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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRX6_IRX4

Z-value: 0.26

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.7 iroquois homeobox 6
IRX4
ENSG00000113430.5 iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_1883003-0.414.2e-01Click!
IRX6hg19_v2_chr16_+_55357672_55357672-0.108.5e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_141264597 0.62 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr12_-_123728548 0.17 ENST00000545406.1
MPHOSPH9
M-phase phosphoprotein 9
chr9_+_26746951 0.17 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chr3_+_53528659 0.16 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr4_-_104119528 0.14 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr3_-_27498235 0.12 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr12_-_76462713 0.11 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr7_+_23210760 0.11 ENST00000366347.4
AC005082.1
Uncharacterized protein
chr15_-_63448973 0.09 ENST00000462430.1
RPS27L
ribosomal protein S27-like
chr6_+_149887377 0.09 ENST00000367419.5
GINM1
glycoprotein integral membrane 1
chr4_-_104119488 0.09 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr1_+_63989004 0.08 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr4_+_130017268 0.08 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr8_+_84824920 0.07 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr3_+_186158169 0.07 ENST00000435548.1
ENST00000421006.1
RP11-78H24.1
RP11-78H24.1
chr7_-_16844611 0.07 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr15_-_64665911 0.07 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr17_+_38673270 0.07 ENST00000578280.1
RP5-1028K7.2
RP5-1028K7.2
chr2_+_160590469 0.06 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr4_+_123653882 0.05 ENST00000433287.1
BBS12
Bardet-Biedl syndrome 12
chr12_+_32655048 0.05 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr8_+_27631903 0.05 ENST00000305188.8
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr1_+_220267429 0.05 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr14_+_56127960 0.04 ENST00000553624.1
KTN1
kinectin 1 (kinesin receptor)
chr14_+_56127989 0.04 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr8_-_17555164 0.04 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr2_+_58655520 0.04 ENST00000455219.3
ENST00000449448.2
AC007092.1
long intergenic non-protein coding RNA 1122
chr4_-_143481822 0.04 ENST00000510812.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr8_+_67976593 0.04 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr17_-_29641104 0.04 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr1_+_212475148 0.04 ENST00000537030.3
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr6_-_33679452 0.04 ENST00000374231.4
ENST00000607484.1
ENST00000374214.3
UQCC2
ubiquinol-cytochrome c reductase complex assembly factor 2
chr22_-_24096562 0.03 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr15_+_81225699 0.03 ENST00000560027.1
KIAA1199
KIAA1199
chr10_+_90660832 0.03 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr20_+_10199468 0.03 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr2_+_58655461 0.03 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr10_-_115904361 0.03 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chrX_-_19988382 0.03 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr2_-_238333919 0.03 ENST00000409162.1
AC112721.1
Uncharacterized protein
chr4_+_113558612 0.02 ENST00000505034.1
ENST00000324052.6
LARP7
La ribonucleoprotein domain family, member 7
chr6_-_117747015 0.02 ENST00000368508.3
ENST00000368507.3
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr3_-_139199589 0.02 ENST00000506825.1
RBP2
retinol binding protein 2, cellular
chr18_-_46784778 0.02 ENST00000582399.1
DYM
dymeclin
chr18_-_28622774 0.02 ENST00000434452.1
DSC3
desmocollin 3
chr18_-_47376197 0.02 ENST00000592688.1
MYO5B
myosin VB
chr13_-_41768654 0.02 ENST00000379483.3
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr3_-_168865522 0.02 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr7_+_6121296 0.02 ENST00000428901.1
AC004895.4
AC004895.4
chr8_-_67976509 0.02 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr4_+_158141899 0.02 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr10_+_86184676 0.01 ENST00000543283.1
CCSER2
coiled-coil serine-rich protein 2
chr1_-_152086556 0.01 ENST00000368804.1
TCHH
trichohyalin
chr2_-_231989808 0.01 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr4_+_158142750 0.01 ENST00000505888.1
ENST00000449365.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr4_-_153303658 0.01 ENST00000296555.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr3_+_111630451 0.01 ENST00000495180.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr2_+_113670548 0.01 ENST00000263326.3
ENST00000352179.3
ENST00000349806.3
ENST00000353225.3
IL37
interleukin 37
chr9_-_27573651 0.01 ENST00000379995.1
ENST00000379997.3
C9orf72
chromosome 9 open reading frame 72
chr18_-_70305745 0.01 ENST00000581073.1
CBLN2
cerebellin 2 precursor
chr1_+_53308398 0.01 ENST00000371528.1
ZYG11A
zyg-11 family member A, cell cycle regulator
chrX_+_99899180 0.01 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr12_+_32655110 0.01 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr16_+_777118 0.01 ENST00000562141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr14_-_106845789 0.00 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr4_+_41361616 0.00 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr3_+_111758553 0.00 ENST00000419127.1
TMPRSS7
transmembrane protease, serine 7
chr21_-_48024986 0.00 ENST00000291700.4
ENST00000367071.4
S100B
S100 calcium binding protein B
chr1_+_67673297 0.00 ENST00000425614.1
ENST00000395227.1
IL23R
interleukin 23 receptor
chr3_+_171561127 0.00 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr14_-_68159152 0.00 ENST00000554035.1
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr15_+_66585555 0.00 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.2 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.2 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.0 0.0 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 0.0 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)