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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRX3

Z-value: 0.58

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Transcription factors associated with IRX3

Gene Symbol Gene ID Gene Info
IRX3
ENSG00000177508.11 iroquois homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX3hg19_v2_chr16_-_54320675_54320715-0.503.2e-01Click!

Activity profile of IRX3 motif

Sorted Z-values of IRX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_2912363 0.62 ENST00000544366.1
FKBP4
FK506 binding protein 4, 59kDa
chr17_+_58018269 0.45 ENST00000591035.1
RP11-178C3.1
Uncharacterized protein
chr15_-_56757329 0.39 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr7_-_92777606 0.38 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr11_-_104480019 0.33 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
RP11-886D15.1
chr9_-_4679419 0.33 ENST00000609131.1
ENST00000607997.1
RP11-6J24.6
RP11-6J24.6
chr8_+_95558771 0.33 ENST00000391679.1
AC023632.1
HCG2009141; PRO2397; Uncharacterized protein
chr15_+_81225699 0.32 ENST00000560027.1
KIAA1199
KIAA1199
chr3_-_122283100 0.30 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283079 0.29 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_+_171561127 0.29 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr19_-_44388116 0.28 ENST00000587539.1
ZNF404
zinc finger protein 404
chr8_-_145060593 0.28 ENST00000313059.5
ENST00000524918.1
ENST00000313028.7
ENST00000525773.1
PARP10
poly (ADP-ribose) polymerase family, member 10
chr10_+_91092241 0.27 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr17_-_7108436 0.27 ENST00000493294.1
DLG4
discs, large homolog 4 (Drosophila)
chr4_+_141264597 0.27 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr1_-_197744763 0.26 ENST00000422998.1
DENND1B
DENN/MADD domain containing 1B
chr2_-_36779411 0.25 ENST00000406220.1
AC007401.2
Uncharacterized protein
chr13_+_97928395 0.25 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr4_+_75480629 0.22 ENST00000380846.3
AREGB
amphiregulin B
chr1_-_62190793 0.22 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr16_-_66864806 0.22 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chr11_-_63330842 0.22 ENST00000255695.1
HRASLS2
HRAS-like suppressor 2
chr2_-_145275109 0.22 ENST00000431672.2
ZEB2
zinc finger E-box binding homeobox 2
chr2_+_234621551 0.21 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr3_+_122044084 0.21 ENST00000264474.3
ENST00000479204.1
CSTA
cystatin A (stefin A)
chr7_-_6388389 0.21 ENST00000578372.1
FAM220A
family with sequence similarity 220, member A
chr14_+_57671888 0.21 ENST00000391612.1
AL391152.1
AL391152.1
chr4_+_156824840 0.21 ENST00000536354.2
TDO2
tryptophan 2,3-dioxygenase
chr3_-_49851313 0.21 ENST00000333486.3
UBA7
ubiquitin-like modifier activating enzyme 7
chr4_+_26344754 0.20 ENST00000515573.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr4_-_70080449 0.20 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr16_+_48657361 0.20 ENST00000565072.1
RP11-42I10.1
RP11-42I10.1
chr4_-_144826682 0.19 ENST00000358615.4
ENST00000437468.2
GYPE
glycophorin E (MNS blood group)
chr17_+_74846230 0.19 ENST00000592919.1
LINC00868
long intergenic non-protein coding RNA 868
chrX_-_83757399 0.19 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
HDX
highly divergent homeobox
chr9_-_19065082 0.19 ENST00000415524.1
HAUS6
HAUS augmin-like complex, subunit 6
chr1_+_87458692 0.19 ENST00000370548.2
ENST00000356813.4
RP5-1052I5.2
HS2ST1
Heparan sulfate 2-O-sulfotransferase 1
heparan sulfate 2-O-sulfotransferase 1
chr3_+_122283064 0.19 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr11_+_57365150 0.19 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr13_-_88323218 0.19 ENST00000436290.2
ENST00000453832.2
ENST00000606590.1
MIR4500HG
MIR4500 host gene (non-protein coding)
chr3_+_122399444 0.19 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr13_-_111522162 0.18 ENST00000538077.1
LINC00346
long intergenic non-protein coding RNA 346
chr1_+_97188188 0.18 ENST00000541987.1
PTBP2
polypyrimidine tract binding protein 2
chr21_-_16374688 0.18 ENST00000411932.1
NRIP1
nuclear receptor interacting protein 1
chr2_-_37068530 0.18 ENST00000593798.1
AC007382.1
Uncharacterized protein
chr13_+_50589390 0.18 ENST00000360473.4
ENST00000312942.1
KCNRG
potassium channel regulator
chr2_-_207629997 0.18 ENST00000454776.2
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr9_+_26746951 0.18 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chr6_+_127587755 0.18 ENST00000368314.1
ENST00000476956.1
ENST00000609447.1
ENST00000356799.2
ENST00000477776.1
ENST00000609944.1
RNF146
ring finger protein 146
chr4_-_39367949 0.17 ENST00000503784.1
ENST00000349703.2
ENST00000381897.1
RFC1
replication factor C (activator 1) 1, 145kDa
chr1_-_197115818 0.17 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr4_+_74606223 0.17 ENST00000307407.3
ENST00000401931.1
IL8
interleukin 8
chrX_-_15683147 0.17 ENST00000380342.3
TMEM27
transmembrane protein 27
chr2_-_113594279 0.17 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr8_+_94767072 0.17 ENST00000452276.1
ENST00000453321.3
ENST00000498673.1
ENST00000518319.1
TMEM67
transmembrane protein 67
chr5_+_68485433 0.16 ENST00000502689.1
CENPH
centromere protein H
chr19_-_695427 0.15 ENST00000329267.7
PRSS57
protease, serine, 57
chr2_+_169658928 0.15 ENST00000317647.7
ENST00000445023.2
NOSTRIN
nitric oxide synthase trafficking
chr7_-_33080506 0.15 ENST00000381626.2
ENST00000409467.1
ENST00000449201.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr8_-_97247759 0.15 ENST00000518406.1
ENST00000523920.1
ENST00000287022.5
UQCRB
ubiquinol-cytochrome c reductase binding protein
chr5_+_118668846 0.15 ENST00000513374.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr12_-_76462713 0.15 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr12_+_21679220 0.15 ENST00000256969.2
C12orf39
chromosome 12 open reading frame 39
chr3_+_180586536 0.15 ENST00000465551.1
FXR1
fragile X mental retardation, autosomal homolog 1
chr1_+_63989004 0.15 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr20_+_10199468 0.15 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr7_+_120591170 0.14 ENST00000431467.1
ING3
inhibitor of growth family, member 3
chr2_+_160590469 0.14 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr12_+_56114151 0.14 ENST00000547072.1
ENST00000552930.1
ENST00000257895.5
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr13_+_113030658 0.14 ENST00000414180.1
ENST00000443541.1
SPACA7
sperm acrosome associated 7
chr14_+_56127989 0.14 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr2_+_46926048 0.14 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chr4_-_104119528 0.14 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr5_+_162887556 0.14 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
HMMR
hyaluronan-mediated motility receptor (RHAMM)
chr18_+_33709834 0.14 ENST00000358232.6
ENST00000351393.6
ENST00000442325.2
ENST00000423854.2
ENST00000350494.6
ENST00000542824.1
ELP2
elongator acetyltransferase complex subunit 2
chr4_-_104119488 0.14 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr6_+_126277842 0.13 ENST00000229633.5
HINT3
histidine triad nucleotide binding protein 3
chr4_+_130017268 0.13 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr11_+_33037652 0.13 ENST00000311388.3
DEPDC7
DEP domain containing 7
chr2_-_70189397 0.13 ENST00000320256.4
ASPRV1
aspartic peptidase, retroviral-like 1
chr2_-_231090344 0.13 ENST00000540870.1
ENST00000416610.1
SP110
SP110 nuclear body protein
chr11_+_114310237 0.13 ENST00000539119.1
REXO2
RNA exonuclease 2
chr9_+_42704004 0.13 ENST00000457288.1
CBWD7
COBW domain containing 7
chr5_+_41904431 0.13 ENST00000381647.2
C5orf51
chromosome 5 open reading frame 51
chr7_-_143892748 0.13 ENST00000378115.2
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr2_+_114163945 0.13 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr12_+_58335360 0.13 ENST00000300145.3
XRCC6BP1
XRCC6 binding protein 1
chr3_-_185641681 0.13 ENST00000259043.7
TRA2B
transformer 2 beta homolog (Drosophila)
chr4_-_141348999 0.13 ENST00000325617.5
CLGN
calmegin
chr7_+_6121296 0.13 ENST00000428901.1
AC004895.4
AC004895.4
chr2_+_234590556 0.13 ENST00000373426.3
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr7_-_22539771 0.13 ENST00000406890.2
ENST00000424363.1
STEAP1B
STEAP family member 1B
chr7_-_45956856 0.12 ENST00000428530.1
IGFBP3
insulin-like growth factor binding protein 3
chr2_+_161993465 0.12 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr18_-_61329118 0.12 ENST00000332821.8
ENST00000283752.5
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr6_+_64346386 0.12 ENST00000509330.1
PHF3
PHD finger protein 3
chr12_-_100486668 0.12 ENST00000550544.1
ENST00000551980.1
ENST00000548045.1
ENST00000545232.2
ENST00000551973.1
UHRF1BP1L
UHRF1 binding protein 1-like
chr5_+_54455946 0.12 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
GPX8
glutathione peroxidase 8 (putative)
chr13_+_96085847 0.12 ENST00000376873.3
CLDN10
claudin 10
chr1_+_242011485 0.12 ENST00000423131.1
ENST00000523590.1
EXO1
exonuclease 1
chr11_+_1718425 0.12 ENST00000382160.1
KRTAP5-6
keratin associated protein 5-6
chr3_-_149470229 0.12 ENST00000473414.1
COMMD2
COMM domain containing 2
chr21_-_48024986 0.12 ENST00000291700.4
ENST00000367071.4
S100B
S100 calcium binding protein B
chr8_-_50466973 0.12 ENST00000520800.1
RP11-738G5.2
Uncharacterized protein
chr17_-_29641104 0.12 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr1_-_89488510 0.12 ENST00000564665.1
ENST00000370481.4
GBP3
guanylate binding protein 3
chr2_+_9983483 0.12 ENST00000263663.5
TAF1B
TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
chr9_-_135230336 0.12 ENST00000224140.5
ENST00000372169.2
ENST00000393220.1
SETX
senataxin
chr11_-_134123142 0.12 ENST00000392595.2
ENST00000341541.3
ENST00000352327.5
ENST00000392594.3
THYN1
thymocyte nuclear protein 1
chr2_+_170440844 0.12 ENST00000260970.3
ENST00000433207.1
ENST00000409714.3
ENST00000462903.1
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr1_+_158985457 0.11 ENST00000567661.1
ENST00000474473.1
IFI16
interferon, gamma-inducible protein 16
chr4_+_56212505 0.11 ENST00000505210.1
SRD5A3
steroid 5 alpha-reductase 3
chr7_-_45957011 0.11 ENST00000417621.1
IGFBP3
insulin-like growth factor binding protein 3
chr11_-_125773085 0.11 ENST00000227474.3
ENST00000534158.1
ENST00000529801.1
PUS3
pseudouridylate synthase 3
chr16_-_3493528 0.11 ENST00000301744.4
ZNF597
zinc finger protein 597
chr9_+_100174232 0.11 ENST00000355295.4
TDRD7
tudor domain containing 7
chr8_+_101349823 0.11 ENST00000519566.1
KB-1991G8.1
KB-1991G8.1
chr12_-_92536433 0.11 ENST00000551563.2
ENST00000546975.1
ENST00000549802.1
C12orf79
chromosome 12 open reading frame 79
chr12_-_123728548 0.11 ENST00000545406.1
MPHOSPH9
M-phase phosphoprotein 9
chr4_-_103998439 0.11 ENST00000503230.1
ENST00000503818.1
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr7_-_16685422 0.11 ENST00000306999.2
ANKMY2
ankyrin repeat and MYND domain containing 2
chr1_+_196788887 0.11 ENST00000320493.5
ENST00000367424.4
ENST00000367421.3
CFHR1
CFHR2
complement factor H-related 1
complement factor H-related 2
chr12_-_13248598 0.11 ENST00000337630.6
ENST00000545699.1
GSG1
germ cell associated 1
chr19_-_23456996 0.11 ENST00000594653.1
RP11-15H20.7
RP11-15H20.7
chr17_+_74729060 0.11 ENST00000587459.1
RP11-318A15.7
Uncharacterized protein
chr2_+_207630081 0.11 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr1_+_207070775 0.11 ENST00000391929.3
ENST00000294984.2
ENST00000367093.3
IL24
interleukin 24
chr2_+_170440902 0.11 ENST00000448752.2
ENST00000418888.1
ENST00000414307.1
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr2_+_161993412 0.11 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chrX_-_15353629 0.10 ENST00000333590.4
ENST00000428964.1
ENST00000542278.1
PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr20_-_36156264 0.10 ENST00000445723.1
ENST00000414080.1
BLCAP
bladder cancer associated protein
chr10_+_79793518 0.10 ENST00000440692.1
ENST00000435275.1
ENST00000372360.3
ENST00000360830.4
RPS24
ribosomal protein S24
chr7_+_116502527 0.10 ENST00000361183.3
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr12_+_14572070 0.10 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
ATF7IP
activating transcription factor 7 interacting protein
chr4_-_70725856 0.10 ENST00000226444.3
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr10_+_118349920 0.10 ENST00000531984.1
PNLIPRP1
pancreatic lipase-related protein 1
chr6_-_111804905 0.10 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr10_-_30637906 0.10 ENST00000417581.1
MTPAP
mitochondrial poly(A) polymerase
chr14_+_56127960 0.10 ENST00000553624.1
KTN1
kinectin 1 (kinesin receptor)
chr2_+_38177575 0.10 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr22_-_50970919 0.10 ENST00000329363.4
ENST00000437588.1
ODF3B
outer dense fiber of sperm tails 3B
chr16_+_20775358 0.10 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr4_+_41992489 0.10 ENST00000264451.7
SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr4_+_75310851 0.10 ENST00000395748.3
ENST00000264487.2
AREG
amphiregulin
chr12_-_26986076 0.10 ENST00000381340.3
ITPR2
inositol 1,4,5-trisphosphate receptor, type 2
chr12_-_10282742 0.10 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr2_-_207630033 0.10 ENST00000449792.1
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr1_+_201924619 0.10 ENST00000367287.4
TIMM17A
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr11_+_35211429 0.10 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
CD44
CD44 molecule (Indian blood group)
chr7_+_33169142 0.10 ENST00000242067.6
ENST00000350941.3
ENST00000396127.2
ENST00000355070.2
ENST00000354265.4
ENST00000425508.2
BBS9
Bardet-Biedl syndrome 9
chr11_+_17281900 0.10 ENST00000530527.1
NUCB2
nucleobindin 2
chr10_+_91461337 0.10 ENST00000260753.4
ENST00000416354.1
ENST00000394289.2
ENST00000371728.3
KIF20B
kinesin family member 20B
chr5_+_115420688 0.10 ENST00000274458.4
COMMD10
COMM domain containing 10
chr7_-_99527243 0.10 ENST00000312891.2
GJC3
gap junction protein, gamma 3, 30.2kDa
chrX_+_108779004 0.10 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr9_-_117568365 0.10 ENST00000374045.4
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr2_-_231989808 0.10 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr8_+_52730143 0.09 ENST00000415643.1
AC090186.1
Uncharacterized protein
chr13_-_37573432 0.09 ENST00000413537.2
ENST00000443765.1
ENST00000239891.3
ALG5
ALG5, dolichyl-phosphate beta-glucosyltransferase
chr10_-_18944123 0.09 ENST00000606425.1
RP11-139J15.7
Uncharacterized protein
chr17_+_22022437 0.09 ENST00000540040.1
MTRNR2L1
MT-RNR2-like 1
chr19_-_20844368 0.09 ENST00000595094.1
ENST00000601440.1
ENST00000291750.6
CTC-513N18.7
ZNF626
CTC-513N18.7
zinc finger protein 626
chr17_-_34207295 0.09 ENST00000463941.1
ENST00000293272.3
CCL5
chemokine (C-C motif) ligand 5
chr21_+_35736302 0.09 ENST00000290310.3
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr2_+_113299990 0.09 ENST00000537335.1
ENST00000417433.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr2_+_143635222 0.09 ENST00000375773.2
ENST00000409512.1
ENST00000410015.2
KYNU
kynureninase
chr13_-_44735393 0.09 ENST00000400419.1
SMIM2
small integral membrane protein 2
chr6_-_88038996 0.09 ENST00000525899.1
GJB7
gap junction protein, beta 7, 25kDa
chr1_+_67395922 0.09 ENST00000401042.3
ENST00000355356.3
MIER1
mesoderm induction early response 1, transcriptional regulator
chr10_-_14614311 0.09 ENST00000479731.1
ENST00000468492.1
FAM107B
family with sequence similarity 107, member B
chr15_+_47631257 0.09 ENST00000560636.1
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr10_+_13628933 0.09 ENST00000417658.1
ENST00000320054.4
PRPF18
pre-mRNA processing factor 18
chr18_-_53303123 0.09 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
TCF4
transcription factor 4
chr6_-_27440837 0.09 ENST00000211936.6
ZNF184
zinc finger protein 184
chr11_+_114166536 0.09 ENST00000299964.3
NNMT
nicotinamide N-methyltransferase
chr7_+_40174565 0.09 ENST00000309930.5
ENST00000401647.2
ENST00000335693.4
ENST00000413931.1
ENST00000416370.1
ENST00000540834.1
C7orf10
succinylCoA:glutarate-CoA transferase
chr1_-_85156417 0.09 ENST00000422026.1
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr4_-_38784592 0.09 ENST00000502321.1
TLR10
toll-like receptor 10
chr10_+_127371798 0.09 ENST00000596068.1
ENST00000607914.1
ENST00000415305.2
ENST00000449693.1
RP11-383C5.3
RP11-383C5.3
chr14_-_31856397 0.09 ENST00000538864.2
ENST00000550366.1
HEATR5A
HEAT repeat containing 5A
chr17_-_74547256 0.09 ENST00000589145.1
CYGB
cytoglobin
chr12_+_133757995 0.09 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268
zinc finger protein 268
chr5_+_118604439 0.09 ENST00000388882.5
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr14_+_29299437 0.09 ENST00000550827.1
ENST00000548087.1
ENST00000551588.1
ENST00000550122.1
CTD-2384A14.1
CTD-2384A14.1
chr4_+_113558612 0.09 ENST00000505034.1
ENST00000324052.6
LARP7
La ribonucleoprotein domain family, member 7
chr20_+_35504522 0.09 ENST00000602922.1
ENST00000217320.3
TLDC2
TBC/LysM-associated domain containing 2
chr1_+_196743943 0.09 ENST00000471440.2
ENST00000391985.3
CFHR3
complement factor H-related 3
chr17_-_63822563 0.09 ENST00000317442.8
CEP112
centrosomal protein 112kDa
chr11_+_60739249 0.08 ENST00000542157.1
ENST00000433107.2
ENST00000452451.2
ENST00000352009.5
CD6
CD6 molecule
chr6_-_79944336 0.08 ENST00000344726.5
ENST00000275036.7
HMGN3
high mobility group nucleosomal binding domain 3
chr5_+_169011033 0.08 ENST00000513795.1
SPDL1
spindle apparatus coiled-coil protein 1
chr14_+_39944025 0.08 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
RP11-111A21.1
chr4_+_41361616 0.08 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr1_+_44584522 0.08 ENST00000372299.3
KLF17
Kruppel-like factor 17
chr15_+_69706643 0.08 ENST00000352331.4
ENST00000260363.4
KIF23
kinesin family member 23
chr5_+_32788945 0.08 ENST00000326958.1
AC026703.1
AC026703.1
chr2_+_202125219 0.08 ENST00000323492.7
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr5_+_64859066 0.08 ENST00000261308.5
ENST00000535264.1
ENST00000538977.1
PPWD1
peptidylprolyl isomerase domain and WD repeat containing 1
chr11_+_57531292 0.08 ENST00000524579.1
CTNND1
catenin (cadherin-associated protein), delta 1

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.3 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.2 GO:0001543 ovarian follicle rupture(GO:0001543)
0.1 0.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.3 GO:0070980 biphenyl catabolic process(GO:0070980)
0.1 0.2 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.0 0.2 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 0.3 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.1 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.0 0.1 GO:0035425 autocrine signaling(GO:0035425)
0.0 0.3 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.1 GO:0001188 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.1 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0071048 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.0 0.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.2 GO:1905068 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.7 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:0016095 polyprenol catabolic process(GO:0016095)
0.0 0.3 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.1 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.3 GO:0070487 monocyte aggregation(GO:0070487)
0.0 0.1 GO:0000921 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.0 0.1 GO:0003095 pressure natriuresis(GO:0003095)
0.0 0.1 GO:0051552 flavone metabolic process(GO:0051552)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.1 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.0 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.0 0.0 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.1 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.1 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.0 0.1 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.1 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.1 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0021767 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.2 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.1 GO:0039506 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.0 0.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.1 GO:0032954 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.0 0.4 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.0 GO:0033488 cholesterol biosynthetic process via 24,25-dihydrolanosterol(GO:0033488)
0.0 0.0 GO:0032730 positive regulation of interleukin-1 alpha production(GO:0032730) positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.1 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.3 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.0 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.1 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.1 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
0.0 0.0 GO:0043105 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.0 0.1 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.0 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.1 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.0 0.1 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.2 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.0 0.1 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.1 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:1904693 midbrain morphogenesis(GO:1904693)
0.0 0.0 GO:0072106 regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.0 0.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.2 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.3 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.1 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:0097636 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 0.1 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.0 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.0 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0070069 cytochrome complex(GO:0070069)
0.0 0.0 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.0 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.2 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160)
0.1 0.2 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.1 0.3 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.6 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.1 GO:0051908 double-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0051908)
0.0 0.1 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.2 GO:0001884 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
0.0 0.2 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.2 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.0 0.3 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.2 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.0 0.1 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.2 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.1 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.0 0.1 GO:0070538 oleic acid binding(GO:0070538)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.1 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.0 1.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.0 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.1 GO:0004040 amidase activity(GO:0004040)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.0 GO:0008398 sterol 14-demethylase activity(GO:0008398)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.1 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.0 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.0 0.1 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.0 GO:0019961 interferon binding(GO:0019961)
0.0 0.0 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.1 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.1 GO:0052828 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.0 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway