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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF6_IRF4_IRF5

Z-value: 6.08

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Transcription factors associated with IRF6_IRF4_IRF5

Gene Symbol Gene ID Gene Info
IRF6
ENSG00000117595.6 interferon regulatory factor 6
IRF4
ENSG00000137265.10 interferon regulatory factor 4
IRF5
ENSG00000128604.14 interferon regulatory factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF5hg19_v2_chr7_+_128577972_128578047-0.681.4e-01Click!
IRF6hg19_v2_chr1_-_209979465_209979494-0.216.9e-01Click!
IRF4hg19_v2_chr6_+_391739_3917590.138.0e-01Click!

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_615942 44.69 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr21_+_42798094 28.19 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr21_+_42792442 27.91 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr9_-_32526184 24.40 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_-_32526299 23.54 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr1_+_948803 19.99 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr21_+_42798124 17.97 ENST00000417963.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr21_+_42798158 17.92 ENST00000441677.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_615570 16.74 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr12_+_113344755 15.63 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr21_+_42797958 15.42 ENST00000419044.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113344582 15.30 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr11_-_321050 14.35 ENST00000399808.4
IFITM3
interferon induced transmembrane protein 3
chr3_-_146262365 14.20 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr12_+_113344811 13.65 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr3_-_122283079 13.44 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283100 13.01 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283424 12.11 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_146262352 11.13 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr2_-_37384175 10.49 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr3_-_146262428 10.49 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr3_-_146262293 10.49 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr3_-_146262488 9.08 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr12_+_113376157 8.40 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr3_-_146262637 8.28 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr9_-_100881466 8.12 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr12_+_113376249 8.02 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr14_+_94577074 7.69 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr3_+_122283064 7.45 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr3_+_122283175 7.32 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr2_-_7005785 6.70 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr20_-_62203808 5.41 ENST00000467148.1
HELZ2
helicase with zinc finger 2, transcriptional coactivator
chr2_-_191878681 5.21 ENST00000409465.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr2_-_191878874 5.00 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
STAT1
signal transducer and activator of transcription 1, 91kDa
chr19_+_10196981 4.91 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr11_-_57335280 4.62 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr2_-_163175133 4.60 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr11_-_321340 4.05 ENST00000526811.1
IFITM3
interferon induced transmembrane protein 3
chrM_+_9207 3.66 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr14_-_102552659 3.53 ENST00000441629.2
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr19_-_17516449 3.23 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr4_+_89378261 3.06 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr10_+_91174314 2.78 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr15_-_45670717 2.68 ENST00000558163.1
ENST00000558336.1
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr5_+_178286925 2.67 ENST00000322434.3
ZNF354B
zinc finger protein 354B
chr2_-_55920952 2.50 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr12_-_62653903 2.44 ENST00000552075.1
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chrX_+_23801280 2.41 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
SAT1
spermidine/spermine N1-acetyltransferase 1
chr19_+_10196781 2.15 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr8_+_40018977 2.04 ENST00000520487.1
RP11-470M17.2
RP11-470M17.2
chr15_-_75748143 2.00 ENST00000568431.1
ENST00000568309.1
ENST00000568190.1
ENST00000570115.1
ENST00000564778.1
SIN3A
SIN3 transcription regulator family member A
chr7_-_33080506 1.97 ENST00000381626.2
ENST00000409467.1
ENST00000449201.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr3_-_182880541 1.96 ENST00000470251.1
ENST00000265598.3
LAMP3
lysosomal-associated membrane protein 3
chr7_+_12250833 1.96 ENST00000396668.3
TMEM106B
transmembrane protein 106B
chr4_+_144258288 1.87 ENST00000514639.1
GAB1
GRB2-associated binding protein 1
chr10_+_91061712 1.76 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr9_+_111696664 1.75 ENST00000374624.3
ENST00000445175.1
FAM206A
family with sequence similarity 206, member A
chr3_-_180707306 1.73 ENST00000479269.1
DNAJC19
DnaJ (Hsp40) homolog, subfamily C, member 19
chr3_-_96337000 1.68 ENST00000600213.2
MTRNR2L12
MT-RNR2-like 12 (pseudogene)
chr18_+_22006646 1.64 ENST00000585067.1
ENST00000578221.1
IMPACT
impact RWD domain protein
chr4_+_95373037 1.57 ENST00000359265.4
ENST00000437932.1
ENST00000380180.3
ENST00000318007.5
ENST00000450793.1
ENST00000538141.1
ENST00000317968.4
ENST00000512274.1
ENST00000503974.1
ENST00000504489.1
ENST00000542407.1
PDLIM5
PDZ and LIM domain 5
chr1_-_238108575 1.57 ENST00000604646.1
MTRNR2L11
MT-RNR2-like 11 (pseudogene)
chr7_-_77045617 1.53 ENST00000257626.7
GSAP
gamma-secretase activating protein
chr9_-_103115135 1.52 ENST00000537512.1
TEX10
testis expressed 10
chr9_+_95820966 1.51 ENST00000375472.3
ENST00000465709.1
SUSD3
sushi domain containing 3
chr20_-_55934878 1.50 ENST00000543500.1
MTRNR2L3
MT-RNR2-like 3
chr6_+_89791507 1.49 ENST00000354922.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr17_-_54991395 1.48 ENST00000316881.4
TRIM25
tripartite motif containing 25
chr11_-_57334732 1.47 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr10_+_91174486 1.44 ENST00000416601.1
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr17_-_54991369 1.40 ENST00000537230.1
TRIM25
tripartite motif containing 25
chr1_-_54411255 1.39 ENST00000371377.3
HSPB11
heat shock protein family B (small), member 11
chr5_+_68788594 1.34 ENST00000396442.2
ENST00000380766.2
OCLN
occludin
chr5_-_79946820 1.32 ENST00000604882.1
MTRNR2L2
MT-RNR2-like 2
chr6_-_86353510 1.32 ENST00000444272.1
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr11_-_10530723 1.32 ENST00000536684.1
MTRNR2L8
MT-RNR2-like 8
chr12_+_69004805 1.31 ENST00000541216.1
RAP1B
RAP1B, member of RAS oncogene family
chr7_-_95064264 1.30 ENST00000536183.1
ENST00000433091.2
ENST00000222572.3
PON2
paraoxonase 2
chr6_-_26285737 1.28 ENST00000377727.1
ENST00000289352.1
HIST1H4H
histone cluster 1, H4h
chr6_+_53794780 1.28 ENST00000505762.1
ENST00000511369.1
ENST00000431554.2
MLIP
RP11-411K7.1
muscular LMNA-interacting protein
RP11-411K7.1
chr12_-_56753858 1.24 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
STAT2
signal transducer and activator of transcription 2, 113kDa
chr19_+_12273866 1.22 ENST00000425827.1
ENST00000439995.1
ENST00000343979.4
ENST00000398616.2
ENST00000418338.1
ZNF136
zinc finger protein 136
chr12_+_8850277 1.22 ENST00000539923.1
ENST00000537189.1
RIMKLB
ribosomal modification protein rimK-like family member B
chr17_+_6659153 1.21 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr1_-_52344416 1.19 ENST00000544028.1
NRD1
nardilysin (N-arginine dibasic convertase)
chr7_-_138794394 1.16 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr3_-_113464906 1.16 ENST00000477813.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr12_+_69004619 1.16 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B
RAP1B, member of RAS oncogene family
chr5_+_138678131 1.14 ENST00000394795.2
ENST00000510080.1
PAIP2
poly(A) binding protein interacting protein 2
chr1_+_179262905 1.14 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr5_+_118668846 1.13 ENST00000513374.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr18_-_812517 1.13 ENST00000584307.1
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr19_+_36705504 1.12 ENST00000456324.1
ZNF146
zinc finger protein 146
chr22_+_18632666 1.10 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr12_+_79258547 1.06 ENST00000457153.2
SYT1
synaptotagmin I
chr6_-_100016678 1.06 ENST00000523799.1
ENST00000520429.1
CCNC
cyclin C
chr3_+_159706537 1.04 ENST00000305579.2
ENST00000480787.1
ENST00000466512.1
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr18_+_22006580 1.04 ENST00000284202.4
IMPACT
impact RWD domain protein
chr5_-_95297534 1.03 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr12_+_79258444 1.02 ENST00000261205.4
SYT1
synaptotagmin I
