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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HMGA2

Z-value: 0.52

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
HMGA2
ENSG00000149948.9 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66217911_662180180.701.2e-01Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_65996599 0.52 ENST00000539116.1
ENST00000541391.1
RP11-221N13.3
RP11-221N13.3
chr19_+_44455368 0.36 ENST00000591168.1
ENST00000587682.1
ENST00000251269.5
ZNF221
zinc finger protein 221
chr6_-_107230334 0.32 ENST00000607090.1
RP1-60O19.1
RP1-60O19.1
chr1_+_196621002 0.29 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr1_+_227751231 0.27 ENST00000343776.5
ENST00000608949.1
ENST00000397097.3
ZNF678
zinc finger protein 678
chr9_+_42704004 0.26 ENST00000457288.1
CBWD7
COBW domain containing 7
chr10_-_36813162 0.24 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr1_+_196621156 0.23 ENST00000359637.2
CFH
complement factor H
chr19_-_38146289 0.23 ENST00000392144.1
ENST00000591444.1
ENST00000351218.2
ENST00000587809.1
ZFP30
ZFP30 zinc finger protein
chr6_+_116892641 0.21 ENST00000487832.2
ENST00000518117.1
RWDD1
RWD domain containing 1
chr1_+_227751281 0.19 ENST00000440339.1
ZNF678
zinc finger protein 678
chr5_-_102455801 0.17 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr14_+_45553296 0.17 ENST00000355765.6
ENST00000553605.1
PRPF39
pre-mRNA processing factor 39
chr19_-_36297632 0.17 ENST00000588266.2
PRODH2
proline dehydrogenase (oxidase) 2
chr4_+_40058411 0.17 ENST00000261435.6
ENST00000515550.1
N4BP2
NEDD4 binding protein 2
chr4_+_25378912 0.16 ENST00000510092.1
ENST00000505991.1
ANAPC4
anaphase promoting complex subunit 4
chr20_+_54967663 0.15 ENST00000452950.1
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr1_-_67600639 0.14 ENST00000544837.1
ENST00000603691.1
C1orf141
chromosome 1 open reading frame 141
chr10_+_96305535 0.14 ENST00000419900.1
ENST00000348459.5
ENST00000394045.1
ENST00000394044.1
ENST00000394036.1
HELLS
helicase, lymphoid-specific
chr6_-_127664736 0.14 ENST00000368291.2
ENST00000309620.9
ENST00000454859.3
ECHDC1
enoyl CoA hydratase domain containing 1
chr15_+_43885252 0.14 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr2_+_170683979 0.13 ENST00000418381.1
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr16_+_66442411 0.13 ENST00000499966.1
LINC00920
long intergenic non-protein coding RNA 920
chr12_-_8765446 0.12 ENST00000537228.1
ENST00000229335.6
AICDA
activation-induced cytidine deaminase
chr6_-_127664683 0.12 ENST00000528402.1
ENST00000454591.2
ECHDC1
enoyl CoA hydratase domain containing 1
chr19_+_11457175 0.12 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chr10_+_86184676 0.12 ENST00000543283.1
CCSER2
coiled-coil serine-rich protein 2
chr3_-_123680246 0.12 ENST00000488653.2
CCDC14
coiled-coil domain containing 14
chr2_+_177134201 0.12 ENST00000452865.1
MTX2
metaxin 2
chr19_+_41882466 0.11 ENST00000436170.2
TMEM91
transmembrane protein 91
chr3_+_106959552 0.11 ENST00000473550.1
LINC00883
long intergenic non-protein coding RNA 883
chr3_+_186501336 0.09 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2
eukaryotic translation initiation factor 4A2
chr18_-_29340827 0.09 ENST00000269205.5
SLC25A52
solute carrier family 25, member 52
chr15_-_70994612 0.09 ENST00000558758.1
ENST00000379983.2
ENST00000560441.1
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr13_+_51483814 0.09 ENST00000336617.3
ENST00000422660.1
RNASEH2B
ribonuclease H2, subunit B
chr12_-_10324716 0.09 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr2_-_287320 0.09 ENST00000401503.1
FAM150B
family with sequence similarity 150, member B
chr2_+_172544182 0.09 ENST00000409197.1
ENST00000456808.1
ENST00000409317.1
ENST00000409773.1
ENST00000411953.1
ENST00000409453.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr2_+_170683942 0.09 ENST00000272793.5
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chrX_-_77150985 0.09 ENST00000358075.6
MAGT1
magnesium transporter 1
chr2_+_172543967 0.09 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr14_+_88852059 0.08 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr17_+_73230799 0.08 ENST00000579838.1
NUP85
nucleoporin 85kDa
chrX_-_7895755 0.08 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
PNPLA4
patatin-like phospholipase domain containing 4
chr6_-_136571400 0.07 ENST00000418509.2
ENST00000420702.1
ENST00000451457.2
MTFR2
mitochondrial fission regulator 2
chr14_-_94759595 0.07 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_-_287299 0.07 ENST00000405290.1
FAM150B
family with sequence similarity 150, member B
chr15_+_84904525 0.06 ENST00000510439.2
GOLGA6L4
golgin A6 family-like 4
chr1_+_179263308 0.06 ENST00000426956.1
SOAT1
sterol O-acyltransferase 1
chr12_+_69979210 0.06 ENST00000544368.2
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr14_-_94759361 0.06 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_+_172544011 0.06 ENST00000508530.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr14_-_94759408 0.06 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr6_-_160209471 0.05 ENST00000539948.1
TCP1
t-complex 1
chr1_+_64014588 0.05 ENST00000371086.2
ENST00000340052.3
DLEU2L
deleted in lymphocytic leukemia 2-like
chr1_+_55464600 0.05 ENST00000371265.4
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr18_+_11851383 0.05 ENST00000526991.2
CHMP1B
charged multivesicular body protein 1B
chrX_+_117480036 0.05 ENST00000371822.5
ENST00000254029.3
ENST00000371825.3
WDR44
WD repeat domain 44
chr16_+_53483983 0.05 ENST00000544545.1
RBL2
retinoblastoma-like 2 (p130)
chr14_+_37641012 0.05 ENST00000556667.1
SLC25A21-AS1
SLC25A21 antisense RNA 1
chr7_-_102985035 0.05 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr11_-_19223523 0.04 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr12_+_69979113 0.04 ENST00000299300.6
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr15_+_82722225 0.04 ENST00000300515.8
GOLGA6L9
golgin A6 family-like 9
chr2_+_177134134 0.04 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2
metaxin 2
chr10_-_62332357 0.04 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr10_+_35456444 0.04 ENST00000361599.4
CREM
cAMP responsive element modulator
chrX_-_153523462 0.04 ENST00000361930.3
ENST00000369926.1
TEX28
testis expressed 28
chr15_+_30427352 0.04 ENST00000569052.1
GOLGA8T
golgin A8 family, member T
chr7_-_102985288 0.04 ENST00000379263.3
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr19_-_43099070 0.04 ENST00000244336.5
CEACAM8
carcinoembryonic antigen-related cell adhesion molecule 8
chrY_+_22918021 0.04 ENST00000288666.5
RPS4Y2
ribosomal protein S4, Y-linked 2
chr2_-_216257849 0.04 ENST00000456923.1
FN1
fibronectin 1
chr15_-_74659978 0.04 ENST00000541301.1
ENST00000416978.1
ENST00000268053.6
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr20_+_46130619 0.03 ENST00000372004.3
NCOA3
nuclear receptor coactivator 3
chr1_-_226374373 0.03 ENST00000366812.5
ACBD3
acyl-CoA binding domain containing 3
chr12_-_10573149 0.03 ENST00000381904.2
ENST00000381903.2
ENST00000396439.2
KLRC3
killer cell lectin-like receptor subfamily C, member 3
chr3_-_157221380 0.03 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr12_+_59194154 0.03 ENST00000548969.1
RP11-362K2.2
Protein LOC100506869
chrX_-_135962876 0.03 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX
RNA binding motif protein, X-linked
chr11_-_18063973 0.03 ENST00000528338.1
TPH1
tryptophan hydroxylase 1
chr6_+_31887761 0.02 ENST00000413154.1
C2
complement component 2
chr5_-_135290651 0.02 ENST00000522943.1
ENST00000514447.2
LECT2
leukocyte cell-derived chemotaxin 2
chr20_+_48884002 0.02 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3
RP11-290F20.3
chr3_-_157221357 0.02 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr2_+_172543919 0.02 ENST00000452242.1
ENST00000340296.4
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr3_+_106959530 0.02 ENST00000466734.1
ENST00000463143.1
ENST00000490441.1
LINC00883
long intergenic non-protein coding RNA 883
chr9_-_115480303 0.02 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
INIP
INTS3 and NABP interacting protein
chr9_+_108463234 0.02 ENST00000374688.1
TMEM38B
transmembrane protein 38B
chr6_-_32908792 0.02 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chrX_+_2670153 0.02 ENST00000509484.2
XG
Xg blood group
chr2_-_151395525 0.02 ENST00000439275.1
RND3
Rho family GTPase 3
chr9_+_104296122 0.02 ENST00000389120.3
RNF20
ring finger protein 20, E3 ubiquitin protein ligase
chr12_-_122750957 0.02 ENST00000451053.2
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr6_+_111580508 0.01 ENST00000368847.4
KIAA1919
KIAA1919
chr2_-_183387064 0.01 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr20_+_46130671 0.01 ENST00000371998.3
ENST00000371997.3
NCOA3
nuclear receptor coactivator 3
chr15_+_28623784 0.01 ENST00000526619.2
ENST00000337838.7
ENST00000532622.2
GOLGA8F
golgin A8 family, member F
chr3_-_106959424 0.01 ENST00000607801.1
ENST00000479612.2
ENST00000484698.1
ENST00000477210.2
ENST00000473636.1
LINC00882
long intergenic non-protein coding RNA 882
chr1_+_197886461 0.01 ENST00000367388.3
ENST00000337020.2
ENST00000367387.4
LHX9
LIM homeobox 9
chr12_-_122751002 0.01 ENST00000267199.4
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr6_+_88106840 0.01 ENST00000369570.4
C6orf164
chromosome 6 open reading frame 164
chr1_+_2487402 0.01 ENST00000451778.1
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr15_+_88120158 0.01 ENST00000560153.1
LINC00052
long intergenic non-protein coding RNA 52
chr1_+_2487800 0.00 ENST00000355716.4
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr20_+_46130601 0.00 ENST00000341724.6
NCOA3
nuclear receptor coactivator 3
chr14_-_65409502 0.00 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chrX_-_77150911 0.00 ENST00000373336.3
MAGT1
magnesium transporter 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.1 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.1 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
0.0 0.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.2 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.3 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.1 GO:0009972 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.1 GO:0042000 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.0 GO:1904235 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.0 0.0 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.2 GO:0000243 commitment complex(GO:0000243)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.2 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.0 0.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.2 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.0 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade