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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E2F2_E2F5

Z-value: 1.09

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Transcription factors associated with E2F2_E2F5

Gene Symbol Gene ID Gene Info
E2F2
ENSG00000007968.6 E2F transcription factor 2
E2F5
ENSG00000133740.6 E2F transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F5hg19_v2_chr8_+_86099884_860999200.882.0e-02Click!
E2F2hg19_v2_chr1_-_23857698_23857733-0.833.9e-02Click!

Activity profile of E2F2_E2F5 motif

Sorted Z-values of E2F2_E2F5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_17935119 1.36 ENST00000317402.7
GEN1
GEN1 Holliday junction 5' flap endonuclease
chr10_+_62538248 1.23 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr2_-_17935059 1.09 ENST00000448223.2
ENST00000381272.4
ENST00000351948.4
SMC6
structural maintenance of chromosomes 6
chr7_+_26241310 1.08 ENST00000396386.2
CBX3
chromobox homolog 3
chr11_-_95522639 1.06 ENST00000536839.1
FAM76B
family with sequence similarity 76, member B
chr19_+_36705504 1.06 ENST00000456324.1
ZNF146
zinc finger protein 146
chr19_+_36706024 1.02 ENST00000443387.2
ZNF146
zinc finger protein 146
chr2_-_17935027 1.02 ENST00000446852.1
SMC6
structural maintenance of chromosomes 6
chr10_+_62538089 0.88 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr7_+_26241325 0.88 ENST00000456948.1
ENST00000409747.1
CBX3
chromobox homolog 3
chr10_+_112327425 0.87 ENST00000361804.4
SMC3
structural maintenance of chromosomes 3
chr11_-_95522907 0.83 ENST00000358780.5
ENST00000542135.1
FAM76B
family with sequence similarity 76, member B
chr14_+_36295638 0.81 ENST00000543183.1
BRMS1L
breast cancer metastasis-suppressor 1-like
chr14_-_50154921 0.73 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr20_-_35724388 0.73 ENST00000344359.3
ENST00000373664.3
RBL1
retinoblastoma-like 1 (p107)
chr8_-_124408652 0.70 ENST00000287394.5
ATAD2
ATPase family, AAA domain containing 2
chr17_+_29158962 0.69 ENST00000321990.4
ATAD5
ATPase family, AAA domain containing 5
chr6_+_24775641 0.67 ENST00000378054.2
ENST00000476555.1
GMNN
geminin, DNA replication inhibitor
chr15_+_71185148 0.67 ENST00000443425.2
ENST00000560755.1
LRRC49
leucine rich repeat containing 49
chr2_-_203103281 0.65 ENST00000392244.3
ENST00000409181.1
ENST00000409712.1
ENST00000409498.2
ENST00000409368.1
ENST00000392245.1
ENST00000392246.2
SUMO1
small ubiquitin-like modifier 1
chr1_-_26232522 0.65 ENST00000399728.1
STMN1
stathmin 1
chr5_+_36876833 0.64 ENST00000282516.8
ENST00000448238.2
NIPBL
Nipped-B homolog (Drosophila)
chr6_+_27114861 0.63 ENST00000377459.1
HIST1H2AH
histone cluster 1, H2ah
chrX_+_123095546 0.59 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
STAG2
stromal antigen 2
chr1_-_91487770 0.59 ENST00000337393.5
ZNF644
zinc finger protein 644
chr14_+_36295504 0.58 ENST00000216807.7
BRMS1L
breast cancer metastasis-suppressor 1-like
chr22_-_38966172 0.56 ENST00000216024.2
DMC1
DNA meiotic recombinase 1
chr3_+_44803322 0.56 ENST00000481166.2
KIF15
kinesin family member 15
chr6_+_24775153 0.55 ENST00000356509.3
ENST00000230056.3
GMNN
geminin, DNA replication inhibitor
chr15_-_66649010 0.54 ENST00000367709.4
ENST00000261881.4
TIPIN
TIMELESS interacting protein
chr10_+_96305610 0.54 ENST00000371332.4
ENST00000239026.6
HELLS
helicase, lymphoid-specific
chr15_+_44719394 0.53 ENST00000260327.4
ENST00000396780.1
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr7_+_86781677 0.53 ENST00000331242.7
ENST00000394702.3
ENST00000413276.2
ENST00000446796.2
ENST00000411766.2
ENST00000420131.1
ENST00000414630.2
ENST00000453049.1
ENST00000428819.1
ENST00000448598.1
ENST00000449088.3
ENST00000430405.3
DMTF1
cyclin D binding myb-like transcription factor 1
chr8_-_120868078 0.53 ENST00000313655.4
DSCC1
DNA replication and sister chromatid cohesion 1
chr2_+_48010312 0.52 ENST00000540021.1
MSH6
mutS homolog 6
chr15_-_71184724 0.52 ENST00000560604.1
THAP10
THAP domain containing 10
chr15_+_71184931 0.51 ENST00000560369.1
ENST00000260382.5
LRRC49
leucine rich repeat containing 49
chr2_-_47168850 0.51 ENST00000409207.1
MCFD2
multiple coagulation factor deficiency 2
chr21_-_30365136 0.51 ENST00000361371.5
ENST00000389194.2
ENST00000389195.2
LTN1
listerin E3 ubiquitin protein ligase 1
chr13_+_32889605 0.51 ENST00000380152.3
ENST00000544455.1
ENST00000530893.2
BRCA2
breast cancer 2, early onset
chr1_-_26232951 0.50 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr1_-_91487013 0.49 ENST00000347275.5
ENST00000370440.1
ZNF644
zinc finger protein 644
chr1_-_100598444 0.49 ENST00000535161.1
ENST00000287482.5
SASS6
spindle assembly 6 homolog (C. elegans)
chr4_+_71859156 0.49 ENST00000286648.5
ENST00000504730.1
ENST00000504952.1
DCK
deoxycytidine kinase
chr10_-_77161004 0.49 ENST00000418818.2
RP11-399K21.11
RP11-399K21.11
chr1_-_222885770 0.48 ENST00000355727.2
ENST00000340020.6
AIDA
axin interactor, dorsalization associated
chr5_+_79950463 0.46 ENST00000265081.6
MSH3
mutS homolog 3
chr7_-_94285472 0.45 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
SGCE
sarcoglycan, epsilon
chr6_+_27782788 0.45 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr2_+_48010221 0.44 ENST00000234420.5
MSH6
mutS homolog 6
chr20_+_5931275 0.44 ENST00000378896.3
ENST00000378883.1
MCM8
minichromosome maintenance complex component 8
chr5_+_56469843 0.43 ENST00000514387.2
GPBP1
GC-rich promoter binding protein 1
chr4_+_154265784 0.43 ENST00000240488.3
MND1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr10_+_96305535 0.43 ENST00000419900.1
ENST00000348459.5
ENST00000394045.1
ENST00000394044.1
ENST00000394036.1
HELLS
helicase, lymphoid-specific
chrX_+_24711997 0.43 ENST00000379068.3
ENST00000379059.3
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr5_-_36152031 0.42 ENST00000296603.4
LMBRD2
LMBR1 domain containing 2
chr7_+_26240776 0.41 ENST00000337620.4
CBX3
chromobox homolog 3
chr6_+_27775899 0.41 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr2_-_47168906 0.41 ENST00000444761.2
ENST00000409147.1
MCFD2
multiple coagulation factor deficiency 2
chr7_-_94285402 0.40 ENST00000428696.2
ENST00000445866.2
SGCE
sarcoglycan, epsilon
chrX_+_123095890 0.40 ENST00000435215.1
STAG2
stromal antigen 2
chr22_+_42394780 0.40 ENST00000328823.9
WBP2NL
WBP2 N-terminal like
chr15_+_44719970 0.38 ENST00000558966.1
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr8_+_94929077 0.38 ENST00000297598.4
ENST00000520614.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr1_+_222885884 0.37 ENST00000340934.5
BROX
BRO1 domain and CAAX motif containing
chr7_+_86781847 0.37 ENST00000432366.2
ENST00000423590.2
ENST00000394703.5
DMTF1
cyclin D binding myb-like transcription factor 1
chr13_+_45694583 0.36 ENST00000340473.6
GTF2F2
general transcription factor IIF, polypeptide 2, 30kDa
chr17_+_30264014 0.36 ENST00000322652.5
ENST00000580398.1
SUZ12
SUZ12 polycomb repressive complex 2 subunit
chr13_-_73356009 0.36 ENST00000377780.4
ENST00000377767.4
DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr5_+_93954358 0.35 ENST00000504099.1
ANKRD32
ankyrin repeat domain 32
chr1_-_26233423 0.35 ENST00000357865.2
STMN1
stathmin 1
chrX_+_123095860 0.34 ENST00000428941.1
STAG2
stromal antigen 2
chr3_+_44803209 0.34 ENST00000326047.4
KIF15
kinesin family member 15
chr8_+_94929168 0.33 ENST00000518107.1
ENST00000396200.3
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr2_-_55277692 0.33 ENST00000394611.2
RTN4
reticulon 4
chr20_+_5931497 0.33 ENST00000378886.2
ENST00000265187.4
MCM8
minichromosome maintenance complex component 8
chr5_+_56469939 0.32 ENST00000506184.2
GPBP1
GC-rich promoter binding protein 1
chr15_-_64673665 0.32 ENST00000300035.4
KIAA0101
KIAA0101
chr2_+_17935383 0.32 ENST00000524465.1
ENST00000381254.2
ENST00000532257.1
GEN1
GEN1 Holliday junction 5' flap endonuclease
chr20_-_5931109 0.32 ENST00000203001.2
TRMT6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr3_-_52719888 0.31 ENST00000458294.1
PBRM1
polybromo 1
chr5_-_79950371 0.31 ENST00000511032.1
ENST00000504396.1
ENST00000505337.1
DHFR
dihydrofolate reductase
chr9_+_17134980 0.30 ENST00000380647.3
CNTLN
centlein, centrosomal protein
chr15_-_64673630 0.30 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr5_+_93954039 0.29 ENST00000265140.5
ANKRD32
ankyrin repeat domain 32
chr1_+_6845384 0.29 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr6_+_27833034 0.29 ENST00000357320.2
HIST1H2AL
histone cluster 1, H2al
chr1_+_25598872 0.29 ENST00000328664.4
RHD
Rh blood group, D antigen
chr2_+_170440844 0.29 ENST00000260970.3
ENST00000433207.1
ENST00000409714.3
ENST00000462903.1
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr11_+_9406169 0.29 ENST00000379719.3
ENST00000527431.1
IPO7
importin 7
chr6_+_88299833 0.28 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
ORC3
origin recognition complex, subunit 3
chr1_-_205719295 0.28 ENST00000367142.4
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr2_-_219433014 0.27 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
USP37
ubiquitin specific peptidase 37
chr17_+_42733803 0.27 ENST00000409122.2
C17orf104
chromosome 17 open reading frame 104
chr7_-_27169801 0.27 ENST00000511914.1
HOXA4
homeobox A4
chr9_+_17135016 0.27 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
CNTLN
centlein, centrosomal protein
chr15_+_32907691 0.27 ENST00000361627.3
ENST00000567348.1
ENST00000563864.1
ENST00000543522.1
ARHGAP11A
Rho GTPase activating protein 11A
chr5_+_56469775 0.27 ENST00000424459.3
GPBP1
GC-rich promoter binding protein 1
chr5_-_74062867 0.27 ENST00000509097.1
GFM2
G elongation factor, mitochondrial 2
chr19_-_409134 0.26 ENST00000332235.6
C2CD4C
C2 calcium-dependent domain containing 4C
chr7_+_86781778 0.26 ENST00000432937.2
DMTF1
cyclin D binding myb-like transcription factor 1
chr7_-_94285511 0.26 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chr16_-_30102547 0.26 ENST00000279386.2
TBX6
T-box 6
chr9_+_106856541 0.26 ENST00000286398.7
ENST00000440179.1
ENST00000374793.3
SMC2
structural maintenance of chromosomes 2
chrX_-_122866874 0.26 ENST00000245838.8
ENST00000355725.4
THOC2
THO complex 2
chr9_+_106856831 0.25 ENST00000303219.8
ENST00000374787.3
SMC2
structural maintenance of chromosomes 2
chr3_+_182511266 0.25 ENST00000323116.5
ENST00000493826.1
ATP11B
ATPase, class VI, type 11B
chr11_+_125495862 0.25 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
CHEK1
checkpoint kinase 1
chr8_+_94929273 0.25 ENST00000518573.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr2_+_170440902 0.24 ENST00000448752.2
ENST00000418888.1
ENST00000414307.1
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr4_-_170679024 0.24 ENST00000393381.2
C4orf27
chromosome 4 open reading frame 27
chr15_+_44719790 0.24 ENST00000558791.1
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr18_+_2655849 0.24 ENST00000261598.8
SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
chr4_+_178230985 0.23 ENST00000264596.3
NEIL3
nei endonuclease VIII-like 3 (E. coli)
chr17_-_17184546 0.23 ENST00000417352.1
COPS3
COP9 signalosome subunit 3
chr22_+_35653445 0.23 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr9_+_86595626 0.23 ENST00000445877.1
ENST00000325875.3
RMI1
RecQ mediated genome instability 1
chr11_-_95523500 0.22 ENST00000540054.1
FAM76B
family with sequence similarity 76, member B
chr3_-_10028366 0.22 ENST00000429759.1
EMC3
ER membrane protein complex subunit 3
chr2_-_203103185 0.22 ENST00000409205.1
SUMO1
small ubiquitin-like modifier 1
chrX_+_131157322 0.22 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4
Serine/threonine-protein kinase MST4
chr1_-_23670817 0.22 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr1_+_6845497 0.22 ENST00000473578.1
ENST00000557126.1
CAMTA1
calmodulin binding transcription activator 1
chr1_-_47779762 0.22 ENST00000371877.3
ENST00000360380.3
ENST00000337817.5
ENST00000447475.2
STIL
SCL/TAL1 interrupting locus
chr15_+_100106155 0.22 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
MEF2A
myocyte enhancer factor 2A
chr10_-_25241499 0.21 ENST00000376378.1
ENST00000376376.3
ENST00000320152.6
PRTFDC1
phosphoribosyl transferase domain containing 1
chr1_+_13910194 0.21 ENST00000376057.4
ENST00000510906.1
PDPN
podoplanin
chr4_-_18023350 0.21 ENST00000539056.1
ENST00000382226.5
ENST00000326877.4
LCORL
ligand dependent nuclear receptor corepressor-like
chr15_+_44719996 0.21 ENST00000559793.1
ENST00000558968.1
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr1_+_212208919 0.21 ENST00000366991.4
ENST00000542077.1
DTL
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr4_+_129730947 0.21 ENST00000452328.2
ENST00000504089.1
PHF17
jade family PHD finger 1
chr6_-_88299678 0.20 ENST00000369536.5
RARS2
arginyl-tRNA synthetase 2, mitochondrial
chr7_-_105516923 0.20 ENST00000478915.1
ATXN7L1
ataxin 7-like 1
chr12_-_31479045 0.20 ENST00000539409.1
ENST00000395766.1
FAM60A
family with sequence similarity 60, member A
chr18_+_19192228 0.20 ENST00000300413.5
ENST00000579618.1
ENST00000582475.1
SNRPD1
small nuclear ribonucleoprotein D1 polypeptide 16kDa
chr5_-_137548997 0.20 ENST00000505120.1
ENST00000394886.2
ENST00000394884.3
CDC23
cell division cycle 23
chr22_-_29137771 0.20 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr3_+_41240925 0.20 ENST00000396183.3
ENST00000349496.5
ENST00000453024.1
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa
chr1_+_66458072 0.19 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chrX_+_131157290 0.19 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chr17_+_42733730 0.19 ENST00000359945.3
ENST00000425535.1
C17orf104
chromosome 17 open reading frame 104
chr11_+_74303575 0.19 ENST00000263681.2
POLD3
polymerase (DNA-directed), delta 3, accessory subunit
chr14_-_69864993 0.19 ENST00000555373.1
ERH
enhancer of rudimentary homolog (Drosophila)
chr7_+_6048856 0.19 ENST00000223029.3
ENST00000400479.2
ENST00000395236.2
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr3_+_14219858 0.19 ENST00000306024.3
LSM3
LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_-_23670813 0.19 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr7_-_158497431 0.19 ENST00000449727.2
ENST00000409339.3
ENST00000409423.1
ENST00000356309.3
NCAPG2
non-SMC condensin II complex, subunit G2
chr7_+_94139105 0.18 ENST00000297273.4
CASD1
CAS1 domain containing 1
chr18_-_54318353 0.18 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr1_-_23670752 0.18 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr4_+_129730779 0.18 ENST00000226319.6
PHF17
jade family PHD finger 1
chr17_+_57642886 0.18 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DHX40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr6_-_26043885 0.18 ENST00000357905.2
HIST1H2BB
histone cluster 1, H2bb
chrX_-_106243451 0.18 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr8_-_95565673 0.18 ENST00000437199.1
ENST00000297591.5
ENST00000421249.2
KIAA1429
KIAA1429
chr2_+_232573208 0.18 ENST00000409115.3
PTMA
prothymosin, alpha
chr11_-_19262486 0.17 ENST00000250024.4
E2F8
E2F transcription factor 8
chr11_+_9595180 0.17 ENST00000450114.2
WEE1
WEE1 G2 checkpoint kinase
chr1_+_27113963 0.17 ENST00000430292.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr2_-_54014055 0.17 ENST00000263634.3
ENST00000406687.1
GPR75-ASB3
GPR75-ASB3 readthrough
chr6_+_4021554 0.17 ENST00000337659.6
PRPF4B
pre-mRNA processing factor 4B
chr18_-_70210764 0.16 ENST00000585159.1
ENST00000584764.1
CBLN2
cerebellin 2 precursor
chr1_+_222988464 0.16 ENST00000420335.1
RP11-452F19.3
RP11-452F19.3
chr12_+_27932803 0.16 ENST00000381271.2
KLHL42
kelch-like family member 42
chr1_-_54303934 0.16 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr3_-_133380731 0.16 ENST00000260810.5
TOPBP1
topoisomerase (DNA) II binding protein 1
chr19_-_36705763 0.16 ENST00000591473.1
ZNF565
zinc finger protein 565
chr15_+_100106244 0.16 ENST00000557942.1
MEF2A
myocyte enhancer factor 2A
chr1_-_91487806 0.15 ENST00000361321.5
ZNF644
zinc finger protein 644
chr19_-_10305302 0.15 ENST00000592054.1
DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr5_+_43120985 0.15 ENST00000515326.1
ZNF131
zinc finger protein 131
chr2_-_55277436 0.15 ENST00000354474.6
RTN4
reticulon 4
chrX_+_100353153 0.15 ENST00000423383.1
ENST00000218507.5
ENST00000403304.2
ENST00000435570.1
CENPI
centromere protein I
chr1_-_24306768 0.15 ENST00000374453.3
ENST00000453840.3
SRSF10
serine/arginine-rich splicing factor 10
chr1_+_33116743 0.15 ENST00000414241.3
ENST00000373493.5
RBBP4
retinoblastoma binding protein 4
chr14_+_35452104 0.15 ENST00000216774.6
ENST00000546080.1
SRP54
signal recognition particle 54kDa
chr2_+_54014168 0.15 ENST00000405123.3
ENST00000185150.4
ENST00000378239.5
ERLEC1
endoplasmic reticulum lectin 1
chr8_-_98290087 0.15 ENST00000322128.3
TSPYL5
TSPY-like 5
chr2_-_54014127 0.15 ENST00000394717.2
GPR75-ASB3
GPR75-ASB3 readthrough
chr6_-_160210604 0.14 ENST00000420894.2
ENST00000539756.1
ENST00000544255.1
TCP1
t-complex 1
chr2_+_47630108 0.14 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
MSH2
mutS homolog 2
chr3_-_52719912 0.14 ENST00000420148.1
PBRM1
polybromo 1
chrX_+_21958814 0.14 ENST00000379404.1
ENST00000415881.2
SMS
spermine synthase
chr2_-_100106419 0.14 ENST00000393445.3
ENST00000258428.3
REV1
REV1, polymerase (DNA directed)
chrX_+_70752917 0.13 ENST00000373719.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr21_+_17961006 0.13 ENST00000602323.1
LINC00478
long intergenic non-protein coding RNA 478
chr2_+_171571827 0.13 ENST00000375281.3
SP5
Sp5 transcription factor
chr5_+_74062806 0.13 ENST00000296802.5
NSA2
NSA2 ribosome biogenesis homolog (S. cerevisiae)
chrX_+_46696372 0.13 ENST00000218340.3
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr2_+_16080659 0.13 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr6_-_160210715 0.13 ENST00000392168.2
ENST00000321394.7
TCP1
t-complex 1
chr2_-_235405679 0.13 ENST00000390645.2
ARL4C
ADP-ribosylation factor-like 4C
chrX_-_106243294 0.13 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr11_+_4116054 0.13 ENST00000423050.2
RRM1
ribonucleotide reductase M1
chr2_-_136633940 0.13 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr16_-_47495170 0.12 ENST00000320640.6
ENST00000544001.2
ITFG1
integrin alpha FG-GAP repeat containing 1
chr1_+_100598691 0.12 ENST00000370143.1
ENST00000370141.2
TRMT13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr3_-_136471204 0.12 ENST00000480733.1
ENST00000383202.2
ENST00000236698.5
ENST00000434713.2
STAG1
stromal antigen 1
chr1_+_35734616 0.12 ENST00000441447.1
ZMYM4
zinc finger, MYM-type 4
chr6_-_17706618 0.12 ENST00000262077.2
ENST00000537253.1
NUP153
nucleoporin 153kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0071139 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.3 2.1 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.3 0.9 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.3 0.3 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.3 0.3 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.2 1.0 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.2 0.6 GO:0061010 external genitalia morphogenesis(GO:0035261) gall bladder development(GO:0061010)
0.2 1.5 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.2 1.2 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.1 2.5 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.4 GO:0007343 egg activation(GO:0007343) female pronucleus assembly(GO:0035038)
0.1 1.6 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.1 1.8 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.4 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.1 0.4 GO:0006272 leading strand elongation(GO:0006272)
0.1 0.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.3 GO:0042000 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.1 0.5 GO:0048478 replication fork protection(GO:0048478)
0.1 0.4 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.1 0.3 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.2 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.1 0.7 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.1 0.2 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.2 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 1.1 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 0.2 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.3 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.1 0.5 GO:0042148 strand invasion(GO:0042148)
0.1 0.7 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.2 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.2 GO:1904793 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.0 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.5 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.2 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.1 GO:0032240 negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.0 0.2 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 0.1 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.5 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262)
0.0 1.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0038162 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.2 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838)
0.0 0.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.6 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.3 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005) ERK5 cascade(GO:0070375)
0.0 0.2 GO:0033504 floor plate development(GO:0033504)
0.0 0.2 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.3 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.5 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157)
0.0 0.2 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.2 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.3 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.1 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.4 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.2 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.3 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.6 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.3 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.1 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.0 0.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.6 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0006284 base-excision repair(GO:0006284)
0.0 0.1 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.0 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.0 GO:0051389 inactivation of MAPKK activity(GO:0051389)
0.0 0.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.2 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.0 GO:0060437 lung growth(GO:0060437)
0.0 0.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 0.5 GO:0032302 MutSbeta complex(GO:0032302)
0.4 2.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.3 2.0 GO:0035061 interchromatin granule(GO:0035061)
0.2 0.9 GO:0005873 plus-end kinesin complex(GO:0005873)
0.2 1.1 GO:0032301 MutSalpha complex(GO:0032301)
0.2 0.9 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.2 0.8 GO:0097362 MCM8-MCM9 complex(GO:0097362)
0.1 0.9 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.1 2.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 1.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.4 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.3 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.4 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.1 0.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.5 GO:0098536 deuterosome(GO:0098536)
0.1 0.7 GO:0000796 condensin complex(GO:0000796)
0.1 0.2 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.5 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.2 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 1.8 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663) PCNA-p21 complex(GO:0070557)
0.0 0.4 GO:0001739 sex chromatin(GO:0001739)
0.0 0.1 GO:1990075 periciliary membrane compartment(GO:1990075)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.2 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.2 GO:0070369 Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.4 GO:0000800 lateral element(GO:0000800)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0034709 methylosome(GO:0034709)
0.0 0.0 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 1.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.2 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.5 GO:0000794 condensed nuclear chromosome(GO:0000794)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0036033 mediator complex binding(GO:0036033)
0.3 1.6 GO:0032142 single guanine insertion binding(GO:0032142)
0.2 2.4 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 1.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 1.7 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 0.9 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.1 0.3 GO:0016768 spermine synthase activity(GO:0016768)
0.1 1.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.4 GO:0051870 methotrexate binding(GO:0051870)
0.1 2.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.5 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.1 0.5 GO:0004137 deoxycytidine kinase activity(GO:0004137)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.1 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.2 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.2 GO:0050733 RS domain binding(GO:0050733)
0.0 0.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.4 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.1 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.1 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106) ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.4 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.0 0.2 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.1 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0 0.0 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 3.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.1 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.0 0.2 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.9 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.1 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 1.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.6 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.9 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.6 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.4 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.9 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.4 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.4 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.1 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.0 0.9 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines