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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HSF1

Z-value: 0.98

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Transcription factors associated with HSF1

Gene Symbol Gene ID Gene Info
HSF1
ENSG00000185122.6 heat shock transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF1hg19_v2_chr8_+_145515263_1455152990.226.7e-01Click!

Activity profile of HSF1 motif

Sorted Z-values of HSF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_139847347 0.65 ENST00000371632.3
LCN12
lipocalin 12
chr19_+_3762703 0.59 ENST00000589174.1
MRPL54
mitochondrial ribosomal protein L54
chr2_-_27851745 0.43 ENST00000394775.3
ENST00000522876.1
CCDC121
coiled-coil domain containing 121
chr19_+_8740061 0.42 ENST00000593792.1
CTD-2586B10.1
CTD-2586B10.1
chrX_+_49020882 0.39 ENST00000454342.1
MAGIX
MAGI family member, X-linked
chr19_+_917287 0.38 ENST00000592648.1
ENST00000234371.5
KISS1R
KISS1 receptor
chr7_-_139763521 0.37 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr1_+_35247859 0.37 ENST00000373362.3
GJB3
gap junction protein, beta 3, 31kDa
chr19_+_1354930 0.35 ENST00000591337.1
MUM1
melanoma associated antigen (mutated) 1
chr17_+_78193443 0.34 ENST00000577155.1
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr11_-_104840093 0.34 ENST00000417440.2
ENST00000444739.2
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr2_-_191878162 0.34 ENST00000540176.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr3_+_112930946 0.33 ENST00000462425.1
BOC
BOC cell adhesion associated, oncogene regulated
chr1_-_1590418 0.31 ENST00000341028.7
CDK11B
cyclin-dependent kinase 11B
chr11_-_64163297 0.31 ENST00000457725.1
AP003774.6
AP003774.6
chr2_-_191878681 0.31 ENST00000409465.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr2_-_191878874 0.30 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
STAT1
signal transducer and activator of transcription 1, 91kDa
chr16_-_4303767 0.30 ENST00000573268.1
ENST00000573042.1
RP11-95P2.1
RP11-95P2.1
chr20_+_36974759 0.30 ENST00000217407.2
LBP
lipopolysaccharide binding protein
chr19_-_4559814 0.29 ENST00000586582.1
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr6_+_160693591 0.28 ENST00000419196.1
RP1-276N6.2
RP1-276N6.2
chr1_-_206671061 0.28 ENST00000367119.1
C1orf147
chromosome 1 open reading frame 147
chr4_+_57396766 0.27 ENST00000512175.2
THEGL
theg spermatid protein-like
chr11_+_28724129 0.27 ENST00000513853.1
RP11-115J23.1
RP11-115J23.1
chr1_+_206138457 0.27 ENST00000367128.3
ENST00000431655.2
FAM72A
family with sequence similarity 72, member A
chr12_-_108154705 0.26 ENST00000547188.1
PRDM4
PR domain containing 4
chr19_-_56904799 0.26 ENST00000589895.1
ENST00000589143.1
ENST00000301310.4
ENST00000586929.1
ZNF582
zinc finger protein 582
chr14_+_63671105 0.26 ENST00000316754.3
RHOJ
ras homolog family member J
chr4_-_170192000 0.26 ENST00000502315.1
SH3RF1
SH3 domain containing ring finger 1
chr12_+_50794947 0.25 ENST00000552445.1
LARP4
La ribonucleoprotein domain family, member 4
chr12_+_50366620 0.24 ENST00000315520.5
AQP6
aquaporin 6, kidney specific
chr9_-_34523027 0.24 ENST00000399775.2
ENHO
energy homeostasis associated
chr1_-_151345159 0.24 ENST00000458566.1
ENST00000447402.3
ENST00000426705.2
ENST00000435071.1
ENST00000368868.5
SELENBP1
selenium binding protein 1
chr6_+_33551515 0.24 ENST00000374458.1
GGNBP1
gametogenetin binding protein 1 (pseudogene)
chr3_-_10334617 0.24 ENST00000429122.1
ENST00000425479.1
ENST00000335542.8
GHRL
ghrelin/obestatin prepropeptide
chr19_+_47813110 0.23 ENST00000355085.3
C5AR1
complement component 5a receptor 1
chr11_+_1049862 0.23 ENST00000534584.1
RP13-870H17.3
RP13-870H17.3
chr14_+_24407940 0.22 ENST00000354854.1
DHRS4-AS1
DHRS4-AS1
chr9_-_34372830 0.22 ENST00000379142.3
KIAA1161
KIAA1161
chr7_-_5821225 0.21 ENST00000416985.1
RNF216
ring finger protein 216
chr19_-_6720686 0.21 ENST00000245907.6
C3
complement component 3
chr19_+_54135310 0.21 ENST00000376650.1
DPRX
divergent-paired related homeobox
chr11_+_72281681 0.21 ENST00000450804.3
RP11-169D4.1
RP11-169D4.1
chr19_+_49055332 0.21 ENST00000201586.2
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr6_+_30294186 0.20 ENST00000458516.1
TRIM39
tripartite motif containing 39
chr22_+_48972118 0.20 ENST00000358295.5
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr20_-_43753104 0.20 ENST00000372785.3
WFDC12
WAP four-disulfide core domain 12
chr16_+_30662050 0.20 ENST00000568754.1
PRR14
proline rich 14
chr17_+_58499844 0.20 ENST00000269127.4
C17orf64
chromosome 17 open reading frame 64
chr16_-_20338748 0.20 ENST00000575582.1
ENST00000341642.5
ENST00000381362.4
ENST00000572347.1
ENST00000572478.1
ENST00000302555.5
GP2
glycoprotein 2 (zymogen granule membrane)
chr8_+_58055238 0.19 ENST00000519314.1
ENST00000519241.1
RP11-513O17.2
RP11-513O17.2
chr3_-_134092561 0.19 ENST00000510560.1
ENST00000504234.1
ENST00000515172.1
AMOTL2
angiomotin like 2
chr7_+_13141097 0.18 ENST00000411542.1
AC011288.2
AC011288.2
chr2_+_103089756 0.18 ENST00000295269.4
SLC9A4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr6_-_38607628 0.18 ENST00000498633.1
BTBD9
BTB (POZ) domain containing 9
chr1_+_92683467 0.18 ENST00000370375.3
ENST00000370373.2
C1orf146
chromosome 1 open reading frame 146
chr19_+_5681011 0.18 ENST00000581893.1
ENST00000411793.2
ENST00000301382.4
ENST00000581773.1
ENST00000423665.2
ENST00000583928.1
ENST00000342970.2
ENST00000422535.2
ENST00000581521.1
ENST00000339423.2
HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
chr19_+_36602104 0.18 ENST00000585332.1
ENST00000262637.4
OVOL3
ovo-like zinc finger 3
chr19_-_44258770 0.18 ENST00000601925.1
ENST00000602222.1
ENST00000599804.1
SMG9
SMG9 nonsense mediated mRNA decay factor
chr6_+_168434678 0.18 ENST00000496008.1
KIF25
kinesin family member 25
chr19_+_4304585 0.18 ENST00000221856.6
FSD1
fibronectin type III and SPRY domain containing 1
chr1_-_143913143 0.17 ENST00000400889.1
FAM72D
family with sequence similarity 72, member D
chr19_-_53193731 0.17 ENST00000598536.1
ENST00000594682.2
ENST00000601257.1
ZNF83
zinc finger protein 83
chr19_-_49567124 0.17 ENST00000301411.3
NTF4
neurotrophin 4
chr12_-_10826612 0.17 ENST00000535345.1
ENST00000542562.1
STYK1
serine/threonine/tyrosine kinase 1
chr2_+_228678550 0.17 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr17_+_79859985 0.17 ENST00000333383.7
NPB
neuropeptide B
chr16_+_28985542 0.17 ENST00000567771.1
ENST00000568388.1
SPNS1
spinster homolog 1 (Drosophila)
chr19_-_4717835 0.16 ENST00000599248.1
DPP9
dipeptidyl-peptidase 9
chr19_+_782755 0.16 ENST00000606242.1
ENST00000586061.1
AC006273.5
AC006273.5
chr16_-_2770216 0.16 ENST00000302641.3
PRSS27
protease, serine 27
chr2_+_109403193 0.16 ENST00000412964.2
ENST00000295124.4
CCDC138
coiled-coil domain containing 138
chr3_+_32433363 0.16 ENST00000465248.1
CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr15_+_89584447 0.16 ENST00000565938.1
RP11-326A19.4
RP11-326A19.4
chr4_+_166128836 0.16 ENST00000511305.1
KLHL2
kelch-like family member 2
chr6_-_170599561 0.16 ENST00000366756.3
DLL1
delta-like 1 (Drosophila)
chrX_+_54947229 0.16 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
TRO
trophinin
chr1_+_15632231 0.16 ENST00000375997.4
ENST00000524761.1
ENST00000375995.3
ENST00000401090.2
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr19_-_55672037 0.16 ENST00000588076.1
DNAAF3
dynein, axonemal, assembly factor 3
chr14_-_36536396 0.16 ENST00000546376.1
RP11-116N8.4
RP11-116N8.4
chr4_-_122085469 0.16 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr2_+_40973618 0.15 ENST00000420187.1
AC007317.1
AC007317.1
chr12_-_15374328 0.15 ENST00000537647.1
RERG
RAS-like, estrogen-regulated, growth inhibitor
chr20_-_23807358 0.15 ENST00000304725.2
CST2
cystatin SA
chr6_-_41701581 0.15 ENST00000394283.1
TFEB
transcription factor EB
chr3_-_128690173 0.15 ENST00000508239.1
RP11-723O4.6
Uncharacterized protein FLJ43738
chr16_-_12184159 0.15 ENST00000312019.2
RP11-276H1.3
RP11-276H1.3
chr19_+_1065922 0.15 ENST00000539243.2
HMHA1
histocompatibility (minor) HA-1
chr22_+_24577183 0.15 ENST00000358321.3
SUSD2
sushi domain containing 2
chr2_+_85981008 0.14 ENST00000306279.3
ATOH8
atonal homolog 8 (Drosophila)
chr2_-_11272234 0.13 ENST00000590207.1
ENST00000417697.2
ENST00000396164.1
ENST00000536743.1
ENST00000544306.1
AC062028.1
AC062028.1
chr19_+_13842559 0.13 ENST00000586600.1
CCDC130
coiled-coil domain containing 130
chr17_+_18996287 0.13 ENST00000399091.1
ENST00000443876.1
ENST00000428928.1
AC007952.5
Uncharacterized protein ENSP00000382042
chr17_+_41005283 0.13 ENST00000592999.1
AOC3
amine oxidase, copper containing 3
chrX_-_152939252 0.13 ENST00000340888.3
PNCK
pregnancy up-regulated nonubiquitous CaM kinase
chr2_-_191885686 0.13 ENST00000432058.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr16_-_3306587 0.13 ENST00000541159.1
ENST00000536379.1
ENST00000219596.1
ENST00000339854.4
MEFV
Mediterranean fever
chr14_+_105212297 0.13 ENST00000556623.1
ENST00000555674.1
ADSSL1
adenylosuccinate synthase like 1
chr13_-_95248511 0.13 ENST00000261296.5
TGDS
TDP-glucose 4,6-dehydratase
chr3_+_124223586 0.13 ENST00000393496.1
KALRN
kalirin, RhoGEF kinase
chr17_-_79106634 0.13 ENST00000575363.1
AATK
apoptosis-associated tyrosine kinase
chr14_+_101293687 0.13 ENST00000455286.1
MEG3
maternally expressed 3 (non-protein coding)
chr1_+_24118452 0.13 ENST00000421070.1
LYPLA2
lysophospholipase II
chr4_-_40632757 0.13 ENST00000511902.1
ENST00000505220.1
RBM47
RNA binding motif protein 47
chr12_-_55042140 0.13 ENST00000293371.6
ENST00000456047.2
DCD
dermcidin
chr9_-_4666421 0.12 ENST00000381895.5
SPATA6L
spermatogenesis associated 6-like
chr8_+_142402089 0.12 ENST00000521578.1
ENST00000520105.1
ENST00000523147.1
PTP4A3
protein tyrosine phosphatase type IVA, member 3
chr5_+_421030 0.12 ENST00000506456.1
AHRR
aryl-hydrocarbon receptor repressor
chr17_-_39041479 0.12 ENST00000167588.3
KRT20
keratin 20
chr12_-_9885888 0.12 ENST00000327839.3
CLECL1
C-type lectin-like 1
chr19_-_10628117 0.12 ENST00000333430.4
S1PR5
sphingosine-1-phosphate receptor 5
chr15_+_89921280 0.12 ENST00000560596.1
ENST00000558692.1
ENST00000538734.2
ENST00000559235.1
LINC00925
long intergenic non-protein coding RNA 925
chr4_-_87515202 0.12 ENST00000502302.1
ENST00000513186.1
MAPK10
mitogen-activated protein kinase 10
chr6_+_161123270 0.12 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chr17_+_45401308 0.12 ENST00000331493.2
ENST00000519772.1
ENST00000517484.1
EFCAB13
EF-hand calcium binding domain 13
chr9_+_6716478 0.12 ENST00000452643.1
RP11-390F4.3
RP11-390F4.3
chr7_-_150020814 0.12 ENST00000477871.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr11_-_107328527 0.12 ENST00000282251.5
ENST00000433523.1
CWF19L2
CWF19-like 2, cell cycle control (S. pombe)
chr2_-_96701722 0.12 ENST00000434632.1
GPAT2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr22_-_46644182 0.12 ENST00000404583.1
ENST00000404744.1
CDPF1
cysteine-rich, DPF motif domain containing 1
chr3_-_52719888 0.12 ENST00000458294.1
PBRM1
polybromo 1
chr7_-_111032971 0.12 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr5_-_141016382 0.12 ENST00000523088.1
ENST00000305264.3
HDAC3
histone deacetylase 3
chr4_-_40632844 0.12 ENST00000505414.1
RBM47
RNA binding motif protein 47
chr19_-_46974741 0.11 ENST00000313683.10
ENST00000602246.1
PNMAL1
paraneoplastic Ma antigen family-like 1
chr7_+_116451100 0.11 ENST00000464223.1
ENST00000484325.1
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr17_+_65027509 0.11 ENST00000375684.1
AC005544.1
Uncharacterized protein
chr2_+_26624775 0.11 ENST00000288710.2
DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr9_-_116102562 0.11 ENST00000374193.4
ENST00000465979.1
WDR31
WD repeat domain 31
chr16_+_57139933 0.11 ENST00000566259.1
CPNE2
copine II
chr11_-_914812 0.11 ENST00000533059.1
CHID1
chitinase domain containing 1
chr6_-_161695042 0.11 ENST00000366908.5
ENST00000366911.5
ENST00000366905.3
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr19_-_18649181 0.11 ENST00000596015.1
FKBP8
FK506 binding protein 8, 38kDa
chr6_-_112081113 0.11 ENST00000517419.1
FYN
FYN oncogene related to SRC, FGR, YES
chr4_-_40632881 0.11 ENST00000511598.1
RBM47
RNA binding motif protein 47
chr3_+_32433154 0.10 ENST00000334983.5
ENST00000349718.4
CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr6_+_4890226 0.10 ENST00000343762.5
CDYL
chromodomain protein, Y-like
chr19_+_42806250 0.10 ENST00000598490.1
ENST00000341747.3
PRR19
proline rich 19
chr20_-_23731569 0.10 ENST00000304749.2
CST1
cystatin SN
chr19_+_49867181 0.10 ENST00000597546.1
DKKL1
dickkopf-like 1
chr16_+_57847684 0.10 ENST00000335616.2
CTD-2600O9.1
uncharacterized protein LOC388282
chr19_-_50528392 0.10 ENST00000600137.1
ENST00000597215.1
VRK3
vaccinia related kinase 3
chr4_-_8430152 0.10 ENST00000514423.1
ENST00000503233.1
ACOX3
acyl-CoA oxidase 3, pristanoyl
chr1_+_202830876 0.10 ENST00000456105.2
RP11-480I12.7
RP11-480I12.7
chr12_+_34175398 0.10 ENST00000538927.1
ALG10
ALG10, alpha-1,2-glucosyltransferase
chr7_+_73275483 0.10 ENST00000320531.2
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr17_+_71228843 0.10 ENST00000582391.1
C17orf80
chromosome 17 open reading frame 80
chr2_-_139259244 0.10 ENST00000414911.1
ENST00000431985.1
AC097721.2
AC097721.2
chr1_-_24469602 0.10 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr19_-_12444491 0.10 ENST00000293725.5
ZNF563
zinc finger protein 563
chrX_-_74743080 0.10 ENST00000373367.3
ZDHHC15
zinc finger, DHHC-type containing 15
chr11_+_33563618 0.10 ENST00000526400.1
KIAA1549L
KIAA1549-like
chr17_-_30668887 0.10 ENST00000581747.1
ENST00000583334.1
ENST00000580558.1
C17orf75
chromosome 17 open reading frame 75
chr16_-_20339123 0.10 ENST00000381360.5
GP2
glycoprotein 2 (zymogen granule membrane)
chr17_+_53828432 0.10 ENST00000573500.1
PCTP
phosphatidylcholine transfer protein
chr4_+_110834033 0.10 ENST00000509793.1
ENST00000265171.5
EGF
epidermal growth factor
chr11_-_102323489 0.10 ENST00000361236.3
TMEM123
transmembrane protein 123
chr10_+_1120312 0.10 ENST00000436154.1
WDR37
WD repeat domain 37
chr11_+_94706973 0.10 ENST00000536741.1
KDM4D
lysine (K)-specific demethylase 4D
chr19_+_19516561 0.10 ENST00000457895.2
GATAD2A
GATA zinc finger domain containing 2A
chr1_-_146054494 0.10 ENST00000401009.2
NBPF11
neuroblastoma breakpoint family, member 11
chr6_-_128222103 0.09 ENST00000434358.1
ENST00000543064.1
ENST00000368248.2
THEMIS
thymocyte selection associated
chr1_+_120839005 0.09 ENST00000369390.3
ENST00000452190.1
FAM72B
family with sequence similarity 72, member B
chr2_+_219247021 0.09 ENST00000539932.1
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr6_-_41909466 0.09 ENST00000414200.2
CCND3
cyclin D3
chr12_-_108154925 0.09 ENST00000228437.5
PRDM4
PR domain containing 4
chr4_-_84030996 0.09 ENST00000411416.2
PLAC8
placenta-specific 8
chr21_-_46221684 0.09 ENST00000330942.5
UBE2G2
ubiquitin-conjugating enzyme E2G 2
chr12_+_4647950 0.09 ENST00000321524.7
ENST00000543041.1
ENST00000228843.9
ENST00000352618.4
ENST00000544927.1
RAD51AP1
RAD51 associated protein 1
chr19_-_44952635 0.09 ENST00000592308.1
ENST00000588931.1
ENST00000291187.4
ZNF229
zinc finger protein 229
chr6_-_41909561 0.09 ENST00000372991.4
CCND3
cyclin D3
chr13_-_79979919 0.09 ENST00000267229.7
RBM26
RNA binding motif protein 26
chr6_+_10694900 0.09 ENST00000379568.3
PAK1IP1
PAK1 interacting protein 1
chr22_+_38453207 0.09 ENST00000404072.3
ENST00000424694.1
PICK1
protein interacting with PRKCA 1
chr12_+_93772326 0.09 ENST00000550056.1
ENST00000549992.1
ENST00000548662.1
ENST00000547014.1
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr5_-_153418407 0.09 ENST00000522858.1
ENST00000522634.1
ENST00000523705.1
ENST00000524246.1
ENST00000520313.1
ENST00000518102.1
ENST00000351797.4
ENST00000520667.1
ENST00000519808.1
ENST00000522395.1
FAM114A2
family with sequence similarity 114, member A2
chr22_-_50708781 0.09 ENST00000449719.2
ENST00000330651.6
MAPK11
mitogen-activated protein kinase 11
chr11_+_112046190 0.09 ENST00000357685.5
ENST00000393032.2
ENST00000361053.4
BCO2
beta-carotene oxygenase 2
chr9_+_36036430 0.09 ENST00000377966.3
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr19_-_12945362 0.09 ENST00000590404.1
ENST00000592204.1
RTBDN
retbindin
chr11_+_94706804 0.09 ENST00000335080.5
KDM4D
lysine (K)-specific demethylase 4D
chr7_-_150020750 0.09 ENST00000539352.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr2_-_101034070 0.09 ENST00000264249.3
CHST10
carbohydrate sulfotransferase 10
chr17_-_4806369 0.09 ENST00000293780.4
CHRNE
cholinergic receptor, nicotinic, epsilon (muscle)
chr13_+_28527647 0.09 ENST00000567234.1
LINC00543
long intergenic non-protein coding RNA 543
chr1_-_204436344 0.09 ENST00000367184.2
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr12_-_57505121 0.09 ENST00000538913.2
ENST00000537215.2
ENST00000454075.3
ENST00000554825.1
ENST00000553275.1
ENST00000300134.3
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr20_-_62168714 0.09 ENST00000542869.1
PTK6
protein tyrosine kinase 6
chr2_+_170655789 0.09 ENST00000409333.1
SSB
Sjogren syndrome antigen B (autoantigen La)
chr8_+_17104401 0.09 ENST00000324815.3
ENST00000518038.1
VPS37A
vacuolar protein sorting 37 homolog A (S. cerevisiae)
chr1_+_196743912 0.09 ENST00000367425.4
CFHR3
complement factor H-related 3
chr12_-_56321397 0.09 ENST00000557259.1
ENST00000549939.1
WIBG
within bgcn homolog (Drosophila)
chr19_-_2051223 0.09 ENST00000309340.7
ENST00000589534.1
ENST00000250896.3
ENST00000589509.1
MKNK2
MAP kinase interacting serine/threonine kinase 2
chr6_+_73331520 0.09 ENST00000342056.2
ENST00000355194.4
KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr2_+_102624977 0.09 ENST00000441002.1
IL1R2
interleukin 1 receptor, type II
chr9_-_19149276 0.09 ENST00000434144.1
PLIN2
perilipin 2
chr1_-_149982624 0.09 ENST00000417191.1
ENST00000369135.4
OTUD7B
OTU domain containing 7B
chr7_-_151433342 0.08 ENST00000433631.2
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr17_+_40714092 0.08 ENST00000420359.1
ENST00000449624.1
ENST00000585811.1
ENST00000585909.1
ENST00000586771.1
ENST00000421097.2
ENST00000591779.1
ENST00000587858.1
ENST00000587214.1
ENST00000587157.1
ENST00000590958.1
ENST00000393818.2
COASY
CoA synthase
chr5_-_43043272 0.08 ENST00000314890.3
ANXA2R
annexin A2 receptor

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.1 0.3 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.1 0.3 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.1 0.2 GO:0038178 complement component C5a signaling pathway(GO:0038178)
0.1 0.2 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.1 0.2 GO:1902283 negative regulation of primary amine oxidase activity(GO:1902283)
0.1 0.2 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.1 0.2 GO:0010160 sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
0.1 0.2 GO:0045360 interleukin-1 biosynthetic process(GO:0042222) regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 0.2 GO:0048633 negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of mechanoreceptor differentiation(GO:0045632) positive regulation of skeletal muscle tissue growth(GO:0048633) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.1 0.2 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.0 0.5 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:0052027 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.0 0.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.1 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.3 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.4 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.1 GO:1902263 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597) apoptotic process involved in embryonic digit morphogenesis(GO:1902263) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.0 0.1 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 0.1 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.1 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.0 0.1 GO:0002309 T cell proliferation involved in immune response(GO:0002309) L-arginine import(GO:0043091) divalent metal ion export(GO:0070839) arginine import(GO:0090467)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.1 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0 0.1 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.0 0.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.1 GO:0045041 B cell cytokine production(GO:0002368) protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.1 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.1 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.1 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.0 GO:0044209 AMP salvage(GO:0044209)
0.0 0.0 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) positive regulation of chondrocyte proliferation(GO:1902732) histone H3-K9 deacetylation(GO:1990619)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.3 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.2 GO:1900016 negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.0 0.0 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.0 0.0 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.0 0.2 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.1 GO:1901906 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.1 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.0 GO:0002818 intracellular defense response(GO:0002818)
0.0 0.0 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.1 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.0 0.0 GO:2001178 mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.0 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.0 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.0 0.0 GO:0034471 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.1 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.1 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.0 0.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.0 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 0.0 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.1 0.2 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.2 GO:0052594 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.3 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.1 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.0 0.3 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.1 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.0 0.1 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.0 0.2 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.3 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.1 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.0 1.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.1 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.0 0.1 GO:0004947 bradykinin receptor activity(GO:0004947)
0.0 0.1 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.0 0.1 GO:1902444 riboflavin binding(GO:1902444)
0.0 0.1 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.1 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.0 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.0 0.7 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.0 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.0 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.0 0.1 GO:0052845 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.1 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.0 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.2 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement