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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CBFB

Z-value: 0.48

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Transcription factors associated with CBFB

Gene Symbol Gene ID Gene Info
CBFB
ENSG00000067955.9 core-binding factor subunit beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CBFBhg19_v2_chr16_+_67063262_670633640.891.8e-02Click!

Activity profile of CBFB motif

Sorted Z-values of CBFB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_209859510 0.55 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr2_+_173955327 0.40 ENST00000422149.1
MLTK
Mitogen-activated protein kinase kinase kinase MLT
chr1_+_196621002 0.37 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr11_+_114310237 0.33 ENST00000539119.1
REXO2
RNA exonuclease 2
chr7_+_7196565 0.33 ENST00000429911.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr1_+_196621156 0.31 ENST00000359637.2
CFH
complement factor H
chr21_+_35107346 0.31 ENST00000456489.1
ITSN1
intersectin 1 (SH3 domain protein)
chr4_-_156297949 0.30 ENST00000515654.1
MAP9
microtubule-associated protein 9
chr15_+_49715449 0.28 ENST00000560979.1
FGF7
fibroblast growth factor 7
chr5_+_131409476 0.28 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr14_-_35183886 0.26 ENST00000298159.6
CFL2
cofilin 2 (muscle)
chr1_-_240775447 0.25 ENST00000318160.4
GREM2
gremlin 2, DAN family BMP antagonist
chr5_-_39203093 0.22 ENST00000515010.1
FYB
FYN binding protein
chr1_+_17634689 0.20 ENST00000375453.1
ENST00000375448.4
PADI4
peptidyl arginine deiminase, type IV
chr9_-_130541017 0.20 ENST00000314830.8
SH2D3C
SH2 domain containing 3C
chr5_+_35856951 0.19 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr15_-_64665911 0.19 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr8_-_96281419 0.17 ENST00000286688.5
C8orf37
chromosome 8 open reading frame 37
chr8_+_104384616 0.17 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr5_-_137878887 0.16 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1
eukaryotic translation termination factor 1
chr6_-_113953705 0.16 ENST00000452675.1
RP11-367G18.1
RP11-367G18.1
chr2_-_127977654 0.16 ENST00000409327.1
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr2_-_87248975 0.15 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr1_+_89246647 0.14 ENST00000544045.1
PKN2
protein kinase N2
chr6_+_30908747 0.14 ENST00000462446.1
ENST00000304311.2
DPCR1
diffuse panbronchiolitis critical region 1
chr17_-_39183452 0.14 ENST00000361883.5
KRTAP1-5
keratin associated protein 1-5
chr15_+_49715293 0.12 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr6_+_27925019 0.12 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr11_-_58343319 0.11 ENST00000395074.2
LPXN
leupaxin
chr11_+_114310164 0.11 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
REXO2
RNA exonuclease 2
chr12_-_53575120 0.11 ENST00000542115.1
CSAD
cysteine sulfinic acid decarboxylase
chr13_-_103019744 0.11 ENST00000437115.2
FGF14-IT1
FGF14 intronic transcript 1 (non-protein coding)
chr13_+_76210448 0.10 ENST00000377499.5
LMO7
LIM domain 7
chr22_+_42665742 0.10 ENST00000332965.3
ENST00000415205.1
ENST00000446578.1
Z83851.3
Z83851.3
chr19_-_14049184 0.10 ENST00000339560.5
PODNL1
podocan-like 1
chr5_-_108745689 0.08 ENST00000361189.2
PJA2
praja ring finger 2, E3 ubiquitin protein ligase
chr1_-_184723942 0.07 ENST00000318130.8
EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr6_-_75912508 0.07 ENST00000416123.2
COL12A1
collagen, type XII, alpha 1
chr12_-_121972556 0.07 ENST00000545022.1
KDM2B
lysine (K)-specific demethylase 2B
chrX_+_115567767 0.07 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr12_-_4754318 0.07 ENST00000536414.1
AKAP3
A kinase (PRKA) anchor protein 3
chr17_+_32582293 0.07 ENST00000580907.1
ENST00000225831.4
CCL2
chemokine (C-C motif) ligand 2
chr12_-_54778244 0.06 ENST00000549937.1
ZNF385A
zinc finger protein 385A
chr11_+_114310102 0.06 ENST00000265881.5
REXO2
RNA exonuclease 2
chr3_+_157154578 0.06 ENST00000295927.3
PTX3
pentraxin 3, long
chr11_-_1912084 0.06 ENST00000391480.1
C11orf89
chromosome 11 open reading frame 89
chr5_+_67576109 0.06 ENST00000522084.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr12_-_4754356 0.06 ENST00000540967.1
AKAP3
A kinase (PRKA) anchor protein 3
chr1_+_66796401 0.06 ENST00000528771.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr16_+_53088885 0.06 ENST00000566029.1
ENST00000447540.1
CHD9
chromodomain helicase DNA binding protein 9
chr21_-_36421626 0.06 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr6_-_34524049 0.05 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr11_-_18343669 0.05 ENST00000396253.3
ENST00000349215.3
ENST00000438420.2
HPS5
Hermansky-Pudlak syndrome 5
chr11_-_66103867 0.05 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chr2_+_207024306 0.04 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr8_+_67624653 0.04 ENST00000521198.2
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr18_-_53089538 0.04 ENST00000566777.1
TCF4
transcription factor 4
chr7_+_120628731 0.04 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr18_-_53089723 0.04 ENST00000561992.1
ENST00000562512.2
TCF4
transcription factor 4
chr12_-_14849470 0.04 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr12_-_54778444 0.04 ENST00000551771.1
ZNF385A
zinc finger protein 385A
chr13_-_28674693 0.04 ENST00000537084.1
ENST00000241453.7
ENST00000380982.4
FLT3
fms-related tyrosine kinase 3
chr2_-_158300556 0.04 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr15_-_64386120 0.04 ENST00000300030.3
FAM96A
family with sequence similarity 96, member A
chr14_-_85996332 0.04 ENST00000380722.1
RP11-497E19.1
RP11-497E19.1
chr14_-_59951112 0.04 ENST00000247194.4
L3HYPDH
L-3-hydroxyproline dehydratase (trans-)
chr20_+_54987305 0.03 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr15_-_64385981 0.03 ENST00000557835.1
ENST00000380290.3
ENST00000559950.1
FAM96A
family with sequence similarity 96, member A
chr3_+_156799587 0.03 ENST00000469196.1
RP11-6F2.5
RP11-6F2.5
chr14_-_59950724 0.02 ENST00000481608.1
L3HYPDH
L-3-hydroxyproline dehydratase (trans-)
chr1_-_184006829 0.02 ENST00000361927.4
COLGALT2
collagen beta(1-O)galactosyltransferase 2
chr21_-_36421401 0.02 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr11_+_18343800 0.02 ENST00000453096.2
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr8_-_60031762 0.01 ENST00000361421.1
TOX
thymocyte selection-associated high mobility group box
chr6_+_45296391 0.01 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr12_-_54778471 0.01 ENST00000550120.1
ENST00000394313.2
ENST00000547210.1
ZNF385A
zinc finger protein 385A
chr20_+_54987168 0.01 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr7_+_117119187 0.01 ENST00000446805.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr17_-_34417479 0.00 ENST00000225245.5
CCL3
chemokine (C-C motif) ligand 3

Network of associatons between targets according to the STRING database.

First level regulatory network of CBFB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.3 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.1 0.4 GO:0060437 lung growth(GO:0060437)
0.1 0.3 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.2 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0042412 taurine biosynthetic process(GO:0042412)
0.0 0.2 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.0 0.6 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.1 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624) negative regulation of natural killer cell chemotaxis(GO:2000502)
0.0 0.2 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.1 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.3 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.1 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.1 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.2 GO:0006449 regulation of translational termination(GO:0006449)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.2 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.0 GO:0031084 BLOC-2 complex(GO:0031084)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.3 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.0 0.2 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.0 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.3 GO:0036122 BMP binding(GO:0036122)
0.0 0.1 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones