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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF3

Z-value: 4.12

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Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
IRF3
ENSG00000126456.11 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50169064_501691320.305.6e-01Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_948803 34.40 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr4_-_169239921 17.56 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr21_+_42792442 16.63 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_615570 14.18 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr11_-_615942 13.66 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr10_+_91087651 13.31 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr2_-_163175133 12.93 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr10_+_91092241 11.34 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_79115503 9.10 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr3_-_122283079 9.00 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283100 8.67 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283424 8.43 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr7_-_92747269 7.98 ENST00000446617.1
ENST00000379958.2
SAMD9
sterile alpha motif domain containing 9
chr12_+_113376157 6.54 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr12_+_113376249 6.24 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr19_-_17516449 6.06 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr12_+_113416191 5.53 ENST00000342315.4
ENST00000392583.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr9_-_32526184 5.14 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_231084659 5.09 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr3_+_122283175 5.05 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr9_-_32526299 4.98 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr3_+_122283064 4.92 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr7_-_92777606 4.79 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr2_-_231084820 4.44 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr12_+_113416265 4.38 ENST00000449768.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr2_-_37384175 3.72 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr3_+_122399444 3.23 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr10_+_91061712 3.14 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr4_-_169401628 3.13 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr11_+_5646213 3.09 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr2_-_231084617 2.79 ENST00000409815.2
SP110
SP110 nuclear body protein
chr22_+_36649170 2.75 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
APOL1
apolipoprotein L, 1
chr19_+_10196781 2.72 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr4_+_89378261 2.71 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr7_-_139756791 2.45 ENST00000489809.1
PARP12
poly (ADP-ribose) polymerase family, member 12
chr11_-_57334732 2.22 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr14_+_24605389 2.21 ENST00000382708.3
ENST00000561435.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr3_+_159706537 2.20 ENST00000305579.2
ENST00000480787.1
ENST00000466512.1
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr19_+_10196981 2.19 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr12_+_133614062 2.17 ENST00000540031.1
ENST00000536123.1
ZNF84
zinc finger protein 84
chr19_+_49977466 2.03 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr22_+_18632666 1.92 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr22_+_36649056 1.91 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1
apolipoprotein L, 1
chr11_-_57335280 1.85 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr14_+_24605361 1.81 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr12_+_113416340 1.79 ENST00000552756.1
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr8_+_26150628 1.74 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr7_-_944631 1.74 ENST00000453175.2
ADAP1
ArfGAP with dual PH domains 1
chr12_+_133613937 1.56 ENST00000539354.1
ENST00000542874.1
ENST00000438628.2
ZNF84
zinc finger protein 84
chr1_-_154580616 1.41 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr3_+_122399697 1.37 ENST00000494811.1
PARP14
poly (ADP-ribose) polymerase family, member 14
chr4_-_74847800 1.33 ENST00000296029.3
PF4
platelet factor 4
chr17_+_8316442 1.30 ENST00000582812.1
NDEL1
nudE neurodevelopment protein 1-like 1
chr20_-_47894569 1.27 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
ZNFX1
zinc finger, NFX1-type containing 1
chr14_-_24615523 1.22 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr2_-_99485825 1.20 ENST00000423771.1
KIAA1211L
KIAA1211-like
chr17_-_40264321 1.20 ENST00000430773.1
ENST00000413196.2
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr3_-_123339343 1.13 ENST00000578202.1
MYLK
myosin light chain kinase
chr4_+_130017268 1.13 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr12_+_133613878 1.10 ENST00000392319.2
ENST00000543758.1
ZNF84
zinc finger protein 84
chr17_-_7166500 1.08 ENST00000575313.1
ENST00000397317.4
CLDN7
claudin 7
chr1_+_76190357 1.05 ENST00000370834.5
ENST00000541113.1
ENST00000543667.1
ENST00000420607.2
ACADM
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
chr22_+_36044411 1.04 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr14_-_24615805 0.96 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr12_-_10022735 0.95 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr10_+_35416223 0.95 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
CREM
cAMP responsive element modulator
chr17_-_40264692 0.95 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr10_+_35415978 0.93 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
CREM
cAMP responsive element modulator
chr1_+_25598872 0.92 ENST00000328664.4
RHD
Rh blood group, D antigen
chr11_-_4414880 0.92 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr9_-_100954910 0.85 ENST00000375077.4
CORO2A
coronin, actin binding protein, 2A
chr8_-_67525473 0.84 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr6_-_36355513 0.79 ENST00000340181.4
ENST00000373737.4
ETV7
ets variant 7
chr15_-_55611306 0.77 ENST00000563262.1
RAB27A
RAB27A, member RAS oncogene family
chr6_-_2876744 0.77 ENST00000420981.2
RP11-420G6.4
RP11-420G6.4
chr10_-_70231639 0.76 ENST00000551118.2
ENST00000358410.3
ENST00000399180.2
ENST00000399179.2
DNA2
DNA replication helicase/nuclease 2
chr14_+_73525229 0.75 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RBM25
RNA binding motif protein 25
chr17_-_30669138 0.73 ENST00000225805.4
ENST00000577809.1
C17orf75
chromosome 17 open reading frame 75
chr2_+_99771418 0.72 ENST00000393473.2
ENST00000393477.3
ENST00000393474.3
ENST00000340066.1
ENST00000393471.2
ENST00000449211.1
ENST00000434566.1
ENST00000410042.1
LIPT1
MRPL30
lipoyltransferase 1
39S ribosomal protein L30, mitochondrial
chr2_+_69240302 0.72 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chr6_-_27840099 0.70 ENST00000328488.2
HIST1H3I
histone cluster 1, H3i
chr5_-_96143796 0.69 ENST00000296754.3
ERAP1
endoplasmic reticulum aminopeptidase 1
chr3_+_184529948 0.67 ENST00000436792.2
ENST00000446204.2
ENST00000422105.1
VPS8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr1_-_177939041 0.67 ENST00000308284.6
SEC16B
SEC16 homolog B (S. cerevisiae)
chr15_+_45003675 0.66 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr3_+_184529929 0.63 ENST00000287546.4
ENST00000437079.3
VPS8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr12_+_133614119 0.62 ENST00000327668.7
ZNF84
zinc finger protein 84
chr14_+_73525144 0.61 ENST00000261973.7
ENST00000540173.1
RBM25
RNA binding motif protein 25
chr14_-_91976874 0.60 ENST00000557018.1
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr4_-_87855851 0.59 ENST00000473559.1
C4orf36
chromosome 4 open reading frame 36
chr9_-_95087838 0.54 ENST00000442668.2
ENST00000421075.2
ENST00000536624.1
NOL8
nucleolar protein 8
chrX_+_119384607 0.53 ENST00000326624.2
ENST00000557385.1
ZBTB33
zinc finger and BTB domain containing 33
chr12_+_97300995 0.53 ENST00000266742.4
ENST00000429527.2
ENST00000554226.1
ENST00000557478.1
ENST00000557092.1
ENST00000411739.2
ENST00000553609.1
NEDD1
neural precursor cell expressed, developmentally down-regulated 1
chr6_+_26440700 0.51 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr6_-_41039567 0.51 ENST00000468811.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr2_+_207139367 0.50 ENST00000374423.3
ZDBF2
zinc finger, DBF-type containing 2
chr11_+_118230287 0.48 ENST00000252108.3
ENST00000431736.2
UBE4A
ubiquitination factor E4A
chr11_+_125461607 0.46 ENST00000527606.1
STT3A
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr15_+_55611128 0.46 ENST00000164305.5
ENST00000539642.1
PIGB
phosphatidylinositol glycan anchor biosynthesis, class B
chr16_-_71323271 0.45 ENST00000565850.1
ENST00000568910.1
ENST00000434935.2
ENST00000338099.5
CMTR2
cap methyltransferase 2
chr5_+_77656339 0.43 ENST00000538629.1
SCAMP1
secretory carrier membrane protein 1
chr6_-_36355486 0.42 ENST00000538992.1
ETV7
ets variant 7
chr7_-_138794394 0.42 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr10_-_14996321 0.41 ENST00000378289.4
DCLRE1C
DNA cross-link repair 1C
chr17_-_63052929 0.40 ENST00000439174.2
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr14_+_86401039 0.39 ENST00000557195.1
CTD-2341M24.1
CTD-2341M24.1
chr16_-_28223229 0.39 ENST00000566073.1
XPO6
exportin 6
chr6_-_28226984 0.39 ENST00000423974.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr7_-_138794081 0.37 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr9_-_95087604 0.36 ENST00000542613.1
ENST00000542053.1
ENST00000358855.4
ENST00000545558.1
ENST00000432670.2
ENST00000433029.2
ENST00000411621.2
NOL8
nucleolar protein 8
chr7_-_32931387 0.36 ENST00000304056.4
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr1_-_177939348 0.35 ENST00000464631.2
SEC16B
SEC16 homolog B (S. cerevisiae)
chr2_-_214017151 0.34 ENST00000452786.1
IKZF2
IKAROS family zinc finger 2 (Helios)
chr19_+_13051206 0.34 ENST00000586760.1
CALR
calreticulin
chr6_+_32821924 0.33 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_121655593 0.33 ENST00000398212.2
TBC1D32
TBC1 domain family, member 32
chr2_-_152118352 0.32 ENST00000331426.5
RBM43
RNA binding motif protein 43
chr14_+_35452104 0.30 ENST00000216774.6
ENST00000546080.1
SRP54
signal recognition particle 54kDa
chr20_+_46988646 0.30 ENST00000416742.1
ENST00000425021.1
LINC00494
long intergenic non-protein coding RNA 494
chr6_-_32806506 0.30 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr8_+_22446763 0.28 ENST00000450780.2
ENST00000430850.2
ENST00000447849.1
AC037459.4
Uncharacterized protein
chr9_+_74764340 0.28 ENST00000376986.1
ENST00000358399.3
GDA
guanine deaminase
chr9_+_5450503 0.28 ENST00000381573.4
ENST00000381577.3
CD274
CD274 molecule
chr17_-_61517572 0.26 ENST00000582997.1
CYB561
cytochrome b561
chr6_-_32821599 0.26 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_89664595 0.25 ENST00000355754.6
GBP4
guanylate binding protein 4
chr2_+_69240415 0.25 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chr1_+_112298514 0.23 ENST00000536167.1
DDX20
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
chr14_+_35452169 0.22 ENST00000555557.1
SRP54
signal recognition particle 54kDa
chrX_+_146993449 0.22 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
FMR1
fragile X mental retardation 1
chr15_+_55611401 0.22 ENST00000566999.1
PIGB
phosphatidylinositol glycan anchor biosynthesis, class B
chr5_-_96143602 0.22 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
ERAP1
endoplasmic reticulum aminopeptidase 1
chr4_-_156875003 0.22 ENST00000433477.3
CTSO
cathepsin O
chr22_-_36635684 0.18 ENST00000358502.5
APOL2
apolipoprotein L, 2
chr1_-_146644122 0.18 ENST00000254101.3
PRKAB2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr12_-_322821 0.17 ENST00000359674.4
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr16_+_75681650 0.16 ENST00000300086.4
TERF2IP
telomeric repeat binding factor 2, interacting protein
chr20_-_47894936 0.15 ENST00000371754.4
ZNFX1
zinc finger, NFX1-type containing 1
chr4_+_124320665 0.15 ENST00000394339.2
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr17_+_6659153 0.14 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr12_-_133613794 0.12 ENST00000443154.3
RP11-386I8.6
RP11-386I8.6
chrX_+_77154935 0.11 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr3_-_125802998 0.09 ENST00000514677.1
SLC41A3
solute carrier family 41, member 3
chrX_-_109561294 0.08 ENST00000372059.2
ENST00000262844.5
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr7_-_126892303 0.07 ENST00000358373.3
GRM8
glutamate receptor, metabotropic 8
chr2_+_219125714 0.07 ENST00000522678.1
ENST00000519574.1
ENST00000521462.1
GPBAR1
G protein-coupled bile acid receptor 1
chr6_+_28193037 0.06 ENST00000531981.1
ENST00000425468.2
ENST00000252207.5
ENST00000531979.1
ENST00000527436.1
ZSCAN9
zinc finger and SCAN domain containing 9
chr3_-_160283348 0.06 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr9_-_95640218 0.06 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
ZNF484
zinc finger protein 484
chr7_-_37382360 0.06 ENST00000455119.1
ELMO1
engulfment and cell motility 1
chr17_+_21729899 0.05 ENST00000583708.1
UBBP4
ubiquitin B pseudogene 4
chr5_+_169758393 0.05 ENST00000521471.1
ENST00000518357.1
ENST00000436248.3
CTB-114C7.3
CTB-114C7.3
chr6_-_110964453 0.04 ENST00000413605.2
CDK19
cyclin-dependent kinase 19
chr3_+_51977294 0.03 ENST00000498510.1
PARP3
poly (ADP-ribose) polymerase family, member 3
chr5_-_180288248 0.03 ENST00000512132.1
ENST00000506439.1
ENST00000502412.1
ENST00000359141.6
ZFP62
ZFP62 zinc finger protein
chr12_-_8218997 0.02 ENST00000307637.4
C3AR1
complement component 3a receptor 1
chr1_-_11042094 0.02 ENST00000377004.4
ENST00000377008.4
C1orf127
chromosome 1 open reading frame 127
chrX_+_146993534 0.02 ENST00000334557.6
ENST00000439526.2
ENST00000370475.4
FMR1
fragile X mental retardation 1
chr2_-_190044480 0.01 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr6_-_32806483 0.01 ENST00000374899.4
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr4_+_144434584 0.01 ENST00000283131.3
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr14_+_73525265 0.01 ENST00000525161.1
RBM25
RNA binding motif protein 25

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.3 27.8 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
5.8 23.0 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
3.4 41.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
3.3 19.7 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
2.4 26.9 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
2.1 27.8 GO:0035457 cellular response to interferon-alpha(GO:0035457)
2.0 6.1 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
1.1 12.8 GO:0060700 regulation of ribonuclease activity(GO:0060700)
1.1 11.7 GO:0018377 protein myristoylation(GO:0018377)
0.9 14.1 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.8 16.6 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.5 1.4 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.4 3.7 GO:0051834 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.3 1.0 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.3 1.0 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.3 2.3 GO:2000508 regulation of dendritic cell chemotaxis(GO:2000508) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.2 1.0 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
0.2 0.9 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.2 1.3 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.2 1.5 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885) regulation of osteoclast proliferation(GO:0090289)
0.2 10.0 GO:0010390 histone monoubiquitination(GO:0010390)
0.2 0.8 GO:0043504 DNA replication, removal of RNA primer(GO:0043137) mitochondrial DNA repair(GO:0043504) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.1 0.4 GO:0036451 cap mRNA methylation(GO:0036451)
0.1 0.3 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 4.7 GO:0019835 cytolysis(GO:0019835)
0.1 0.8 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 1.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 0.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.5 GO:0043686 co-translational protein modification(GO:0043686)
0.1 1.7 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.9 GO:1902570 protein localization to nucleolus(GO:1902570)
0.1 1.9 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.1 0.4 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 1.0 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.2 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.0 4.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 3.1 GO:0070206 protein trimerization(GO:0070206)
0.0 1.1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 1.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0 0.3 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.7 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0038183 bile acid signaling pathway(GO:0038183)
0.0 1.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.5 GO:0015695 organic cation transport(GO:0015695)
0.0 0.5 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.9 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.2 GO:0008537 proteasome activator complex(GO:0008537)
0.4 1.3 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.3 1.3 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.2 1.4 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 2.2 GO:0031906 late endosome lumen(GO:0031906)
0.2 4.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 0.7 GO:0031905 early endosome lumen(GO:0031905)
0.1 1.3 GO:0033263 CORVET complex(GO:0033263)
0.1 0.9 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 6.8 GO:0005771 multivesicular body(GO:0005771)
0.1 16.7 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.5 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 11.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 8.7 GO:0005769 early endosome(GO:0005769)
0.0 1.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 32.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 21.9 GO:0010008 endosome membrane(GO:0010008)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 29.8 GO:0005739 mitochondrion(GO:0005739)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 34.4 GO:0031386 protein tag(GO:0031386)
2.0 24.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.9 26.9 GO:0070403 NAD+ binding(GO:0070403)
0.8 6.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.7 6.8 GO:0042296 ISG15 transferase activity(GO:0042296)
0.6 3.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.4 1.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 42.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 1.3 GO:0070012 oligopeptidase activity(GO:0070012)
0.3 2.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.3 1.0 GO:0070991 medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
0.2 0.9 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
0.2 7.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 27.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 6.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 1.7 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 0.4 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1 0.8 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 0.4 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 1.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.7 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 0.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 1.7 GO:0048156 tau protein binding(GO:0048156)
0.1 0.3 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 0.6 GO:0015440 peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977) TAP1 binding(GO:0046978)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 16.6 GO:0008017 microtubule binding(GO:0008017)
0.0 4.7 GO:0005254 chloride channel activity(GO:0005254)
0.0 10.0 GO:0042393 histone binding(GO:0042393)
0.0 0.5 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 3.4 GO:0004386 helicase activity(GO:0004386)
0.0 1.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 1.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 27.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.2 PID IL27 PATHWAY IL27-mediated signaling events
0.0 3.7 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 1.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.7 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 50.9 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.1 98.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 0.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 6.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 1.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 5.1 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.9 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 3.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 6.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.8 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.3 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.4 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor