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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ETS1

Z-value: 0.62

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Transcription factors associated with ETS1

Gene Symbol Gene ID Gene Info
ETS1
ENSG00000134954.10 ETS proto-oncogene 1, transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ETS1hg19_v2_chr11_-_128392085_128392232-0.246.4e-01Click!

Activity profile of ETS1 motif

Sorted Z-values of ETS1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_108209897 0.70 ENST00000313516.5
THAP5
THAP domain containing 5
chr4_-_153700864 0.68 ENST00000304337.2
TIGD4
tigger transposable element derived 4
chr15_-_71184724 0.65 ENST00000560604.1
THAP10
THAP domain containing 10
chr15_+_71184931 0.60 ENST00000560369.1
ENST00000260382.5
LRRC49
leucine rich repeat containing 49
chr15_+_71185148 0.56 ENST00000443425.2
ENST00000560755.1
LRRC49
leucine rich repeat containing 49
chr16_-_30393752 0.52 ENST00000566517.1
ENST00000605106.1
SEPT1
SEPT1
septin 1
Uncharacterized protein
chr11_-_118122996 0.51 ENST00000525386.1
ENST00000527472.1
ENST00000278949.4
MPZL3
myelin protein zero-like 3
chr16_-_31085033 0.44 ENST00000414399.1
ZNF668
zinc finger protein 668
chr12_+_72058130 0.42 ENST00000547843.1
THAP2
THAP domain containing, apoptosis associated protein 2
chr11_+_34642656 0.36 ENST00000257831.3
ENST00000450654.2
EHF
ets homologous factor
chr2_+_231280954 0.35 ENST00000409824.1
ENST00000409341.1
ENST00000409112.1
ENST00000340126.4
ENST00000341950.4
SP100
SP100 nuclear antigen
chr7_+_108210012 0.33 ENST00000249356.3
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr2_+_177134201 0.32 ENST00000452865.1
MTX2
metaxin 2
chr5_-_102455801 0.32 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr2_-_201753717 0.32 ENST00000409264.2
PPIL3
peptidylprolyl isomerase (cyclophilin)-like 3
chr4_-_54424366 0.31 ENST00000306888.2
LNX1
ligand of numb-protein X 1, E3 ubiquitin protein ligase
chr2_+_231280908 0.31 ENST00000427101.2
ENST00000432979.1
SP100
SP100 nuclear antigen
chr5_+_82373379 0.31 ENST00000396027.4
ENST00000511817.1
XRCC4
X-ray repair complementing defective repair in Chinese hamster cells 4
chr5_+_82373317 0.30 ENST00000282268.3
ENST00000338635.6
XRCC4
X-ray repair complementing defective repair in Chinese hamster cells 4
chr2_-_191399073 0.30 ENST00000421038.1
TMEM194B
transmembrane protein 194B
chr14_-_45431091 0.29 ENST00000579157.1
ENST00000396128.4
ENST00000556500.1
KLHL28
kelch-like family member 28
chr16_+_58549412 0.29 ENST00000447443.1
SETD6
SET domain containing 6
chr4_-_156297949 0.29 ENST00000515654.1
MAP9
microtubule-associated protein 9
chr12_+_9102632 0.29 ENST00000539240.1
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr15_-_80263506 0.28 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr1_+_209859510 0.28 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr1_+_16083098 0.27 ENST00000496928.2
ENST00000508310.1
FBLIM1
filamin binding LIM protein 1
chr16_-_20817753 0.27 ENST00000389345.5
ENST00000300005.3
ENST00000357967.4
ENST00000569729.1
ERI2
ERI1 exoribonuclease family member 2
chr2_-_231090344 0.27 ENST00000540870.1
ENST00000416610.1
SP110
SP110 nuclear body protein
chr19_+_10197463 0.27 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr20_+_10199468 0.26 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr19_+_17862274 0.26 ENST00000596536.1
ENST00000593870.1
ENST00000598086.1
ENST00000598932.1
ENST00000595023.1
ENST00000594068.1
ENST00000596507.1
ENST00000595033.1
ENST00000597718.1
FCHO1
FCH domain only 1
chr15_+_83209620 0.26 ENST00000568285.1
RP11-379H8.1
Uncharacterized protein
chr19_-_10305302 0.26 ENST00000592054.1
DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr1_-_1590418 0.26 ENST00000341028.7
CDK11B
cyclin-dependent kinase 11B
chr15_+_34517251 0.26 ENST00000559421.1
EMC4
ER membrane protein complex subunit 4
chr17_+_39846114 0.25 ENST00000586699.1
EIF1
eukaryotic translation initiation factor 1
chr2_+_177134134 0.25 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2
metaxin 2
chr17_+_28443819 0.25 ENST00000479218.2
NSRP1
nuclear speckle splicing regulatory protein 1
chr7_-_108210048 0.25 ENST00000415914.3
ENST00000438865.1
THAP5
THAP domain containing 5
chr5_-_43515125 0.24 ENST00000509489.1
C5orf34
chromosome 5 open reading frame 34
chr21_-_27107198 0.24 ENST00000400094.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr7_+_86781677 0.24 ENST00000331242.7
ENST00000394702.3
ENST00000413276.2
ENST00000446796.2
ENST00000411766.2
ENST00000420131.1
ENST00000414630.2
ENST00000453049.1
ENST00000428819.1
ENST00000448598.1
ENST00000449088.3
ENST00000430405.3
DMTF1
cyclin D binding myb-like transcription factor 1
chr8_-_77912431 0.24 ENST00000357039.4
ENST00000522527.1
PEX2
peroxisomal biogenesis factor 2
chr3_-_15469045 0.24 ENST00000450816.2
METTL6
methyltransferase like 6
chr4_+_184427235 0.24 ENST00000412117.1
ENST00000434682.2
ING2
inhibitor of growth family, member 2
chr1_+_169337412 0.24 ENST00000426663.1
BLZF1
basic leucine zipper nuclear factor 1
chr9_+_134001455 0.23 ENST00000531584.1
NUP214
nucleoporin 214kDa
chr13_+_31191920 0.23 ENST00000255304.4
USPL1
ubiquitin specific peptidase like 1
chr5_-_126409159 0.23 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr16_+_1583567 0.23 ENST00000566264.1
TMEM204
transmembrane protein 204
chr9_-_88969303 0.23 ENST00000277141.6
ENST00000375963.3
ZCCHC6
zinc finger, CCHC domain containing 6
chr1_+_169337172 0.23 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
BLZF1
basic leucine zipper nuclear factor 1
chr5_+_35856951 0.23 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr17_-_62503015 0.23 ENST00000581806.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr4_-_39034542 0.23 ENST00000344606.6
TMEM156
transmembrane protein 156
chr9_-_88969339 0.23 ENST00000375960.2
ENST00000375961.2
ZCCHC6
zinc finger, CCHC domain containing 6
chr2_+_169659121 0.22 ENST00000397206.2
ENST00000397209.2
ENST00000421711.2
NOSTRIN
nitric oxide synthase trafficking
chr16_-_20817857 0.22 ENST00000563117.1
ERI2
ERI1 exoribonuclease family member 2
chr5_+_158690089 0.22 ENST00000296786.6
UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr12_-_58159361 0.22 ENST00000546567.1
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr10_-_18948208 0.22 ENST00000607346.1
ARL5B-AS1
ARL5B antisense RNA 1
chr21_-_27107344 0.22 ENST00000457143.2
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr7_+_157129738 0.22 ENST00000437030.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr22_-_38349552 0.22 ENST00000422191.1
ENST00000249079.2
ENST00000418863.1
ENST00000403305.1
ENST00000403026.1
C22orf23
chromosome 22 open reading frame 23
chr16_-_56485257 0.22 ENST00000300291.5
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr6_-_8435758 0.22 ENST00000426876.1
ENST00000339306.5
SLC35B3
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
chr3_+_134204881 0.21 ENST00000511574.1
ENST00000337090.3
ENST00000383229.3
CEP63
centrosomal protein 63kDa
chr12_+_52306113 0.21 ENST00000547400.1
ENST00000550683.1
ENST00000419526.2
ACVRL1
activin A receptor type II-like 1
chr1_+_222886694 0.21 ENST00000426638.1
ENST00000537020.1
ENST00000539697.1
BROX
BRO1 domain and CAAX motif containing
chr12_+_110562135 0.21 ENST00000361948.4
ENST00000552912.1
ENST00000242591.5
ENST00000546374.1
IFT81
intraflagellar transport 81 homolog (Chlamydomonas)
chr6_-_27440460 0.21 ENST00000377419.1
ZNF184
zinc finger protein 184
chr19_+_18485509 0.21 ENST00000597765.1
GDF15
growth differentiation factor 15
chr10_-_18948156 0.21 ENST00000414939.1
ENST00000449529.1
ENST00000456217.1
ENST00000444660.1
ARL5B-AS1
ARL5B antisense RNA 1
chr4_+_76439649 0.21 ENST00000507557.1
THAP6
THAP domain containing 6
chr15_+_63889822 0.21 ENST00000560325.1
FBXL22
F-box and leucine-rich repeat protein 22
chr9_+_103204553 0.21 ENST00000502978.1
ENST00000334943.6
MSANTD3-TMEFF1
TMEFF1
MSANTD3-TMEFF1 readthrough
transmembrane protein with EGF-like and two follistatin-like domains 1
chr12_-_89918982 0.21 ENST00000549504.1
POC1B
POC1 centriolar protein B
chr14_+_57735725 0.21 ENST00000431972.2
AP5M1
adaptor-related protein complex 5, mu 1 subunit
chr4_-_140005443 0.21 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
ELF2
E74-like factor 2 (ets domain transcription factor)
chr6_+_111303218 0.21 ENST00000441448.2
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr17_+_62503147 0.21 ENST00000553412.1
CEP95
centrosomal protein 95kDa
chr2_-_148778323 0.21 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
ORC4
origin recognition complex, subunit 4
chr1_-_59012365 0.20 ENST00000456980.1
ENST00000482274.2
ENST00000453710.1
ENST00000419242.1
ENST00000358603.2
ENST00000371226.3
ENST00000426139.1
OMA1
OMA1 zinc metallopeptidase
chr22_-_40929812 0.20 ENST00000422851.1
MKL1
megakaryoblastic leukemia (translocation) 1
chr12_-_57030096 0.20 ENST00000549506.1
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr4_+_79567362 0.20 ENST00000512322.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr11_+_65407331 0.20 ENST00000527525.1
SIPA1
signal-induced proliferation-associated 1
chr4_-_111120334 0.20 ENST00000503885.1
ELOVL6
ELOVL fatty acid elongase 6
chr16_-_30125177 0.20 ENST00000406256.3
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr10_-_121302195 0.20 ENST00000369103.2
RGS10
regulator of G-protein signaling 10
chr11_+_5617952 0.20 ENST00000354852.5
TRIM6-TRIM34
TRIM6-TRIM34 readthrough
chr12_-_100660833 0.20 ENST00000551642.1
ENST00000416321.1
ENST00000550587.1
ENST00000549249.1
DEPDC4
DEP domain containing 4
chr12_+_21679220 0.19 ENST00000256969.2
C12orf39
chromosome 12 open reading frame 39
chr15_+_63889577 0.19 ENST00000534939.1
ENST00000539570.3
FBXL22
F-box and leucine-rich repeat protein 22
chr17_+_62503073 0.19 ENST00000580188.1
ENST00000581056.1
CEP95
centrosomal protein 95kDa
chr7_-_37488547 0.19 ENST00000453399.1
ELMO1
engulfment and cell motility 1
chr12_-_93835665 0.19 ENST00000552442.1
ENST00000550657.1
UBE2N
ubiquitin-conjugating enzyme E2N
chr20_-_49575081 0.19 ENST00000371588.5
ENST00000371582.4
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr2_+_169658928 0.19 ENST00000317647.7
ENST00000445023.2
NOSTRIN
nitric oxide synthase trafficking
chr1_+_186798073 0.19 ENST00000367466.3
ENST00000442353.2
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr21_-_30365136 0.19 ENST00000361371.5
ENST00000389194.2
ENST00000389195.2
LTN1
listerin E3 ubiquitin protein ligase 1
chr11_+_118230287 0.19 ENST00000252108.3
ENST00000431736.2
UBE4A
ubiquitination factor E4A
chr4_+_79567057 0.19 ENST00000503259.1
ENST00000507802.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chrX_-_131352152 0.19 ENST00000342983.2
RAP2C
RAP2C, member of RAS oncogene family
chr10_+_94590910 0.18 ENST00000371547.4
EXOC6
exocyst complex component 6
chr3_+_179065474 0.18 ENST00000471841.1
ENST00000280653.7
MFN1
mitofusin 1
chr8_-_102987548 0.18 ENST00000520690.1
NCALD
neurocalcin delta
chr7_-_3083573 0.18 ENST00000396946.4
CARD11
caspase recruitment domain family, member 11
chr14_-_24616426 0.18 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_+_84944926 0.18 ENST00000370656.1
ENST00000370654.5
RPF1
ribosome production factor 1 homolog (S. cerevisiae)
chr8_-_42396721 0.18 ENST00000518384.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr14_-_57735528 0.18 ENST00000340918.7
ENST00000413566.2
EXOC5
exocyst complex component 5
chr5_+_131409476 0.18 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr7_+_5085452 0.18 ENST00000353796.3
ENST00000396912.1
ENST00000396904.2
RBAK
RBAK-RBAKDN
RB-associated KRAB zinc finger
RBAK-RBAKDN readthrough
chr1_-_222886526 0.18 ENST00000541237.1
AIDA
axin interactor, dorsalization associated
chr6_-_41254403 0.18 ENST00000589614.1
ENST00000334475.6
ENST00000591620.1
ENST00000244709.4
TREM1
triggering receptor expressed on myeloid cells 1
chr6_-_10694766 0.17 ENST00000460742.2
ENST00000259983.3
ENST00000379586.1
C6orf52
chromosome 6 open reading frame 52
chr15_-_55489097 0.17 ENST00000260443.4
RSL24D1
ribosomal L24 domain containing 1
chr3_+_130613001 0.17 ENST00000504948.1
ENST00000513801.1
ENST00000505072.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr1_-_197744763 0.17 ENST00000422998.1
DENND1B
DENN/MADD domain containing 1B
chr6_-_27440837 0.17 ENST00000211936.6
ZNF184
zinc finger protein 184
chr18_+_77867177 0.17 ENST00000560752.1
ADNP2
ADNP homeobox 2
chr7_-_32338917 0.17 ENST00000396193.1
PDE1C
phosphodiesterase 1C, calmodulin-dependent 70kDa
chr2_+_9563769 0.17 ENST00000475482.1
CPSF3
cleavage and polyadenylation specific factor 3, 73kDa
chr3_+_197464046 0.17 ENST00000428738.1
FYTTD1
forty-two-three domain containing 1
chr9_+_139839686 0.17 ENST00000371634.2
C8G
complement component 8, gamma polypeptide
chr2_-_133104839 0.17 ENST00000608279.1
RP11-725P16.2
RP11-725P16.2
chr4_-_77069533 0.17 ENST00000514987.1
ENST00000458189.2
ENST00000514901.1
ENST00000342467.6
NUP54
nucleoporin 54kDa
chr8_+_29953163 0.17 ENST00000518192.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr17_-_76975925 0.17 ENST00000591274.1
ENST00000589906.1
ENST00000591778.1
ENST00000589775.2
ENST00000585407.1
ENST00000262776.3
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr14_+_24616588 0.17 ENST00000324103.6
ENST00000559260.1
RNF31
ring finger protein 31
chr2_+_158733088 0.17 ENST00000605860.1
UPP2
uridine phosphorylase 2
chr18_-_47013586 0.17 ENST00000318240.3
ENST00000579820.1
C18orf32
chromosome 18 open reading frame 32
chr6_+_31620191 0.17 ENST00000375918.2
ENST00000375920.4
APOM
apolipoprotein M
chr2_-_17935027 0.17 ENST00000446852.1
SMC6
structural maintenance of chromosomes 6
chr18_-_12884259 0.17 ENST00000353319.4
ENST00000327283.3
PTPN2
protein tyrosine phosphatase, non-receptor type 2
chr3_-_132378672 0.17 ENST00000481970.2
ACAD11
acyl-CoA dehydrogenase family, member 11
chr9_-_125675576 0.16 ENST00000373659.3
ZBTB6
zinc finger and BTB domain containing 6
chr6_+_126307576 0.16 ENST00000334379.5
ENST00000450358.1
ENST00000368332.3
TRMT11
tRNA methyltransferase 11 homolog (S. cerevisiae)
chr3_-_19988462 0.16 ENST00000344838.4
EFHB
EF-hand domain family, member B
chr10_-_32217717 0.16 ENST00000396144.4
ENST00000375245.4
ENST00000344936.2
ENST00000375250.5
ARHGAP12
Rho GTPase activating protein 12
chr2_-_201753980 0.16 ENST00000443398.1
ENST00000286175.8
ENST00000409449.1
PPIL3
peptidylprolyl isomerase (cyclophilin)-like 3
chr15_-_59981479 0.16 ENST00000607373.1
BNIP2
BCL2/adenovirus E1B 19kDa interacting protein 2
chr6_-_75994025 0.16 ENST00000518161.1
TMEM30A
transmembrane protein 30A
chr14_+_65170820 0.16 ENST00000555982.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_+_70820451 0.16 ENST00000361764.4
ENST00000359875.5
ENST00000370940.5
ENST00000531950.1
ENST00000432224.1
HHLA3
HERV-H LTR-associating 3
chr3_+_32726774 0.16 ENST00000538368.1
CNOT10
CCR4-NOT transcription complex, subunit 10
chr18_+_61420169 0.16 ENST00000425392.1
ENST00000336429.2
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr3_-_72897545 0.16 ENST00000325599.8
SHQ1
SHQ1, H/ACA ribonucleoprotein assembly factor
chr17_+_28256874 0.16 ENST00000541045.1
ENST00000536908.2
EFCAB5
EF-hand calcium binding domain 5
chr17_-_62502639 0.16 ENST00000225792.5
ENST00000581697.1
ENST00000584279.1
ENST00000577922.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr2_-_203103185 0.16 ENST00000409205.1
SUMO1
small ubiquitin-like modifier 1
chr3_-_135915146 0.16 ENST00000473093.1
MSL2
male-specific lethal 2 homolog (Drosophila)
chr1_-_38455650 0.16 ENST00000448721.2
SF3A3
splicing factor 3a, subunit 3, 60kDa
chr11_+_86667117 0.16 ENST00000531827.1
RP11-736K20.6
RP11-736K20.6
chr5_-_39270725 0.16 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr4_+_184426147 0.16 ENST00000302327.3
ING2
inhibitor of growth family, member 2
chr1_-_169337176 0.16 ENST00000472647.1
ENST00000367811.3
NME7
NME/NM23 family member 7
chr5_-_87564620 0.16 ENST00000506536.1
ENST00000512429.1
ENST00000514135.1
ENST00000296595.6
ENST00000509387.1
TMEM161B
transmembrane protein 161B
chr2_+_46926048 0.16 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chr9_+_100174344 0.16 ENST00000422139.2
TDRD7
tudor domain containing 7
chr1_-_101360374 0.15 ENST00000535414.1
EXTL2
exostosin-like glycosyltransferase 2
chr5_+_93954358 0.15 ENST00000504099.1
ANKRD32
ankyrin repeat domain 32
chr1_+_109234907 0.15 ENST00000370025.4
ENST00000370022.5
ENST00000370021.1
PRPF38B
pre-mRNA processing factor 38B
chr11_-_27528301 0.15 ENST00000524596.1
ENST00000278193.2
LIN7C
lin-7 homolog C (C. elegans)
chr16_-_30394143 0.15 ENST00000321367.3
ENST00000571393.1
SEPT1
septin 1
chr5_+_61874562 0.15 ENST00000334994.5
ENST00000409534.1
LRRC70
IPO11
leucine rich repeat containing 70
importin 11
chr15_-_41120896 0.15 ENST00000299174.5
ENST00000427255.2
PPP1R14D
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr12_+_41221794 0.15 ENST00000547849.1
CNTN1
contactin 1
chr21_+_27107672 0.15 ENST00000400075.3
GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr11_-_95657231 0.15 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
MTMR2
myotubularin related protein 2
chr13_-_108870623 0.15 ENST00000405925.1
LIG4
ligase IV, DNA, ATP-dependent
chr8_-_82644562 0.15 ENST00000520604.1
ENST00000521742.1
ENST00000520635.1
ZFAND1
zinc finger, AN1-type domain 1
chr12_-_56221330 0.15 ENST00000546837.1
RP11-762I7.5
Uncharacterized protein
chr1_+_40505891 0.15 ENST00000372797.3
ENST00000372802.1
ENST00000449311.1
CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr17_+_76422409 0.15 ENST00000600087.1
AC061992.1
Uncharacterized protein
chr2_+_187350973 0.15 ENST00000544130.1
ZC3H15
zinc finger CCCH-type containing 15
chr11_-_102962874 0.15 ENST00000531543.1
DCUN1D5
DCN1, defective in cullin neddylation 1, domain containing 5
chr11_+_10772847 0.15 ENST00000524523.1
CTR9
CTR9, Paf1/RNA polymerase II complex component
chr4_-_156298028 0.15 ENST00000433024.1
ENST00000379248.2
MAP9
microtubule-associated protein 9
chr15_-_55488817 0.15 ENST00000569386.1
RSL24D1
ribosomal L24 domain containing 1
chr20_+_21283941 0.15 ENST00000377191.3
ENST00000430571.2
XRN2
5'-3' exoribonuclease 2
chr10_+_89264625 0.15 ENST00000371996.4
ENST00000371994.4
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr11_-_111944704 0.15 ENST00000532211.1
PIH1D2
PIH1 domain containing 2
chr19_+_44455368 0.15 ENST00000591168.1
ENST00000587682.1
ENST00000251269.5
ZNF221
zinc finger protein 221
chr1_+_204485571 0.15 ENST00000454264.2
ENST00000367183.3
MDM4
Mdm4 p53 binding protein homolog (mouse)
chr11_+_6260298 0.15 ENST00000379936.2
CNGA4
cyclic nucleotide gated channel alpha 4
chr19_+_44764031 0.15 ENST00000592581.1
ENST00000590668.1
ENST00000588489.1
ENST00000391958.2
ZNF233
zinc finger protein 233
chr12_-_120907374 0.15 ENST00000550458.1
SRSF9
serine/arginine-rich splicing factor 9
chr3_+_23847432 0.15 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr2_+_33661382 0.15 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_-_93836028 0.15 ENST00000318066.2
UBE2N
ubiquitin-conjugating enzyme E2N
chr15_+_90234028 0.15 ENST00000268130.7
ENST00000560294.1
ENST00000558000.1
WDR93
WD repeat domain 93
chr10_+_127408110 0.14 ENST00000356792.4
C10orf137
erythroid differentiation regulatory factor 1
chr2_-_153573887 0.14 ENST00000493468.2
ENST00000545856.1
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr19_+_35741466 0.14 ENST00000599658.1
LSR
lipolysis stimulated lipoprotein receptor
chr2_+_170440844 0.14 ENST00000260970.3
ENST00000433207.1
ENST00000409714.3
ENST00000462903.1
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr6_+_142622991 0.14 ENST00000230173.6
ENST00000367608.2
GPR126
G protein-coupled receptor 126
chr17_-_33288522 0.14 ENST00000314144.5
CCT6B
chaperonin containing TCP1, subunit 6B (zeta 2)

Network of associatons between targets according to the STRING database.

First level regulatory network of ETS1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.1 0.3 GO:1902232 regulation of positive thymic T cell selection(GO:1902232)
0.1 0.3 GO:1902559 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)
0.1 0.3 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.1 0.7 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.1 0.3 GO:0042000 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.1 0.2 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.1 0.3 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.1 0.4 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 0.3 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.6 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 0.2 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 0.3 GO:0042631 cellular response to water deprivation(GO:0042631)
0.1 0.1 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.2 GO:0046041 ITP metabolic process(GO:0046041)
0.1 0.2 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
0.1 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.2 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.0 0.4 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.1 GO:0097359 UDP-glucosylation(GO:0097359)
0.0 0.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.0 GO:1900244 positive regulation of synaptic vesicle endocytosis(GO:1900244) positive regulation of synaptic vesicle recycling(GO:1903423)
0.0 0.1 GO:1904586 response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586) hepatocyte dedifferentiation(GO:1990828)
0.0 0.3 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.0 0.2 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 0.2 GO:2001162 regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
0.0 0.3 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.6 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.1 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.1 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.0 0.2 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.0 0.0 GO:2000395 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 0.2 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.0 0.1 GO:0097032 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.0 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.2 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.0 0.2 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.2 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.2 GO:0071500 cellular response to nitrosative stress(GO:0071500)
0.0 0.4 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.2 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.3 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.2 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.2 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.2 GO:0035983 response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.0 0.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 0.3 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.0 0.1 GO:2000426 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) T-helper 1 cell activation(GO:0035711) negative regulation of apoptotic cell clearance(GO:2000426)
0.0 0.4 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.2 GO:0046108 uridine metabolic process(GO:0046108)
0.0 0.4 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0061010 external genitalia morphogenesis(GO:0035261) gall bladder development(GO:0061010)
0.0 0.0 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.1 GO:0080120 prenylated protein catabolic process(GO:0030327) CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.0 0.1 GO:0018283 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.0 0.1 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.1 GO:0098904 regulation of AV node cell action potential(GO:0098904)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.3 GO:1990822 basic amino acid transmembrane transport(GO:1990822)
0.0 0.2 GO:0023035 CD40 signaling pathway(GO:0023035)
0.0 0.3 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.3 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.5 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.3 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.3 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.2 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.8 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 0.2 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.2 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.2 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.2 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.1 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.0 0.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.1 GO:0030047 actin modification(GO:0030047)
0.0 0.2 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 0.1 GO:0043323 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.0 0.1 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.2 GO:1902739 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) telomerase RNA stabilization(GO:0090669) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.0 0.1 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.0 0.2 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.3 GO:0015074 DNA integration(GO:0015074)
0.0 0.3 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0 0.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.1 GO:0035801 adrenal cortex development(GO:0035801) adrenal cortex formation(GO:0035802)
0.0 0.0 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.0 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.0 0.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.2 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.0 0.1 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0 0.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.1 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.2 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.0 0.1 GO:0090069 regulation of ribosome biogenesis(GO:0090069) regulation of rRNA processing(GO:2000232)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.2 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.2 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 0.1 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 0.4 GO:0033182 regulation of histone ubiquitination(GO:0033182)
0.0 0.1 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.0 0.1 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.1 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.1 GO:0035350 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.2 GO:1902570 protein localization to nucleolus(GO:1902570)
0.0 0.3 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 0.2 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.0 GO:0072434 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.0 0.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.2 GO:0051149 positive regulation of muscle cell differentiation(GO:0051149)
0.0 0.1 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.0 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.1 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.1 GO:0039533 regulation of MDA-5 signaling pathway(GO:0039533)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.0 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.0 0.0 GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.1 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.3 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.1 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.0 GO:0060981 cell migration involved in coronary angiogenesis(GO:0060981)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.1 GO:0001923 B-1 B cell differentiation(GO:0001923)
0.0 0.1 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.0 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.0 0.1 GO:0044565 dendritic cell proliferation(GO:0044565)
0.0 0.2 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.0 0.0 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:1900180 regulation of protein localization to nucleus(GO:1900180)
0.0 0.1 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.0 0.4 GO:0043101 purine-containing compound salvage(GO:0043101)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.0 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.0 0.1 GO:0007135 meiosis II(GO:0007135)
0.0 0.1 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.0 GO:0060178 regulation of exocyst assembly(GO:0001928) regulation of exocyst localization(GO:0060178)
0.0 0.1 GO:0055069 zinc ion homeostasis(GO:0055069)
0.0 0.1 GO:0035927 RNA import into mitochondrion(GO:0035927)
0.0 0.0 GO:1900195 positive regulation of oocyte maturation(GO:1900195)
0.0 0.1 GO:0015747 urate transport(GO:0015747)
0.0 0.1 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.1 GO:0031437 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.1 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.0 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.1 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.0 GO:0031943 regulation of glucocorticoid metabolic process(GO:0031943)
0.0 0.0 GO:0038178 complement component C5a signaling pathway(GO:0038178)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.3 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.2 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.1 GO:0010959 regulation of metal ion transport(GO:0010959)
0.0 0.3 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.0 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0 0.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.0 GO:1990637 response to prolactin(GO:1990637)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.3 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.1 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.3 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.0 GO:0032964 collagen biosynthetic process(GO:0032964)
0.0 0.1 GO:0051665 membrane raft localization(GO:0051665)
0.0 0.1 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 0.0 GO:0061312 BMP signaling pathway involved in heart development(GO:0061312)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 0.8 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1 0.1 GO:0032010 phagolysosome(GO:0032010)
0.1 0.3 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 0.2 GO:0031379 RNA-directed RNA polymerase complex(GO:0031379)
0.1 0.5 GO:1902560 GMP reductase complex(GO:1902560)
0.1 0.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.2 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 0.3 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.1 0.2 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.1 0.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.7 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.0 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.3 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.2 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0045293 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.5 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.1 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.1 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.1 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.1 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.0 0.2 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0097422 tubular endosome(GO:0097422)
0.0 0.3 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.1 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.2 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.5 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.1 GO:0000502 proteasome complex(GO:0000502)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0030914 STAGA complex(GO:0030914)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.2 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.0 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.0 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.0 GO:0034455 t-UTP complex(GO:0034455)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.0 GO:0043291 RAVE complex(GO:0043291)
0.0 0.1 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.0 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.1 0.3 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.1 0.3 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.8 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 0.3 GO:0070991 medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
0.1 0.5 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.1 0.2 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.1 0.3 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 0.5 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.2 GO:0071566 UFM1 activating enzyme activity(GO:0071566)
0.1 0.3 GO:0097677 STAT family protein binding(GO:0097677)
0.1 0.2 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.1 0.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.3 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.5 GO:0035500 MH2 domain binding(GO:0035500)
0.1 0.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 0.2 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0 0.1 GO:0008969 phosphohistidine phosphatase activity(GO:0008969)
0.0 0.1 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 0.4 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.1 GO:0031071 cysteine desulfurase activity(GO:0031071)
0.0 0.2 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.2 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 0.2 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.2 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.0 0.4 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.1 GO:0015235 cobalamin transporter activity(GO:0015235)
0.0 0.2 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.3 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 0.2 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.1 GO:0032427 GBD domain binding(GO:0032427)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.2 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.0 0.1 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.2 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.2 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.2 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0 0.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.1 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.1 GO:0031626 beta-endorphin binding(GO:0031626)
0.0 0.1 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.0 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.3 GO:0051400 BH domain binding(GO:0051400)
0.0 0.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0000248 C-5 sterol desaturase activity(GO:0000248) sterol desaturase activity(GO:0070704)
0.0 0.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.2 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.0 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0070990 snRNP binding(GO:0070990)
0.0 0.0 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.1 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.0 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.0 GO:0004663 protein geranylgeranyltransferase activity(GO:0004661) Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.0 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.0 GO:0004992 platelet activating factor receptor activity(GO:0004992) platelet-derived growth factor beta-receptor activity(GO:0005019)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.1 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.7 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.1 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.6 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.6 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.3 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.6 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.2 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.8 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.4 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle