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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DDIT3

Z-value: 0.63

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Transcription factors associated with DDIT3

Gene Symbol Gene ID Gene Info
DDIT3
ENSG00000175197.6 DNA damage inducible transcript 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DDIT3hg19_v2_chr12_-_57914275_579143040.777.5e-02Click!

Activity profile of DDIT3 motif

Sorted Z-values of DDIT3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_77967433 0.79 ENST00000571872.1
TBC1D16
TBC1 domain family, member 16
chr3_-_9595480 0.42 ENST00000287585.6
LHFPL4
lipoma HMGIC fusion partner-like 4
chr6_+_144606817 0.38 ENST00000433557.1
UTRN
utrophin
chr2_+_7118755 0.36 ENST00000433456.1
RNF144A
ring finger protein 144A
chr15_+_41245160 0.31 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr1_+_149804218 0.23 ENST00000610125.1
HIST2H4A
histone cluster 2, H4a
chr14_+_64565442 0.22 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr15_+_59730348 0.22 ENST00000288228.5
ENST00000559628.1
ENST00000557914.1
ENST00000560474.1
FAM81A
family with sequence similarity 81, member A
chr4_+_157997273 0.20 ENST00000541722.1
ENST00000512619.1
GLRB
glycine receptor, beta
chr12_-_25102252 0.20 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chrX_+_16188506 0.20 ENST00000329538.5
MAGEB17
melanoma antigen family B, 17
chr1_-_67519782 0.19 ENST00000235345.5
SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr20_+_24929866 0.19 ENST00000480798.1
ENST00000376835.2
CST7
cystatin F (leukocystatin)
chr15_+_85923797 0.18 ENST00000559362.1
AKAP13
A kinase (PRKA) anchor protein 13
chr4_+_141178440 0.18 ENST00000394205.3
SCOC
short coiled-coil protein
chr12_-_25101920 0.18 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr14_-_23446003 0.18 ENST00000553911.1
AJUBA
ajuba LIM protein
chr6_-_48036363 0.18 ENST00000543600.1
ENST00000398738.2
ENST00000339488.4
PTCHD4
patched domain containing 4
chr3_-_45883558 0.17 ENST00000445698.1
ENST00000296135.6
LZTFL1
leucine zipper transcription factor-like 1
chr10_-_17659234 0.16 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chrX_-_100129128 0.15 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr2_-_159313214 0.15 ENST00000409889.1
ENST00000283233.5
ENST00000536771.1
CCDC148
coiled-coil domain containing 148
chr7_-_130597935 0.14 ENST00000447307.1
ENST00000418546.1
MIR29B1
microRNA 29a
chr2_-_208030295 0.14 ENST00000458272.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr19_+_1450112 0.14 ENST00000590469.1
ENST00000233607.2
ENST00000238483.4
ENST00000590877.1
APC2
adenomatosis polyposis coli 2
chr2_+_63816126 0.13 ENST00000454035.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr12_-_53074182 0.12 ENST00000252244.3
KRT1
keratin 1
chr2_-_43453734 0.12 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr2_+_75185619 0.12 ENST00000483063.1
POLE4
polymerase (DNA-directed), epsilon 4, accessory subunit
chr11_+_20044096 0.12 ENST00000533917.1
NAV2
neuron navigator 2
chr7_-_56101826 0.11 ENST00000421626.1
PSPH
phosphoserine phosphatase
chr9_+_80912059 0.11 ENST00000347159.2
ENST00000376588.3
PSAT1
phosphoserine aminotransferase 1
chr15_+_85923856 0.11 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
AKAP13
A kinase (PRKA) anchor protein 13
chr16_-_18908196 0.11 ENST00000565324.1
ENST00000561947.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr1_-_114447412 0.11 ENST00000369567.1
ENST00000369566.3
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr19_-_49258606 0.11 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr17_-_46691990 0.10 ENST00000576562.1
HOXB8
homeobox B8
chr11_-_8816375 0.10 ENST00000530580.1
ST5
suppression of tumorigenicity 5
chr12_-_63328817 0.10 ENST00000228705.6
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr13_-_24007815 0.10 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr1_-_161277210 0.09 ENST00000491222.2
MPZ
myelin protein zero
chr8_+_24151553 0.09 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28
ADAM metallopeptidase domain 28
chr11_-_8680383 0.09 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr10_-_17659357 0.09 ENST00000326961.6
ENST00000361271.3
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr5_+_112074029 0.09 ENST00000512211.2
APC
adenomatous polyposis coli
chr1_-_152196669 0.08 ENST00000368801.2
HRNR
hornerin
chr16_-_68269971 0.08 ENST00000565858.1
ESRP2
epithelial splicing regulatory protein 2
chr12_+_64798826 0.08 ENST00000540203.1
XPOT
exportin, tRNA
chr10_-_116444371 0.08 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr2_-_32390801 0.08 ENST00000608489.1
RP11-563N4.1
RP11-563N4.1
chr9_+_70971815 0.08 ENST00000396392.1
ENST00000396396.1
PGM5
phosphoglucomutase 5
chr16_+_56965960 0.08 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr6_-_24489842 0.08 ENST00000230036.1
GPLD1
glycosylphosphatidylinositol specific phospholipase D1
chr6_-_157744531 0.07 ENST00000400788.4
ENST00000367144.4
TMEM242
transmembrane protein 242
chr11_-_8739566 0.07 ENST00000533020.1
ST5
suppression of tumorigenicity 5
chr22_+_31518938 0.07 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr2_+_63816269 0.06 ENST00000432309.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr14_-_74226961 0.06 ENST00000286523.5
ENST00000435371.1
ELMSAN1
ELM2 and Myb/SANT-like domain containing 1
chr2_+_63816295 0.06 ENST00000539945.1
ENST00000544381.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr17_+_56315936 0.06 ENST00000543544.1
LPO
lactoperoxidase
chr1_+_174844645 0.06 ENST00000486220.1
RABGAP1L
RAB GTPase activating protein 1-like
chr2_-_101925055 0.06 ENST00000295317.3
RNF149
ring finger protein 149
chr3_+_38017264 0.05 ENST00000436654.1
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr2_+_223289208 0.05 ENST00000321276.7
SGPP2
sphingosine-1-phosphate phosphatase 2
chr4_-_184243561 0.05 ENST00000514470.1
ENST00000541814.1
CLDN24
claudin 24
chr2_+_63816087 0.05 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr15_-_88799948 0.05 ENST00000394480.2
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr15_-_64126084 0.05 ENST00000560316.1
ENST00000443617.2
ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr17_-_34257771 0.05 ENST00000394529.3
ENST00000293273.6
RDM1
RAD52 motif 1
chr14_+_102276132 0.04 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr14_+_32798462 0.04 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr17_+_56315787 0.04 ENST00000262290.4
ENST00000421678.2
LPO
lactoperoxidase
chr5_+_72143988 0.04 ENST00000506351.2
TNPO1
transportin 1
chr9_-_124991124 0.04 ENST00000394319.4
ENST00000340587.3
LHX6
LIM homeobox 6
chr7_+_44040488 0.04 ENST00000258704.3
SPDYE1
speedy/RINGO cell cycle regulator family member E1
chr1_+_90308981 0.04 ENST00000527156.1
LRRC8D
leucine rich repeat containing 8 family, member D
chr1_-_114447683 0.04 ENST00000256658.4
ENST00000369564.1
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr5_+_154135029 0.04 ENST00000518297.1
LARP1
La ribonucleoprotein domain family, member 1
chr17_-_2117600 0.04 ENST00000572369.1
SMG6
SMG6 nonsense mediated mRNA decay factor
chr14_+_102276192 0.04 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr17_-_77813186 0.04 ENST00000448310.1
ENST00000269397.4
CBX4
chromobox homolog 4
chr2_-_208030647 0.03 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr11_-_104972158 0.03 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr8_+_24151620 0.03 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr4_-_99578789 0.03 ENST00000511651.1
ENST00000505184.1
TSPAN5
tetraspanin 5
chr11_+_62495541 0.03 ENST00000530625.1
ENST00000513247.2
TTC9C
tetratricopeptide repeat domain 9C
chr19_+_33865218 0.03 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr2_-_63815628 0.03 ENST00000409562.3
WDPCP
WD repeat containing planar cell polarity effector
chr1_-_207143802 0.03 ENST00000324852.4
ENST00000400962.3
FCAMR
Fc receptor, IgA, IgM, high affinity
chr1_+_111770294 0.03 ENST00000474304.2
CHI3L2
chitinase 3-like 2
chr8_-_18744528 0.03 ENST00000523619.1
PSD3
pleckstrin and Sec7 domain containing 3
chr17_+_4336955 0.03 ENST00000355530.2
SPNS3
spinster homolog 3 (Drosophila)
chr2_-_179672142 0.03 ENST00000342992.6
ENST00000360870.5
ENST00000460472.2
ENST00000589042.1
ENST00000591111.1
ENST00000342175.6
ENST00000359218.5
TTN
titin
chr5_+_145583156 0.02 ENST00000265271.5
RBM27
RNA binding motif protein 27
chr10_-_13523073 0.02 ENST00000440282.1
BEND7
BEN domain containing 7
chr10_-_103874692 0.02 ENST00000361198.5
LDB1
LIM domain binding 1
chr11_-_56310757 0.02 ENST00000528616.2
OR5M11
olfactory receptor, family 5, subfamily M, member 11
chr20_+_54987168 0.02 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr9_+_125486269 0.02 ENST00000259466.1
OR1L4
olfactory receptor, family 1, subfamily L, member 4
chr8_-_21669826 0.02 ENST00000517328.1
GFRA2
GDNF family receptor alpha 2
chr8_-_11058847 0.02 ENST00000297303.4
ENST00000416569.2
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr1_+_169079823 0.02 ENST00000367813.3
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr1_+_222910625 0.02 ENST00000360827.2
FAM177B
family with sequence similarity 177, member B
chr5_-_131630931 0.02 ENST00000431054.1
P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
chr7_-_44530479 0.02 ENST00000355451.7
NUDCD3
NudC domain containing 3
chr1_+_40840320 0.02 ENST00000372708.1
SMAP2
small ArfGAP2
chr17_+_7477040 0.02 ENST00000581384.1
ENST00000577929.1
EIF4A1
eukaryotic translation initiation factor 4A1
chr14_-_23446021 0.02 ENST00000553592.1
AJUBA
ajuba LIM protein
chr16_+_56970567 0.02 ENST00000563911.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr14_+_62462541 0.01 ENST00000430451.2
SYT16
synaptotagmin XVI
chr10_+_60028818 0.01 ENST00000333926.5
CISD1
CDGSH iron sulfur domain 1
chr17_+_4337199 0.01 ENST00000333476.2
SPNS3
spinster homolog 3 (Drosophila)
chr14_+_32798547 0.01 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr7_-_130598059 0.01 ENST00000432045.2
MIR29B1
microRNA 29a
chr1_+_154229547 0.01 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr5_-_66492562 0.01 ENST00000256447.4
CD180
CD180 molecule
chr3_+_44840679 0.01 ENST00000425755.1
KIF15
kinesin family member 15
chr2_-_161350305 0.01 ENST00000348849.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chr19_+_41497178 0.01 ENST00000324071.4
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr2_-_40680578 0.00 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr6_-_31864977 0.00 ENST00000395728.3
ENST00000375528.4
EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr18_-_55288973 0.00 ENST00000423481.2
ENST00000587194.1
ENST00000591599.1
ENST00000588661.1
NARS
asparaginyl-tRNA synthetase
chrX_-_138724677 0.00 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr8_+_26435915 0.00 ENST00000523027.1
DPYSL2
dihydropyrimidinase-like 2
chr10_+_12391481 0.00 ENST00000378847.3
CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr12_+_50144381 0.00 ENST00000552370.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr22_-_30901637 0.00 ENST00000381982.3
ENST00000255858.7
ENST00000540456.1
ENST00000392772.2
SEC14L4
SEC14-like 4 (S. cerevisiae)
chr12_+_106994905 0.00 ENST00000357881.4
RFX4
regulatory factor X, 4 (influences HLA class II expression)

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 0.2 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.3 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.2 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0 0.2 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.4 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.2 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.0 0.1 GO:0010982 negative regulation of triglyceride catabolic process(GO:0010897) regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.0 0.3 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0021564 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.0 0.8 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.1 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.2 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.0 GO:0019056 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.0 0.1 GO:0036457 keratohyalin granule(GO:0036457)
0.0 0.4 GO:0070938 contractile ring(GO:0070938)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0071438 invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.3 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
0.1 0.4 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.2 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism