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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for LEF1

Z-value: 0.46

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Transcription factors associated with LEF1

Gene Symbol Gene ID Gene Info
LEF1
ENSG00000138795.5 lymphoid enhancer binding factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LEF1hg19_v2_chr4_-_109087872_1090878810.177.5e-01Click!

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_65533390 0.41 ENST00000448344.1
RP4-535B20.1
RP4-535B20.1
chr10_+_54074033 0.33 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr21_+_35553045 0.30 ENST00000416145.1
ENST00000430922.1
ENST00000419881.2
LINC00310
long intergenic non-protein coding RNA 310
chrX_-_45629661 0.29 ENST00000602507.1
ENST00000602461.1
RP6-99M1.2
RP6-99M1.2
chr6_+_64282447 0.26 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr4_+_113152978 0.25 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr17_-_63557309 0.25 ENST00000580513.1
AXIN2
axin 2
chr6_+_12008986 0.25 ENST00000491710.1
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chrX_+_80457442 0.23 ENST00000373212.5
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr11_+_28724129 0.23 ENST00000513853.1
RP11-115J23.1
RP11-115J23.1
chr3_-_148804275 0.23 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
HLTF
helicase-like transcription factor
chr15_-_52944231 0.22 ENST00000546305.2
FAM214A
family with sequence similarity 214, member A
chr4_+_90033968 0.22 ENST00000317005.2
TIGD2
tigger transposable element derived 2
chr1_+_196621002 0.22 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr4_+_95174445 0.22 ENST00000509418.1
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr3_+_171561127 0.22 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr1_+_6845578 0.21 ENST00000467404.2
ENST00000439411.2
CAMTA1
calmodulin binding transcription activator 1
chr4_+_76649797 0.21 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr7_+_89975979 0.21 ENST00000257659.8
ENST00000222511.6
ENST00000417207.1
GTPBP10
GTP-binding protein 10 (putative)
chr3_-_52719888 0.20 ENST00000458294.1
PBRM1
polybromo 1
chr18_+_20494078 0.20 ENST00000579124.1
ENST00000577588.1
ENST00000582354.1
ENST00000581819.1
RBBP8
retinoblastoma binding protein 8
chr16_+_53242350 0.20 ENST00000565442.1
CHD9
chromodomain helicase DNA binding protein 9
chr1_-_108231101 0.20 ENST00000544443.1
ENST00000415432.2
VAV3
vav 3 guanine nucleotide exchange factor
chr17_-_63556414 0.20 ENST00000585045.1
AXIN2
axin 2
chr4_+_95128748 0.20 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr4_+_95129061 0.20 ENST00000354268.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr2_-_47572207 0.20 ENST00000441997.1
AC073283.4
AC073283.4
chr6_-_64029879 0.19 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN
lengsin, lens protein with glutamine synthetase domain
chr1_+_196621156 0.19 ENST00000359637.2
CFH
complement factor H
chrX_-_119694538 0.19 ENST00000371322.5
CUL4B
cullin 4B
chr9_+_36036430 0.19 ENST00000377966.3
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr11_-_102323489 0.18 ENST00000361236.3
TMEM123
transmembrane protein 123
chr22_+_37959647 0.18 ENST00000415670.1
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr1_+_6845497 0.18 ENST00000473578.1
ENST00000557126.1
CAMTA1
calmodulin binding transcription activator 1
chr2_+_196440692 0.18 ENST00000458054.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr1_-_93645818 0.18 ENST00000370280.1
ENST00000479918.1
TMED5
transmembrane emp24 protein transport domain containing 5
chr14_+_58797974 0.18 ENST00000417477.2
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr17_+_57297807 0.18 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
GDPD1
glycerophosphodiester phosphodiesterase domain containing 1
chr4_-_157892055 0.18 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr4_+_95128996 0.18 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr15_-_35280426 0.18 ENST00000559564.1
ENST00000356321.4
ZNF770
zinc finger protein 770
chrX_+_106045891 0.18 ENST00000357242.5
ENST00000310452.2
ENST00000481617.2
ENST00000276175.3
TBC1D8B
TBC1 domain family, member 8B (with GRAM domain)
chr14_-_51027838 0.18 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr14_-_71107921 0.17 ENST00000553982.1
ENST00000500016.1
CTD-2540L5.5
CTD-2540L5.6
CTD-2540L5.5
CTD-2540L5.6
chr19_-_19739321 0.17 ENST00000588461.1
LPAR2
lysophosphatidic acid receptor 2
chr3_+_107244229 0.17 ENST00000456419.1
ENST00000402163.2
BBX
bobby sox homolog (Drosophila)
chr2_+_201676908 0.17 ENST00000409226.1
ENST00000452790.2
BZW1
basic leucine zipper and W2 domains 1
chr20_+_10199566 0.17 ENST00000430336.1
SNAP25
synaptosomal-associated protein, 25kDa
chr22_+_27053567 0.17 ENST00000449717.1
ENST00000453023.1
MIAT
myocardial infarction associated transcript (non-protein coding)
chr1_+_82266053 0.17 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr3_+_149535022 0.16 ENST00000466795.1
RNF13
ring finger protein 13
chr20_+_10199468 0.16 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr2_-_165697717 0.16 ENST00000439313.1
COBLL1
cordon-bleu WH2 repeat protein-like 1
chr12_+_21654714 0.16 ENST00000542038.1
ENST00000540141.1
ENST00000229314.5
GOLT1B
golgi transport 1B
chr12_+_104359576 0.16 ENST00000392872.3
ENST00000436021.2
TDG
thymine-DNA glycosylase
chr15_+_52311398 0.16 ENST00000261845.5
MAPK6
mitogen-activated protein kinase 6
chr1_+_93645314 0.15 ENST00000343253.7
CCDC18
coiled-coil domain containing 18
chr7_+_116451100 0.15 ENST00000464223.1
ENST00000484325.1
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr12_-_104359475 0.15 ENST00000553183.1
C12orf73
chromosome 12 open reading frame 73
chr1_-_54304212 0.15 ENST00000540001.1
NDC1
NDC1 transmembrane nucleoporin
chr2_-_170681324 0.15 ENST00000409340.1
METTL5
methyltransferase like 5
chrY_-_15591818 0.15 ENST00000382893.1
UTY
ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
chr4_-_36245561 0.15 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr12_+_95611569 0.15 ENST00000261219.6
ENST00000551472.1
ENST00000552821.1
VEZT
vezatin, adherens junctions transmembrane protein
chr15_+_78730531 0.14 ENST00000258886.8
IREB2
iron-responsive element binding protein 2
chr1_+_100435315 0.14 ENST00000370155.3
ENST00000465289.1
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr13_+_38923959 0.14 ENST00000379649.1
ENST00000239878.4
ENST00000437952.1
ENST00000379641.1
UFM1
ubiquitin-fold modifier 1
chr8_-_17104099 0.14 ENST00000524358.1
CNOT7
CCR4-NOT transcription complex, subunit 7
chr5_+_112074029 0.14 ENST00000512211.2
APC
adenomatous polyposis coli
chr11_-_46141338 0.14 ENST00000529782.1
ENST00000532010.1
ENST00000525438.1
ENST00000533757.1
ENST00000527782.1
PHF21A
PHD finger protein 21A
chr4_+_78079450 0.14 ENST00000395640.1
ENST00000512918.1
CCNG2
cyclin G2
chr10_+_18948311 0.14 ENST00000377275.3
ARL5B
ADP-ribosylation factor-like 5B
chr1_+_100818156 0.14 ENST00000336454.3
CDC14A
cell division cycle 14A
chr14_-_35344093 0.14 ENST00000382422.2
BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr1_+_100435535 0.14 ENST00000427993.2
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr1_+_78383813 0.14 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr11_-_102323740 0.14 ENST00000398136.2
TMEM123
transmembrane protein 123
chr1_+_47799542 0.14 ENST00000471289.2
ENST00000450808.2
CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr12_+_31079652 0.14 ENST00000546076.1
ENST00000535215.1
ENST00000544427.1
ENST00000261177.9
TSPAN11
tetraspanin 11
chr18_+_9136758 0.14 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ANKRD12
ankyrin repeat domain 12
chr6_-_27440460 0.14 ENST00000377419.1
ZNF184
zinc finger protein 184
chr3_+_141105235 0.14 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr12_+_7167980 0.14 ENST00000360817.5
ENST00000402681.3
C1S
complement component 1, s subcomponent
chr6_-_11807277 0.13 ENST00000379415.2
ADTRP
androgen-dependent TFPI-regulating protein
chr8_-_17104356 0.13 ENST00000361272.4
ENST00000523917.1
CNOT7
CCR4-NOT transcription complex, subunit 7
chr5_-_90679145 0.13 ENST00000265138.3
ARRDC3
arrestin domain containing 3
chr15_+_43885252 0.13 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr8_-_128231299 0.13 ENST00000500112.1
CCAT1
colon cancer associated transcript 1 (non-protein coding)
chr16_-_3350614 0.13 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr2_-_38829768 0.13 ENST00000378915.3
HNRNPLL
heterogeneous nuclear ribonucleoprotein L-like
chr8_+_42873548 0.13 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chrX_+_95939638 0.13 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2
diaphanous-related formin 2
chr4_-_157892498 0.13 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr16_+_67063262 0.13 ENST00000565389.1
CBFB
core-binding factor, beta subunit
chr8_+_107593198 0.13 ENST00000517686.1
OXR1
oxidation resistance 1
chr1_+_16330723 0.13 ENST00000329454.2
C1orf64
chromosome 1 open reading frame 64
chr21_+_37692481 0.13 ENST00000400485.1
MORC3
MORC family CW-type zinc finger 3
chr14_+_64971292 0.12 ENST00000358738.3
ENST00000394712.2
ZBTB1
zinc finger and BTB domain containing 1
chr18_-_45456693 0.12 ENST00000587421.1
SMAD2
SMAD family member 2
chr2_+_233385173 0.12 ENST00000449534.2
PRSS56
protease, serine, 56
chr2_+_171571827 0.12 ENST00000375281.3
SP5
Sp5 transcription factor
chr9_+_8858102 0.12 ENST00000447950.1
ENST00000430766.1
RP11-75C9.1
RP11-75C9.1
chr1_+_6845384 0.12 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr2_+_181845843 0.12 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr1_+_66797687 0.12 ENST00000371045.5
ENST00000531025.1
ENST00000526197.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr10_-_14050522 0.12 ENST00000342409.2
FRMD4A
FERM domain containing 4A
chr5_+_66124590 0.12 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr21_+_30671690 0.12 ENST00000399921.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr5_-_65018834 0.12 ENST00000506816.1
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr7_+_7811992 0.12 ENST00000406829.1
RPA3-AS1
RPA3 antisense RNA 1
chr13_+_39612442 0.12 ENST00000470258.1
ENST00000379600.3
NHLRC3
NHL repeat containing 3
chr6_-_153304148 0.12 ENST00000229758.3
FBXO5
F-box protein 5
chr6_+_119215308 0.12 ENST00000229595.5
ASF1A
anti-silencing function 1A histone chaperone
chr4_+_102734967 0.12 ENST00000444316.2
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr5_+_138678131 0.12 ENST00000394795.2
ENST00000510080.1
PAIP2
poly(A) binding protein interacting protein 2
chr2_+_220309379 0.12 ENST00000451076.1
SPEG
SPEG complex locus
chr1_-_115292591 0.12 ENST00000438362.2
CSDE1
cold shock domain containing E1, RNA-binding
chr8_+_29953163 0.12 ENST00000518192.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr2_+_234621551 0.12 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr13_+_97928395 0.12 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr4_+_26165074 0.12 ENST00000512351.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr12_+_7456880 0.12 ENST00000399422.4
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr1_-_54303934 0.12 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr17_+_48611853 0.11 ENST00000507709.1
ENST00000515126.1
ENST00000507467.1
EPN3
epsin 3
chr1_+_100818009 0.11 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
CDC14A
cell division cycle 14A
chr2_-_39348137 0.11 ENST00000426016.1
SOS1
son of sevenless homolog 1 (Drosophila)
chr14_+_56078695 0.11 ENST00000416613.1
KTN1
kinectin 1 (kinesin receptor)
chr7_-_140178726 0.11 ENST00000480552.1
MKRN1
makorin ring finger protein 1
chr11_-_85430204 0.11 ENST00000389958.3
ENST00000527794.1
SYTL2
synaptotagmin-like 2
chrX_+_95939711 0.11 ENST00000373049.4
ENST00000324765.8
DIAPH2
diaphanous-related formin 2
chr5_+_110073853 0.11 ENST00000513807.1
ENST00000509442.2
SLC25A46
solute carrier family 25, member 46
chr2_-_211341411 0.11 ENST00000233714.4
ENST00000443314.1
ENST00000441020.3
ENST00000450366.2
ENST00000431941.2
LANCL1
LanC lantibiotic synthetase component C-like 1 (bacterial)
chr11_-_94965667 0.11 ENST00000542176.1
ENST00000278499.2
SESN3
sestrin 3
chr7_-_80548667 0.11 ENST00000265361.3
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr4_+_96012585 0.11 ENST00000502683.1
BMPR1B
bone morphogenetic protein receptor, type IB
chrY_-_15591485 0.11 ENST00000382896.4
ENST00000537580.1
ENST00000540140.1
ENST00000545955.1
ENST00000538878.1
UTY
ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
chr5_+_54455946 0.11 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
GPX8
glutathione peroxidase 8 (putative)
chr8_+_29952914 0.11 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr17_+_19030782 0.11 ENST00000344415.4
ENST00000577213.1
GRAPL
GRB2-related adaptor protein-like
chr5_+_56469843 0.11 ENST00000514387.2
GPBP1
GC-rich promoter binding protein 1
chr14_+_52456327 0.11 ENST00000556760.1
C14orf166
chromosome 14 open reading frame 166
chr1_+_84630574 0.11 ENST00000413538.1
ENST00000417530.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_95612006 0.11 ENST00000551311.1
ENST00000546445.1
VEZT
vezatin, adherens junctions transmembrane protein
chr2_-_170681375 0.11 ENST00000410097.1
ENST00000308099.3
ENST00000409837.1
ENST00000538491.1
ENST00000260953.5
ENST00000409965.1
ENST00000392640.2
METTL5
methyltransferase like 5
chr1_+_27113963 0.11 ENST00000430292.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr4_-_111120334 0.11 ENST00000503885.1
ELOVL6
ELOVL fatty acid elongase 6
chr21_-_34144157 0.11 ENST00000331923.4
PAXBP1
PAX3 and PAX7 binding protein 1
chr14_+_57857262 0.10 ENST00000555166.1
ENST00000556492.1
ENST00000554703.1
NAA30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr6_-_27440837 0.10 ENST00000211936.6
ZNF184
zinc finger protein 184
chr14_-_35099377 0.10 ENST00000362031.4
SNX6
sorting nexin 6
chr4_+_79567362 0.10 ENST00000512322.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr5_+_65222438 0.10 ENST00000380938.2
ERBB2IP
erbb2 interacting protein
chr4_+_95916947 0.10 ENST00000506363.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr1_+_166808692 0.10 ENST00000367876.4
POGK
pogo transposable element with KRAB domain
chr14_+_54976546 0.10 ENST00000216420.7
CGRRF1
cell growth regulator with ring finger domain 1
chr11_-_10822029 0.10 ENST00000528839.1
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr12_+_95611516 0.10 ENST00000436874.1
VEZT
vezatin, adherens junctions transmembrane protein
chrX_+_119384607 0.10 ENST00000326624.2
ENST00000557385.1
ZBTB33
zinc finger and BTB domain containing 33
chr15_+_52043813 0.10 ENST00000435126.2
TMOD2
tropomodulin 2 (neuronal)
chr14_+_54863739 0.10 ENST00000541304.1
CDKN3
cyclin-dependent kinase inhibitor 3
chr6_+_64281906 0.10 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_+_201677390 0.10 ENST00000447069.1
BZW1
basic leucine zipper and W2 domains 1
chr15_+_90735145 0.10 ENST00000559792.1
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr6_-_135424186 0.10 ENST00000529882.1
HBS1L
HBS1-like (S. cerevisiae)
chr8_-_40755333 0.10 ENST00000297737.6
ENST00000315769.7
ZMAT4
zinc finger, matrin-type 4
chr6_+_13925318 0.10 ENST00000423553.2
ENST00000537388.1
RNF182
ring finger protein 182
chr2_-_9143786 0.10 ENST00000462696.1
ENST00000305997.3
MBOAT2
membrane bound O-acyltransferase domain containing 2
chr14_-_35099315 0.10 ENST00000396526.3
ENST00000396534.3
ENST00000355110.5
ENST00000557265.1
SNX6
sorting nexin 6
chr1_+_53793885 0.10 ENST00000445039.2
RP4-784A16.5
RP4-784A16.5
chr2_-_165424973 0.10 ENST00000543549.1
GRB14
growth factor receptor-bound protein 14
chr1_-_226496898 0.10 ENST00000481685.1
LIN9
lin-9 homolog (C. elegans)
chr3_+_151531810 0.09 ENST00000232892.7
AADAC
arylacetamide deacetylase
chr2_-_25194963 0.09 ENST00000264711.2
DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr13_+_37581115 0.09 ENST00000481013.1
EXOSC8
exosome component 8
chr7_-_27239703 0.09 ENST00000222753.4
HOXA13
homeobox A13
chr14_+_54976603 0.09 ENST00000557317.1
CGRRF1
cell growth regulator with ring finger domain 1
chr1_-_115259337 0.09 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr3_-_33700933 0.09 ENST00000480013.1
CLASP2
cytoplasmic linker associated protein 2
chr3_-_139195350 0.09 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr2_+_70056762 0.09 ENST00000282570.3
GMCL1
germ cell-less, spermatogenesis associated 1
chr19_+_50003781 0.09 ENST00000602157.1
hsa-mir-150
hsa-mir-150
chr17_-_39093672 0.09 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr17_-_46035187 0.09 ENST00000300557.2
PRR15L
proline rich 15-like
chr19_-_6690723 0.09 ENST00000601008.1
C3
complement component 3
chr14_-_35182994 0.09 ENST00000341223.3
CFL2
cofilin 2 (muscle)
chr2_-_171571077 0.09 ENST00000409786.1
AC007405.2
long intergenic non-protein coding RNA 1124
chr7_-_19748640 0.09 ENST00000222567.5
TWISTNB
TWIST neighbor
chr4_-_111120132 0.09 ENST00000506625.1
ELOVL6
ELOVL fatty acid elongase 6
chr16_+_53241854 0.09 ENST00000565803.1
CHD9
chromodomain helicase DNA binding protein 9
chr1_-_54303949 0.09 ENST00000234725.8
NDC1
NDC1 transmembrane nucleoporin
chr12_-_31477072 0.09 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr5_+_93954039 0.09 ENST00000265140.5
ANKRD32
ankyrin repeat domain 32
chr1_+_93913713 0.09 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr3_-_69402828 0.09 ENST00000460709.1
FRMD4B
FERM domain containing 4B
chr4_+_78078304 0.09 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
CCNG2
cyclin G2
chr12_+_79258547 0.09 ENST00000457153.2
SYT1
synaptotagmin I
chr15_+_57511609 0.09 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
TCF12
transcription factor 12
chr12_-_76817036 0.09 ENST00000546946.1
OSBPL8
oxysterol binding protein-like 8
chr8_-_17579726 0.09 ENST00000381861.3
MTUS1
microtubule associated tumor suppressor 1
chr3_-_52719912 0.09 ENST00000420148.1
PBRM1
polybromo 1

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.1 0.4 GO:0051300 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.3 GO:0090381 negative regulation of mesodermal cell fate specification(GO:0042662) regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012)
0.1 0.3 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.3 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.1 0.3 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.1 0.2 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.1 0.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.1 0.2 GO:1903217 negative regulation of late endosome to lysosome transport(GO:1902823) regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.1 0.1 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.1 0.2 GO:0035188 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.2 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.2 GO:2000174 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.0 0.1 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0 0.1 GO:0051796 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.0 0.2 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.0 0.2 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.2 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.9 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.1 GO:0002894 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.2 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.1 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 0.3 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.3 GO:0051013 microtubule severing(GO:0051013)
0.0 0.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 0.1 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.1 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:1904693 midbrain morphogenesis(GO:1904693)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.2 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.0 0.3 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.1 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.3 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.2 GO:0061317 canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.1 GO:1904235 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0002669 regulation of tolerance induction dependent upon immune response(GO:0002652) positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0 0.1 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
0.0 0.1 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.1 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.1 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.4 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 0.1 GO:1990697 protein depalmitoleylation(GO:1990697)
0.0 0.2 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.1 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.0 GO:0060931 sinoatrial node development(GO:0003163) sinoatrial node cell differentiation(GO:0060921) sinoatrial node cell development(GO:0060931)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.1 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:0061143 alveolar primary septum development(GO:0061143)
0.0 0.2 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.0 0.1 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.1 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.0 GO:0061056 sclerotome development(GO:0061056)
0.0 0.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.0 GO:0035262 gonad morphogenesis(GO:0035262)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.3 GO:0075341 host cell PML body(GO:0075341)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 0.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.2 GO:0044753 amphisome(GO:0044753)
0.0 0.2 GO:0097422 tubular endosome(GO:0097422)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.1 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.0 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.1 0.2 GO:0030350 iron-responsive element binding(GO:0030350)
0.1 0.3 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 0.3 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.1 0.2 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.0 0.2 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.1 GO:0009041 uridylate kinase activity(GO:0009041)
0.0 0.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.4 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.1 GO:1990175 EH domain binding(GO:1990175)
0.0 0.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0072591 citrate-L-glutamate ligase activity(GO:0072591)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.3 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.2 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 0.5 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.0 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions