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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for LHX3

Z-value: 0.38

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Transcription factors associated with LHX3

Gene Symbol Gene ID Gene Info
LHX3
ENSG00000107187.11 LIM homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX3hg19_v2_chr9_-_139094988_1390950120.325.4e-01Click!

Activity profile of LHX3 motif

Sorted Z-values of LHX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_61151306 0.36 ENST00000580068.1
ENST00000580466.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr11_-_63376013 0.32 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr14_+_29241910 0.28 ENST00000399387.4
ENST00000552957.1
ENST00000548213.1
C14orf23
chromosome 14 open reading frame 23
chr14_-_57197224 0.27 ENST00000554597.1
ENST00000556696.1
RP11-1085N6.3
Uncharacterized protein
chr12_-_118628315 0.26 ENST00000540561.1
TAOK3
TAO kinase 3
chr4_-_120243545 0.25 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr8_-_66750978 0.25 ENST00000523253.1
PDE7A
phosphodiesterase 7A
chr2_+_29001711 0.24 ENST00000418910.1
PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr6_-_138833630 0.14 ENST00000533765.1
NHSL1
NHS-like 1
chr18_+_61616510 0.13 ENST00000408945.3
HMSD
histocompatibility (minor) serpin domain containing
chr15_+_75970672 0.12 ENST00000435356.1
AC105020.1
Uncharacterized protein; cDNA FLJ12988 fis, clone NT2RP3000080
chr4_+_3344141 0.12 ENST00000306648.7
RGS12
regulator of G-protein signaling 12
chr22_+_23487513 0.10 ENST00000263116.2
ENST00000341989.4
RAB36
RAB36, member RAS oncogene family
chr14_-_21566731 0.10 ENST00000360947.3
ZNF219
zinc finger protein 219
chr6_-_47445214 0.09 ENST00000604014.1
RP11-385F7.1
RP11-385F7.1
chr9_-_21482312 0.09 ENST00000448696.3
IFNE
interferon, epsilon
chr17_-_4938712 0.09 ENST00000254853.5
ENST00000424747.1
SLC52A1
solute carrier family 52 (riboflavin transporter), member 1
chr16_+_89334512 0.09 ENST00000602042.1
AC137932.1
AC137932.1
chr9_-_128246769 0.09 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr6_+_26104104 0.08 ENST00000377803.2
HIST1H4C
histone cluster 1, H4c
chr8_-_25281747 0.08 ENST00000421054.2
GNRH1
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr10_-_90611566 0.08 ENST00000371930.4
ANKRD22
ankyrin repeat domain 22
chr11_-_58378759 0.08 ENST00000601906.1
AP001350.1
Uncharacterized protein
chr13_+_24144796 0.08 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr19_+_48949087 0.07 ENST00000598711.1
GRWD1
glutamate-rich WD repeat containing 1
chr19_+_11457232 0.07 ENST00000587531.1
CCDC159
coiled-coil domain containing 159
chr14_-_45252031 0.07 ENST00000556405.1
RP11-398E10.1
RP11-398E10.1
chr16_-_28937027 0.07 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr17_-_8263538 0.07 ENST00000535173.1
AC135178.1
HCG1985372; Uncharacterized protein; cDNA FLJ37541 fis, clone BRCAN2026340
chr3_+_186692745 0.07 ENST00000438590.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr5_+_59783941 0.06 ENST00000506884.1
ENST00000504876.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr4_+_74301880 0.06 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chrX_+_107288239 0.06 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr12_-_52761262 0.06 ENST00000257901.3
KRT85
keratin 85
chr19_+_48949030 0.06 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chrX_+_107288197 0.06 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr7_+_134671234 0.06 ENST00000436302.2
ENST00000359383.3
ENST00000458078.1
ENST00000435976.2
ENST00000455283.2
AGBL3
ATP/GTP binding protein-like 3
chr8_+_119294456 0.06 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr14_-_101295407 0.06 ENST00000596284.1
AL117190.2
AL117190.2
chr9_+_125133315 0.06 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_+_11457175 0.06 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chr7_-_84122033 0.05 ENST00000424555.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr14_+_55494323 0.05 ENST00000339298.2
SOCS4
suppressor of cytokine signaling 4
chr17_-_39623681 0.05 ENST00000225899.3
KRT32
keratin 32
chrX_-_13835147 0.05 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr1_+_244214577 0.05 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr7_+_30185496 0.05 ENST00000455738.1
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr9_-_100000957 0.05 ENST00000366109.2
ENST00000607322.1
RP11-498P14.5
RP11-498P14.5
chr1_-_48866517 0.05 ENST00000371841.1
SPATA6
spermatogenesis associated 6
chr6_+_130339710 0.05 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr17_-_72772462 0.05 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr12_-_118628350 0.05 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr7_+_30185406 0.05 ENST00000324489.5
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr10_+_695888 0.05 ENST00000441152.2
PRR26
proline rich 26
chr11_-_559377 0.05 ENST00000486629.1
C11orf35
chromosome 11 open reading frame 35
chr9_+_125132803 0.05 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_20053741 0.04 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chr16_+_15489629 0.04 ENST00000396385.3
MPV17L
MPV17 mitochondrial membrane protein-like
chr14_+_55493920 0.04 ENST00000395472.2
ENST00000555846.1
SOCS4
suppressor of cytokine signaling 4
chr18_+_616711 0.04 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr1_-_231005310 0.04 ENST00000470540.1
C1orf198
chromosome 1 open reading frame 198
chr15_+_64680003 0.04 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr2_+_26624775 0.04 ENST00000288710.2
DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr1_+_15668240 0.04 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr19_-_51920952 0.03 ENST00000356298.5
ENST00000339313.5
ENST00000529627.1
ENST00000439889.2
ENST00000353836.5
ENST00000432469.2
SIGLEC10
sialic acid binding Ig-like lectin 10
chr14_+_20215587 0.03 ENST00000331723.1
OR4Q3
olfactory receptor, family 4, subfamily Q, member 3
chr2_-_99871570 0.03 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr1_-_94147385 0.03 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr15_+_65843130 0.03 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr1_-_24126023 0.03 ENST00000429356.1
GALE
UDP-galactose-4-epimerase
chr12_+_49740700 0.03 ENST00000549441.2
ENST00000395069.3
DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr17_-_72772425 0.03 ENST00000578822.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr7_-_4901625 0.03 ENST00000404991.1
PAPOLB
poly(A) polymerase beta (testis specific)
chr18_+_616672 0.03 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr10_+_104263743 0.03 ENST00000369902.3
ENST00000369899.2
ENST00000423559.2
SUFU
suppressor of fused homolog (Drosophila)
chr10_+_18549645 0.03 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr5_+_140529630 0.03 ENST00000543635.1
PCDHB6
protocadherin beta 6
chr2_+_135596106 0.03 ENST00000356140.5
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr2_+_54785485 0.03 ENST00000333896.5
SPTBN1
spectrin, beta, non-erythrocytic 1
chr10_+_696000 0.03 ENST00000381489.5
PRR26
proline rich 26
chr16_+_15489603 0.03 ENST00000568766.1
ENST00000287594.7
RP11-1021N1.1
MPV17L
Uncharacterized protein
MPV17 mitochondrial membrane protein-like
chr15_-_75748143 0.03 ENST00000568431.1
ENST00000568309.1
ENST00000568190.1
ENST00000570115.1
ENST00000564778.1
SIN3A
SIN3 transcription regulator family member A
chr14_+_21566980 0.02 ENST00000418511.2
ENST00000554329.2
TMEM253
transmembrane protein 253
chr17_-_27418537 0.02 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr11_-_128894053 0.02 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chrM_+_10053 0.02 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr13_-_81801115 0.02 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr14_-_21567009 0.02 ENST00000556174.1
ENST00000554478.1
ENST00000553980.1
ENST00000421093.2
ZNF219
zinc finger protein 219
chr7_-_122840015 0.02 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr7_-_140482926 0.02 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr12_-_86650077 0.02 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr8_-_57123815 0.02 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr16_+_28565230 0.02 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr12_-_86650045 0.02 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr4_-_185275104 0.02 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chr10_-_27529486 0.02 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr5_+_169011033 0.02 ENST00000513795.1
SPDL1
spindle apparatus coiled-coil protein 1
chr19_+_50016610 0.02 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr17_+_35851570 0.01 ENST00000394386.1
DUSP14
dual specificity phosphatase 14
chr3_-_48130707 0.01 ENST00000360240.6
ENST00000383737.4
MAP4
microtubule-associated protein 4
chr15_-_99057551 0.01 ENST00000558256.1
FAM169B
family with sequence similarity 169, member B
chr4_-_41884620 0.01 ENST00000504870.1
LINC00682
long intergenic non-protein coding RNA 682
chr5_-_1882858 0.01 ENST00000511126.1
ENST00000231357.2
IRX4
iroquois homeobox 4
chrX_+_9431324 0.01 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr4_-_23891658 0.01 ENST00000507380.1
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chrX_-_110655306 0.01 ENST00000371993.2
DCX
doublecortin
chr14_+_101295638 0.01 ENST00000523671.2
MEG3
maternally expressed 3 (non-protein coding)
chr1_-_24126051 0.01 ENST00000445705.1
GALE
UDP-galactose-4-epimerase
chr19_+_50016411 0.01 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr6_-_49712123 0.01 ENST00000263045.4
CRISP3
cysteine-rich secretory protein 3
chr6_-_9933500 0.01 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr4_-_36245561 0.01 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_71384257 0.01 ENST00000339336.4
AMTN
amelotin
chr16_-_28634874 0.01 ENST00000395609.1
ENST00000350842.4
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr3_-_47517302 0.01 ENST00000441517.2
ENST00000545718.1
SCAP
SREBF chaperone
chr3_+_148415571 0.01 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
AGTR1
angiotensin II receptor, type 1
chr10_-_128359074 0.01 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr4_+_41937131 0.01 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chr2_-_145278475 0.01 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr1_-_160924589 0.01 ENST00000368029.3
ITLN2
intelectin 2
chr11_-_67980744 0.00 ENST00000401547.2
ENST00000453170.1
ENST00000304363.4
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr5_+_166711804 0.00 ENST00000518659.1
ENST00000545108.1
TENM2
teneurin transmembrane protein 2
chr9_+_125133467 0.00 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr12_+_59989918 0.00 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chrX_+_108779004 0.00 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr12_+_40787194 0.00 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr1_+_168250194 0.00 ENST00000367821.3
TBX19
T-box 19
chr19_-_43969796 0.00 ENST00000244333.3
LYPD3
LY6/PLAUR domain containing 3
chr2_-_99279928 0.00 ENST00000414521.2
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr6_-_49712072 0.00 ENST00000423399.2
CRISP3
cysteine-rich secretory protein 3
chr9_-_116065551 0.00 ENST00000297894.5
RNF183
ring finger protein 183
chr10_-_74283694 0.00 ENST00000398763.4
ENST00000418483.2
ENST00000489666.2
MICU1
mitochondrial calcium uptake 1
chr2_-_207078154 0.00 ENST00000447845.1
GPR1
G protein-coupled receptor 1
chr1_+_81771806 0.00 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
LPHN2
latrophilin 2
chr8_-_30670384 0.00 ENST00000221138.4
ENST00000518243.1
PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637) regulation of ovarian follicle development(GO:2000354)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.1 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 0.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0097475 motor neuron migration(GO:0097475)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.0 GO:0097224 sperm connecting piece(GO:0097224)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.2 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.0 GO:0003978 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors