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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MECOM

Z-value: 1.17

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Transcription factors associated with MECOM

Gene Symbol Gene ID Gene Info
MECOM
ENSG00000085276.13 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MECOMhg19_v2_chr3_-_168864315_1688643560.483.4e-01Click!

Activity profile of MECOM motif

Sorted Z-values of MECOM motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_17316870 1.68 ENST00000458064.2
NUCB2
nucleobindin 2
chr8_-_90993869 0.95 ENST00000517772.1
NBN
nibrin
chr19_+_23257988 0.90 ENST00000594318.1
ENST00000600223.1
ENST00000593635.1
CTD-2291D10.4
ZNF730
CTD-2291D10.4
zinc finger protein 730
chr3_-_96337000 0.84 ENST00000600213.2
MTRNR2L12
MT-RNR2-like 12 (pseudogene)
chr16_-_90096309 0.79 ENST00000408886.2
C16orf3
chromosome 16 open reading frame 3
chr10_+_78078088 0.77 ENST00000496424.2
C10orf11
chromosome 10 open reading frame 11
chr12_+_113344755 0.77 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr4_+_26323764 0.76 ENST00000514730.1
ENST00000507574.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr12_+_113344582 0.72 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr12_+_113344811 0.71 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr2_-_145275109 0.69 ENST00000431672.2
ZEB2
zinc finger E-box binding homeobox 2
chr1_+_209859510 0.68 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr1_-_68962744 0.68 ENST00000525124.1
DEPDC1
DEP domain containing 1
chr7_+_142374104 0.66 ENST00000604952.1
MTRNR2L6
MT-RNR2-like 6
chr4_+_130014836 0.63 ENST00000502887.1
C4orf33
chromosome 4 open reading frame 33
chr1_-_238108575 0.63 ENST00000604646.1
MTRNR2L11
MT-RNR2-like 11 (pseudogene)
chr5_-_79946820 0.63 ENST00000604882.1
MTRNR2L2
MT-RNR2-like 2
chr15_+_71185148 0.62 ENST00000443425.2
ENST00000560755.1
LRRC49
leucine rich repeat containing 49
chr11_-_10530723 0.60 ENST00000536684.1
MTRNR2L8
MT-RNR2-like 8
chr12_-_112443830 0.59 ENST00000550037.1
ENST00000549425.1
TMEM116
transmembrane protein 116
chr6_+_49431073 0.58 ENST00000335783.3
CENPQ
centromere protein Q
chr1_+_172422026 0.58 ENST00000367725.4
C1orf105
chromosome 1 open reading frame 105
chr15_-_30686052 0.55 ENST00000562729.1
CHRFAM7A
CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
chr14_-_24551195 0.54 ENST00000560550.1
NRL
neural retina leucine zipper
chr4_+_26324474 0.54 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr5_+_64920826 0.53 ENST00000438419.2
ENST00000231526.4
ENST00000505553.1
ENST00000545191.1
TRAPPC13
trafficking protein particle complex 13
chr10_+_57358750 0.53 ENST00000512524.2
MTRNR2L5
MT-RNR2-like 5
chr1_-_68962805 0.53 ENST00000370966.5
DEPDC1
DEP domain containing 1
chr1_-_68962782 0.53 ENST00000456315.2
DEPDC1
DEP domain containing 1
chr3_-_130746462 0.50 ENST00000505545.1
ASTE1
asteroid homolog 1 (Drosophila)
chr5_+_56471592 0.48 ENST00000511209.1
GPBP1
GC-rich promoter binding protein 1
chr1_-_85156417 0.47 ENST00000422026.1
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr6_-_56492816 0.46 ENST00000522360.1
DST
dystonin
chr17_+_22022437 0.46 ENST00000540040.1
MTRNR2L1
MT-RNR2-like 1
chr1_-_63153944 0.46 ENST00000340370.5
ENST00000404627.2
ENST00000251157.5
DOCK7
dedicator of cytokinesis 7
chr21_+_45595354 0.46 ENST00000411956.1
AP001056.1
AP001056.1
chr10_+_116524547 0.45 ENST00000436932.1
RP11-106M7.1
RP11-106M7.1
chr21_+_17214724 0.44 ENST00000449491.1
USP25
ubiquitin specific peptidase 25
chr11_+_65266507 0.44 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr12_-_10320190 0.44 ENST00000543993.1
ENST00000339968.6
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr2_+_172544294 0.43 ENST00000358002.6
ENST00000435234.1
ENST00000443458.1
ENST00000412370.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr20_-_55934878 0.43 ENST00000543500.1
MTRNR2L3
MT-RNR2-like 3
chr4_+_155484155 0.43 ENST00000509493.1
FGB
fibrinogen beta chain
chr14_-_24551137 0.42 ENST00000396995.1
NRL
neural retina leucine zipper
chr14_-_38028689 0.42 ENST00000553425.1
RP11-356O9.2
RP11-356O9.2
chr4_+_164415785 0.42 ENST00000513272.1
ENST00000513134.1
TMA16
translation machinery associated 16 homolog (S. cerevisiae)
chr12_+_28605426 0.41 ENST00000542801.1
CCDC91
coiled-coil domain containing 91
chr19_-_22966893 0.40 ENST00000596209.1
ZNF99
zinc finger protein 99
chr4_-_76598296 0.40 ENST00000395719.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr9_+_33240157 0.39 ENST00000379721.3
SPINK4
serine peptidase inhibitor, Kazal type 4
chrX_+_67718863 0.38 ENST00000374622.2
YIPF6
Yip1 domain family, member 6
chr5_+_159895275 0.38 ENST00000517927.1
MIR146A
microRNA 146a
chrX_-_55208866 0.38 ENST00000545075.1
MTRNR2L10
MT-RNR2-like 10
chr9_+_26746951 0.36 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chr13_+_60971080 0.35 ENST00000377894.2
TDRD3
tudor domain containing 3
chr4_+_155484103 0.35 ENST00000302068.4
FGB
fibrinogen beta chain
chr1_-_98386543 0.35 ENST00000423006.2
ENST00000370192.3
ENST00000306031.5
DPYD
dihydropyrimidine dehydrogenase
chr5_+_64920543 0.35 ENST00000399438.3
ENST00000510585.2
TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr17_+_70036164 0.34 ENST00000602013.1
AC007461.1
Uncharacterized protein
chr12_+_7169887 0.34 ENST00000542978.1
C1S
complement component 1, s subcomponent
chr8_-_133637624 0.33 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr3_-_145968923 0.33 ENST00000493382.1
ENST00000354952.2
ENST00000383083.2
PLSCR4
phospholipid scramblase 4
chr8_-_122653630 0.33 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr2_+_172544182 0.33 ENST00000409197.1
ENST00000456808.1
ENST00000409317.1
ENST00000409773.1
ENST00000411953.1
ENST00000409453.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr5_+_74807886 0.32 ENST00000514296.1
POLK
polymerase (DNA directed) kappa
chr2_+_29001711 0.32 ENST00000418910.1
PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr20_+_32782375 0.32 ENST00000568305.1
ASIP
agouti signaling protein
chr3_-_112738565 0.32 ENST00000383675.2
ENST00000314400.5
C3orf17
chromosome 3 open reading frame 17
chr6_-_31514516 0.31 ENST00000303892.5
ENST00000483251.1
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr5_-_130868688 0.31 ENST00000504575.1
ENST00000513227.1
RAPGEF6
Rap guanine nucleotide exchange factor (GEF) 6
chr2_-_56150910 0.31 ENST00000424836.2
ENST00000438672.1
ENST00000440439.1
ENST00000429909.1
ENST00000424207.1
ENST00000452337.1
ENST00000355426.3
ENST00000439193.1
ENST00000421664.1
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr10_+_106034637 0.30 ENST00000401888.2
GSTO2
glutathione S-transferase omega 2
chr6_+_27215471 0.30 ENST00000421826.2
PRSS16
protease, serine, 16 (thymus)
chr14_-_82089405 0.30 ENST00000554211.1
RP11-799P8.1
RP11-799P8.1
chr13_+_108870714 0.30 ENST00000375898.3
ABHD13
abhydrolase domain containing 13
chr2_+_242289502 0.29 ENST00000451310.1
SEPT2
septin 2
chr2_+_97779233 0.29 ENST00000461153.2
ENST00000420699.2
ANKRD36
ankyrin repeat domain 36
chr1_+_161035655 0.29 ENST00000600454.1
AL591806.1
Uncharacterized protein
chrX_-_43741594 0.28 ENST00000536181.1
ENST00000378069.4
MAOB
monoamine oxidase B
chrX_-_106243451 0.28 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr7_+_73275483 0.28 ENST00000320531.2
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr12_+_124457746 0.28 ENST00000392404.3
ENST00000538932.2
ENST00000337815.4
ENST00000540762.2
ZNF664
FAM101A
zinc finger protein 664
family with sequence similarity 101, member A
chr10_-_18940501 0.27 ENST00000377304.4
NSUN6
NOP2/Sun domain family, member 6
chr14_+_73563735 0.27 ENST00000532192.1
RBM25
RNA binding motif protein 25
chr15_-_55562451 0.27 ENST00000568803.1
RAB27A
RAB27A, member RAS oncogene family
chr8_-_6420759 0.26 ENST00000523120.1
ANGPT2
angiopoietin 2
chr3_+_184534994 0.26 ENST00000441141.1
ENST00000445089.1
VPS8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr7_+_17338239 0.26 ENST00000242057.4
AHR
aryl hydrocarbon receptor
chr10_-_48806939 0.26 ENST00000374233.3
ENST00000507417.1
ENST00000512321.1
ENST00000395660.2
ENST00000374235.2
ENST00000395661.3
PTPN20B
protein tyrosine phosphatase, non-receptor type 20B
chr5_-_96209315 0.25 ENST00000504056.1
CTD-2260A17.2
Uncharacterized protein
chr15_-_83837983 0.25 ENST00000562702.1
HDGFRP3
Hepatoma-derived growth factor-related protein 3
chr2_+_172543967 0.24 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr7_-_15601595 0.24 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr3_-_149093499 0.24 ENST00000472441.1
TM4SF1
transmembrane 4 L six family member 1
chr8_+_39759794 0.24 ENST00000518804.1
ENST00000519154.1
ENST00000522495.1
ENST00000522840.1
IDO1
indoleamine 2,3-dioxygenase 1
chr6_-_52860171 0.24 ENST00000370963.4
GSTA4
glutathione S-transferase alpha 4
chrX_-_85302531 0.24 ENST00000537751.1
ENST00000358786.4
ENST00000357749.2
CHM
choroideremia (Rab escort protein 1)
chr10_-_21186144 0.23 ENST00000377119.1
NEBL
nebulette
chr11_-_8964580 0.23 ENST00000325884.1
ASCL3
achaete-scute family bHLH transcription factor 3
chr19_-_20844368 0.22 ENST00000595094.1
ENST00000601440.1
ENST00000291750.6
CTC-513N18.7
ZNF626
CTC-513N18.7
zinc finger protein 626
chr3_-_145968857 0.22 ENST00000433593.2
ENST00000476202.1
ENST00000460885.1
PLSCR4
phospholipid scramblase 4
chr2_+_172544011 0.22 ENST00000508530.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr5_+_102201722 0.21 ENST00000274392.9
ENST00000455264.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr14_-_76447494 0.21 ENST00000238682.3
TGFB3
transforming growth factor, beta 3
chr6_+_27215494 0.21 ENST00000230582.3
PRSS16
protease, serine, 16 (thymus)
chr6_-_52859968 0.21 ENST00000370959.1
GSTA4
glutathione S-transferase alpha 4
chr22_-_29137771 0.21 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr3_-_145968900 0.21 ENST00000460350.1
PLSCR4
phospholipid scramblase 4
chr1_+_82266053 0.20 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr4_-_177162822 0.20 ENST00000512254.1
ASB5
ankyrin repeat and SOCS box containing 5
chr2_+_55746722 0.20 ENST00000339012.3
CCDC104
coiled-coil domain containing 104
chr12_-_12837423 0.20 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chrX_-_106243294 0.19 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr2_+_190541153 0.19 ENST00000313581.4
ENST00000438402.2
ENST00000431575.2
ENST00000281412.6
ANKAR
ankyrin and armadillo repeat containing
chr4_-_76944621 0.19 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr5_+_96211643 0.19 ENST00000437043.3
ENST00000510373.1
ERAP2
endoplasmic reticulum aminopeptidase 2
chr5_+_102201430 0.19 ENST00000438793.3
ENST00000346918.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr5_+_102201509 0.18 ENST00000348126.2
ENST00000379787.4
PAM
peptidylglycine alpha-amidating monooxygenase
chr4_-_99851766 0.18 ENST00000450253.2
EIF4E
eukaryotic translation initiation factor 4E
chr12_+_27863706 0.18 ENST00000081029.3
ENST00000538315.1
ENST00000542791.1
MRPS35
mitochondrial ribosomal protein S35
chr3_-_27498235 0.18 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr7_-_29152509 0.17 ENST00000448959.1
CPVL
carboxypeptidase, vitellogenic-like
chr12_-_112443767 0.17 ENST00000550233.1
ENST00000546962.1
ENST00000550800.2
TMEM116
transmembrane protein 116
chr16_+_9449445 0.16 ENST00000564305.1
RP11-243A14.1
RP11-243A14.1
chr11_+_47586982 0.16 ENST00000426530.2
ENST00000534775.1
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr9_+_6645887 0.16 ENST00000413145.1
RP11-390F4.6
RP11-390F4.6
chr17_+_19314432 0.16 ENST00000575165.2
RNF112
ring finger protein 112
chr4_-_76598544 0.16 ENST00000515457.1
ENST00000357854.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr19_-_53324884 0.16 ENST00000457749.2
ENST00000414252.2
ENST00000391783.2
ZNF28
zinc finger protein 28
chr17_+_53344945 0.16 ENST00000575345.1
HLF
hepatic leukemia factor
chr15_-_48470558 0.15 ENST00000324324.7
MYEF2
myelin expression factor 2
chr2_+_55746746 0.15 ENST00000406691.3
ENST00000349456.4
ENST00000407816.3
ENST00000403007.3
CCDC104
coiled-coil domain containing 104
chr11_-_126810521 0.15 ENST00000530572.1
RP11-688I9.4
RP11-688I9.4
chr15_-_48470544 0.15 ENST00000267836.6
MYEF2
myelin expression factor 2
chr15_+_40532837 0.15 ENST00000560806.1
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr16_-_50402836 0.14 ENST00000394688.3
BRD7
bromodomain containing 7
chr8_-_17942432 0.14 ENST00000381733.4
ENST00000314146.10
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr5_-_133340682 0.14 ENST00000265333.3
VDAC1
voltage-dependent anion channel 1
chr16_-_69419871 0.14 ENST00000603068.1
ENST00000254942.3
ENST00000567296.2
TERF2
telomeric repeat binding factor 2
chr11_+_125703204 0.14 ENST00000534411.1
ENST00000457514.2
PATE4
prostate and testis expressed 4
chr4_+_117220016 0.13 ENST00000604093.1
MTRNR2L13
MT-RNR2-like 13 (pseudogene)
chr16_-_50402690 0.13 ENST00000394689.2
BRD7
bromodomain containing 7
chr12_+_32638897 0.13 ENST00000531134.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr7_-_135612198 0.13 ENST00000589735.1
LUZP6
leucine zipper protein 6
chr7_-_112726393 0.13 ENST00000449591.1
ENST00000449735.1
ENST00000438062.1
ENST00000424100.1
GPR85
G protein-coupled receptor 85
chr4_-_40859132 0.13 ENST00000543538.1
ENST00000502841.1
ENST00000504305.1
ENST00000513516.1
ENST00000510670.1
APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr17_-_40346477 0.12 ENST00000593209.1
ENST00000587427.1
ENST00000588352.1
ENST00000414034.3
ENST00000590249.1
GHDC
GH3 domain containing
chr19_-_17014408 0.12 ENST00000594249.1
CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr11_+_47587129 0.12 ENST00000326656.8
ENST00000326674.9
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr15_+_42566384 0.12 ENST00000440615.2
ENST00000318010.8
GANC
glucosidase, alpha; neutral C
chr8_+_134203273 0.12 ENST00000250160.6
WISP1
WNT1 inducible signaling pathway protein 1
chr19_-_35981358 0.12 ENST00000484218.2
ENST00000338897.3
KRTDAP
keratinocyte differentiation-associated protein
chr1_+_160160346 0.12 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr7_+_6797288 0.12 ENST00000433859.2
ENST00000359718.3
RSPH10B2
radial spoke head 10 homolog B2 (Chlamydomonas)
chr12_+_72079842 0.12 ENST00000266673.5
ENST00000550524.1
TMEM19
transmembrane protein 19
chr10_-_5652705 0.11 ENST00000425246.1
RP11-336A10.5
RP11-336A10.5
chr7_-_130418888 0.11 ENST00000310992.4
KLF14
Kruppel-like factor 14
chr2_+_172543919 0.11 ENST00000452242.1
ENST00000340296.4
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr12_+_12202785 0.11 ENST00000586576.1
ENST00000464885.2
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr11_-_18656028 0.11 ENST00000336349.5
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr5_+_140165876 0.11 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
PCDHA1
protocadherin alpha 1
chr8_-_49834299 0.11 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr15_-_38852251 0.10 ENST00000558432.1
RASGRP1
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr11_-_73689037 0.10 ENST00000544615.1
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr17_+_72363597 0.10 ENST00000335666.4
GPR142
G protein-coupled receptor 142
chr7_-_8302298 0.10 ENST00000446305.1
ICA1
islet cell autoantigen 1, 69kDa
chr6_-_154568815 0.10 ENST00000519344.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr4_-_111563279 0.10 ENST00000511837.1
PITX2
paired-like homeodomain 2
chr14_-_39639523 0.10 ENST00000330149.5
ENST00000554018.1
ENST00000347691.5
TRAPPC6B
trafficking protein particle complex 6B
chr16_+_2867228 0.10 ENST00000005995.3
ENST00000574813.1
PRSS21
protease, serine, 21 (testisin)
chr6_-_41168920 0.10 ENST00000483722.1
TREML2
triggering receptor expressed on myeloid cells-like 2
chr3_+_177534653 0.10 ENST00000436078.1
RP11-91K9.1
RP11-91K9.1
chr12_-_76879852 0.10 ENST00000548341.1
OSBPL8
oxysterol binding protein-like 8
chr12_-_27235447 0.09 ENST00000429849.2
C12orf71
chromosome 12 open reading frame 71
chr2_+_27805880 0.09 ENST00000379717.1
ENST00000355467.4
ENST00000556601.1
ENST00000416005.2
ZNF512
zinc finger protein 512
chr3_+_152552685 0.09 ENST00000305097.3
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr3_+_99357319 0.09 ENST00000452013.1
ENST00000261037.3
ENST00000273342.4
COL8A1
collagen, type VIII, alpha 1
chr5_+_167956121 0.09 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr3_+_4344988 0.09 ENST00000358065.4
SETMAR
SET domain and mariner transposase fusion gene
chr1_+_248031277 0.09 ENST00000537741.1
OR2W3
olfactory receptor, family 2, subfamily W, member 3
chr2_+_37571717 0.09 ENST00000338415.3
ENST00000404976.1
QPCT
glutaminyl-peptide cyclotransferase
chr2_+_190540711 0.09 ENST00000520309.1
ANKAR
ankyrin and armadillo repeat containing
chr3_+_44916098 0.09 ENST00000296125.4
TGM4
transglutaminase 4
chr3_-_139195350 0.09 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr16_+_31225337 0.09 ENST00000322122.3
TRIM72
tripartite motif containing 72
chr13_+_31309645 0.09 ENST00000380490.3
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr1_+_160160283 0.09 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr2_-_171571077 0.09 ENST00000409786.1
AC007405.2
long intergenic non-protein coding RNA 1124
chr8_-_80993010 0.09 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
TPD52
tumor protein D52
chr12_+_12202774 0.09 ENST00000589718.1
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr11_-_94965667 0.08 ENST00000542176.1
ENST00000278499.2
SESN3
sestrin 3
chr7_+_6796986 0.08 ENST00000297186.3
RSPH10B2
radial spoke head 10 homolog B2 (Chlamydomonas)
chr17_-_56494882 0.08 ENST00000584437.1
RNF43
ring finger protein 43
chr1_-_208084729 0.08 ENST00000310833.7
ENST00000356522.4
CD34
CD34 molecule
chr12_+_20848377 0.08 ENST00000540354.1
ENST00000266509.2
ENST00000381552.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr6_+_69942298 0.07 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr2_-_145275211 0.07 ENST00000462355.1
ZEB2
zinc finger E-box binding homeobox 2
chr12_-_16758059 0.07 ENST00000261169.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_106976678 0.07 ENST00000392842.1
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr9_+_82186872 0.07 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0045872 regulation of rhodopsin gene expression(GO:0007468) positive regulation of rhodopsin gene expression(GO:0045872)
0.2 1.3 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.2 1.0 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.1 0.4 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) beta-alanine metabolic process(GO:0019482) thymine metabolic process(GO:0019859) uracil metabolic process(GO:0019860)
0.1 1.3 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.5 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.5 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.1 0.1 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.3 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.8 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.2 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.2 GO:0036269 swimming behavior(GO:0036269)
0.0 0.3 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.0 0.7 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:0018032 protein amidation(GO:0018032)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:1903824 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.0 0.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.3 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.8 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.1 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.0 0.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.0 0.1 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.1 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0 0.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.5 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.7 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.4 GO:0090487 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.0 0.1 GO:0072011 glomerular endothelium development(GO:0072011)
0.0 0.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.4 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.4 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.4 GO:1904293 negative regulation of ERAD pathway(GO:1904293)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 2.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:0010819 regulation of T cell chemotaxis(GO:0010819)
0.0 0.3 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0060578 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.0 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.5 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.3 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0042704 detection of oxygen(GO:0003032) uterine wall breakdown(GO:0042704)
0.0 0.4 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 0.1 GO:1902715 secretory granule localization(GO:0032252) positive regulation of interferon-gamma secretion(GO:1902715)
0.0 0.0 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0 0.6 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:0045208 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.1 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 1.0 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.5 GO:0031673 H zone(GO:0031673)
0.1 0.8 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 1.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.3 GO:0033263 CORVET complex(GO:0033263)
0.0 0.2 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.3 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.3 GO:0097227 sperm annulus(GO:0097227)
0.0 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0042383 sarcolemma(GO:0042383)
0.0 1.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 2.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.4 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 1.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.3 GO:0000150 recombinase activity(GO:0000150)
0.1 0.3 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.1 0.3 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 0.3 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 0.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.4 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.1 0.2 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.3 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 1.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.2 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.8 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.1 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.0 0.1 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 0.3 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 1.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0001042 RNA polymerase I core binding(GO:0001042)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID ATM PATHWAY ATM pathway
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 1.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.0 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 1.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 2.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 1.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.1 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D