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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IRF2_STAT2_IRF8_IRF1
Z-value: 10.00
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Transcription factors associated with IRF2_STAT2_IRF8_IRF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000168310.6 | interferon regulatory factor 2 | |
| ENSG00000170581.9 | signal transducer and activator of transcription 2 | |
| ENSG00000140968.6 | interferon regulatory factor 8 | |
| ENSG00000125347.9 | interferon regulatory factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT2 | hg19_v2_chr12_-_56753858_56753930 | 0.94 | 5.3e-03 | Click! |
| IRF8 | hg19_v2_chr16_+_85942594_85942635 | -0.58 | 2.2e-01 | Click! |
| IRF2 | hg19_v2_chr4_-_185395191_185395340 | 0.31 | 5.5e-01 | Click! |
| IRF1 | hg19_v2_chr5_-_131826457_131826514 | 0.24 | 6.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.3 | 135.6 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 1.4 | 120.5 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 5.5 | 114.7 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 36.6 | 109.8 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 9.0 | 99.1 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 22.8 | 91.4 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 6.0 | 77.6 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 18.7 | 75.0 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 10.1 | 60.5 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 4.8 | 52.4 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 233.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 198.3 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.3 | 126.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 110.0 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.6 | 79.2 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.5 | 60.4 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.2 | 46.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 46.6 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 30.1 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 1.1 | 23.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 171.0 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 1.0 | 144.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 11.3 | 135.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.3 | 127.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 8.1 | 105.4 | GO:0031386 | protein tag(GO:0031386) |
| 2.6 | 79.4 | GO:0070403 | NAD+ binding(GO:0070403) |
| 1.7 | 64.1 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 62.0 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 38.1 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.1 | 34.1 | GO:0042393 | histone binding(GO:0042393) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 106.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.5 | 63.6 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 4.2 | 55.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.2 | 15.5 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.4 | 13.5 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.2 | 11.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.3 | 10.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 9.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 8.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 6.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.2 | 736.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 9.1 | 191.9 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.7 | 38.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.5 | 29.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 25.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 20.1 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.2 | 12.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 12.3 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 7.4 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 5.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |