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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for GMEB1
Z-value: 1.34
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Transcription factors associated with GMEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GMEB1 | hg19_v2_chr1_+_28995258_28995322 | -0.76 | 7.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GMEB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.6 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.2 | 1.9 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.2 | 1.9 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.6 | 1.8 | GO:0051102 | DNA ligation involved in DNA recombination(GO:0051102) |
| 0.1 | 1.7 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.1 | 1.5 | GO:0002759 | regulation of antimicrobial humoral response(GO:0002759) |
| 0.1 | 1.5 | GO:0090646 | mitochondrial tRNA processing(GO:0090646) |
| 0.0 | 1.5 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.0 | 1.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.2 | 1.3 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 2.1 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.0 | 2.1 | GO:0000776 | kinetochore(GO:0000776) |
| 0.1 | 2.0 | GO:0005818 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.0 | 1.6 | GO:0005844 | polysome(GO:0005844) |
| 0.2 | 1.5 | GO:0030678 | mitochondrial ribonuclease P complex(GO:0030678) |
| 0.0 | 1.4 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.1 | 1.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 1.2 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 1.2 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.7 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
| 0.1 | 1.7 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 1.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 1.6 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 1.2 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 1.1 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.0 | 1.1 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 1.0 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 0.9 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 0.9 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 2.0 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.7 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.6 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 0.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.4 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.3 | 0.3 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 2.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 2.3 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 2.0 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 1.6 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 1.6 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.2 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.1 | 1.1 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 1.1 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 1.1 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |