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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXB5

Z-value: 0.39

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.5 homeobox B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_466713230.079.0e-01Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_102704783 0.33 ENST00000522534.1
MOK
MOK protein kinase
chr1_+_146373546 0.16 ENST00000446760.2
NBPF12
neuroblastoma breakpoint family, member 12
chr1_+_154229547 0.15 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr17_-_17140436 0.13 ENST00000285071.4
ENST00000389169.5
ENST00000417064.1
FLCN
folliculin
chr1_+_113263199 0.12 ENST00000361886.3
FAM19A3
family with sequence similarity 19 (chemokine (C-C motif)-like), member A3
chr7_-_102252589 0.12 ENST00000520042.1
RASA4
RAS p21 protein activator 4
chrX_+_47077632 0.11 ENST00000457458.2
CDK16
cyclin-dependent kinase 16
chr7_+_125557914 0.11 ENST00000411856.1
AC005276.1
AC005276.1
chr6_-_31509506 0.10 ENST00000449757.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr3_+_190281229 0.10 ENST00000453359.1
IL1RAP
interleukin 1 receptor accessory protein
chr19_-_16045220 0.10 ENST00000326742.8
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr8_-_133097902 0.09 ENST00000262283.5
OC90
Otoconin-90
chr20_-_6034672 0.09 ENST00000378858.4
LRRN4
leucine rich repeat neuronal 4
chr16_-_84651647 0.09 ENST00000564057.1
COTL1
coactosin-like 1 (Dictyostelium)
chr5_+_133842243 0.08 ENST00000515627.2
AC005355.2
AC005355.2
chr12_-_53614155 0.08 ENST00000543726.1
RARG
retinoic acid receptor, gamma
chr12_-_53614043 0.08 ENST00000338561.5
RARG
retinoic acid receptor, gamma
chr19_-_42724261 0.07 ENST00000595337.1
DEDD2
death effector domain containing 2
chr16_-_58004992 0.07 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
CNGB1
cyclic nucleotide gated channel beta 1
chr1_+_162351503 0.07 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr12_-_6798616 0.06 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr6_-_97285336 0.06 ENST00000229955.3
ENST00000417980.1
GPR63
G protein-coupled receptor 63
chr17_+_46970127 0.06 ENST00000355938.5
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr2_-_70409953 0.06 ENST00000419381.1
C2orf42
chromosome 2 open reading frame 42
chr16_-_28936007 0.06 ENST00000568703.1
ENST00000567483.1
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr17_+_46970178 0.06 ENST00000393366.2
ENST00000506855.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr12_-_6798410 0.06 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
ZNF384
zinc finger protein 384
chr1_+_155579979 0.06 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
MSTO1
misato 1, mitochondrial distribution and morphology regulator
chr1_+_41157421 0.06 ENST00000372654.1
NFYC
nuclear transcription factor Y, gamma
chr15_-_72523454 0.06 ENST00000565154.1
ENST00000565184.1
ENST00000389093.3
ENST00000449901.2
ENST00000335181.5
ENST00000319622.6
PKM
pyruvate kinase, muscle
chr1_+_157963391 0.06 ENST00000359209.6
ENST00000416935.2
KIRREL
kin of IRRE like (Drosophila)
chr16_-_1821721 0.05 ENST00000219302.3
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr6_-_31509714 0.05 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr3_-_127541194 0.05 ENST00000453507.2
MGLL
monoglyceride lipase
chr20_-_48184638 0.05 ENST00000244043.4
PTGIS
prostaglandin I2 (prostacyclin) synthase
chr12_+_53693466 0.05 ENST00000267103.5
ENST00000548632.1
C12orf10
chromosome 12 open reading frame 10
chr11_-_57089774 0.05 ENST00000527207.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr12_+_56915713 0.05 ENST00000262031.5
ENST00000552247.2
RBMS2
RNA binding motif, single stranded interacting protein 2
chr12_-_6798523 0.05 ENST00000319770.3
ZNF384
zinc finger protein 384
chr19_+_34745442 0.04 ENST00000299505.6
ENST00000588470.1
ENST00000589583.1
ENST00000588338.2
KIAA0355
KIAA0355
chr9_-_130700080 0.04 ENST00000373110.4
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr5_+_175298573 0.04 ENST00000512824.1
CPLX2
complexin 2
chr16_-_30381580 0.04 ENST00000409939.3
TBC1D10B
TBC1 domain family, member 10B
chr1_-_119530428 0.03 ENST00000369429.3
TBX15
T-box 15
chr10_-_103603568 0.03 ENST00000356640.2
KCNIP2
Kv channel interacting protein 2
chr2_-_220173685 0.03 ENST00000423636.2
ENST00000442029.1
ENST00000412847.1
PTPRN
protein tyrosine phosphatase, receptor type, N
chr1_+_41157361 0.03 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
NFYC
nuclear transcription factor Y, gamma
chr6_-_31510181 0.03 ENST00000458640.1
ENST00000396172.1
ENST00000417556.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr13_-_64650144 0.03 ENST00000456627.1
LINC00355
long intergenic non-protein coding RNA 355
chr19_-_50143452 0.03 ENST00000246792.3
RRAS
related RAS viral (r-ras) oncogene homolog
chr15_+_41913690 0.03 ENST00000563576.1
MGA
MGA, MAX dimerization protein
chr4_-_68620053 0.03 ENST00000420975.2
ENST00000226413.4
GNRHR
gonadotropin-releasing hormone receptor
chr10_-_103603523 0.03 ENST00000370046.1
KCNIP2
Kv channel interacting protein 2
chr20_+_44074071 0.03 ENST00000595203.1
AL031663.2
CDNA FLJ26875 fis, clone PRS08969; Uncharacterized protein
chr6_-_133119649 0.02 ENST00000367918.1
SLC18B1
solute carrier family 18, subfamily B, member 1
chr17_+_46970134 0.02 ENST00000503641.1
ENST00000514808.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr12_+_56915776 0.02 ENST00000550726.1
ENST00000542360.1
RBMS2
RNA binding motif, single stranded interacting protein 2
chr14_-_24020858 0.02 ENST00000419474.3
ZFHX2
zinc finger homeobox 2
chr1_+_116915855 0.02 ENST00000295598.5
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr7_+_120969045 0.02 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr3_+_187420101 0.02 ENST00000449623.1
ENST00000437407.1
RP11-211G3.3
Uncharacterized protein
chr11_-_57089671 0.02 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr3_-_164914640 0.02 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr15_-_75017711 0.02 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr12_+_57984943 0.02 ENST00000422156.3
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chrX_+_100333709 0.01 ENST00000372930.4
TMEM35
transmembrane protein 35
chr12_-_56101647 0.01 ENST00000347027.6
ENST00000257879.6
ENST00000257880.7
ENST00000394230.2
ENST00000394229.2
ITGA7
integrin, alpha 7
chrX_-_107225600 0.01 ENST00000302917.1
TEX13B
testis expressed 13B
chr6_+_167525277 0.01 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr15_+_74218787 0.01 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr4_-_114900831 0.01 ENST00000315366.7
ARSJ
arylsulfatase family, member J
chrX_+_48380205 0.01 ENST00000446158.1
ENST00000414061.1
EBP
emopamil binding protein (sterol isomerase)
chr6_-_133119668 0.01 ENST00000275227.4
ENST00000538764.1
SLC18B1
solute carrier family 18, subfamily B, member 1
chr1_+_154975110 0.01 ENST00000535420.1
ENST00000368426.3
ZBTB7B
zinc finger and BTB domain containing 7B
chr16_-_1821496 0.01 ENST00000564628.1
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr7_-_102252038 0.00 ENST00000461209.1
RASA4
RAS p21 protein activator 4
chr14_+_21945335 0.00 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
TOX4
TOX high mobility group box family member 4
chr16_-_9770700 0.00 ENST00000561538.1
RP11-297M9.1
Uncharacterized protein
chr18_+_32558208 0.00 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr8_+_91233750 0.00 ENST00000523406.1
LINC00534
long intergenic non-protein coding RNA 534

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:2000506 negative regulation of energy homeostasis(GO:2000506)
0.0 0.2 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.0 0.1 GO:1903979 negative regulation of microglial cell activation(GO:1903979)
0.0 0.1 GO:0042377 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.0 0.2 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.1 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.1 GO:1902912 pyruvate kinase complex(GO:1902912)
0.0 0.0 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.0 0.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.0 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)