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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DUXA

Z-value: 1.17

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Transcription factors associated with DUXA

Gene Symbol Gene ID Gene Info
DUXA
ENSG00000258873.2 double homeobox A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DUXAhg19_v2_chr19_-_57678811_576788110.493.2e-01Click!

Activity profile of DUXA motif

Sorted Z-values of DUXA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_27998689 2.08 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
IFI6
interferon, alpha-inducible protein 6
chr1_+_95616933 2.01 ENST00000604203.1
RP11-57H12.6
TMEM56-RWDD3 readthrough
chr12_-_91546926 1.89 ENST00000550758.1
DCN
decorin
chr10_-_112255945 1.54 ENST00000609514.1
ENST00000607952.1
RP11-525A16.4
RP11-525A16.4
chr2_+_228678550 1.52 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr17_+_61151306 0.98 ENST00000580068.1
ENST00000580466.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr15_-_34447023 0.94 ENST00000560310.1
KATNBL1
katanin p80 subunit B-like 1
chr12_+_72061563 0.92 ENST00000551238.1
THAP2
THAP domain containing, apoptosis associated protein 2
chr7_+_30589829 0.79 ENST00000579437.1
RP4-777O23.1
RP4-777O23.1
chr2_+_161993465 0.78 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr7_-_34978980 0.76 ENST00000428054.1
DPY19L1
dpy-19-like 1 (C. elegans)
chrX_+_69501943 0.75 ENST00000509895.1
ENST00000374473.2
ENST00000276066.4
RAB41
RAB41, member RAS oncogene family
chrX_+_154444643 0.75 ENST00000286428.5
VBP1
von Hippel-Lindau binding protein 1
chr15_-_80263506 0.71 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr1_+_219347203 0.69 ENST00000366927.3
LYPLAL1
lysophospholipase-like 1
chr5_-_111312622 0.69 ENST00000395634.3
NREP
neuronal regeneration related protein
chr1_+_74663994 0.67 ENST00000472069.1
FPGT
fucose-1-phosphate guanylyltransferase
chr4_+_79567057 0.66 ENST00000503259.1
ENST00000507802.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr6_-_26199499 0.64 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr15_+_71228826 0.64 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
LRRC49
leucine rich repeat containing 49
chr4_+_79567362 0.64 ENST00000512322.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr4_+_76649797 0.60 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr12_+_28299014 0.60 ENST00000538586.1
ENST00000536154.1
CCDC91
coiled-coil domain containing 91
chr9_-_6015607 0.60 ENST00000259569.5
RANBP6
RAN binding protein 6
chr19_-_57967854 0.59 ENST00000321039.3
VN1R1
vomeronasal 1 receptor 1
chr21_-_16254231 0.59 ENST00000412426.1
ENST00000418954.1
AF127936.7
AF127936.7
chr12_+_32115400 0.59 ENST00000381054.3
KIAA1551
KIAA1551
chr21_+_47013566 0.59 ENST00000441095.1
ENST00000424569.1
AL133493.2
AL133493.2
chr1_-_115124257 0.59 ENST00000369541.3
BCAS2
breast carcinoma amplified sequence 2
chr12_-_118628315 0.59 ENST00000540561.1
TAOK3
TAO kinase 3
chr2_+_160590469 0.58 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr9_+_88556444 0.58 ENST00000376040.1
NAA35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr2_+_29001711 0.58 ENST00000418910.1
PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr6_+_89791507 0.58 ENST00000354922.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr9_-_19065082 0.56 ENST00000415524.1
HAUS6
HAUS augmin-like complex, subunit 6
chr2_+_161993412 0.56 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr4_-_112993808 0.56 ENST00000511219.1
RP11-269F21.3
RP11-269F21.3
chr12_-_90049878 0.55 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr1_-_74663825 0.55 ENST00000370911.3
ENST00000370909.2
ENST00000354431.4
LRRIQ3
leucine-rich repeats and IQ motif containing 3
chr6_+_26251835 0.54 ENST00000356350.2
HIST1H2BH
histone cluster 1, H2bh
chr16_+_31724552 0.54 ENST00000539915.1
ENST00000316491.9
ENST00000399681.3
ENST00000398696.3
ENST00000534369.1
ZNF720
zinc finger protein 720
chr3_-_148939598 0.53 ENST00000455472.3
CP
ceruloplasmin (ferroxidase)
chr21_+_35107346 0.52 ENST00000456489.1
ITSN1
intersectin 1 (SH3 domain protein)
chr6_+_168434678 0.51 ENST00000496008.1
KIF25
kinesin family member 25
chr7_+_135611542 0.50 ENST00000416501.1
AC015987.2
AC015987.2
chr5_+_154237778 0.49 ENST00000523698.1
ENST00000517876.1
ENST00000520472.1
CNOT8
CCR4-NOT transcription complex, subunit 8
chr5_-_89705537 0.48 ENST00000522864.1
ENST00000522083.1
ENST00000522565.1
ENST00000522842.1
ENST00000283122.3
CETN3
centrin, EF-hand protein, 3
chr2_+_86333340 0.48 ENST00000409783.2
ENST00000409277.3
PTCD3
pentatricopeptide repeat domain 3
chr3_+_108321623 0.48 ENST00000497905.1
ENST00000463306.1
DZIP3
DAZ interacting zinc finger protein 3
chr16_+_77756399 0.47 ENST00000564085.1
ENST00000268533.5
ENST00000568787.1
ENST00000437314.3
ENST00000563839.1
NUDT7
nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr2_+_198380763 0.47 ENST00000448447.2
ENST00000409360.1
MOB4
MOB family member 4, phocein
chr4_+_76649753 0.47 ENST00000603759.1
USO1
USO1 vesicle transport factor
chr3_+_93781728 0.47 ENST00000314622.4
NSUN3
NOP2/Sun domain family, member 3
chr4_+_48833312 0.46 ENST00000508293.1
ENST00000513391.2
OCIAD1
OCIA domain containing 1
chr6_+_86195088 0.45 ENST00000437581.1
NT5E
5'-nucleotidase, ecto (CD73)
chr3_+_108015382 0.45 ENST00000463019.3
ENST00000491820.1
ENST00000467562.1
ENST00000482430.1
ENST00000462629.1
HHLA2
HERV-H LTR-associating 2
chr12_-_90049828 0.44 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chrX_+_133733457 0.44 ENST00000440614.1
RP11-308B5.2
RP11-308B5.2
chr5_+_154238096 0.43 ENST00000517568.1
ENST00000524105.1
ENST00000285896.6
CNOT8
CCR4-NOT transcription complex, subunit 8
chr1_+_92632542 0.43 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr11_-_95522639 0.42 ENST00000536839.1
FAM76B
family with sequence similarity 76, member B
chr18_+_61445007 0.42 ENST00000447428.1
ENST00000546027.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr14_-_80697396 0.42 ENST00000557010.1
DIO2
deiodinase, iodothyronine, type II
chr11_+_13690200 0.42 ENST00000354817.3
FAR1
fatty acyl CoA reductase 1
chr11_-_95522907 0.41 ENST00000358780.5
ENST00000542135.1
FAM76B
family with sequence similarity 76, member B
chr1_+_40997233 0.41 ENST00000372699.3
ENST00000372697.3
ENST00000372696.3
ZNF684
zinc finger protein 684
chr5_+_68513622 0.40 ENST00000512880.1
ENST00000602380.1
MRPS36
mitochondrial ribosomal protein S36
chr3_-_149093499 0.40 ENST00000472441.1
TM4SF1
transmembrane 4 L six family member 1
chr12_+_25348186 0.40 ENST00000555711.1
ENST00000556885.1
ENST00000554266.1
ENST00000556351.1
ENST00000556927.1
ENST00000556402.1
ENST00000553788.1
LYRM5
LYR motif containing 5
chr10_+_78078088 0.39 ENST00000496424.2
C10orf11
chromosome 10 open reading frame 11
chr11_-_114271139 0.38 ENST00000325636.4
C11orf71
chromosome 11 open reading frame 71
chr11_+_95523621 0.37 ENST00000325542.5
ENST00000325486.5
ENST00000544522.1
ENST00000541365.1
CEP57
centrosomal protein 57kDa
chr10_-_48806939 0.37 ENST00000374233.3
ENST00000507417.1
ENST00000512321.1
ENST00000395660.2
ENST00000374235.2
ENST00000395661.3
PTPN20B
protein tyrosine phosphatase, non-receptor type 20B
chrX_+_100878079 0.35 ENST00000471229.2
ARMCX3
armadillo repeat containing, X-linked 3
chr13_+_21141208 0.35 ENST00000351808.5
IFT88
intraflagellar transport 88 homolog (Chlamydomonas)
chrM_+_10758 0.34 ENST00000361381.2
MT-ND4
mitochondrially encoded NADH dehydrogenase 4
chr11_+_43333513 0.34 ENST00000534695.1
ENST00000455725.2
ENST00000531273.1
ENST00000420461.2
ENST00000378852.3
ENST00000534600.1
API5
apoptosis inhibitor 5
chr14_+_67831576 0.34 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_+_60983361 0.34 ENST00000238714.3
PAPOLG
poly(A) polymerase gamma
chr3_+_97483366 0.34 ENST00000463745.1
ENST00000462412.1
ARL6
ADP-ribosylation factor-like 6
chr5_+_154238042 0.34 ENST00000519211.1
ENST00000522458.1
ENST00000519903.1
ENST00000521450.1
ENST00000403027.2
CNOT8
CCR4-NOT transcription complex, subunit 8
chr13_+_21141270 0.34 ENST00000319980.6
ENST00000537103.1
ENST00000389373.3
IFT88
intraflagellar transport 88 homolog (Chlamydomonas)
chr1_+_74663896 0.33 ENST00000370898.3
ENST00000467578.2
ENST00000370894.5
ENST00000482102.2
ENST00000609362.1
ENST00000534056.1
ENST00000557284.2
ENST00000370899.3
ENST00000370895.1
ENST00000534632.1
ENST00000370893.1
ENST00000370891.2
FPGT
FPGT-TNNI3K
TNNI3K
fucose-1-phosphate guanylyltransferase
FPGT-TNNI3K readthrough
TNNI3 interacting kinase
chr15_+_44719970 0.33 ENST00000558966.1
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr5_-_95297534 0.32 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr6_-_76072719 0.32 ENST00000370020.1
FILIP1
filamin A interacting protein 1
chr12_-_76817036 0.32 ENST00000546946.1
OSBPL8
oxysterol binding protein-like 8
chr16_-_15149917 0.31 ENST00000287706.3
NTAN1
N-terminal asparagine amidase
chr11_+_10772847 0.30 ENST00000524523.1
CTR9
CTR9, Paf1/RNA polymerase II complex component
chr5_+_154238149 0.30 ENST00000519430.1
ENST00000520671.1
ENST00000521583.1
ENST00000518028.1
ENST00000519404.1
ENST00000519394.1
ENST00000518775.1
CNOT8
CCR4-NOT transcription complex, subunit 8
chr5_-_74326724 0.30 ENST00000322348.4
GCNT4
glucosaminyl (N-acetyl) transferase 4, core 2
chr8_-_86575726 0.30 ENST00000379010.2
REXO1L1
REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1, pseudogene
chr5_-_75919217 0.30 ENST00000504899.1
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr6_-_150346607 0.30 ENST00000367341.1
ENST00000286380.2
RAET1L
retinoic acid early transcript 1L
chr12_+_31812121 0.30 ENST00000395763.3
METTL20
methyltransferase like 20
chr1_+_64014588 0.30 ENST00000371086.2
ENST00000340052.3
DLEU2L
deleted in lymphocytic leukemia 2-like
chr14_-_102552659 0.30 ENST00000441629.2
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr1_+_53480598 0.29 ENST00000430330.2
ENST00000408941.3
ENST00000478274.2
ENST00000484100.1
ENST00000435345.2
ENST00000488965.1
SCP2
sterol carrier protein 2
chr6_-_71666732 0.29 ENST00000230053.6
B3GAT2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr13_-_31191642 0.29 ENST00000405805.1
HMGB1
high mobility group box 1
chr10_-_112064665 0.29 ENST00000369603.5
SMNDC1
survival motor neuron domain containing 1
chr2_+_234600253 0.29 ENST00000373424.1
ENST00000441351.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr1_+_66458072 0.29 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr4_+_79567314 0.28 ENST00000503539.1
ENST00000504675.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr2_+_190722119 0.28 ENST00000452382.1
PMS1
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
chr11_+_114270752 0.28 ENST00000540163.1
RBM7
RNA binding motif protein 7
chr15_+_21145765 0.28 ENST00000553416.1
CT60
cancer/testis antigen 60 (non-protein coding)
chr12_-_75784669 0.28 ENST00000552497.1
ENST00000551829.1
ENST00000436898.1
ENST00000442339.2
CAPS2
calcyphosine 2
chr18_+_68002675 0.28 ENST00000584919.1
RP11-41O4.1
Uncharacterized protein
chr15_-_49912987 0.28 ENST00000560246.1
ENST00000558594.1
FAM227B
family with sequence similarity 227, member B
chr2_-_24299308 0.28 ENST00000233468.4
SF3B14
Pre-mRNA branch site protein p14
chr2_-_201753717 0.28 ENST00000409264.2
PPIL3
peptidylprolyl isomerase (cyclophilin)-like 3
chr6_-_75953484 0.27 ENST00000472311.2
ENST00000460985.1
ENST00000377978.3
ENST00000509698.1
ENST00000230459.4
ENST00000370089.2
COX7A2
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
chr6_+_130339710 0.27 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr5_+_32585605 0.27 ENST00000265073.4
ENST00000515355.1
ENST00000502897.1
ENST00000510442.1
SUB1
SUB1 homolog (S. cerevisiae)
chr10_-_46620012 0.27 ENST00000508602.1
ENST00000374339.3
ENST00000502254.1
ENST00000437863.1
ENST00000374342.2
ENST00000395722.3
PTPN20A
protein tyrosine phosphatase, non-receptor type 20A
chr1_+_78383813 0.27 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr12_+_28605426 0.27 ENST00000542801.1
CCDC91
coiled-coil domain containing 91
chr15_+_44719790 0.26 ENST00000558791.1
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr4_+_156775910 0.26 ENST00000506072.1
ENST00000507590.1
TDO2
tryptophan 2,3-dioxygenase
chr14_+_85994943 0.26 ENST00000553678.1
RP11-497E19.2
Uncharacterized protein
chr4_+_40751914 0.26 ENST00000381782.2
ENST00000316607.5
NSUN7
NOP2/Sun domain family, member 7
chr16_+_21623392 0.25 ENST00000562961.1
METTL9
methyltransferase like 9
chr12_-_118796971 0.25 ENST00000542902.1
TAOK3
TAO kinase 3
chr8_+_67104940 0.25 ENST00000517689.1
LINC00967
long intergenic non-protein coding RNA 967
chrX_-_55187588 0.25 ENST00000472571.2
ENST00000332132.4
ENST00000425133.2
ENST00000358460.4
FAM104B
family with sequence similarity 104, member B
chr6_-_133055896 0.25 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
VNN3
vanin 3
chr4_+_77941685 0.25 ENST00000506731.1
SEPT11
septin 11
chr12_-_118796910 0.25 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr8_-_82754427 0.25 ENST00000353788.4
ENST00000520618.1
ENST00000518183.1
ENST00000396330.2
ENST00000519119.1
ENST00000345957.4
SNX16
sorting nexin 16
chr3_+_179280668 0.25 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
ACTL6A
actin-like 6A
chr5_+_68860949 0.24 ENST00000507595.1
GTF2H2C
general transcription factor IIH, polypeptide 2C
chr8_-_17752996 0.24 ENST00000381841.2
ENST00000427924.1
FGL1
fibrinogen-like 1
chr1_-_110933663 0.24 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
SLC16A4
solute carrier family 16, member 4
chr1_-_110933611 0.24 ENST00000472422.2
ENST00000437429.2
SLC16A4
solute carrier family 16, member 4
chr1_-_91487770 0.24 ENST00000337393.5
ZNF644
zinc finger protein 644
chr6_+_31553978 0.24 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr4_-_71532668 0.23 ENST00000510437.1
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chrX_-_154689596 0.23 ENST00000369444.2
H2AFB3
H2A histone family, member B3
chr12_-_51422017 0.23 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr11_-_95523500 0.23 ENST00000540054.1
FAM76B
family with sequence similarity 76, member B
chr16_+_24549014 0.22 ENST00000564314.1
ENST00000567686.1
RBBP6
retinoblastoma binding protein 6
chr14_-_75536182 0.22 ENST00000555463.1
ACYP1
acylphosphatase 1, erythrocyte (common) type
chr15_-_66679019 0.22 ENST00000568216.1
ENST00000562124.1
ENST00000570251.1
TIPIN
TIMELESS interacting protein
chr2_+_32390925 0.22 ENST00000440718.1
ENST00000379343.2
ENST00000282587.5
ENST00000435660.1
ENST00000538303.1
ENST00000357055.3
ENST00000406369.1
SLC30A6
solute carrier family 30 (zinc transporter), member 6
chr3_-_120461378 0.22 ENST00000273375.3
RABL3
RAB, member of RAS oncogene family-like 3
chr3_-_93781750 0.21 ENST00000314636.2
DHFRL1
dihydrofolate reductase-like 1
chr4_-_87028478 0.21 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr1_-_234667504 0.21 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr4_-_77069573 0.21 ENST00000264883.3
NUP54
nucleoporin 54kDa
chr2_-_161350305 0.21 ENST00000348849.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chr14_+_61447927 0.21 ENST00000451406.1
SLC38A6
solute carrier family 38, member 6
chr4_+_56719782 0.20 ENST00000381295.2
ENST00000346134.7
ENST00000349598.6
EXOC1
exocyst complex component 1
chr11_-_2924970 0.20 ENST00000533594.1
SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr19_-_54663473 0.20 ENST00000222224.3
LENG1
leukocyte receptor cluster (LRC) member 1
chr3_+_107364683 0.20 ENST00000413213.1
BBX
bobby sox homolog (Drosophila)
chr5_+_145826867 0.20 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr2_-_69180083 0.20 ENST00000328895.4
GKN2
gastrokine 2
chr9_+_139877445 0.19 ENST00000408973.2
LCNL1
lipocalin-like 1
chr5_-_77590480 0.19 ENST00000519295.1
ENST00000255194.6
AP3B1
adaptor-related protein complex 3, beta 1 subunit
chr4_-_69536346 0.19 ENST00000338206.5
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr1_-_42801540 0.19 ENST00000372573.1
FOXJ3
forkhead box J3
chr11_-_5526834 0.19 ENST00000380237.1
ENST00000396895.1
ENST00000380252.1
HBE1
HBG2
hemoglobin, epsilon 1
hemoglobin, gamma G
chr1_+_170501270 0.18 ENST00000367763.3
ENST00000367762.1
GORAB
golgin, RAB6-interacting
chr14_+_61447832 0.18 ENST00000354886.2
ENST00000267488.4
SLC38A6
solute carrier family 38, member 6
chr14_-_61447752 0.18 ENST00000555420.1
ENST00000553903.1
TRMT5
tRNA methyltransferase 5
chr10_+_70661014 0.18 ENST00000373585.3
DDX50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr12_-_14967095 0.18 ENST00000316048.2
SMCO3
single-pass membrane protein with coiled-coil domains 3
chr2_-_201753980 0.18 ENST00000443398.1
ENST00000286175.8
ENST00000409449.1
PPIL3
peptidylprolyl isomerase (cyclophilin)-like 3
chr10_-_17171785 0.17 ENST00000377823.1
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr4_-_106629796 0.17 ENST00000416543.1
ENST00000515819.1
ENST00000420368.2
ENST00000503746.1
ENST00000340139.5
ENST00000433009.1
INTS12
integrator complex subunit 12
chr15_-_43398274 0.17 ENST00000382177.2
ENST00000290650.4
UBR1
ubiquitin protein ligase E3 component n-recognin 1
chr6_-_49604545 0.17 ENST00000371175.4
ENST00000229810.7
RHAG
Rh-associated glycoprotein
chrX_+_46306624 0.17 ENST00000360017.5
KRBOX4
KRAB box domain containing 4
chr21_+_17566643 0.17 ENST00000419952.1
ENST00000445461.2
LINC00478
long intergenic non-protein coding RNA 478
chr5_+_31532373 0.17 ENST00000325366.9
ENST00000355907.3
ENST00000507818.2
C5orf22
chromosome 5 open reading frame 22
chr10_-_33281363 0.17 ENST00000534049.1
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr3_-_194188956 0.17 ENST00000256031.4
ENST00000446356.1
ATP13A3
ATPase type 13A3
chr9_-_75695323 0.16 ENST00000419959.1
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr5_+_102201687 0.16 ENST00000304400.7
PAM
peptidylglycine alpha-amidating monooxygenase
chrX_-_122756660 0.16 ENST00000441692.1
THOC2
THO complex 2
chr3_+_118892362 0.16 ENST00000497685.1
ENST00000264234.3
UPK1B
uroplakin 1B
chr1_-_220219775 0.16 ENST00000609181.1
EPRS
glutamyl-prolyl-tRNA synthetase
chr3_+_107364769 0.16 ENST00000449271.1
ENST00000425868.1
ENST00000449213.1
BBX
bobby sox homolog (Drosophila)
chr1_+_104159999 0.16 ENST00000414303.2
ENST00000423678.1
AMY2A
amylase, alpha 2A (pancreatic)
chr12_-_12837423 0.16 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr12_-_10601963 0.16 ENST00000543893.1
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr6_-_74104856 0.16 ENST00000441145.1
OOEP
oocyte expressed protein
chr7_+_1126437 0.16 ENST00000413368.1
ENST00000397092.1
GPER1
G protein-coupled estrogen receptor 1
chr11_+_13690249 0.16 ENST00000532701.1
FAR1
fatty acyl CoA reductase 1
chr7_+_93690435 0.15 ENST00000438538.1
AC003092.1
AC003092.1
chr4_-_76649546 0.15 ENST00000508510.1
ENST00000509561.1
ENST00000499709.2
ENST00000511868.1
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr17_+_74463650 0.15 ENST00000392492.3
AANAT
aralkylamine N-acetyltransferase
chr5_-_1882858 0.15 ENST00000511126.1
ENST00000231357.2
IRX4
iroquois homeobox 4
chr6_+_150920999 0.14 ENST00000367328.1
ENST00000367326.1
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr7_+_134331550 0.14 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
BPGM
2,3-bisphosphoglycerate mutase
chr13_-_76111945 0.14 ENST00000355801.4
ENST00000406936.3
COMMD6
COMM domain containing 6
chr5_-_66492562 0.14 ENST00000256447.4
CD180
CD180 molecule
chr12_-_54653313 0.14 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chr4_-_130692631 0.14 ENST00000500092.2
ENST00000509105.1
RP11-519M16.1
RP11-519M16.1

Network of associatons between targets according to the STRING database.

First level regulatory network of DUXA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0045360 interleukin-1 biosynthetic process(GO:0042222) regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 1.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 2.1 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.2 1.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 0.5 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.2 0.5 GO:0046356 acetyl-CoA catabolic process(GO:0046356)
0.2 0.5 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.1 0.6 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1 1.0 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.1 0.3 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 0.6 GO:0019236 response to pheromone(GO:0019236)
0.1 0.4 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
0.1 0.5 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.1 0.3 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 0.3 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 0.4 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.1 0.2 GO:0030264 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264)
0.1 1.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 0.3 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) T-helper 1 cell activation(GO:0035711) negative regulation of apoptotic cell clearance(GO:2000426)
0.1 0.8 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.3 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.2 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.7 GO:0002084 protein depalmitoylation(GO:0002084)
0.1 0.3 GO:0043335 protein unfolding(GO:0043335)
0.1 0.2 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.1 0.2 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.1 0.6 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.2 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.0 0.1 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.3 GO:0018032 protein amidation(GO:0018032)
0.0 1.0 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.3 GO:0032377 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.1 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.0 0.2 GO:0010710 regulation of collagen catabolic process(GO:0010710)
0.0 0.6 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.2 GO:0015692 lead ion transport(GO:0015692)
0.0 0.2 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.6 GO:0002643 regulation of tolerance induction(GO:0002643)
0.0 0.1 GO:1903216 regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.4 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.3 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.2 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.0 0.2 GO:0048478 replication fork protection(GO:0048478)
0.0 0.3 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.0 0.6 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 1.2 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.5 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.6 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 0.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.4 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.4 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.3 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.0 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.6 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.4 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.0 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)
0.0 0.4 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.0 0.7 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 0.0 GO:0021779 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.1 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.0 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.2 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0 0.5 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.1 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.6 GO:0031417 NatC complex(GO:0031417)
0.1 0.3 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) astrocyte end-foot(GO:0097450) glial limiting end-foot(GO:0097451)
0.1 1.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.7 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.3 GO:0005879 axonemal microtubule(GO:0005879)
0.1 0.5 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 1.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.2 GO:0034677 integrin alpha7-beta1 complex(GO:0034677)
0.1 0.2 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.0 0.5 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.6 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.3 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.6 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0097452 GAIT complex(GO:0097452)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.9 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 1.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 1.0 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.5 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 0.6 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.1 0.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.3 GO:0070538 oleic acid binding(GO:0070538)
0.1 0.5 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.1 0.2 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.1 0.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.4 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.2 GO:0030492 hemoglobin binding(GO:0030492)
0.1 0.3 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1 0.3 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1 0.5 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 0.2 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.1 1.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.2 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.1 0.4 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.7 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.3 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.3 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.3 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.2 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 0.2 GO:0015094 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 1.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0051499 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.0 0.7 GO:0051400 BH domain binding(GO:0051400)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.6 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.5 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.3 GO:0030911 TPR domain binding(GO:0030911)
0.0 2.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.2 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.0 GO:0004145 diamine N-acetyltransferase activity(GO:0004145) polyamine binding(GO:0019808)
0.0 0.0 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532) copper-dependent protein binding(GO:0032767)
0.0 0.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0002114 interleukin-33 receptor activity(GO:0002114)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID ARF 3PATHWAY Arf1 pathway
0.0 1.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 1.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.9 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.7 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism