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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DLX5

Z-value: 0.56

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Transcription factors associated with DLX5

Gene Symbol Gene ID Gene Info
DLX5
ENSG00000105880.4 distal-less homeobox 5

Activity profile of DLX5 motif

Sorted Z-values of DLX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_99716914 0.66 ENST00000431404.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr15_+_89631647 0.48 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr7_-_86849836 0.43 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr13_+_110958124 0.43 ENST00000400163.2
COL4A2
collagen, type IV, alpha 2
chr4_-_89442940 0.42 ENST00000527353.1
PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chr11_+_115498761 0.36 ENST00000424313.2
AP000997.1
AP000997.1
chr14_-_95236551 0.34 ENST00000238558.3
GSC
goosecoid homeobox
chr1_+_202317855 0.31 ENST00000356764.2
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr7_+_100770328 0.28 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr3_-_52567792 0.27 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
NT5DC2
5'-nucleotidase domain containing 2
chr14_-_68283291 0.25 ENST00000555452.1
ENST00000347230.4
ZFYVE26
zinc finger, FYVE domain containing 26
chr11_+_76092353 0.24 ENST00000530460.1
ENST00000321844.4
RP11-111M22.2
Homo sapiens putative uncharacterized protein FLJ37770-like (LOC100506127), mRNA.
chr8_-_124553437 0.24 ENST00000517956.1
ENST00000443022.2
FBXO32
F-box protein 32
chr4_+_169575875 0.24 ENST00000503457.1
PALLD
palladin, cytoskeletal associated protein
chr7_-_99716952 0.23 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr14_+_32798547 0.22 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr1_+_202317815 0.22 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr7_-_99717463 0.22 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr8_-_22526597 0.21 ENST00000519513.1
ENST00000276416.6
ENST00000520292.1
ENST00000522268.1
BIN3
bridging integrator 3
chr7_+_97736197 0.20 ENST00000297293.5
LMTK2
lemur tyrosine kinase 2
chr11_+_818902 0.19 ENST00000336615.4
PNPLA2
patatin-like phospholipase domain containing 2
chr3_-_105588231 0.19 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr7_+_99717230 0.18 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr7_-_99716940 0.17 ENST00000440225.1
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr6_-_33256664 0.17 ENST00000444176.1
WDR46
WD repeat domain 46
chr15_+_89631381 0.16 ENST00000352732.5
ABHD2
abhydrolase domain containing 2
chr11_-_26743546 0.16 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr9_-_34329198 0.16 ENST00000379166.2
ENST00000345050.2
KIF24
kinesin family member 24
chr4_+_77356248 0.16 ENST00000296043.6
SHROOM3
shroom family member 3
chr12_+_52695617 0.16 ENST00000293525.5
KRT86
keratin 86
chr9_+_116225999 0.15 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr1_-_21620877 0.15 ENST00000527991.1
ECE1
endothelin converting enzyme 1
chr17_+_42264556 0.14 ENST00000319511.6
ENST00000589785.1
ENST00000592825.1
ENST00000589184.1
TMUB2
transmembrane and ubiquitin-like domain containing 2
chr6_-_78173490 0.14 ENST00000369947.2
HTR1B
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
chr1_-_201140673 0.14 ENST00000367333.2
TMEM9
transmembrane protein 9
chr2_-_220118631 0.14 ENST00000248437.4
TUBA4A
tubulin, alpha 4a
chr12_+_7014064 0.14 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr10_+_99205894 0.13 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr3_+_11178779 0.13 ENST00000438284.2
HRH1
histamine receptor H1
chr19_+_36605850 0.13 ENST00000221855.3
TBCB
tubulin folding cofactor B
chr2_-_220117867 0.12 ENST00000456818.1
ENST00000447205.1
TUBA4A
tubulin, alpha 4a
chr17_+_43238438 0.12 ENST00000593138.1
ENST00000586681.1
HEXIM2
hexamethylene bis-acetamide inducible 2
chr1_+_54569968 0.12 ENST00000391366.1
AL161915.1
Uncharacterized protein
chr14_+_96000930 0.12 ENST00000331334.4
GLRX5
glutaredoxin 5
chr5_+_142286887 0.12 ENST00000451259.1
ARHGAP26
Rho GTPase activating protein 26
chr14_-_24711470 0.12 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr14_-_24711806 0.11 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr11_-_71823715 0.10 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr15_+_89164520 0.10 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chr17_+_36508826 0.10 ENST00000580660.1
SOCS7
suppressor of cytokine signaling 7
chr5_-_42811986 0.10 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr14_-_24711865 0.10 ENST00000399423.4
ENST00000267415.7
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr1_-_198906528 0.10 ENST00000432296.1
MIR181A1HG
MIR181A1 host gene (non-protein coding)
chr2_+_228735763 0.09 ENST00000373666.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr12_+_7013897 0.09 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr6_-_33160231 0.09 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr11_-_26593649 0.09 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr19_-_19302931 0.09 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
MEF2BNB-MEF2B
MEF2BNB
MEF2B
MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr2_+_228736335 0.09 ENST00000440997.1
ENST00000545118.1
DAW1
dynein assembly factor with WDR repeat domains 1
chr10_+_99205959 0.09 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr2_+_95963052 0.08 ENST00000295225.5
KCNIP3
Kv channel interacting protein 3, calsenilin
chr14_-_24711764 0.08 ENST00000557921.1
ENST00000558476.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr11_-_71823266 0.08 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr12_+_54378849 0.08 ENST00000515593.1
HOXC10
homeobox C10
chr19_+_4007644 0.08 ENST00000262971.2
PIAS4
protein inhibitor of activated STAT, 4
chr2_+_196313239 0.08 ENST00000413290.1
AC064834.1
AC064834.1
chr10_-_99205607 0.07 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr6_-_27860956 0.07 ENST00000359611.2
HIST1H2AM
histone cluster 1, H2am
chr3_-_105587879 0.07 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr1_-_151762900 0.07 ENST00000440583.2
TDRKH
tudor and KH domain containing
chr5_-_42812143 0.07 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr19_+_54641444 0.07 ENST00000221232.5
ENST00000358389.3
CNOT3
CCR4-NOT transcription complex, subunit 3
chr4_-_8873531 0.07 ENST00000400677.3
HMX1
H6 family homeobox 1
chr17_+_59489112 0.07 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr1_-_78444776 0.06 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr11_-_102709441 0.06 ENST00000434103.1
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr19_-_36606181 0.05 ENST00000221859.4
POLR2I
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
chr17_-_47786375 0.04 ENST00000511657.1
SLC35B1
solute carrier family 35, member B1
chr12_-_57039739 0.04 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr14_+_32798462 0.04 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr5_-_20575959 0.04 ENST00000507958.1
CDH18
cadherin 18, type 2
chr1_-_242612779 0.04 ENST00000427495.1
PLD5
phospholipase D family, member 5
chr18_-_53255379 0.04 ENST00000565908.2
TCF4
transcription factor 4
chr16_+_58010339 0.04 ENST00000290871.5
ENST00000441824.2
TEPP
testis, prostate and placenta expressed
chr19_+_36606354 0.04 ENST00000589996.1
ENST00000591296.1
TBCB
tubulin folding cofactor B
chr1_-_78444738 0.04 ENST00000436586.2
ENST00000370768.2
FUBP1
far upstream element (FUSE) binding protein 1
chr22_-_30960876 0.03 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr17_-_37009882 0.03 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
RPL23
ribosomal protein L23
chr5_-_160279207 0.03 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr1_+_61547894 0.03 ENST00000403491.3
NFIA
nuclear factor I/A
chr18_+_55888767 0.02 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr2_+_228736321 0.02 ENST00000309931.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr9_+_34646651 0.02 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr3_+_186560476 0.02 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr7_-_14029283 0.02 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr4_+_151503077 0.02 ENST00000317605.4
MAB21L2
mab-21-like 2 (C. elegans)
chr7_+_70597109 0.01 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr4_-_69111401 0.01 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr17_-_47785504 0.01 ENST00000514907.1
ENST00000503334.1
ENST00000508520.1
SLC35B1
solute carrier family 35, member B1
chr4_-_66536057 0.01 ENST00000273854.3
EPHA5
EPH receptor A5
chr10_-_97200772 0.01 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
SORBS1
sorbin and SH3 domain containing 1
chr12_-_50616382 0.00 ENST00000552783.1
LIMA1
LIM domain and actin binding 1

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0001300 chronological cell aging(GO:0001300)
0.1 0.2 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.1 0.4 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.0 0.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.2 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.2 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.6 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.3 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.1 GO:0015785 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.0 0.1 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 0.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 1.3 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.1 GO:1902231 positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.4 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 1.1 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0071547 piP-body(GO:0071547)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway