_-_46769694 0.18 ENST00000522587.1
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr10_-_21806759 0.17 ENST00000444772.3
SKI/DACH domain containing 1
chr17_+_56315787 0.17 ENST00000262290.4
ENST00000421678.2
lactoperoxidase
chr12_+_57623477 0.16 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr17_-_46703826 0.16 ENST00000550387.1
ENST00000311177.5
homeobox B9
chr11_+_62649158 0.16 ENST00000539891.1
ENST00000536981.1
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr22_+_42229100 0.16 ENST00000361204.4
sterol regulatory element binding transcription factor 2
chr17_-_79895097 0.16 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
pyrroline-5-carboxylate reductase 1
chr12_+_57624059 0.15 ENST00000557427.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr5_+_154135029 0.15 ENST00000518297.1
La ribonucleoprotein domain family, member 1
chr17_-_79895154 0.15 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
pyrroline-5-carboxylate reductase 1
chr12_+_57623907 0.15 ENST00000553529.1
ENST00000554310.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_-_44497024 0.15 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr12_+_57624085 0.14 ENST00000553474.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr17_-_76836729 0.14 ENST00000587783.1
ENST00000542802.3
ENST00000586531.1
ENST00000589424.1
ENST00000590546.2
ubiquitin specific peptidase 36
chr7_-_48068699 0.14 ENST00000412142.1
ENST00000395572.2
Sad1 and UNC84 domain containing 3
chrX_+_48398053 0.13 ENST00000537536.1
ENST00000418627.1
TBC1 domain family, member 25
chr14_+_75894714 0.13 ENST00000559060.1
Jun dimerization protein 2
chr16_+_67694849 0.13 ENST00000602551.1
ENST00000458121.2
ENST00000219255.3
par-6 family cell polarity regulator alpha
chr1_+_212782012 0.12 ENST00000341491.4
ENST00000366985.1
activating transcription factor 3
chr14_+_75894391 0.12 ENST00000419727.2
Jun dimerization protein 2
chr12_+_57624119 0.12 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
serine hydroxymethyltransferase 2 (mitochondrial)
chr12_+_57623869 0.12 ENST00000414700.3
ENST00000557703.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr11_+_58938903 0.12 ENST00000532982.1
deltex homolog 4 (Drosophila)
chrX_-_68385274 0.12 ENST00000374584.3
ENST00000590146.1
praja ring finger 1, E3 ubiquitin protein ligase
chr21_-_44495964 0.11 ENST00000398168.1
ENST00000398165.3
cystathionine-beta-synthase
chr14_+_24563510 0.11 ENST00000545054.2
ENST00000561286.1
ENST00000558096.1
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr19_-_51014460 0.11 ENST00000595669.1
Josephin domain containing 2
chr19_-_51014345 0.11 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
Josephin domain containing 2
chr12_-_25102252 0.11 ENST00000261192.7
branched chain amino-acid transaminase 1, cytosolic
chrX_-_68385354 0.11 ENST00000361478.1
praja ring finger 1, E3 ubiquitin protein ligase
chr1_+_154244987 0.11 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HCLS1 associated protein X-1
chr17_-_77813186 0.10 ENST00000448310.1
ENST00000269397.4
chromobox homolog 4
chrX_-_15332665 0.10 ENST00000537676.1
ENST00000344384.4
ankyrin repeat and SOCS box containing 11
chr11_-_3078838 0.10 ENST00000397111.5
cysteinyl-tRNA synthetase
chr5_+_174151536 0.10 ENST00000239243.6
ENST00000507785.1
msh homeobox 2
chr16_-_67694597 0.10 ENST00000393919.4
ENST00000219251.8
adrenocortical dysplasia homolog (mouse)
chrX_-_133792480 0.10 ENST00000359237.4
placenta-specific 1
chr22_+_50919995 0.10 ENST00000362068.2
ENST00000395737.1
adrenomedullin 2
chr3_-_48130707 0.10 ENST00000360240.6
ENST00000383737.4
microtubule-associated protein 4
chr1_+_162602244 0.10 ENST00000367922.3
ENST00000367921.3
discoidin domain receptor tyrosine kinase 2
chr3_+_11314099 0.10 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
autophagy related 7
chr7_-_48068671 0.09 ENST00000297325.4
Sad1 and UNC84 domain containing 3
chr17_+_1665306 0.09 ENST00000571360.1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_+_24563262 0.09 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chrX_+_9431324 0.09 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr1_+_241815577 0.08 ENST00000366552.2
ENST00000437684.2
WD repeat domain 64
chr7_-_99006443 0.08 ENST00000350498.3
PDGFA associated protein 1
chr12_+_56862301 0.08 ENST00000338146.5
SPRY domain containing 4
chr8_-_116680833 0.08 ENST00000220888.5
trichorhinophalangeal syndrome I
chr16_-_18908196 0.08 ENST00000565324.1
ENST00000561947.1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr1_-_38412683 0.08 ENST00000373024.3
ENST00000373023.2
inositol polyphosphate-5-phosphatase, 75kDa
chr7_-_115670792 0.08 ENST00000265440.7
ENST00000393485.1
transcription factor EC
chr1_-_44497118 0.08 ENST00000537678.1
ENST00000466926.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr5_+_143584814 0.07 ENST00000507359.3
potassium channel tetramerization domain containing 16
chr16_+_56965960 0.07 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_+_1665345 0.07 ENST00000576406.1
ENST00000571149.1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_-_51014588 0.07 ENST00000598418.1
Josephin domain containing 2
chr21_-_44495919 0.07 ENST00000398158.1
cystathionine-beta-synthase
chr7_-_115670804 0.06 ENST00000320239.7
transcription factor EC
chr7_+_48211048 0.06 ENST00000435803.1
ATP-binding cassette, sub-family A (ABC1), member 13
chr22_+_50919944 0.06 ENST00000395738.2
adrenomedullin 2
chr8_-_38008783 0.05 ENST00000276449.4
steroidogenic acute regulatory protein
chr10_+_14880287 0.05 ENST00000437161.2
heat shock 70kDa protein 14
chr16_+_46918235 0.05 ENST00000340124.4
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr5_+_167956121 0.04 ENST00000338333.4
fibrillarin-like 1
chr7_-_50860565 0.04 ENST00000403097.1
growth factor receptor-bound protein 10
chr17_-_40828969 0.04 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr20_+_23342783 0.04 ENST00000544236.1
ENST00000338121.5
ENST00000542987.1
ENST00000424216.1
GDNF-inducible zinc finger protein 1
chr12_-_25101920 0.04 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
branched chain amino-acid transaminase 1, cytosolic
chr6_+_151187615 0.04 ENST00000441122.1
ENST00000423867.1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr17_+_46133307 0.03 ENST00000580037.1
nuclear factor, erythroid 2-like 1
chr8_-_116681686 0.03 ENST00000519815.1
trichorhinophalangeal syndrome I
chr12_+_93963590 0.03 ENST00000340600.2
suppressor of cytokine signaling 2
chrX_-_80457385 0.03 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
high mobility group nucleosome binding domain 5
chr12_-_92539614 0.03 ENST00000256015.3
B-cell translocation gene 1, anti-proliferative
chr3_-_48130314 0.03 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
microtubule-associated protein 4
chr11_+_118955583 0.03 ENST00000278715.3
ENST00000536813.1
ENST00000537841.1
ENST00000542729.1
ENST00000546302.1
ENST00000442944.2
ENST00000544387.1
ENST00000543090.1
hydroxymethylbilane synthase
chr11_-_128737259 0.03 ENST00000440599.2
ENST00000392666.1
ENST00000324036.3
potassium inwardly-rectifying channel, subfamily J, member 1
chr11_+_93754513 0.03 ENST00000315765.9
hephaestin-like 1
chr12_+_6493406 0.03 ENST00000543190.1
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr10_+_63661053 0.02 ENST00000279873.7
AT rich interactive domain 5B (MRF1-like)
chr1_-_207143802 0.02 ENST00000324852.4
ENST00000400962.3
Fc receptor, IgA, IgM, high affinity
chr11_-_128737163 0.02 ENST00000324003.3
ENST00000392665.2
potassium inwardly-rectifying channel, subfamily J, member 1
chr11_-_77185094 0.02 ENST00000278568.4
ENST00000356341.3
p21 protein (Cdc42/Rac)-activated kinase 1
chr1_-_52521831 0.01 ENST00000371626.4
thioredoxin domain containing 12 (endoplasmic reticulum)
chr8_-_11324273 0.01 ENST00000284486.4
family with sequence similarity 167, member A
chr1_+_112016414 0.01 ENST00000343534.5
ENST00000369718.3
chromosome 1 open reading frame 162
chr12_+_57849048 0.01 ENST00000266646.2
inhibin, beta E
chr9_+_80912059 0.01 ENST00000347159.2
ENST00000376588.3
phosphoserine aminotransferase 1
chr11_-_57092381 0.01 ENST00000358252.3
tankyrase 1 binding protein 1, 182kDa
chr2_+_7118755 0.01 ENST00000433456.1
ring finger protein 144A
chr17_-_40829026 0.01 ENST00000412503.1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr1_-_178840157 0.01 ENST00000367629.1
ENST00000234816.2
angiopoietin-like 1
chr4_-_153457197 0.00 ENST00000281708.4
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr7_-_48068643 0.00 ENST00000453192.2
Sad1 and UNC84 domain containing 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.6 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.1 0.5 GO:0010585 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.1 0.3 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.1 1.7 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 0.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.8 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.1 0.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.2 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.2 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533)
0.0 0.2 GO:0006535 cysteine biosynthetic process from serine(GO:0006535) cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0 0.3 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.0 0.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.7 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.1 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.0 0.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.2 GO:0006116 NADH oxidation(GO:0006116)
0.0 0.1 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.2 GO:0072752 cellular response to rapamycin(GO:0072752)
0.0 0.1 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.2 GO:0060356 leucine import(GO:0060356)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.4 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.1 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.0 0.0 GO:0006524 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080)
0.0 0.0 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.6 GO:0001919 regulation of receptor recycling(GO:0001919)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.2 0.5 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.8 GO:0070552 BRISC complex(GO:0070552)
0.1 0.4 GO:1990037 Lewy body core(GO:1990037)
0.0 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.9 GO:0010369 chromocenter(GO:0010369)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.9 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.3 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.1 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.8 GO:0004793 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.2 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 0.2 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.5 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 0.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.2 GO:0004122 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.0 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.0 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters