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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 10.00

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol Gene ID Gene Info
ENSG00000168310.6 interferon regulatory factor 2
ENSG00000170581.9 signal transducer and activator of transcription 2
ENSG00000140968.6 interferon regulatory factor 8
ENSG00000125347.9 interferon regulatory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STAT2hg19_v2_chr12_-_56753858_567539300.945.3e-03Click!
IRF8hg19_v2_chr16_+_85942594_85942635-0.582.2e-01Click!
IRF2hg19_v2_chr4_-_185395191_1853953400.315.5e-01Click!
IRF1hg19_v2_chr5_-_131826457_1318265140.246.5e-01Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_948803 105.40 ENST00000379389.4
ISG15 ubiquitin-like modifier
chr10_+_91152303 91.36 ENST00000371804.3
interferon-induced protein with tetratricopeptide repeats 1
chr11_-_615942 65.98 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
interferon regulatory factor 7
chr14_+_94577074 61.62 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
interferon, alpha-inducible protein 27
chr1_-_27998689 52.70 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
interferon, alpha-inducible protein 6
chr4_-_169239921 48.22 ENST00000514995.1
ENST00000393743.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr21_+_42792442 46.21 ENST00000398600.2
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_615570 43.86 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
interferon regulatory factor 7
chr10_+_91087651 34.90 ENST00000371818.4
interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91092241 32.63 ENST00000371811.4
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_79115503 27.23 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr3_-_122283079 27.21 ENST00000471785.1
ENST00000466126.1
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283100 26.27 ENST00000492382.1
ENST00000462315.1
poly (ADP-ribose) polymerase family, member 9
chr2_-_163175133 25.85 ENST00000421365.2
ENST00000263642.2
interferon induced with helicase C domain 1
chr9_-_32526184 25.51 ENST00000545044.1
ENST00000379868.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr21_+_42798094 25.34 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr3_-_122283424 25.24 ENST00000477522.2
ENST00000360356.2
poly (ADP-ribose) polymerase family, member 9
chr9_-_32526299 25.12 ENST00000379882.1
ENST00000379883.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_+_113376157 22.43 ENST00000228928.7
2'-5'-oligoadenylate synthetase 3, 100kDa
chr12_+_113416191 22.43 ENST00000342315.4
ENST00000392583.2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr12_+_113376249 21.68 ENST00000551007.1
ENST00000548514.1
2'-5'-oligoadenylate synthetase 3, 100kDa
chr2_-_7005785 21.08 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr19_-_17516449 20.54 ENST00000252593.6
bone marrow stromal cell antigen 2
chr8_-_145060593 19.73 ENST00000313059.5
ENST00000524918.1
ENST00000313028.7
ENST00000525773.1
poly (ADP-ribose) polymerase family, member 10
chr2_-_191878681 18.46 ENST00000409465.1
signal transducer and activator of transcription 1, 91kDa
chr2_-_191878874 17.70 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
signal transducer and activator of transcription 1, 91kDa
chr1_+_79086088 17.66 ENST00000370751.5
ENST00000342282.3
interferon-induced protein 44-like
chr21_+_42798158 16.91 ENST00000441677.1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113416265 16.80 ENST00000449768.2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr21_+_42798124 16.45 ENST00000417963.1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr14_+_24630465 16.10 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
interferon regulatory factor 9
chr3_+_122283175 15.85 ENST00000383661.3
deltex 3-like (Drosophila)
chr2_-_231084659 15.66 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110 nuclear body protein
chr3_+_122283064 15.29 ENST00000296161.4
deltex 3-like (Drosophila)
chr7_-_92777606 14.85 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
sterile alpha motif domain containing 9-like
chr11_-_64764435 14.75 ENST00000534177.1
ENST00000301887.4
basic leucine zipper transcription factor, ATF-like 2
chr2_-_231084820 14.67 ENST00000258382.5
ENST00000338556.3
SP110 nuclear body protein
chr9_-_100881466 14.48 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
tripartite motif containing 14
chr12_+_113344811 14.22 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr21_+_42797958 13.88 ENST00000419044.1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr22_+_18632666 13.00 ENST00000215794.7
ubiquitin specific peptidase 18
chr10_+_91174486 12.44 ENST00000416601.1
interferon-induced protein with tetratricopeptide repeats 5
chr2_-_37384175 12.42 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
eukaryotic translation initiation factor 2-alpha kinase 2
chr10_+_91174314 12.12 ENST00000371795.4
interferon-induced protein with tetratricopeptide repeats 5
chr11_+_313503 12.11 ENST00000528780.1
ENST00000328221.5
interferon induced transmembrane protein 1
chr11_+_5646213 11.17 ENST00000429814.2
tripartite motif containing 34
chr2_+_231280954 10.86 ENST00000409824.1
ENST00000409341.1
ENST00000409112.1
ENST00000340126.4
ENST00000341950.4
SP100 nuclear antigen
chr1_-_89488510 10.32 ENST00000564665.1
ENST00000370481.4
guanylate binding protein 3
chr10_+_91061712 10.10 ENST00000371826.3
interferon-induced protein with tetratricopeptide repeats 2
chr2_+_231280908 9.86 ENST00000427101.2
ENST00000432979.1
SP100 nuclear antigen
chr4_-_169401628 9.83 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr4_+_89378261 9.68 ENST00000264350.3
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr3_+_122399444 9.63 ENST00000474629.2
poly (ADP-ribose) polymerase family, member 14
chr11_-_321050 9.36 ENST00000399808.4
interferon induced transmembrane protein 3
chr12_+_113344755 9.19 ENST00000550883.1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr12_+_113344582 9.00 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr19_+_10196781 8.62 ENST00000253110.11
chromosome 19 open reading frame 66
chr4_-_187112626 8.56 ENST00000596414.1
Uncharacterized protein
chr1_-_89531041 8.44 ENST00000370473.4
guanylate binding protein 1, interferon-inducible
chr7_-_92747269 8.40 ENST00000446617.1
ENST00000379958.2
sterile alpha motif domain containing 9
chr1_+_158979680 7.90 ENST00000368131.4
ENST00000340979.6
interferon, gamma-inducible protein 16
chr2_-_231084617 7.77 ENST00000409815.2
SP110 nuclear body protein
chr3_-_49851313 7.67 ENST00000333486.3
ubiquitin-like modifier activating enzyme 7
chr11_-_63330842 7.40 ENST00000255695.1
HRAS-like suppressor 2
chr13_+_50070491 7.25 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
PHD finger protein 11
chr9_+_100174344 7.16 ENST00000422139.2
tudor domain containing 7
chr19_+_10196981 6.97 ENST00000591813.1
chromosome 19 open reading frame 66
chr13_+_50070077 6.94 ENST00000378319.3
ENST00000426879.1
PHD finger protein 11
chr17_-_40264321 6.71 ENST00000430773.1
ENST00000413196.2
DEXH (Asp-Glu-X-His) box polypeptide 58
chr11_-_57334732 6.70 ENST00000526659.1
ENST00000527022.1
ubiquitin-conjugating enzyme E2L 6
chr4_-_76944621 6.66 ENST00000306602.1
chemokine (C-X-C motif) ligand 10
chr22_+_36649170 6.59 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
apolipoprotein L, 1
chr12_+_113416340 6.56 ENST00000552756.1
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr1_+_158979686 6.31 ENST00000368132.3
ENST00000295809.7
interferon, gamma-inducible protein 16
chr9_+_100174232 6.25 ENST00000355295.4
tudor domain containing 7
chr11_-_57335280 6.13 ENST00000287156.4
ubiquitin-conjugating enzyme E2L 6
chr12_-_121477039 6.12 ENST00000257570.5
2'-5'-oligoadenylate synthetase-like
chr12_-_121476959 6.08 ENST00000339275.5
2'-5'-oligoadenylate synthetase-like
chr1_+_158979792 6.02 ENST00000359709.3
ENST00000430894.2
interferon, gamma-inducible protein 16
chr19_-_49371711 6.02 ENST00000355496.5
ENST00000263265.6
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr2_-_55920952 5.92 ENST00000447944.2
polyribonucleotide nucleotidyltransferase 1
chr16_+_57023406 5.87 ENST00000262510.6
ENST00000308149.7
ENST00000436936.1
NLR family, CARD domain containing 5
chr3_-_146262365 5.83 ENST00000448787.2
phospholipid scramblase 1
chr15_-_80263506 5.75 ENST00000335661.6
BCL2-related protein A1
chr3_+_159706537 5.41 ENST00000305579.2
ENST00000480787.1
ENST00000466512.1
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr17_-_76975925 5.37 ENST00000591274.1
ENST00000589906.1
ENST00000591778.1
ENST00000589775.2
ENST00000585407.1
ENST00000262776.3
lectin, galactoside-binding, soluble, 3 binding protein
chr17_-_40264692 5.32 ENST00000591220.1
ENST00000251642.3
DEXH (Asp-Glu-X-His) box polypeptide 58
chr10_-_77161004 5.18 ENST00000418818.2
RP11-399K21.11
chr1_-_154580616 5.15 ENST00000368474.4
adenosine deaminase, RNA-specific
chr21_+_35107346 5.10 ENST00000456489.1
intersectin 1 (SH3 domain protein)
chr22_+_36649056 4.60 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
apolipoprotein L, 1
chr11_+_34663913 4.60 ENST00000532302.1
ets homologous factor
chr17_+_76311791 4.56 ENST00000586321.1
AC061992.2
chr3_-_146262352 4.52 ENST00000462666.1
phospholipid scramblase 1
chr2_+_85811525 4.37 ENST00000306384.4
vesicle-associated membrane protein 5
chr3_-_146262428 4.29 ENST00000486631.1
phospholipid scramblase 1
chr2_+_202122826 4.10 ENST00000413726.1
caspase 8, apoptosis-related cysteine peptidase
chr3_-_146262293 4.05 ENST00000448205.1
phospholipid scramblase 1
chr15_+_45003675 4.03 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
beta-2-microglobulin
chr15_+_89182178 3.88 ENST00000559876.1
interferon stimulated exonuclease gene 20kDa
chr17_+_41158742 3.84 ENST00000415816.2
ENST00000438323.2
interferon-induced protein 35
chr8_+_27184320 3.70 ENST00000522517.1
protein tyrosine kinase 2 beta
chr11_-_104905840 3.69 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
caspase 1, apoptosis-related cysteine peptidase
chr12_-_8693469 3.65 ENST00000545274.1
ENST00000446457.2
C-type lectin domain family 4, member E
chr3_-_146262488 3.64 ENST00000487389.1
phospholipid scramblase 1
chr6_+_126240442 3.64 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
nuclear receptor coactivator 7
chr11_-_4414880 3.61 ENST00000254436.7
ENST00000543625.1
tripartite motif containing 21
chr11_-_14358620 3.56 ENST00000531421.1
related RAS viral (r-ras) oncogene homolog 2
chr1_-_150693318 3.45 ENST00000442853.1
ENST00000368995.4
ENST00000368993.2
ENST00000361824.2
ENST00000322343.7
HORMA domain containing 1
chr3_-_28390120 3.42 ENST00000334100.6
5-azacytidine induced 2
chr12_-_10324716 3.40 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
oxidized low density lipoprotein (lectin-like) receptor 1
chr14_+_24605389 3.36 ENST00000382708.3
ENST00000561435.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr3_-_146262637 3.36 ENST00000472349.1
ENST00000342435.4
phospholipid scramblase 1
chr15_+_89182156 3.35 ENST00000379224.5
interferon stimulated exonuclease gene 20kDa
chr3_+_122399697 3.25 ENST00000494811.1
poly (ADP-ribose) polymerase family, member 14
chr12_-_12715266 3.15 ENST00000228862.2
dual specificity phosphatase 16
chr6_+_26440700 3.14 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
butyrophilin, subfamily 3, member A3
chr10_-_18948208 3.08 ENST00000607346.1
ARL5B antisense RNA 1
chr20_-_47894569 3.06 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
zinc finger, NFX1-type containing 1
chr17_-_54991395 2.95 ENST00000316881.4
tripartite motif containing 25
chr6_+_32821924 2.93 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr17_+_6659153 2.92 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XIAP associated factor 1
chr17_+_28443819 2.92 ENST00000479218.2
nuclear speckle splicing regulatory protein 1
chr12_-_56753858 2.91 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
signal transducer and activator of transcription 2, 113kDa
chr17_-_54991369 2.89 ENST00000537230.1
tripartite motif containing 25
chr5_-_96143796 2.86 ENST00000296754.3
endoplasmic reticulum aminopeptidase 1
chr6_+_32811885 2.81 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAP1 and PSMB8 antisense RNA 1
proteasome (prosome, macropain) subunit, beta type, 9
chr8_+_107630340 2.75 ENST00000497705.1
oxidation resistance 1
chr14_+_24605361 2.69 ENST00000206451.6
ENST00000559123.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr12_-_8693539 2.67 ENST00000299663.3
C-type lectin domain family 4, member E
chr15_+_89181974 2.66 ENST00000306072.5
interferon stimulated exonuclease gene 20kDa
chr4_+_26165074 2.65 ENST00000512351.1
recombination signal binding protein for immunoglobulin kappa J region
chr10_-_18948156 2.65 ENST00000414939.1
ENST00000449529.1
ENST00000456217.1
ENST00000444660.1
ARL5B antisense RNA 1
chr7_-_102985288 2.60 ENST00000379263.3
DnaJ (Hsp40) homolog, subfamily C, member 2
chr6_+_32811861 2.59 ENST00000453426.1
TAP1 and PSMB8 antisense RNA 1
chr3_+_97483572 2.58 ENST00000335979.2
ENST00000394206.1
ADP-ribosylation factor-like 6
chr22_+_36044411 2.55 ENST00000409652.4
apolipoprotein L, 6
chr15_+_75491203 2.54 ENST00000562637.1
chromosome 15 open reading frame 39
chr15_+_78832747 2.53 ENST00000560217.1
ENST00000044462.7
ENST00000559082.1
ENST00000559948.1
ENST00000413382.2
ENST00000559146.1
ENST00000558281.1
proteasome (prosome, macropain) subunit, alpha type, 4
chr20_-_5100591 2.48 ENST00000379143.5
proliferating cell nuclear antigen
chr14_+_58711539 2.48 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
proteasome (prosome, macropain) subunit, alpha type, 3
chr12_-_10022735 2.48 ENST00000228438.2
C-type lectin domain family 2, member B
chr9_-_33402506 2.44 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
aquaporin 7
chr6_-_31324943 2.44 ENST00000412585.2
ENST00000434333.1
major histocompatibility complex, class I, B
chr5_+_96211643 2.41 ENST00000437043.3
ENST00000510373.1
endoplasmic reticulum aminopeptidase 2
chr4_-_130014729 2.39 ENST00000281142.5
ENST00000434680.1
sodium channel and clathrin linker 1
chr5_-_39203093 2.37 ENST00000515010.1
FYN binding protein
chr1_-_150693305 2.37 ENST00000368987.1
HORMA domain containing 1
chr1_+_110453109 2.31 ENST00000525659.1
colony stimulating factor 1 (macrophage)
chr2_+_231191875 2.30 ENST00000444636.1
ENST00000415673.2
ENST00000243810.6
ENST00000396563.4
SP140 nuclear body protein-like
chr1_-_114430169 2.27 ENST00000393316.3
BCL2-like 15
chr1_-_24469602 2.27 ENST00000270800.1
interleukin 22 receptor, alpha 1
chrX_+_54947229 2.25 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
trophinin
chr1_-_60392452 2.24 ENST00000371204.3
cytochrome P450, family 2, subfamily J, polypeptide 2
chrX_-_119693745 2.24 ENST00000371323.2
cullin 4B
chr15_+_74287035 2.20 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
promyelocytic leukemia
chr3_-_167452262 2.17 ENST00000487947.2
programmed cell death 10
chr9_+_108424738 2.16 ENST00000334077.3
T-cell acute lymphocytic leukemia 2
chr9_-_107754034 2.15 ENST00000457720.1
RP11-217B7.3
chr3_+_48507210 2.15 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
three prime repair exonuclease 1
chr6_-_113953705 2.14 ENST00000452675.1
RP11-367G18.1
chr7_-_30066233 2.14 ENST00000222803.5
FK506 binding protein 14, 22 kDa
chr19_+_11708229 2.13 ENST00000361113.5
zinc finger protein 627
chr11_+_46402297 2.09 ENST00000405308.2
midkine (neurite growth-promoting factor 2)
chr21_+_37692481 2.07 ENST00000400485.1
MORC family CW-type zinc finger 3
chr12_+_28299014 2.04 ENST00000538586.1
ENST00000536154.1
coiled-coil domain containing 91
chr6_-_32811771 2.04 ENST00000395339.3
ENST00000374882.3
proteasome (prosome, macropain) subunit, beta type, 8
chr11_+_46402744 2.03 ENST00000533952.1
midkine (neurite growth-promoting factor 2)
chr12_-_62653903 2.01 ENST00000552075.1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr3_-_10028366 2.00 ENST00000429759.1
ER membrane protein complex subunit 3
chr14_-_24615523 1.99 ENST00000559056.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr11_-_321340 1.95 ENST00000526811.1
interferon induced transmembrane protein 3
chr3_+_48507621 1.95 ENST00000456089.1
three prime repair exonuclease 1
chr6_+_25963020 1.93 ENST00000357085.3
tripartite motif containing 38
chr11_+_5710919 1.85 ENST00000379965.3
ENST00000425490.1
tripartite motif containing 22
chr3_+_164924716 1.84 ENST00000470138.1
ENST00000498616.1
RP11-85M11.2
chr12_+_40618764 1.83 ENST00000343742.2
leucine-rich repeat kinase 2
chr9_+_33264861 1.82 ENST00000223500.8
charged multivesicular body protein 5
chr4_-_130014532 1.80 ENST00000506368.1
ENST00000439369.2
ENST00000503215.1
sodium channel and clathrin linker 1
chr14_-_35099315 1.76 ENST00000396526.3
ENST00000396534.3
ENST00000355110.5
ENST00000557265.1
sorting nexin 6
chr19_+_49977466 1.74 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
fms-related tyrosine kinase 3 ligand
chr9_+_5450503 1.73 ENST00000381573.4
ENST00000381577.3
CD274 molecule
chr19_-_50400212 1.72 ENST00000391826.2
interleukin 4 induced 1
chr6_-_8102714 1.72 ENST00000502429.1
ENST00000429723.2
ENST00000507463.1
ENST00000379715.5
eukaryotic translation elongation factor 1 epsilon 1
chr3_+_160822462 1.69 ENST00000468606.1
ENST00000460503.1
NMD3 ribosome export adaptor
chr2_+_210288760 1.68 ENST00000199940.6
microtubule-associated protein 2
chr9_+_4985016 1.67 ENST00000539801.1
Janus kinase 2
chr22_+_39417118 1.67 ENST00000216099.8
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr1_+_186798073 1.67 ENST00000367466.3
ENST00000442353.2
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr11_+_308143 1.67 ENST00000399817.4
interferon induced transmembrane protein 2
chr6_+_27925019 1.67 ENST00000244623.1
olfactory receptor, family 2, subfamily B, member 6
chr19_-_18197714 1.65 ENST00000322153.7
interleukin 12 receptor, beta 1
chr17_+_57233087 1.64 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
proline rich 11
chr11_+_34642656 1.64 ENST00000257831.3
ENST00000450654.2
ets homologous factor
chr2_-_99485825 1.64 ENST00000423771.1
KIAA1211-like
chr2_-_162931052 1.63 ENST00000360534.3
dipeptidyl-peptidase 4
chr6_-_32821599 1.62 ENST00000354258.4
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_+_29691198 1.59 ENST00000440587.2
ENST00000434407.2
major histocompatibility complex, class I, F
chr2_+_202122703 1.59 ENST00000447616.1
ENST00000358485.4
caspase 8, apoptosis-related cysteine peptidase
chr2_-_180871780 1.59 ENST00000410053.3
ENST00000295749.6
ENST00000404136.2
CWC22 spliceosome-associated protein homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
36.6 109.8 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
22.8 91.4 GO:0051097 negative regulation of helicase activity(GO:0051097)
18.7 75.0 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
11.3 135.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
10.1 60.5 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
9.0 36.2 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
9.0 99.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
6.8 20.5 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
6.0 77.6 GO:0035457 cellular response to interferon-alpha(GO:0035457)
5.5 114.7 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
5.3 21.1 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
4.8 52.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
4.2 45.8 GO:0018377 protein myristoylation(GO:0018377)
3.7 44.4 GO:0060700 regulation of ribonuclease activity(GO:0060700)
2.7 43.9 GO:0035455 response to interferon-alpha(GO:0035455)
2.6 20.7 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
2.6 25.7 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
2.0 9.9 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
2.0 5.9 GO:2000625 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
1.9 5.8 GO:0060629 regulation of homologous chromosome segregation(GO:0060629)
1.4 5.7 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
1.4 7.1 GO:0039507 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
1.4 120.5 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
1.2 7.4 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
1.2 1.2 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
1.1 6.9 GO:0030421 defecation(GO:0030421)
1.1 7.8 GO:0010819 regulation of T cell chemotaxis(GO:0010819)
1.0 15.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.9 3.7 GO:0045208 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.9 3.4 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.8 4.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.8 1.6 GO:0046967 cytosol to ER transport(GO:0046967)
0.8 2.3 GO:0045062 extrathymic T cell selection(GO:0045062)
0.8 45.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.7 0.7 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.7 16.4 GO:0042832 defense response to protozoan(GO:0042832)
0.7 2.0 GO:1904604 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.6 2.6 GO:1903445 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.6 2.5 GO:1902990 leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.6 3.1 GO:1903974 mammary gland fat development(GO:0060611) regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) regulation of response to macrophage colony-stimulating factor(GO:1903969) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141)
0.6 1.8 GO:1903216 negative regulation of late endosome to lysosome transport(GO:1902823) regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.6 1.8 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.6 4.8 GO:0044565 dendritic cell proliferation(GO:0044565)
0.6 30.7 GO:0010390 histone monoubiquitination(GO:0010390)
0.6 3.6 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.5 1.6 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.5 1.6 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.5 3.1 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.5 14.5 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.5 1.9 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.4 1.7 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.4 2.0 GO:0046292 spermatid nucleus elongation(GO:0007290) formaldehyde metabolic process(GO:0046292)
0.4 3.7 GO:0060844 arterial endothelial cell fate commitment(GO:0060844)
0.4 0.4 GO:0002856 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
0.4 13.4 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.4 0.4 GO:0051595 response to methylglyoxal(GO:0051595)
0.4 1.4 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.4 1.1 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.3 2.4 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.3 1.0 GO:1904253 lipid transport involved in lipid storage(GO:0010877) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.3 1.7 GO:1902728 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.3 0.7 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.3 1.0 GO:0019085 early viral transcription(GO:0019085)
0.3 2.6 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.3 0.9 GO:0060931 sinoatrial node cell development(GO:0060931)
0.3 2.4 GO:0015793 glycerol transport(GO:0015793)
0.3 0.3 GO:0070316 regulation of G0 to G1 transition(GO:0070316) positive regulation of G0 to G1 transition(GO:0070318)
0.3 6.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.3 1.7 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.3 1.1 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.3 10.5 GO:0044364 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.3 1.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.3 1.1 GO:0032687 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.2 0.2 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.2 1.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 1.2 GO:0043335 protein unfolding(GO:0043335)
0.2 3.0 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 0.9 GO:0035668 TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.2 0.7 GO:0051795 apoptotic process involved in outflow tract morphogenesis(GO:0003275) uterine wall breakdown(GO:0042704) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) regulation of complement-dependent cytotoxicity(GO:1903659)
0.2 1.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.2 0.7 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.2 1.9 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.2 0.8 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.2 1.4 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.2 1.7 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.2 0.9 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.2 0.6 GO:0006481 C-terminal protein methylation(GO:0006481)
0.2 1.1 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.2 5.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 0.6 GO:1902868 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.2 3.0 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.2 1.7 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.2 0.7 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.2 0.5 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.2 0.7 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535)
0.2 0.4 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.2 1.7 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.2 1.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.2 2.0 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.2 0.8 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.2 1.8 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 1.1 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.2 1.0 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.2 0.2 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.2 1.4 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.2 0.8 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.2 1.1 GO:0051133 regulation of NK T cell activation(GO:0051133) positive regulation of NK T cell activation(GO:0051135)
0.2 0.9 GO:0009804 coumarin metabolic process(GO:0009804)
0.2 0.8 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.2 1.2 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 1.8 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.2 0.9 GO:0010793 regulation of mRNA export from nucleus(GO:0010793) regulation of ribonucleoprotein complex localization(GO:2000197)
0.2 0.5 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.6 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.6 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.1 0.7 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.1 0.1 GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis(GO:0060664)
0.1 1.4 GO:0097338 response to clozapine(GO:0097338)
0.1 51.1 GO:0009615 response to virus(GO:0009615)
0.1 0.7 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.1 1.1 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.9 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.6 GO:0035617 stress granule disassembly(GO:0035617)
0.1 1.2 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.5 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.9 GO:2000152 regulation of ubiquitin-specific protease activity(GO:2000152) positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 2.0 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 11.8 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 0.2 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 0.8 GO:0072161 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.3 GO:0035989 tendon development(GO:0035989)
0.1 0.9 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1 0.4 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 6.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.5 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
0.1 0.8 GO:0016584 nucleosome positioning(GO:0016584)
0.1 1.0 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.3 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 0.3 GO:0032661 central nervous system myelin formation(GO:0032289) regulation of interleukin-18 production(GO:0032661) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.1 2.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.3 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 1.1 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.1 0.7 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 1.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 2.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.8 GO:0006021 inositol biosynthetic process(GO:0006021)
0.1 1.3 GO:0006293 nucleotide-excision repair, preincision complex stabilization(GO:0006293)
0.1 2.7 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.1 0.3 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 4.7 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 2.5 GO:0006825 copper ion transport(GO:0006825)
0.1 1.7 GO:0021794 thalamus development(GO:0021794)
0.1 0.3 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.1 0.3 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 5.1 GO:0006298 mismatch repair(GO:0006298)
0.1 1.2 GO:0033227 dsRNA transport(GO:0033227)
0.1 1.9 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 1.4 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.9 GO:0032480 negative regulation of type I interferon production(GO:0032480)
0.1 0.7 GO:0006294 nucleotide-excision repair, preincision complex assembly(GO:0006294)
0.1 0.5 GO:0051106 positive regulation of DNA ligation(GO:0051106)
0.1 3.9 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 0.3 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.1 0.7 GO:0060174 pulmonary myocardium development(GO:0003350) limb bud formation(GO:0060174)
0.1 1.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.4 GO:0006574 valine catabolic process(GO:0006574)
0.1 1.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.3 GO:0043686 co-translational protein modification(GO:0043686)
0.1 0.3 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501) peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 0.7 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.2 GO:0060336 negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336) regulation of cholesterol transporter activity(GO:0060694) pancreatic stellate cell proliferation(GO:0072343) regulation of pancreatic stellate cell proliferation(GO:2000229) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.4 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 4.2 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 0.5 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 0.4 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.1 0.5 GO:0015747 urate transport(GO:0015747)
0.1 1.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.4 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 0.9 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 0.2 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1 1.1 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.1 0.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.3 GO:0044254 angiotensin catabolic process in blood(GO:0002005) multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266)
0.1 0.8 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.2 GO:0010040 response to iron(II) ion(GO:0010040)
0.1 0.3 GO:0072319 vacuolar transmembrane transport(GO:0034486) late endosomal microautophagy(GO:0061738) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741) clathrin coat disassembly(GO:0072318) vesicle uncoating(GO:0072319) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.1 0.7 GO:0030575 nuclear body organization(GO:0030575)
0.1 1.9 GO:0007050 cell cycle arrest(GO:0007050)
0.1 0.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.8 GO:0007379 segment specification(GO:0007379)
0.1 0.4 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952)
0.1 0.2 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.1 0.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 1.6 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.9 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0002441 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.0 0.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 4.8 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 1.8 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.3 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.8 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.1 GO:0035441 cell migration involved in vasculogenesis(GO:0035441)
0.0 2.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.4 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 0.4 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 1.0 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.2 GO:0001302 replicative cell aging(GO:0001302)
0.0 0.4 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.1 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205)
0.0 0.2 GO:0072602 interleukin-4 secretion(GO:0072602)
0.0 1.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.4 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.4 GO:1900045 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.2 GO:1990523 bone regeneration(GO:1990523)
0.0 0.3 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0070904 L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 0.7 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.9 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.0 1.5 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 2.4 GO:0007566 embryo implantation(GO:0007566)
0.0 0.5 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.2 GO:0048539 bone marrow development(GO:0048539)
0.0 0.5 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.1 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.0 0.1 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 1.2 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.4 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.8 GO:0016180 snRNA processing(GO:0016180)
0.0 0.5 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.9 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.6 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.3 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.3 GO:0048593 camera-type eye morphogenesis(GO:0048593)
0.0 0.6 GO:0009409 response to cold(GO:0009409)
0.0 0.4 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.3 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.2 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0 0.3 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.0 GO:0048865 ganglion mother cell fate determination(GO:0007402) stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0 1.2 GO:0006968 cellular defense response(GO:0006968)
0.0 0.3 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.9 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 1.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.4 GO:0006105 succinate metabolic process(GO:0006105)
0.0 3.5 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 1.5 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 2.7 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.2 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.7 GO:0071711 basement membrane organization(GO:0071711)
0.0 0.5 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
0.0 0.4 GO:0006833 water transport(GO:0006833)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.2 GO:0071910 determination of pancreatic left/right asymmetry(GO:0035469) determination of liver left/right asymmetry(GO:0071910)
0.0 4.3 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.3 GO:0015866 ADP transport(GO:0015866)
0.0 0.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.4 GO:0031643 positive regulation of myelination(GO:0031643)
0.0 0.1 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 1.0 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0061462 protein targeting to lysosome(GO:0006622) protein localization to lysosome(GO:0061462)
0.0 0.1 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.5 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.6 GO:0010470 regulation of gastrulation(GO:0010470)
0.0 0.2 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.3 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 1.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0051972 regulation of telomerase activity(GO:0051972)
0.0 0.3 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.5 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.4 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.0 0.9 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.2 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128)
0.0 1.0 GO:0048477 oogenesis(GO:0048477)
0.0 0.6 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.0 0.2 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.4 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.2 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0045687 positive regulation of glial cell differentiation(GO:0045687)
0.0 0.2 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0046034 ATP metabolic process(GO:0046034)
0.0 0.1 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0 0.1 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.1 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.5 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.1 GO:0035799 ureter maturation(GO:0035799)
0.0 0.5 GO:0007586 digestion(GO:0007586)
0.0 0.0 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 21.1 GO:0030870 Mre11 complex(GO:0030870)
1.6 9.6 GO:0008537 proteasome activator complex(GO:0008537)
1.1 23.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.9 4.7 GO:0031905 early endosome lumen(GO:0031905)
0.9 5.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.8 2.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.7 3.0 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.7 13.0 GO:0033391 chromatoid body(GO:0033391)
0.6 79.2 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.6 5.9 GO:0042788 polysomal ribosome(GO:0042788)
0.6 7.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.6 2.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.5 1.6 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.5 60.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.5 2.6 GO:0005879 axonemal microtubule(GO:0005879)
0.5 3.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.5 1.9 GO:0031213 RSF complex(GO:0031213)
0.5 1.8 GO:0044753 amphisome(GO:0044753)
0.4 12.5 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.4 1.2 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.4 1.6 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.3 2.6 GO:0097422 tubular endosome(GO:0097422)
0.3 20.9 GO:0005771 multivesicular body(GO:0005771)
0.3 1.9 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.3 4.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.3 126.1 GO:0031965 nuclear membrane(GO:0031965)
0.3 2.9 GO:0031906 late endosome lumen(GO:0031906)
0.3 2.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 2.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 1.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.2 0.9 GO:0005579 membrane attack complex(GO:0005579)
0.2 0.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.2 46.9 GO:0032587 ruffle membrane(GO:0032587)
0.2 3.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 1.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 46.6 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.2 1.4 GO:0031262 Ndc80 complex(GO:0031262)
0.2 1.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 1.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.2 1.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 0.7 GO:0070985 TFIIK complex(GO:0070985)
0.2 1.1 GO:0071439 clathrin complex(GO:0071439)
0.2 1.1 GO:1902560 GMP reductase complex(GO:1902560)
0.2 110.0 GO:0010008 endosome membrane(GO:0010008)
0.2 1.1 GO:0035061 interchromatin granule(GO:0035061)
0.1 12.1 GO:0015030 Cajal body(GO:0015030)
0.1 2.0 GO:0005577 fibrinogen complex(GO:0005577)
0.1 2.0 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 1.7 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 2.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.7 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 4.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.8 GO:0097149 centralspindlin complex(GO:0097149)
0.1 5.8 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.8 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 1.4 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 1.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 1.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.7 GO:0001741 XY body(GO:0001741)
0.1 1.2 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.3 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1 0.6 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 0.4 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.4 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.1 1.5 GO:0046930 pore complex(GO:0046930)
0.1 2.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 1.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 233.9 GO:0005739 mitochondrion(GO:0005739)
0.1 0.6 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.3 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.8 GO:0005827 polar microtubule(GO:0005827)
0.1 1.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.2 GO:0005602 complement component C1 complex(GO:0005602)
0.1 1.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 5.0 GO:0031201 SNARE complex(GO:0031201)
0.1 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.6 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.8 GO:0032039 integrator complex(GO:0032039)
0.1 1.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.8 GO:0072487 MSL complex(GO:0072487)
0.1 30.1 GO:0000790 nuclear chromatin(GO:0000790)
0.1 1.3 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.3 GO:0097165 nuclear stress granule(GO:0097165)
0.1 0.4 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 1.4 GO:0000242 pericentriolar material(GO:0000242)
0.0 8.5 GO:0005769 early endosome(GO:0005769)
0.0 3.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 9.8 GO:0005840 ribosome(GO:0005840)
0.0 198.3 GO:0005654 nucleoplasm(GO:0005654)
0.0 1.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.5 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.4 GO:0071953 elastic fiber(GO:0071953)
0.0 2.6 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0097444 spine apparatus(GO:0097444)
0.0 1.0 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 20.8 GO:0005730 nucleolus(GO:0005730)
0.0 1.4 GO:0000785 chromatin(GO:0000785)
0.0 2.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.4 GO:0033269 internode region of axon(GO:0033269)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.8 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.1 GO:0070703 inner mucus layer(GO:0070702) outer mucus layer(GO:0070703)
0.0 0.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.4 GO:0034399 nuclear matrix(GO:0016363) nuclear periphery(GO:0034399)
0.0 3.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.2 GO:1990752 microtubule end(GO:1990752)
0.0 0.5 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.0 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0099738 cell cortex region(GO:0099738)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 9.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.5 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
11.3 135.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
8.1 105.4 GO:0031386 protein tag(GO:0031386)
5.3 21.1 GO:0009041 uridylate kinase activity(GO:0009041)
3.3 9.9 GO:0008859 exoribonuclease II activity(GO:0008859)
2.6 79.4 GO:0070403 NAD+ binding(GO:0070403)
2.4 7.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
2.3 20.7 GO:0070087 chromo shadow domain binding(GO:0070087)
2.3 22.5 GO:0042296 ISG15 transferase activity(GO:0042296)
2.1 12.5 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
1.7 64.1 GO:0005521 lamin binding(GO:0005521)
1.2 25.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
1.2 9.6 GO:0061133 endopeptidase activator activity(GO:0061133)
1.2 171.0 GO:0003727 single-stranded RNA binding(GO:0003727)
1.1 8.0 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
1.1 4.3 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
1.1 33.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
1.0 144.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.9 6.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.9 2.6 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.8 7.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.7 5.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.7 2.0 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.7 20.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.6 2.5 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.6 2.4 GO:0015254 glycerol channel activity(GO:0015254)
0.6 0.6 GO:0099609 microtubule lateral binding(GO:0099609)
0.6 3.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.4 2.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.3 2.4 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.3 3.3 GO:0023029 MHC class Ib protein binding(GO:0023029)
0.3 2.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 2.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.3 1.8 GO:0042015 interleukin-20 binding(GO:0042015)
0.3 1.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.3 6.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 5.8 GO:0051400 BH domain binding(GO:0051400)
0.3 127.3 GO:0003924 GTPase activity(GO:0003924)
0.2 1.0 GO:0004967 glucagon receptor activity(GO:0004967)
0.2 1.5 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.2 2.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.2 1.2 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.2 1.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.2 4.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 0.4 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.2 0.6 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
0.2 1.2 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 38.1 GO:0001047 core promoter binding(GO:0001047)
0.2 0.6 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.2 3.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 1.3 GO:0001849 complement component C1q binding(GO:0001849)
0.2 0.9 GO:0035276 ethanol binding(GO:0035276)
0.2 0.8 GO:0031208 POZ domain binding(GO:0031208)
0.2 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 1.1 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.2 5.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.0 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.2 1.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 2.6 GO:0034452 dynactin binding(GO:0034452)
0.1 0.6 GO:0005019 platelet-derived growth factor beta-receptor activity(GO:0005019)
0.1 1.5 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.1 0.6 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.1 0.6 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.1 0.4 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 1.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 1.5 GO:0015288 porin activity(GO:0015288)
0.1 0.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.1 1.4 GO:0048156 tau protein binding(GO:0048156)
0.1 1.4 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 0.4 GO:0051499 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.1 0.9 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 0.5 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 2.1 GO:0032183 SUMO binding(GO:0032183)
0.1 34.1 GO:0042393 histone binding(GO:0042393)
0.1 1.2 GO:0030911 TPR domain binding(GO:0030911)
0.1 0.5 GO:0008308 voltage-gated anion channel activity(GO:0008308)
0.1 0.8 GO:0052832 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1 0.9 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 13.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 0.3 GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity(GO:0008441)
0.1 1.0 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 2.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.8 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.1 2.2 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.7 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 3.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 16.0 GO:0005525 GTP binding(GO:0005525)
0.1 2.4 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 0.7 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.5 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.3 GO:0030492 hemoglobin binding(GO:0030492)
0.1 0.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 10.3 GO:0005254 chloride channel activity(GO:0005254)
0.1 1.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 11.8 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 1.0 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 4.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 2.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 3.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.6 GO:0034618 arginine binding(GO:0034618)
0.1 0.5 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 3.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.6 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.3 GO:0099589 G-protein coupled serotonin receptor activity(GO:0004993) amine binding(GO:0043176) serotonin binding(GO:0051378) serotonin receptor activity(GO:0099589)
0.1 0.8 GO:0036122 BMP binding(GO:0036122)
0.1 0.5 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.3 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.8 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.3 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.6 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 1.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.3 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 1.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.3 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 2.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 8.2 GO:0004386 helicase activity(GO:0004386)
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.4 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.2 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 3.8 GO:0005125 cytokine activity(GO:0005125)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.8 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 1.0 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.2 GO:0015094 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.4 GO:0015250 water channel activity(GO:0015250)
0.0 1.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.1 GO:0008520 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.3 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:1902379 receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379)
0.0 3.8 GO:0038024 cargo receptor activity(GO:0038024)
0.0 0.3 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.2 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.0 0.1 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.0 0.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.0 1.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.4 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 62.0 GO:0003723 RNA binding(GO:0003723)
0.0 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.0 2.2 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.4 GO:0005539 glycosaminoglycan binding(GO:0005539) heparin binding(GO:0008201) sulfur compound binding(GO:1901681)
0.0 0.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.5 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 6.6 GO:0016746 transferase activity, transferring acyl groups(GO:0016746)
0.0 0.7 GO:0001948 glycoprotein binding(GO:0001948)
0.0 0.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 1.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.3 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.3 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 1.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.5 GO:0008009 chemokine activity(GO:0008009)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 1.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.5 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 1.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 3.3 GO:0008083 growth factor activity(GO:0008083)
0.0 0.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.0 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) aromatase activity(GO:0070330)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.2 GO:0004568 chitinase activity(GO:0004568)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.6 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 0.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 55.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.6 106.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.5 63.6 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.4 13.5 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.3 1.7 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.3 10.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3 4.6 PID IL27 PATHWAY IL27-mediated signaling events
0.2 15.5 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.2 3.8 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 1.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 11.5 PID AURORA A PATHWAY Aurora A signaling
0.1 1.2 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.1 9.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 6.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 8.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 5.3 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 3.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 5.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 6.1 PID AURORA B PATHWAY Aurora B signaling
0.1 4.8 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.1 2.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 5.8 PID BCR 5PATHWAY BCR signaling pathway
0.1 4.0 PID BARD1 PATHWAY BARD1 signaling events
0.1 1.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 1.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 1.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.1 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 2.0 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.9 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.9 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 4.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.4 PID ARF6 PATHWAY Arf6 signaling events
0.0 2.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 2.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 2.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.1 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.4 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.6 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.2 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.7 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
9.1 191.9 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
8.2 736.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
1.3 5.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.7 38.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.5 29.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.4 20.1 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.2 7.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 3.5 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 2.8 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 12.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 1.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 1.0 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.4 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 5.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 12.3 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 2.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 25.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 2.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 3.0 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 4.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.7 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 1.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.1 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.1 1.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 1.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 2.2 REACTOME KINESINS Genes involved in Kinesins
0.0 1.7 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 2.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 1.0 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 2.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.5 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.2 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.6 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.9 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.7 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.0 0.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 3.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.7 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 1.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.0 0.7 REACTOME TRANSCRIPTION Genes involved in Transcription
0.0 1.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.1 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 1.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 1.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis