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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for BHLHE22_BHLHA15_BHLHE23

Z-value: 0.76

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Transcription factors associated with BHLHE22_BHLHA15_BHLHE23

Gene Symbol Gene ID Gene Info
BHLHE22
ENSG00000180828.1 basic helix-loop-helix family member e22
BHLHA15
ENSG00000180535.3 basic helix-loop-helix family member a15
BHLHE23
ENSG00000125533.4 basic helix-loop-helix family member e23

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE22hg19_v2_chr8_+_65492756_654928140.739.9e-02Click!
BHLHA15hg19_v2_chr7_+_97840739_97840786-0.197.2e-01Click!

Activity profile of BHLHE22_BHLHA15_BHLHE23 motif

Sorted Z-values of BHLHE22_BHLHA15_BHLHE23 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_66918558 0.82 ENST00000435389.1
ENST00000428590.1
ENST00000412944.1
AC007392.3
AC007392.3
chr6_+_135502501 0.62 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr3_-_178984759 0.45 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr16_-_69385681 0.41 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr6_+_163148161 0.39 ENST00000337019.3
ENST00000366889.2
PACRG
PARK2 co-regulated
chr8_+_67782984 0.35 ENST00000396592.3
ENST00000422365.2
ENST00000492775.1
MCMDC2
minichromosome maintenance domain containing 2
chr1_+_185126598 0.30 ENST00000450350.1
SWT1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr5_-_159766528 0.28 ENST00000505287.2
CCNJL
cyclin J-like
chrX_+_70798261 0.28 ENST00000373696.3
ACRC
acidic repeat containing
chr7_-_101212244 0.26 ENST00000451953.1
ENST00000434537.1
ENST00000437900.1
LINC01007
long intergenic non-protein coding RNA 1007
chr17_+_75316336 0.26 ENST00000591934.1
SEPT9
septin 9
chr11_-_26743546 0.25 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr15_+_40650408 0.25 ENST00000267889.3
DISP2
dispatched homolog 2 (Drosophila)
chr1_-_186344802 0.23 ENST00000451586.1
TPR
translocated promoter region, nuclear basket protein
chr1_-_98515395 0.23 ENST00000424528.2
MIR137HG
MIR137 host gene (non-protein coding)
chr11_+_65405556 0.23 ENST00000534313.1
ENST00000533361.1
ENST00000526137.1
SIPA1
signal-induced proliferation-associated 1
chr19_+_57874835 0.22 ENST00000543226.1
ENST00000596755.1
ENST00000282282.3
ENST00000597658.1
TRAPPC2P1
ZNF547
AC003002.4
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
Uncharacterized protein
chr10_+_89124746 0.21 ENST00000465545.1
NUTM2D
NUT family member 2D
chr17_+_7211656 0.21 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr12_-_94673956 0.20 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr3_-_121379739 0.19 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr4_+_55095428 0.18 ENST00000508170.1
ENST00000512143.1
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr3_+_75713481 0.18 ENST00000308062.3
ENST00000464571.1
FRG2C
FSHD region gene 2 family, member C
chr14_-_107283278 0.17 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr1_+_81106951 0.16 ENST00000443565.1
RP5-887A10.1
RP5-887A10.1
chr3_-_114477962 0.15 ENST00000471418.1
ZBTB20
zinc finger and BTB domain containing 20
chr15_+_65843130 0.15 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr13_+_28813645 0.15 ENST00000282391.5
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr8_+_38239882 0.15 ENST00000607047.1
RP11-350N15.5
RP11-350N15.5
chr1_+_244214577 0.13 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr7_-_38403077 0.12 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr7_-_27205136 0.12 ENST00000396345.1
ENST00000343483.6
HOXA9
homeobox A9
chr20_+_33292507 0.12 ENST00000414082.1
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr3_-_114477787 0.11 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr8_-_101724989 0.11 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chrX_+_105855160 0.11 ENST00000372544.2
ENST00000372548.4
CXorf57
chromosome X open reading frame 57
chr17_+_46048497 0.11 ENST00000583352.1
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr19_+_42041702 0.11 ENST00000487420.2
AC006129.4
AC006129.4
chr21_-_36421401 0.10 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr14_+_32414059 0.10 ENST00000553330.1
RP11-187E13.1
Uncharacterized protein
chr1_-_168464875 0.10 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr17_-_73874654 0.09 ENST00000254816.2
TRIM47
tripartite motif containing 47
chr15_-_55700216 0.09 ENST00000569205.1
CCPG1
cell cycle progression 1
chr14_-_69444957 0.09 ENST00000556571.1
ENST00000553659.1
ENST00000555616.1
ACTN1
actinin, alpha 1
chr5_-_111312622 0.08 ENST00000395634.3
NREP
neuronal regeneration related protein
chr7_-_48068699 0.08 ENST00000412142.1
ENST00000395572.2
SUN3
Sad1 and UNC84 domain containing 3
chr1_+_186344945 0.08 ENST00000419367.3
ENST00000287859.6
C1orf27
chromosome 1 open reading frame 27
chr3_+_72201910 0.08 ENST00000469178.1
ENST00000485404.1
LINC00870
long intergenic non-protein coding RNA 870
chr16_+_31119615 0.08 ENST00000394950.3
ENST00000287507.3
ENST00000219794.6
ENST00000561755.1
BCKDK
branched chain ketoacid dehydrogenase kinase
chr5_+_173316341 0.08 ENST00000520867.1
ENST00000334035.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr18_-_70305745 0.08 ENST00000581073.1
CBLN2
cerebellin 2 precursor
chr11_-_115127611 0.08 ENST00000545094.1
CADM1
cell adhesion molecule 1
chr8_-_135522425 0.07 ENST00000521673.1
ZFAT
zinc finger and AT hook domain containing
chrX_+_107288239 0.07 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr17_+_7211280 0.07 ENST00000419711.2
ENST00000571955.1
ENST00000573714.1
EIF5A
eukaryotic translation initiation factor 5A
chr1_-_205091115 0.07 ENST00000264515.6
ENST00000367164.1
RBBP5
retinoblastoma binding protein 5
chrX_+_107288197 0.07 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr6_-_108278456 0.07 ENST00000429168.1
SEC63
SEC63 homolog (S. cerevisiae)
chr11_+_66008698 0.07 ENST00000531597.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr4_+_74301880 0.06 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr10_-_15902449 0.06 ENST00000277632.3
FAM188A
family with sequence similarity 188, member A
chr3_-_55515400 0.06 ENST00000497027.1
WNT5A
wingless-type MMTV integration site family, member 5A
chr15_+_85144217 0.06 ENST00000540936.1
ENST00000448803.2
ENST00000546275.1
ENST00000546148.1
ENST00000442073.3
ENST00000334141.3
ENST00000358472.3
ENST00000502939.2
ENST00000379358.3
ENST00000327179.6
ZSCAN2
zinc finger and SCAN domain containing 2
chr19_+_42041860 0.06 ENST00000483481.2
ENST00000494375.2
AC006129.4
AC006129.4
chr3_+_62304648 0.05 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
C3orf14
chromosome 3 open reading frame 14
chr2_+_219840955 0.05 ENST00000598002.1
ENST00000432733.1
LINC00608
long intergenic non-protein coding RNA 608
chr3_-_55515202 0.05 ENST00000482079.1
WNT5A
wingless-type MMTV integration site family, member 5A
chr3_-_150264272 0.05 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
SERP1
stress-associated endoplasmic reticulum protein 1
chrX_-_15402498 0.05 ENST00000297904.3
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr9_-_10612703 0.04 ENST00000463477.1
PTPRD
protein tyrosine phosphatase, receptor type, D
chr16_+_72142195 0.04 ENST00000563819.1
ENST00000567142.2
DHX38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr10_+_17794251 0.04 ENST00000377495.1
ENST00000338221.5
TMEM236
transmembrane protein 236
chr17_-_47286729 0.04 ENST00000300406.2
ENST00000511277.1
ENST00000511673.1
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr1_+_180897269 0.04 ENST00000367587.1
KIAA1614
KIAA1614
chr15_+_63354769 0.04 ENST00000558910.1
TPM1
tropomyosin 1 (alpha)
chr6_+_4087664 0.04 ENST00000430835.2
C6orf201
chromosome 6 open reading frame 201
chr7_-_48068671 0.04 ENST00000297325.4
SUN3
Sad1 and UNC84 domain containing 3
chr13_+_49551020 0.04 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr4_-_113207048 0.04 ENST00000361717.3
TIFA
TRAF-interacting protein with forkhead-associated domain
chr1_+_12524965 0.04 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr1_-_44818599 0.03 ENST00000537474.1
ERI3
ERI1 exoribonuclease family member 3
chr4_-_141075330 0.03 ENST00000509479.2
MAML3
mastermind-like 3 (Drosophila)
chr12_+_2912363 0.03 ENST00000544366.1
FKBP4
FK506 binding protein 4, 59kDa
chr3_-_52719546 0.03 ENST00000439181.1
ENST00000449505.1
PBRM1
polybromo 1
chr19_-_52227221 0.03 ENST00000222115.1
ENST00000540069.2
HAS1
hyaluronan synthase 1
chr7_-_97881429 0.03 ENST00000420697.1
ENST00000379795.3
ENST00000415086.1
ENST00000542604.1
ENST00000447648.2
TECPR1
tectonin beta-propeller repeat containing 1
chr3_+_185300270 0.03 ENST00000430355.1
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr11_+_120107344 0.03 ENST00000260264.4
POU2F3
POU class 2 homeobox 3
chr6_+_116442320 0.03 ENST00000430695.1
AL121963.1
Uncharacterized protein
chr5_+_71475449 0.03 ENST00000504492.1
MAP1B
microtubule-associated protein 1B
chr16_-_4896205 0.03 ENST00000589389.1
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr12_+_79371565 0.03 ENST00000551304.1
SYT1
synaptotagmin I
chr12_+_58166431 0.03 ENST00000333012.5
METTL21B
methyltransferase like 21B
chr1_+_100810575 0.02 ENST00000542213.1
CDC14A
cell division cycle 14A
chrX_-_19817869 0.02 ENST00000379698.4
SH3KBP1
SH3-domain kinase binding protein 1
chr10_+_99627889 0.02 ENST00000596005.1
GOLGA7B
Golgin subfamily A member 7B; cDNA FLJ43465 fis, clone OCBBF2036476
chr3_-_33700589 0.02 ENST00000461133.3
ENST00000496954.2
CLASP2
cytoplasmic linker associated protein 2
chr17_-_56492989 0.02 ENST00000583753.1
RNF43
ring finger protein 43
chr8_+_21823726 0.02 ENST00000433566.4
XPO7
exportin 7
chr11_-_44972418 0.02 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
TP53I11
tumor protein p53 inducible protein 11
chr2_+_210444298 0.02 ENST00000445941.1
MAP2
microtubule-associated protein 2
chr17_+_80858418 0.02 ENST00000574422.1
TBCD
tubulin folding cofactor D
chr15_-_55700522 0.02 ENST00000564092.1
ENST00000310958.6
CCPG1
cell cycle progression 1
chr1_+_170633047 0.02 ENST00000239461.6
ENST00000497230.2
PRRX1
paired related homeobox 1
chr7_+_116502605 0.02 ENST00000458284.2
ENST00000490693.1
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr8_-_67976509 0.02 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr12_-_95397442 0.02 ENST00000547157.1
ENST00000547986.1
ENST00000327772.2
NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr4_+_115519894 0.02 ENST00000507710.1
UGT8
UDP glycosyltransferase 8
chr10_-_74114714 0.02 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DNAJB12
DnaJ (Hsp40) homolog, subfamily B, member 12
chr15_-_55700457 0.01 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
CCPG1
cell cycle progression 1
chr9_+_12775011 0.01 ENST00000319264.3
LURAP1L
leucine rich adaptor protein 1-like
chr5_-_171433579 0.01 ENST00000265094.5
ENST00000393802.2
FBXW11
F-box and WD repeat domain containing 11
chrX_+_107334895 0.01 ENST00000372232.3
ENST00000345734.3
ENST00000372254.3
ATG4A
autophagy related 4A, cysteine peptidase
chr9_+_108424738 0.01 ENST00000334077.3
TAL2
T-cell acute lymphocytic leukemia 2
chr2_+_162480918 0.01 ENST00000272716.5
ENST00000446997.1
SLC4A10
solute carrier family 4, sodium bicarbonate transporter, member 10
chr11_+_94501497 0.01 ENST00000317829.8
ENST00000317837.9
ENST00000433060.2
AMOTL1
angiomotin like 1
chr16_+_14726672 0.01 ENST00000261658.2
ENST00000563971.1
BFAR
bifunctional apoptosis regulator
chr14_-_51297837 0.01 ENST00000245441.5
ENST00000389868.3
ENST00000382041.3
ENST00000324330.9
ENST00000453196.1
ENST00000453401.2
NIN
ninein (GSK3B interacting protein)
chr4_+_55095264 0.01 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr14_-_51297197 0.01 ENST00000382043.4
NIN
ninein (GSK3B interacting protein)
chr4_-_100575781 0.01 ENST00000511828.1
RP11-766F14.2
Protein LOC285556
chr2_+_181845843 0.01 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr11_-_44972476 0.01 ENST00000527685.1
ENST00000308212.5
TP53I11
tumor protein p53 inducible protein 11
chr9_+_125796806 0.01 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chr6_-_112115103 0.01 ENST00000462598.3
FYN
FYN oncogene related to SRC, FGR, YES
chr2_-_32490859 0.01 ENST00000404025.2
NLRC4
NLR family, CARD domain containing 4
chrX_+_128913906 0.01 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chrX_-_84363974 0.01 ENST00000395409.3
ENST00000332921.5
ENST00000509231.1
SATL1
spermidine/spermine N1-acetyl transferase-like 1
chr15_-_98417780 0.01 ENST00000503874.3
LINC00923
long intergenic non-protein coding RNA 923
chr4_-_159094194 0.01 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B
family with sequence similarity 198, member B
chr2_-_227050079 0.00 ENST00000423838.1
AC068138.1
AC068138.1
chrX_-_13835147 0.00 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr2_-_32490801 0.00 ENST00000360906.5
ENST00000342905.6
NLRC4
NLR family, CARD domain containing 4
chr13_+_111766897 0.00 ENST00000317133.5
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr12_-_91573132 0.00 ENST00000550563.1
ENST00000546370.1
DCN
decorin
chr17_-_47286244 0.00 ENST00000503070.1
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr12_+_50794891 0.00 ENST00000517559.1
LARP4
La ribonucleoprotein domain family, member 4
chr10_+_18629628 0.00 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chrX_+_69509927 0.00 ENST00000374403.3
KIF4A
kinesin family member 4A
chr5_-_171433819 0.00 ENST00000296933.6
FBXW11
F-box and WD repeat domain containing 11
chrX_-_13835461 0.00 ENST00000316715.4
ENST00000356942.5
GPM6B
glycoprotein M6B
chr11_-_62359027 0.00 ENST00000494385.1
ENST00000308436.7
TUT1
terminal uridylyl transferase 1, U6 snRNA-specific
chr5_-_114631958 0.00 ENST00000395557.4
CCDC112
coiled-coil domain containing 112
chr2_+_108994466 0.00 ENST00000272452.2
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE22_BHLHA15_BHLHE23

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 0.3 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.1 0.2 GO:0045799 negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.0 0.2 GO:0042631 cellular response to water deprivation(GO:0042631)
0.0 0.3 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0061348 chemoattraction of serotonergic neuron axon(GO:0036517) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) chemoattraction of axon(GO:0061642) melanocyte proliferation(GO:0097325) negative regulation of cell proliferation in midbrain(GO:1904934) planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation(GO:1904955)
0.0 0.2 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0 0.5 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.1 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005018 platelet-derived growth factor alpha-receptor activity(GO:0005018)
0.0 0.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0005115 receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.3 GO:0017070 U6 snRNA binding(GO:0017070)