chr6_+_64282447 1.01 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr18_-_51884204 1.00 ENST00000577499.1
ENST00000584040.1
ENST00000581310.1
STARD6
StAR-related lipid transfer (START) domain containing 6
chr5_-_159846066 0.99 ENST00000519349.1
ENST00000520664.1
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr8_+_107630340 0.99 ENST00000497705.1
OXR1
oxidation resistance 1
chr11_+_5710919 0.98 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr15_+_74287035 0.98 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr12_+_49760639 0.96 ENST00000549538.1
ENST00000548654.1
ENST00000550643.1
ENST00000548710.1
ENST00000549179.1
ENST00000548377.1
SPATS2
spermatogenesis associated, serine-rich 2
chr15_-_52263937 0.92 ENST00000315141.5
ENST00000299601.5
LEO1
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chrM_+_10053 0.92 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr4_-_104119528 0.90 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr7_-_138794081 0.90 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr2_+_120770645 0.88 ENST00000443902.2
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr20_-_20033052 0.87 ENST00000536226.1
CRNKL1
crooked neck pre-mRNA splicing factor 1
chr4_-_129208030 0.87 ENST00000503872.1
PGRMC2
progesterone receptor membrane component 2
chr9_-_103115185 0.86 ENST00000374902.4
TEX10
testis expressed 10
chr14_-_45603657 0.86 ENST00000396062.3
FKBP3
FK506 binding protein 3, 25kDa
chr4_-_83295296 0.85 ENST00000507010.1
ENST00000503822.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr7_+_12250886 0.85 ENST00000444443.1
ENST00000396667.3
TMEM106B
transmembrane protein 106B
chr12_+_62654119 0.85 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr18_-_812231 0.84 ENST00000314574.4
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr2_+_85811525 0.83 ENST00000306384.4
VAMP5
vesicle-associated membrane protein 5
chrX_-_77041685 0.82 ENST00000373344.5
ENST00000395603.3
ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr3_+_172468505 0.81 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr17_+_22022437 0.81 ENST00000540040.1
MTRNR2L1
MT-RNR2-like 1
chr19_-_9649303 0.81 ENST00000253115.2
ZNF426
zinc finger protein 426
chr13_+_51483814 0.80 ENST00000336617.3
ENST00000422660.1
RNASEH2B
ribonuclease H2, subunit B
chr1_-_169680745 0.80 ENST00000236147.4
SELL
selectin L
chr5_-_133706695 0.79 ENST00000521755.1
ENST00000523054.1
ENST00000435240.2
ENST00000609654.1
ENST00000536186.1
ENST00000609383.1
CDKL3
cyclin-dependent kinase-like 3
chr7_-_98467629 0.79 ENST00000339375.4
TMEM130
transmembrane protein 130
chr17_-_26903900 0.78 ENST00000395319.3
ENST00000581807.1
ENST00000584086.1
ENST00000395321.2
ALDOC
aldolase C, fructose-bisphosphate
chr3_+_88199099 0.77 ENST00000486971.1
C3orf38
chromosome 3 open reading frame 38
chr2_-_198299726 0.76 ENST00000409915.4
ENST00000487698.1
ENST00000414963.2
ENST00000335508.6
SF3B1
splicing factor 3b, subunit 1, 155kDa
chr4_+_144257915 0.75 ENST00000262995.4
GAB1
GRB2-associated binding protein 1
chr4_-_118006697 0.74 ENST00000310754.4
TRAM1L1
translocation associated membrane protein 1-like 1
chr19_+_11466167 0.73 ENST00000591608.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr7_+_151038850 0.73 ENST00000355851.4
ENST00000566856.1
ENST00000470229.1
NUB1
negative regulator of ubiquitin-like proteins 1
chr3_-_108308241 0.72 ENST00000295746.8
KIAA1524
KIAA1524
chr2_+_113299990 0.70 ENST00000537335.1
ENST00000417433.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr1_-_154580616 0.70 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr4_-_83295103 0.69 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr22_+_36044411 0.68 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr2_+_32390925 0.68 ENST00000440718.1
ENST00000379343.2
ENST00000282587.5
ENST00000435660.1
ENST00000538303.1
ENST00000357055.3
ENST00000406369.1
SLC30A6
solute carrier family 30 (zinc transporter), member 6
chr12_-_51663959 0.68 ENST00000604188.1
ENST00000398453.3
SMAGP
small cell adhesion glycoprotein
chr14_+_105266933 0.68 ENST00000555360.1
ZBTB42
zinc finger and BTB domain containing 42
chr7_+_106809406 0.66 ENST00000468410.1
ENST00000478930.1
ENST00000464009.1
ENST00000222574.4
HBP1
HMG-box transcription factor 1
chr8_+_19536083 0.66 ENST00000519803.1
RP11-1105O14.1
RP11-1105O14.1
chr2_-_99797473 0.65 ENST00000409107.1
ENST00000289359.2
MITD1
MIT, microtubule interacting and transport, domain containing 1
chr1_-_52344471 0.65 ENST00000352171.7
ENST00000354831.7
NRD1
nardilysin (N-arginine dibasic convertase)
chr5_-_76788024 0.64 ENST00000515253.1
ENST00000414719.2
ENST00000507654.1
ENST00000514559.1
ENST00000511791.1
WDR41
WD repeat domain 41
chr2_-_197664366 0.64 ENST00000409364.3
ENST00000263956.3
GTF3C3
general transcription factor IIIC, polypeptide 3, 102kDa
chr2_-_111435610 0.63 ENST00000447014.1
ENST00000420328.1
ENST00000535254.1
ENST00000409311.1
ENST00000302759.6
BUB1
BUB1 mitotic checkpoint serine/threonine kinase
chr12_-_122711968 0.63 ENST00000485724.1
DIABLO
diablo, IAP-binding mitochondrial protein
chr14_+_39736582 0.62 ENST00000556148.1
ENST00000348007.3
CTAGE5
CTAGE family, member 5
chr4_-_11431188 0.61 ENST00000510712.1
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chrX_-_119077695 0.61 ENST00000371410.3
NKAP
NFKB activating protein
chr2_+_120770686 0.60 ENST00000331393.4
ENST00000443124.1
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr10_+_105881906 0.60 ENST00000369727.3
ENST00000336358.5
SFR1
SWI5-dependent recombination repair 1
chr20_+_48789121 0.59 ENST00000411453.1
RP11-112L6.4
RP11-112L6.4
chr12_-_31477072 0.59 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr19_-_9649253 0.59 ENST00000593003.1
ZNF426
zinc finger protein 426
chr4_+_86396265 0.59 ENST00000395184.1
ARHGAP24
Rho GTPase activating protein 24
chr11_-_85522172 0.58 ENST00000316356.4
ENST00000389960.4
ENST00000527523.1
SYTL2
synaptotagmin-like 2
chr11_-_47736896 0.58 ENST00000525123.1
ENST00000528244.1
ENST00000532595.1
ENST00000529154.1
ENST00000530969.1
AGBL2
ATP/GTP binding protein-like 2
chr9_+_102668915 0.58 ENST00000259400.6
ENST00000531035.1
ENST00000525640.1
ENST00000534052.1
ENST00000526607.1
STX17
syntaxin 17
chr11_-_2162162 0.58 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr8_+_82066514 0.57 ENST00000519412.1
ENST00000521953.1
RP11-1149M10.2
RP11-1149M10.2
chr18_+_52385068 0.57 ENST00000586570.1
RAB27B
RAB27B, member RAS oncogene family
chr3_+_52448539 0.57 ENST00000461861.1
PHF7
PHD finger protein 7
chr16_-_3068171 0.55 ENST00000572154.1
ENST00000328796.4
CLDN6
claudin 6
chr2_-_99797390 0.54 ENST00000422537.2
MITD1
MIT, microtubule interacting and transport, domain containing 1
chr4_+_86396321 0.54 ENST00000503995.1
ARHGAP24
Rho GTPase activating protein 24
chr2_+_217277271 0.54 ENST00000425815.1
SMARCAL1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
chr3_-_142166796 0.54 ENST00000392981.2
XRN1
5'-3' exoribonuclease 1
chr5_-_61699698 0.53 ENST00000506390.1
ENST00000199320.4
DIMT1
DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
chr14_+_90528109 0.53 ENST00000282146.4
KCNK13
potassium channel, subfamily K, member 13
chr14_+_89029336 0.53 ENST00000556945.1
ENST00000556158.1
ENST00000557607.1
ZC3H14
zinc finger CCCH-type containing 14
chr4_-_104119488 0.51 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr12_+_54402790 0.51 ENST00000040584.4
HOXC8
homeobox C8
chr1_-_25558963 0.50 ENST00000354361.3
SYF2
SYF2 pre-mRNA-splicing factor
chr6_-_160209471 0.48 ENST00000539948.1
TCP1
t-complex 1
chr12_+_75874460 0.48 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr11_-_2162468 0.48 ENST00000434045.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_+_40118773 0.47 ENST00000472031.1
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr7_-_19748640 0.47 ENST00000222567.5
TWISTNB
TWIST neighbor
chr7_-_98467543 0.46 ENST00000345589.4
TMEM130
transmembrane protein 130
chr12_-_51664058 0.46 ENST00000605627.1
SMAGP
small cell adhesion glycoprotein
chr6_-_82462425 0.45 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr19_-_3029011 0.45 ENST00000590536.1
ENST00000587137.1
ENST00000455444.2
ENST00000262953.6
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr7_-_107883678 0.45 ENST00000417701.1
NRCAM
neuronal cell adhesion molecule
chr8_-_101962777 0.45 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr14_+_89029253 0.44 ENST00000251038.5
ENST00000359301.3
ENST00000302216.8
ZC3H14
zinc finger CCCH-type containing 14
chr3_+_118892411 0.44 ENST00000479520.1
ENST00000494855.1
UPK1B
uroplakin 1B
chr7_-_130598059 0.44 ENST00000432045.2
MIR29B1
microRNA 29a
chr9_+_112542572 0.43 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr2_+_217277137 0.43 ENST00000430374.1
ENST00000357276.4
ENST00000444508.1
SMARCAL1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
chr4_-_103748271 0.43 ENST00000343106.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr5_+_56205878 0.42 ENST00000423328.1
SETD9
SET domain containing 9
chr14_-_103989033 0.41 ENST00000553878.1
ENST00000557530.1
CKB
creatine kinase, brain
chrX_-_85302531 0.41 ENST00000537751.1
ENST00000358786.4
ENST00000357749.2
CHM
choroideremia (Rab escort protein 1)
chr7_-_98467489 0.40 ENST00000416379.2
TMEM130
transmembrane protein 130

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
20.5 61.4 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
13.1 52.5 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
6.4 63.7 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
5.0 104.8 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
3.7 40.6 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
2.6 10.2 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
2.4 29.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.7 6.7 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
1.4 16.4 GO:0060700 regulation of ribonuclease activity(GO:0060700)
1.2 36.5 GO:0035455 response to interferon-alpha(GO:0035455)
0.9 2.7 GO:0071264 regulation of eIF2 alpha phosphorylation by amino acid starvation(GO:0060733) regulation of translational initiation in response to starvation(GO:0071262) positive regulation of translational initiation in response to starvation(GO:0071264)
0.8 2.5 GO:2000625 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.8 2.4 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.7 3.5 GO:0043335 protein unfolding(GO:0043335)
0.5 41.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.5 1.5 GO:1904586 response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586) hepatocyte dedifferentiation(GO:1990828)
0.5 1.5 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.5 1.9 GO:0006601 creatine biosynthetic process(GO:0006601)
0.4 2.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.3 2.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.3 15.7 GO:0010390 histone monoubiquitination(GO:0010390)
0.3 0.8 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.3 8.1 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.2 0.8 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 1.4 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.2 2.6 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 1.5 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.2 1.0 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.2 0.6 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.1 3.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.2 GO:0009447 putrescine catabolic process(GO:0009447)
0.1 0.5 GO:0051808 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.1 1.3 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.6 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.6 GO:0016240 autophagosome docking(GO:0016240)
0.1 2.0 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 1.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 1.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 1.0 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.1 2.5 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 5.9 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.1 2.3 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 1.1 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 0.3 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.9 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 1.3 GO:0070673 response to interleukin-18(GO:0070673)
0.1 2.0 GO:0036120 response to platelet-derived growth factor(GO:0036119) cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.1 0.6 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 0.2 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.1 0.2 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 1.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 1.4 GO:0070986 left/right axis specification(GO:0070986)
0.1 0.4 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 2.3 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.1 0.3 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.1 1.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 1.0 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.1 0.1 GO:1905064 negative regulation of vascular smooth muscle cell differentiation(GO:1905064)
0.1 0.7 GO:0007000 nucleolus organization(GO:0007000)
0.1 0.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 2.8 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.1 0.3 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.1 0.7 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.1 1.3 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.6 GO:0040013 negative regulation of locomotion(GO:0040013)
0.0 0.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.8 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 1.0 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.2 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.6 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.8 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.2 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.0 1.6 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.3 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.1 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 1.1 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.1 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.0 0.2 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.5 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0050748 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) negative regulation of lipoprotein metabolic process(GO:0050748)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 2.1 GO:0048806 genitalia development(GO:0048806)
0.0 0.4 GO:0090168 Golgi reassembly(GO:0090168)
0.0 2.3 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 1.8 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.2 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.5 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.1 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.1 GO:0038183 bile acid signaling pathway(GO:0038183)
0.0 1.1 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 0.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.3 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.8 GO:0033198 response to ATP(GO:0033198)
0.0 0.6 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.8 GO:0097484 dendrite extension(GO:0097484)
0.0 0.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.3 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 0.8 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.0 GO:0032268 regulation of cellular protein metabolic process(GO:0032268)
0.0 0.7 GO:0030855 epithelial cell differentiation(GO:0030855)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.3 0.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 56.3 GO:0032587 ruffle membrane(GO:0032587)
0.2 2.1 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.2 1.3 GO:0097452 GAIT complex(GO:0097452)
0.2 0.8 GO:0031933 telomeric heterochromatin(GO:0031933)
0.2 112.3 GO:0031965 nuclear membrane(GO:0031965)
0.2 3.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.2 2.5 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.6 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.1 1.2 GO:0031415 NatA complex(GO:0031415)
0.1 0.8 GO:0097149 centralspindlin complex(GO:0097149)
0.1 1.5 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 64.6 GO:0045121 membrane raft(GO:0045121)
0.1 2.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 1.0 GO:0031906 late endosome lumen(GO:0031906)
0.1 69.6 GO:0010008 endosome membrane(GO:0010008)
0.1 0.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 2.7 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.9 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 0.8 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.6 GO:0030897 HOPS complex(GO:0030897)
0.1 2.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.6 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 1.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 1.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 9.0 GO:0005840 ribosome(GO:0005840)
0.0 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.8 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 70.2 GO:0005739 mitochondrion(GO:0005739)
0.0 0.6 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.2 GO:0030686 90S preribosome(GO:0030686)
0.0 1.2 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 1.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.5 GO:0043194 axon initial segment(GO:0043194)
0.0 8.8 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.4 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.8 GO:0014704 intercalated disc(GO:0014704)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.0 GO:0005884 actin filament(GO:0005884)
0.0 1.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 47.9 GO:0005654 nucleoplasm(GO:0005654)
0.0 0.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 61.0 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
3.0 63.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
1.7 10.5 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
1.7 6.7 GO:0009041 uridylate kinase activity(GO:0009041)
1.3 39.9 GO:0070403 NAD+ binding(GO:0070403)
1.2 15.7 GO:0031386 protein tag(GO:0031386)
0.9 9.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.8 2.4 GO:0004145 diamine N-acetyltransferase activity(GO:0004145) polyamine binding(GO:0019808)
0.6 1.9 GO:0015067 amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068)
0.5 67.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.4 1.3 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.4 61.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.4 1.2 GO:0072591 citrate-L-glutamate ligase activity(GO:0072591)
0.4 2.0 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.3 1.0 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.3 1.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.3 1.1 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.3 0.3 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.3 3.5 GO:0030911 TPR domain binding(GO:0030911)
0.3 0.8 GO:0043208 glycosphingolipid binding(GO:0043208)
0.2 7.7 GO:0005521 lamin binding(GO:0005521)
0.2 104.1 GO:0008017 microtubule binding(GO:0008017)
0.2 2.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.2 0.8 GO:0015616 DNA translocase activity(GO:0015616)
0.1 1.0 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 0.7 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 2.9 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.8 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.9 GO:0050815 phosphoserine binding(GO:0050815)
0.1 3.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.5 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.6 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.1 3.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.4 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.1 0.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 1.0 GO:0036310 annealing helicase activity(GO:0036310) annealing activity(GO:0097617)
0.1 6.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.3 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.2 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 13.7 GO:0042393 histone binding(GO:0042393)
0.0 3.1 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.4 GO:0004111 creatine kinase activity(GO:0004111)
0.0 1.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 2.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.3 GO:0051880 5'-3' exoribonuclease activity(GO:0004534) G-quadruplex DNA binding(GO:0051880)
0.0 3.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 2.7 GO:0043022 ribosome binding(GO:0043022)
0.0 2.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 1.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 1.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0008124 phenylalanine 4-monooxygenase activity(GO:0004505) 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
0.0 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 1.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0038181 bile acid receptor activity(GO:0038181)
0.0 0.5 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 1.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.3 GO:0008061 chitin binding(GO:0008061)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.0 GO:0000405 bubble DNA binding(GO:0000405)
0.0 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.1 GO:1903136 cuprous ion binding(GO:1903136)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 11.5 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.3 63.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 1.0 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 12.8 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 3.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 8.1 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 2.6 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 1.0 PID IL27 PATHWAY IL27-mediated signaling events
0.1 2.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 2.1 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 2.9 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.1 PID ATR PATHWAY ATR signaling pathway
0.0 0.7 PID MYC PATHWAY C-MYC pathway
0.0 1.1 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 116.9 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
2.5 223.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 9.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 6.6 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.1 2.1 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.1 10.5 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 2.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.5 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 1.5 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 11.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 1.4 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 1.1 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.8 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.4 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 5.9 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.5 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.1 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint