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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GATA6

Z-value: 0.52

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.4 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19749386_19749404-0.503.1e-01Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_10920714 0.36 ENST00000533941.1
CTD-2003C8.2
CTD-2003C8.2
chr19_-_39303576 0.36 ENST00000594209.1
LGALS4
lectin, galactoside-binding, soluble, 4
chr10_+_118349920 0.31 ENST00000531984.1
PNLIPRP1
pancreatic lipase-related protein 1
chr17_+_4835580 0.17 ENST00000329125.5
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr17_+_4675175 0.16 ENST00000270560.3
TM4SF5
transmembrane 4 L six family member 5
chr2_+_102927962 0.16 ENST00000233954.1
ENST00000393393.3
ENST00000410040.1
IL1RL1
IL18R1
interleukin 1 receptor-like 1
interleukin 18 receptor 1
chr14_-_38028689 0.16 ENST00000553425.1
RP11-356O9.2
RP11-356O9.2
chr5_-_135290651 0.15 ENST00000522943.1
ENST00000514447.2
LECT2
leukocyte cell-derived chemotaxin 2
chr14_-_38036271 0.14 ENST00000556024.1
RP11-356O9.2
RP11-356O9.2
chr1_-_42630389 0.14 ENST00000357001.2
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr5_-_141703713 0.13 ENST00000511815.1
SPRY4
sprouty homolog 4 (Drosophila)
chr12_+_53818855 0.12 ENST00000550839.1
AMHR2
anti-Mullerian hormone receptor, type II
chr11_-_116708302 0.12 ENST00000375320.1
ENST00000359492.2
ENST00000375329.2
ENST00000375323.1
APOA1
apolipoprotein A-I
chr2_+_220436917 0.11 ENST00000243786.2
INHA
inhibin, alpha
chr12_-_21928515 0.11 ENST00000537950.1
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr11_+_10326918 0.11 ENST00000528544.1
ADM
adrenomedullin
chr10_-_21186144 0.10 ENST00000377119.1
NEBL
nebulette
chr1_-_167487758 0.09 ENST00000362089.5
CD247
CD247 molecule
chr9_+_125796806 0.09 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chr9_+_33795533 0.09 ENST00000379405.3
PRSS3
protease, serine, 3
chr10_-_99531709 0.09 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr11_-_1036706 0.08 ENST00000421673.2
MUC6
mucin 6, oligomeric mucus/gel-forming
chr19_-_13213954 0.08 ENST00000590974.1
LYL1
lymphoblastic leukemia derived sequence 1
chr17_+_19314505 0.08 ENST00000461366.1
RNF112
ring finger protein 112
chr20_-_60294804 0.07 ENST00000317652.1
RP11-429E11.3
Uncharacterized protein
chr1_-_205912577 0.07 ENST00000367135.3
ENST00000367134.2
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr4_-_48683188 0.06 ENST00000505759.1
FRYL
FRY-like
chr15_-_38852251 0.06 ENST00000558432.1
RASGRP1
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr17_+_19314432 0.06 ENST00000575165.2
RNF112
ring finger protein 112
chr17_+_56833184 0.06 ENST00000308249.2
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr8_-_116681686 0.05 ENST00000519815.1
TRPS1
trichorhinophalangeal syndrome I
chr1_-_167487808 0.05 ENST00000392122.3
CD247
CD247 molecule
chr6_-_30128657 0.05 ENST00000449742.2
ENST00000376704.3
TRIM10
tripartite motif containing 10
chr12_+_122880045 0.05 ENST00000539034.1
ENST00000535976.1
RP11-450K4.1
RP11-450K4.1
chr10_+_71075516 0.05 ENST00000436817.1
HK1
hexokinase 1
chr20_+_43935474 0.05 ENST00000372743.1
ENST00000372741.3
ENST00000343694.3
RBPJL
recombination signal binding protein for immunoglobulin kappa J region-like
chr20_+_43029911 0.05 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4, alpha
chr2_-_44065889 0.05 ENST00000543989.1
ENST00000405322.1
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr1_-_120354079 0.05 ENST00000354219.1
ENST00000369401.4
ENST00000256585.5
REG4
regenerating islet-derived family, member 4
chr14_-_23284675 0.04 ENST00000555959.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr4_-_186696561 0.04 ENST00000445115.1
ENST00000451701.1
ENST00000457247.1
ENST00000435480.1
ENST00000425679.1
ENST00000457934.1
SORBS2
sorbin and SH3 domain containing 2
chr10_-_127505167 0.04 ENST00000368786.1
UROS
uroporphyrinogen III synthase
chr3_+_69812877 0.04 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr7_-_100239132 0.04 ENST00000223051.3
ENST00000431692.1
TFR2
transferrin receptor 2
chr16_+_333152 0.03 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
PDIA2
protein disulfide isomerase family A, member 2
chr5_-_135290705 0.03 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr17_+_74381343 0.03 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr12_-_122879969 0.03 ENST00000540304.1
CLIP1
CAP-GLY domain containing linker protein 1
chr3_+_88188254 0.03 ENST00000309495.5
ZNF654
zinc finger protein 654
chr1_+_171217622 0.03 ENST00000433267.1
ENST00000367750.3
FMO1
flavin containing monooxygenase 1
chr4_-_186696636 0.03 ENST00000444771.1
SORBS2
sorbin and SH3 domain containing 2
chr19_-_11494975 0.03 ENST00000222139.6
ENST00000592375.2
EPOR
erythropoietin receptor
chr4_+_166794383 0.03 ENST00000061240.2
ENST00000507499.1
TLL1
tolloid-like 1
chr14_-_23285011 0.03 ENST00000397532.3
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr8_-_38008783 0.02 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr12_-_56221330 0.02 ENST00000546837.1
RP11-762I7.5
Uncharacterized protein
chr12_+_111843749 0.02 ENST00000341259.2
SH2B3
SH2B adaptor protein 3
chr11_-_47374246 0.02 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
MYBPC3
myosin binding protein C, cardiac
chr10_+_71075552 0.02 ENST00000298649.3
HK1
hexokinase 1
chr11_-_26743546 0.02 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr17_-_4806369 0.02 ENST00000293780.4
CHRNE
cholinergic receptor, nicotinic, epsilon (muscle)
chr7_+_150690857 0.02 ENST00000484524.1
ENST00000467517.1
NOS3
nitric oxide synthase 3 (endothelial cell)
chr20_+_54967663 0.02 ENST00000452950.1
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr3_+_69812701 0.02 ENST00000472437.1
MITF
microphthalmia-associated transcription factor
chr4_-_186697044 0.02 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr12_+_70219052 0.02 ENST00000552032.2
ENST00000547771.2
MYRFL
myelin regulatory factor-like
chr17_-_38938786 0.02 ENST00000301656.3
KRT27
keratin 27
chr5_+_159848807 0.02 ENST00000352433.5
PTTG1
pituitary tumor-transforming 1
chr17_-_62084241 0.01 ENST00000449662.2
ICAM2
intercellular adhesion molecule 2
chr15_+_49715449 0.01 ENST00000560979.1
FGF7
fibroblast growth factor 7
chr13_-_46716969 0.01 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_-_52995291 0.01 ENST00000293745.2
ENST00000354310.4
KRT72
keratin 72
chr9_-_114937676 0.01 ENST00000374270.3
SUSD1
sushi domain containing 1
chr2_-_152830441 0.01 ENST00000534999.1
ENST00000397327.2
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr14_-_21945057 0.01 ENST00000397762.1
RAB2B
RAB2B, member RAS oncogene family
chr2_-_152830479 0.01 ENST00000360283.6
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr14_-_23285069 0.01 ENST00000554758.1
ENST00000397528.4
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr4_-_103266355 0.01 ENST00000424970.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr20_+_54967409 0.01 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr1_+_171217677 0.01 ENST00000402921.2
FMO1
flavin containing monooxygenase 1
chr7_+_128379346 0.01 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
CALU
calumenin
chr12_+_109785708 0.01 ENST00000310903.5
MYO1H
myosin IH
chr9_+_118950325 0.01 ENST00000534838.1
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr12_-_6233828 0.01 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr1_-_158656488 0.01 ENST00000368147.4
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr16_+_67022582 0.01 ENST00000541479.1
ENST00000338718.4
CES4A
carboxylesterase 4A
chr2_+_173792893 0.01 ENST00000535187.1
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr16_+_67022476 0.01 ENST00000540947.2
CES4A
carboxylesterase 4A
chr11_+_118958689 0.01 ENST00000535253.1
ENST00000392841.1
HMBS
hydroxymethylbilane synthase
chr14_-_23284703 0.01 ENST00000555911.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr11_-_66206260 0.00 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
MRPL11
mitochondrial ribosomal protein L11
chr5_-_33984786 0.00 ENST00000296589.4
SLC45A2
solute carrier family 45, member 2
chr2_-_202298268 0.00 ENST00000440597.1
TRAK2
trafficking protein, kinesin binding 2
chr11_+_10326612 0.00 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
ADM
adrenomedullin
chr2_+_102928009 0.00 ENST00000404917.2
ENST00000447231.1
IL1RL1
interleukin 1 receptor-like 1
chr20_-_54967187 0.00 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA
aurora kinase A
chr5_-_33984741 0.00 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
SLC45A2
solute carrier family 45, member 2
chr1_-_27240455 0.00 ENST00000254227.3
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr16_+_71560154 0.00 ENST00000539698.3
CHST4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr17_-_29645836 0.00 ENST00000578584.1
CTD-2370N5.3
CTD-2370N5.3

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901) regulation of Cdc42 protein signal transduction(GO:0032489)
0.0 0.1 GO:0046882 negative regulation of B cell differentiation(GO:0045578) negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.2 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.0 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal lipid absorption(GO:1904729)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.1 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.0 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363) discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.1 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.1 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.1 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.2 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.0 0.0 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse