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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ISL2

Z-value: 0.69

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Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ISL2
ENSG00000159556.5 ISL LIM homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL2hg19_v2_chr15_+_76629064_76629073-0.039.5e-01Click!

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_4710288 0.71 ENST00000571067.1
RP11-81A22.5
RP11-81A22.5
chr14_+_61449197 0.59 ENST00000533744.2
SLC38A6
solute carrier family 38, member 6
chr4_+_95128748 0.54 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr10_+_63422695 0.43 ENST00000330194.2
ENST00000389639.3
C10orf107
chromosome 10 open reading frame 107
chr7_-_81635106 0.37 ENST00000443883.1
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr4_+_169013666 0.36 ENST00000359299.3
ANXA10
annexin A10
chr5_+_40841410 0.35 ENST00000381677.3
CARD6
caspase recruitment domain family, member 6
chr12_+_75784850 0.32 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr3_+_172468505 0.30 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr14_-_51027838 0.29 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr3_+_172468472 0.28 ENST00000232458.5
ENST00000392692.3
ECT2
epithelial cell transforming sequence 2 oncogene
chr3_+_136649311 0.28 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr5_-_54988448 0.27 ENST00000503817.1
ENST00000512595.1
SLC38A9
solute carrier family 38, member 9
chr14_+_57671888 0.26 ENST00000391612.1
AL391152.1
AL391152.1
chr18_-_64271316 0.26 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chrX_-_84634737 0.25 ENST00000262753.4
POF1B
premature ovarian failure, 1B
chr9_-_99540328 0.24 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr11_-_58378759 0.24 ENST00000601906.1
AP001350.1
Uncharacterized protein
chr16_+_53133070 0.22 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr18_-_53303123 0.22 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
TCF4
transcription factor 4
chr4_+_128702969 0.21 ENST00000508776.1
ENST00000439123.2
HSPA4L
heat shock 70kDa protein 4-like
chr1_+_152178320 0.21 ENST00000429352.1
RP11-107M16.2
RP11-107M16.2
chr11_-_28129656 0.21 ENST00000263181.6
KIF18A
kinesin family member 18A
chr4_+_25162253 0.21 ENST00000512921.1
PI4K2B
phosphatidylinositol 4-kinase type 2 beta
chrM_+_10053 0.21 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr5_+_32788945 0.21 ENST00000326958.1
AC026703.1
AC026703.1
chr15_-_98417780 0.21 ENST00000503874.3
LINC00923
long intergenic non-protein coding RNA 923
chr12_+_64798095 0.20 ENST00000332707.5
XPOT
exportin, tRNA
chr2_-_87248975 0.20 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chrX_+_108779004 0.19 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr10_-_115904361 0.19 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chrM_+_9207 0.18 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr12_-_58212487 0.18 ENST00000549994.1
AVIL
advillin
chr6_-_111804905 0.18 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr4_+_26344754 0.17 ENST00000515573.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr5_+_110427983 0.17 ENST00000513710.2
ENST00000505303.1
WDR36
WD repeat domain 36
chr4_+_95128996 0.17 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr16_-_3350614 0.17 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr3_-_20227619 0.16 ENST00000425061.1
ENST00000443724.1
ENST00000421451.1
ENST00000452020.1
ENST00000417364.1
ENST00000306698.2
ENST00000419233.2
ENST00000263753.4
ENST00000383774.1
ENST00000437051.1
ENST00000412868.1
ENST00000429446.3
ENST00000442720.1
SGOL1
shugoshin-like 1 (S. pombe)
chr11_+_28129795 0.15 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15
methyltransferase like 15
chr14_-_73997901 0.15 ENST00000557603.1
ENST00000556455.1
HEATR4
HEAT repeat containing 4
chr4_-_185275104 0.15 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chr14_+_45605157 0.15 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chr16_-_1538765 0.15 ENST00000447419.2
ENST00000440447.2
PTX4
pentraxin 4, long
chr15_+_90735145 0.15 ENST00000559792.1
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr3_+_138327542 0.14 ENST00000360570.3
ENST00000393035.2
FAIM
Fas apoptotic inhibitory molecule
chr1_+_99127225 0.14 ENST00000370189.5
ENST00000529992.1
SNX7
sorting nexin 7
chr18_+_61575200 0.14 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr8_-_121457608 0.14 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chr3_+_138327417 0.14 ENST00000338446.4
FAIM
Fas apoptotic inhibitory molecule
chr4_+_156775910 0.14 ENST00000506072.1
ENST00000507590.1
TDO2
tryptophan 2,3-dioxygenase
chrX_-_21676442 0.14 ENST00000379499.2
