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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GRHL1

Z-value: 0.37

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.13 grainyhead like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg19_v2_chr2_+_10091815_100918640.108.4e-01Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_31107127 0.32 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr8_-_130799134 0.25 ENST00000276708.4
GSDMC
gasdermin C
chr21_+_33671264 0.22 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr3_-_172241250 0.21 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr5_+_138611798 0.21 ENST00000502394.1
MATR3
matrin 3
chr4_-_110736505 0.19 ENST00000609440.1
RP11-602N24.3
RP11-602N24.3
chr4_+_26859300 0.19 ENST00000494628.2
STIM2
stromal interaction molecule 2
chr19_-_4043154 0.19 ENST00000535853.1
AC016586.1
AC016586.1
chr11_+_15095108 0.18 ENST00000324229.6
ENST00000533448.1
CALCB
calcitonin-related polypeptide beta
chr22_+_18560743 0.18 ENST00000399744.3
PEX26
peroxisomal biogenesis factor 26
chr11_+_706595 0.15 ENST00000531348.1
ENST00000530636.1
EPS8L2
EPS8-like 2
chr11_-_111636772 0.14 ENST00000531373.1
PPP2R1B
protein phosphatase 2, regulatory subunit A, beta
chr5_+_125759140 0.14 ENST00000543198.1
GRAMD3
GRAM domain containing 3
chr11_+_119039069 0.14 ENST00000422249.1
NLRX1
NLR family member X1
chr11_+_119038897 0.14 ENST00000454811.1
ENST00000449394.1
NLRX1
NLR family member X1
chr5_+_134303591 0.13 ENST00000282611.6
CATSPER3
cation channel, sperm associated 3
chr20_-_18038521 0.12 ENST00000278780.6
OVOL2
ovo-like zinc finger 2
chr14_-_23540826 0.11 ENST00000357481.2
ACIN1
apoptotic chromatin condensation inducer 1
chr12_+_123874589 0.11 ENST00000437502.1
SETD8
SET domain containing (lysine methyltransferase) 8
chr14_-_23540747 0.11 ENST00000555566.1
ENST00000338631.6
ENST00000557515.1
ENST00000397341.3
ACIN1
apoptotic chromatin condensation inducer 1
chr2_+_95940186 0.11 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
PROM2
prominin 2
chr9_+_130565568 0.10 ENST00000423577.1
FPGS
folylpolyglutamate synthase
chr3_-_49142178 0.10 ENST00000452739.1
ENST00000414533.1
ENST00000417025.1
QARS
glutaminyl-tRNA synthetase
chr19_-_12146483 0.10 ENST00000455504.2
ENST00000547560.1
ENST00000552904.1
ENST00000419886.2
ENST00000550507.1
ENST00000344980.6
ENST00000550745.1
ENST00000411841.1
ZNF433
zinc finger protein 433
chr7_-_80551671 0.10 ENST00000419255.2
ENST00000544525.1
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr7_-_102283238 0.10 ENST00000340457.8
UPK3BL
uroplakin 3B-like
chr7_+_76139833 0.09 ENST00000257632.5
UPK3B
uroplakin 3B
chr9_+_140122018 0.09 ENST00000445101.2
RNF224
ring finger protein 224
chr3_-_113415441 0.09 ENST00000491165.1
ENST00000316407.4
KIAA2018
KIAA2018
chr11_+_76493294 0.09 ENST00000533752.1
TSKU
tsukushi, small leucine rich proteoglycan
chr20_-_25320367 0.09 ENST00000450393.1
ENST00000491682.1
ABHD12
abhydrolase domain containing 12
chr5_+_125758813 0.09 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr1_+_155023757 0.09 ENST00000356955.2
ENST00000449910.2
ENST00000359280.4
ENST00000360674.4
ENST00000368412.3
ENST00000355956.2
ENST00000368410.2
ENST00000271836.6
ENST00000368413.1
ENST00000531455.1
ENST00000447332.3
ADAM15
ADAM metallopeptidase domain 15
chr16_+_2564254 0.08 ENST00000565223.1
ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr9_+_130565487 0.08 ENST00000373225.3
ENST00000431857.1
FPGS
folylpolyglutamate synthase
chr3_-_49142504 0.08 ENST00000306125.6
ENST00000420147.2
QARS
glutaminyl-tRNA synthetase
chr7_+_76139741 0.08 ENST00000334348.3
ENST00000419923.2
ENST00000448265.3
ENST00000443097.2
UPK3B
uroplakin 3B
chr6_-_43027105 0.08 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
MRPL2
mitochondrial ribosomal protein L2
chr18_+_9475001 0.08 ENST00000019317.4
RALBP1
ralA binding protein 1
chr22_+_18560675 0.07 ENST00000329627.7
PEX26
peroxisomal biogenesis factor 26
chr1_+_44440575 0.07 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr14_+_23938891 0.07 ENST00000408901.3
ENST00000397154.3
ENST00000555128.1
NGDN
neuroguidin, EIF4E binding protein
chr19_+_10736183 0.07 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
SLC44A2
solute carrier family 44 (choline transporter), member 2
chr1_-_52520828 0.07 ENST00000610127.1
TXNDC12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr11_-_93583697 0.07 ENST00000409977.1
VSTM5
V-set and transmembrane domain containing 5
chr2_-_190446738 0.06 ENST00000427419.1
ENST00000455320.1
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr9_+_77703414 0.06 ENST00000346234.6
OSTF1
osteoclast stimulating factor 1
chr9_+_71736177 0.06 ENST00000606364.1
ENST00000453658.2
TJP2
tight junction protein 2
chr14_-_80677613 0.06 ENST00000556811.1
DIO2
deiodinase, iodothyronine, type II
chr19_-_17356697 0.06 ENST00000291442.3
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr11_+_119039414 0.06 ENST00000409991.1
ENST00000292199.2
ENST00000409265.4
ENST00000409109.1
NLRX1
NLR family member X1
chr5_+_125758865 0.06 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr5_-_132299290 0.06 ENST00000378595.3
AFF4
AF4/FMR2 family, member 4
chr7_-_102184083 0.05 ENST00000379357.5
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J3
chr18_+_44497455 0.05 ENST00000592005.1
KATNAL2
katanin p60 subunit A-like 2
chr18_-_55470320 0.05 ENST00000536015.1
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr16_-_23568651 0.04 ENST00000563232.1
ENST00000563459.1
ENST00000449606.1
EARS2
glutamyl-tRNA synthetase 2, mitochondrial
chr3_+_186383741 0.04 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr2_-_85641162 0.04 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
CAPG
capping protein (actin filament), gelsolin-like
chr14_-_80677815 0.03 ENST00000557125.1
ENST00000555750.1
DIO2
deiodinase, iodothyronine, type II
chr3_-_129513259 0.03 ENST00000329333.5
TMCC1
transmembrane and coiled-coil domain family 1
chr1_-_201368653 0.03 ENST00000367313.3
LAD1
ladinin 1
chr4_+_156588249 0.03 ENST00000393832.3
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr8_+_27950619 0.02 ENST00000542181.1
ENST00000524103.1
ENST00000537665.1
ENST00000380353.4
ENST00000520288.1
ELP3
elongator acetyltransferase complex subunit 3
chr7_+_76139925 0.02 ENST00000394849.1
UPK3B
uroplakin 3B
chr20_-_54967187 0.02 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA
aurora kinase A
chr19_-_14945933 0.02 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr2_+_113299990 0.02 ENST00000537335.1
ENST00000417433.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr6_+_168227552 0.02 ENST00000400825.4
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr1_-_51425772 0.01 ENST00000371778.4
FAF1
Fas (TNFRSF6) associated factor 1
chr6_+_168227611 0.01 ENST00000344191.4
ENST00000351017.4
ENST00000392108.3
ENST00000366806.2
ENST00000392112.1
ENST00000400824.4
ENST00000447894.2
ENST00000400822.3
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr12_+_118814185 0.01 ENST00000543473.1
SUDS3
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr1_-_51425902 0.01 ENST00000396153.2
FAF1
Fas (TNFRSF6) associated factor 1
chr8_+_144821557 0.01 ENST00000534398.1
FAM83H-AS1
FAM83H antisense RNA 1 (head to head)
chr12_+_56498312 0.01 ENST00000552766.1
PA2G4
proliferation-associated 2G4, 38kDa
chr19_+_58038683 0.01 ENST00000240719.3
ENST00000376233.3
ENST00000594943.1
ENST00000602149.1
ZNF549
zinc finger protein 549
chr19_-_291133 0.01 ENST00000327790.3
PPAP2C
phosphatidic acid phosphatase type 2C
chr19_+_19496624 0.01 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATAD2A
GATA zinc finger domain containing 2A
chr18_-_35145728 0.00 ENST00000361795.5
ENST00000603232.1
CELF4
CUGBP, Elav-like family member 4
chr19_+_12035913 0.00 ENST00000591944.1
ZNF763
Uncharacterized protein; Zinc finger protein 763
chr18_-_35145981 0.00 ENST00000420428.2
ENST00000412753.1
CELF4
CUGBP, Elav-like family member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.1 0.2 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.0 0.1 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.0 0.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:1903414 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.0 0.1 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.1 GO:0060214 endocardium formation(GO:0060214)
0.0 0.3 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.2 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.0 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.0 0.0 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.0 0.1 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.0 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.1 GO:0044393 microspike(GO:0044393)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.2 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326) dihydrofolate synthase activity(GO:0008841)
0.1 0.2 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.0 0.1 GO:0097689 iron channel activity(GO:0097689)
0.0 0.0 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)