KLHL34
kelch-like family member 34
chr5_-_54988559 0.13 ENST00000502247.1
SLC38A9
solute carrier family 38, member 9
chr6_+_64345698 0.13 ENST00000506783.1
ENST00000481385.2
ENST00000515594.1
ENST00000494284.2
ENST00000262043.3
PHF3
PHD finger protein 3
chr14_+_61449076 0.13 ENST00000526105.1
SLC38A6
solute carrier family 38, member 6
chr5_-_130500922 0.13 ENST00000513012.1
ENST00000508488.1
ENST00000506908.1
ENST00000304043.5
HINT1
histidine triad nucleotide binding protein 1
chr3_-_183145873 0.13 ENST00000447025.2
ENST00000414362.2
ENST00000328913.3
MCF2L2
MCF.2 cell line derived transforming sequence-like 2
chr2_+_86669118 0.12 ENST00000427678.1
ENST00000542128.1
KDM3A
lysine (K)-specific demethylase 3A
chr2_-_190446738 0.12 ENST00000427419.1
ENST00000455320.1
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr1_-_223853348 0.12 ENST00000366872.5
CAPN8
calpain 8
chr13_+_24144796 0.12 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr12_+_122356488 0.11 ENST00000397454.2
WDR66
WD repeat domain 66
chr2_+_32502952 0.11 ENST00000238831.4
YIPF4
Yip1 domain family, member 4
chrX_-_84634708 0.11 ENST00000373145.3
POF1B
premature ovarian failure, 1B
chrX_+_96138907 0.11 ENST00000373040.3
RPA4
replication protein A4, 30kDa
chr4_+_26324474 0.11 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr12_-_110937351 0.11 ENST00000552130.2
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr1_-_238108575 0.11 ENST00000604646.1
MTRNR2L11
MT-RNR2-like 11 (pseudogene)
chr2_+_105050794 0.10 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr11_+_73498898 0.10 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr3_-_193096600 0.10 ENST00000446087.1
ENST00000342358.4
ATP13A5
ATPase type 13A5
chr18_-_64271363 0.10 ENST00000262150.2
CDH19
cadherin 19, type 2
chr1_-_152779104 0.09 ENST00000606576.1
ENST00000368768.1
LCE1C
late cornified envelope 1C
chr21_-_30445886 0.09 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr2_+_231921574 0.09 ENST00000308696.6
ENST00000373635.4
ENST00000440838.1
ENST00000409643.1
PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr3_-_141747950 0.09 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_+_113568207 0.09 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr1_-_228613026 0.09 ENST00000366696.1
HIST3H3
histone cluster 3, H3
chr14_-_53258314 0.09 ENST00000216410.3
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr12_+_64798826 0.09 ENST00000540203.1
XPOT
exportin, tRNA
chr14_-_60043524 0.09 ENST00000537690.2
ENST00000281581.4
CCDC175
coiled-coil domain containing 175
chr13_+_24144509 0.09 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr14_-_74025625 0.09 ENST00000553558.1
ENST00000563329.1
ENST00000334988.2
ENST00000560393.1
HEATR4
HEAT repeat containing 4
chr12_-_54689532 0.08 ENST00000540264.2
ENST00000312156.4
NFE2
nuclear factor, erythroid 2
chr6_-_24358264 0.08 ENST00000378454.3
DCDC2
doublecortin domain containing 2
chr9_+_35042205 0.08 ENST00000312292.5
ENST00000378745.3
C9orf131
chromosome 9 open reading frame 131
chr2_+_234668894 0.08 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UGT1A8
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr14_+_102276132 0.08 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr13_+_49551020 0.08 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr13_+_78315295 0.08 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr6_+_26440700 0.08 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr7_-_16844611 0.08 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr11_-_107729287 0.08 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr21_+_15588499 0.07 ENST00000400577.3
RBM11
RNA binding motif protein 11
chrX_-_55208866 0.07 ENST00000545075.1
MTRNR2L10
MT-RNR2-like 10
chr11_-_107729504 0.07 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr17_-_64225508 0.07 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr10_-_27529486 0.07 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr13_+_78315348 0.07 ENST00000441784.1
SLAIN1
SLAIN motif family, member 1
chr3_-_121740969 0.07 ENST00000393631.1
ENST00000273691.3
ENST00000344209.5
ILDR1
immunoglobulin-like domain containing receptor 1
chr1_-_93257951 0.06 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
EVI5
ecotropic viral integration site 5
chr14_-_55907334 0.06 ENST00000247219.5
TBPL2
TATA box binding protein like 2
chr12_-_10282742 0.06 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr12_+_26164645 0.06 ENST00000542004.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr2_+_88047606 0.06 ENST00000359481.4
PLGLB2
plasminogen-like B2
chr1_-_168464875 0.06 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr13_-_20806440 0.05 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
GJB6
gap junction protein, beta 6, 30kDa
chr1_+_171227069 0.05 ENST00000354841.4
FMO1
flavin containing monooxygenase 1
chr19_+_29456034 0.05 ENST00000589921.1
LINC00906
long intergenic non-protein coding RNA 906
chr4_-_120243545 0.05 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr2_-_40680578 0.05 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr7_-_37488777 0.05 ENST00000445322.1
ENST00000448602.1
ELMO1
engulfment and cell motility 1
chr12_+_104337515 0.05 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr3_-_157221380 0.04 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr15_-_83378638 0.04 ENST00000261722.3
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr11_-_63376013 0.04 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr3_+_134514093 0.04 ENST00000398015.3
EPHB1
EPH receptor B1
chr3_-_72150076 0.04 ENST00000488545.1
ENST00000608654.1
LINC00877
long intergenic non-protein coding RNA 877
chr2_-_231860596 0.03 ENST00000441063.1
ENST00000434094.1
ENST00000418330.1
ENST00000457803.1
ENST00000414876.1
ENST00000446741.1
ENST00000426904.1
AC105344.2
SPATA3 antisense RNA 1 (head to head)
chr5_+_68860949 0.03 ENST00000507595.1
GTF2H2C
general transcription factor IIH, polypeptide 2C
chr4_-_69111401 0.03 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr2_-_136633940 0.03 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr7_+_13141010 0.03 ENST00000443947.1
AC011288.2
AC011288.2
chr5_+_40909354 0.03 ENST00000313164.9
C7
complement component 7
chr2_-_217559517 0.02 ENST00000449583.1
IGFBP5
insulin-like growth factor binding protein 5
chr11_-_327537 0.02 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr11_-_92931098 0.02 ENST00000326402.4
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chrX_-_32173579 0.02 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr14_-_23058063 0.02 ENST00000538631.1
ENST00000543337.1
ENST00000250498.4
DAD1
defender against cell death 1
chr17_-_33390667 0.02 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr6_+_130339710 0.02 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr5_+_40841276 0.02 ENST00000254691.5
CARD6
caspase recruitment domain family, member 6
chr2_+_234580525 0.02 ENST00000609637.1
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr1_+_66820058 0.01 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr12_+_59194154 0.01 ENST00000548969.1
RP11-362K2.2
Protein LOC100506869
chr20_-_50722183 0.01 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr5_-_41794313 0.01 ENST00000512084.1
OXCT1
3-oxoacid CoA transferase 1
chr1_+_234765057 0.01 ENST00000429269.1
LINC00184
long intergenic non-protein coding RNA 184
chr3_+_139063372 0.00 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr2_+_234580499 0.00 ENST00000354728.4
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr7_-_37488834 0.00 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr19_-_51920952 0.00 ENST00000356298.5
ENST00000339313.5
ENST00000529627.1
ENST00000439889.2
ENST00000353836.5
ENST00000432469.2
SIGLEC10
sialic acid binding Ig-like lectin 10
chr2_-_207078154 0.00 ENST00000447845.1
GPR1
G protein-coupled receptor 1
chr19_-_36001113 0.00 ENST00000434389.1
DMKN
dermokine

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.4 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.0 0.1 GO:0060345 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.0 0.3 GO:1905068 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.7 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0046292 spermatid nucleus elongation(GO:0007290) formaldehyde metabolic process(GO:0046292)
0.0 0.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.1 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.2 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.0 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.0 GO:0051389 inactivation of MAPKK activity(GO:0051389)
0.0 0.1 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.2 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 0.1 GO:1903899 lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481) positive regulation of PERK-mediated unfolded protein response(GO:1903899)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.1 GO:0001534 radial spoke(GO:0001534)
0.0 0.1 GO:0034515 proteasome storage granule(GO:0034515)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.4 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.8 GO:0043596 nuclear replication fork(GO:0043596)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.1 0.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.1 GO:0097689 iron channel activity(GO:0097689)
0.0 0.2 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway