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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MIXL1_GSX1_BSX_MEOX2_LHX4

Z-value: 0.46

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Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4

Gene Symbol Gene ID Gene Info
MIXL1
ENSG00000185155.7 Mix paired-like homeobox
GSX1
ENSG00000169840.4 GS homeobox 1
BSX
ENSG00000188909.4 brain specific homeobox
MEOX2
ENSG00000106511.5 mesenchyme homeobox 2
LHX4
ENSG00000121454.4 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX4hg19_v2_chr1_+_180199393_180199426-0.853.0e-02Click!
MIXL1hg19_v2_chr1_+_226411319_226411366-0.631.8e-01Click!
MEOX2hg19_v2_chr7_-_15726296_157264370.562.5e-01Click!

Activity profile of MIXL1_GSX1_BSX_MEOX2_LHX4 motif

Sorted Z-values of MIXL1_GSX1_BSX_MEOX2_LHX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_92777606 1.23 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chrM_+_10758 0.84 ENST00000361381.2
MT-ND4
mitochondrially encoded NADH dehydrogenase 4
chrM_+_10464 0.65 ENST00000361335.1
MT-ND4L
mitochondrially encoded NADH dehydrogenase 4L
chr13_-_86373536 0.57 ENST00000400286.2
SLITRK6
SLIT and NTRK-like family, member 6
chr14_+_20187174 0.50 ENST00000557414.1
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr17_-_38821373 0.47 ENST00000394052.3
KRT222
keratin 222
chr4_+_95916947 0.46 ENST00000506363.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr4_-_155533787 0.44 ENST00000407946.1
ENST00000405164.1
ENST00000336098.3
ENST00000393846.2
ENST00000404648.3
ENST00000443553.1
FGG
fibrinogen gamma chain
chr6_+_105404899 0.44 ENST00000345080.4
LIN28B
lin-28 homolog B (C. elegans)
chr4_-_36245561 0.41 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_+_53133070 0.40 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr4_+_183065793 0.38 ENST00000512480.1
TENM3
teneurin transmembrane protein 3
chr6_+_76330355 0.38 ENST00000483859.2
SENP6
SUMO1/sentrin specific peptidase 6
chr7_-_33102399 0.35 ENST00000242210.7
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr1_-_27998689 0.35 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
IFI6
interferon, alpha-inducible protein 6
chr11_+_35222629 0.34 ENST00000526553.1
CD44
CD44 molecule (Indian blood group)
chrM_+_14741 0.34 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b
chr22_-_40929812 0.32 ENST00000422851.1
MKL1
megakaryoblastic leukemia (translocation) 1
chr1_-_242612726 0.32 ENST00000459864.1
PLD5
phospholipase D family, member 5
chr7_-_33102338 0.32 ENST00000610140.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr7_-_92747269 0.31 ENST00000446617.1
ENST00000379958.2
SAMD9
sterile alpha motif domain containing 9
chr10_-_104866395 0.30 ENST00000458345.1
NT5C2
5'-nucleotidase, cytosolic II
chr12_+_28410128 0.30 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr14_-_51027838 0.29 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr9_-_3469181 0.29 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr5_-_126409159 0.28 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr3_-_151034734 0.28 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr15_+_63188009 0.28 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr2_+_172309634 0.26 ENST00000339506.3
DCAF17
DDB1 and CUL4 associated factor 17
chr7_+_77428149 0.26 ENST00000415251.2
ENST00000275575.7
PHTF2
putative homeodomain transcription factor 2
chr4_-_105416039 0.26 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr2_+_149402989 0.26 ENST00000397424.2
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr2_+_170440844 0.25 ENST00000260970.3
ENST00000433207.1
ENST00000409714.3
ENST00000462903.1
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chrX_+_134654540 0.24 ENST00000370752.4
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr16_-_3350614 0.24 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chrM_+_8366 0.24 ENST00000361851.1
MT-ATP8
mitochondrially encoded ATP synthase 8
chrM_+_7586 0.24 ENST00000361739.1
MT-CO2
mitochondrially encoded cytochrome c oxidase II
chr4_-_89205705 0.23 ENST00000295908.7
ENST00000510548.2
ENST00000508256.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chrM_-_14670 0.23 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr10_-_105110890 0.22 ENST00000369847.3
PCGF6
polycomb group ring finger 6
chr4_+_86748898 0.22 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr3_-_143567262 0.22 ENST00000474151.1
ENST00000316549.6
SLC9A9
solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
chr17_-_57229155 0.22 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr17_+_19091325 0.22 ENST00000584923.1
SNORD3A
small nucleolar RNA, C/D box 3A
chr4_+_26324474 0.21 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr3_-_33686925 0.21 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr14_-_81425828 0.21 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr18_-_33709268 0.20 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr5_-_102455801 0.20 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr5_-_24645078 0.20 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr11_-_121986923 0.20 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr13_-_36788718 0.19 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr3_-_69129501 0.19 ENST00000540295.1
ENST00000415609.2
ENST00000361055.4
ENST00000349511.4
UBA3
ubiquitin-like modifier activating enzyme 3
chr10_-_115904361 0.19 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr4_+_90033968 0.19 ENST00000317005.2
TIGD2
tigger transposable element derived 2
chr6_-_32157947 0.19 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chrX_-_71458802 0.19 ENST00000373657.1
ENST00000334463.3
ERCC6L
excision repair cross-complementing rodent repair deficiency, complementation group 6-like
chr10_-_36812323 0.19 ENST00000543053.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chrX_-_106243451 0.19 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr6_-_76072719 0.19 ENST00000370020.1
FILIP1
filamin A interacting protein 1
chr18_-_61329118 0.19 ENST00000332821.8
ENST00000283752.5
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr2_-_61697862 0.18 ENST00000398571.2
USP34
ubiquitin specific peptidase 34
chr17_-_38956205 0.18 ENST00000306658.7
KRT28
keratin 28
chr6_-_26235206 0.18 ENST00000244534.5
HIST1H1D
histone cluster 1, H1d
chrM_+_9207 0.18 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr10_-_21186144 0.17 ENST00000377119.1
NEBL
nebulette
chr12_+_113344582 0.17 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr8_-_90996459 0.17 ENST00000517337.1
ENST00000409330.1
NBN
nibrin
chr17_-_39341594 0.17 ENST00000398472.1
KRTAP4-1
keratin associated protein 4-1
chr12_+_41136144 0.17 ENST00000548005.1
ENST00000552248.1
CNTN1
contactin 1
chr14_+_67831576 0.17 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chrM_+_8527 0.17 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase 6
chr8_+_107460147 0.17 ENST00000442977.2
OXR1
oxidation resistance 1
chr5_-_148929848 0.16 ENST00000504676.1
ENST00000515435.1
CSNK1A1
casein kinase 1, alpha 1
chrX_-_106243294 0.16 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr15_-_55562451 0.16 ENST00000568803.1
RAB27A
RAB27A, member RAS oncogene family
chr3_+_148447887 0.16 ENST00000475347.1
ENST00000474935.1
ENST00000461609.1
AGTR1
angiotensin II receptor, type 1
chr6_+_111408698 0.16 ENST00000368851.5
SLC16A10
solute carrier family 16 (aromatic amino acid transporter), member 10
chr7_-_87342564 0.16 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chrX_+_123097014 0.16 ENST00000394478.1
STAG2
stromal antigen 2
chr14_+_62164340 0.16 ENST00000557538.1
ENST00000539097.1
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr14_-_88200641 0.16 ENST00000556168.1
RP11-1152H15.1
RP11-1152H15.1
chr12_-_88974236 0.16 ENST00000228280.5
ENST00000552044.1
ENST00000357116.4
KITLG
KIT ligand
chr19_-_51522955 0.16 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr11_-_117747434 0.16 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6
FXYD domain containing ion transport regulator 6
chr10_+_118349920 0.16 ENST00000531984.1
PNLIPRP1
pancreatic lipase-related protein 1
chr11_-_33913708 0.16 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_66796401 0.16 ENST00000528771.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr4_+_86749045 0.15 ENST00000514229.1
ARHGAP24
Rho GTPase activating protein 24
chr14_-_75083313 0.15 ENST00000556652.1
ENST00000555313.1
CTD-2207P18.2
CTD-2207P18.2
chr14_+_57671888 0.15 ENST00000391612.1
AL391152.1
AL391152.1
chr3_-_108248169 0.15 ENST00000273353.3
MYH15
myosin, heavy chain 15
chr6_-_31107127 0.15 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr17_-_73937028 0.15 ENST00000586631.2
FBF1
Fas (TNFRSF6) binding factor 1
chr13_-_88323218 0.15 ENST00000436290.2
ENST00000453832.2
ENST00000606590.1
MIR4500HG
MIR4500 host gene (non-protein coding)
chr1_-_54411255 0.15 ENST00000371377.3
HSPB11
heat shock protein family B (small), member 11
chrX_-_55208866 0.15 ENST00000545075.1
MTRNR2L10
MT-RNR2-like 10
chr19_-_44388116 0.15 ENST00000587539.1
ZNF404
zinc finger protein 404
chr1_-_101360331 0.15 ENST00000416479.1
ENST00000370113.3
EXTL2
exostosin-like glycosyltransferase 2
chr15_+_80351910 0.15 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr3_+_130569429 0.14 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr2_-_136678123 0.14 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr2_-_55647057 0.14 ENST00000436346.1
CCDC88A
coiled-coil domain containing 88A
chr10_-_105110831 0.14 ENST00000337211.4
PCGF6
polycomb group ring finger 6
chr7_-_73038822 0.14 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
MLXIPL
MLX interacting protein-like
chr6_-_56492816 0.14 ENST00000522360.1
DST
dystonin
chr3_-_98619999 0.14 ENST00000449482.1
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr3_+_136649311 0.14 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chrX_+_591524 0.14 ENST00000554971.1
ENST00000381575.1
SHOX
short stature homeobox
chr7_+_77428066 0.14 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
PHTF2
putative homeodomain transcription factor 2
chr11_+_77532233 0.14 ENST00000525409.1
AAMDC
adipogenesis associated, Mth938 domain containing
chr13_-_41593425 0.14 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_+_78315528 0.14 ENST00000496045.1
SLAIN1
SLAIN motif family, member 1
chr4_-_185694872 0.14 ENST00000505492.1
ACSL1
acyl-CoA synthetase long-chain family member 1
chr4_+_71384300 0.14 ENST00000504451.1
AMTN
amelotin
chr5_+_68860949 0.14 ENST00000507595.1
GTF2H2C
general transcription factor IIH, polypeptide 2C
chr17_+_48823975 0.13 ENST00000513969.1
ENST00000503728.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr13_-_31191642 0.13 ENST00000405805.1
HMGB1
high mobility group box 1
chrM_+_12331 0.13 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr1_+_205682497 0.13 ENST00000598338.1
AC119673.1
AC119673.1
chr7_-_27169801 0.13 ENST00000511914.1
HOXA4
homeobox A4
chr11_-_104905840 0.13 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1
caspase 1, apoptosis-related cysteine peptidase
chr17_-_19015945 0.13 ENST00000573866.2
SNORD3D
small nucleolar RNA, C/D box 3D
chrX_-_11129229 0.13 ENST00000608176.1
ENST00000433747.2
ENST00000608576.1
ENST00000608916.1
RP11-120D5.1
RP11-120D5.1
chr1_-_235098935 0.13 ENST00000423175.1
RP11-443B7.1
RP11-443B7.1
chr12_+_1099675 0.13 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr2_-_17981462 0.13 ENST00000402989.1
ENST00000428868.1
SMC6
structural maintenance of chromosomes 6
chr5_-_39219641 0.12 ENST00000509072.1
ENST00000504542.1
ENST00000505428.1
ENST00000506557.1
FYB
FYN binding protein
chr5_-_142780280 0.12 ENST00000424646.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr12_+_81110684 0.12 ENST00000228644.3
MYF5
myogenic factor 5
chr2_+_182850551 0.12 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr3_-_180397256 0.12 ENST00000442201.2
CCDC39
coiled-coil domain containing 39
chr12_+_20963647 0.12 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr8_-_128231299 0.12 ENST00000500112.1
CCAT1
colon cancer associated transcript 1 (non-protein coding)
chr1_-_101360205 0.12 ENST00000450240.1
EXTL2
exostosin-like glycosyltransferase 2
chr14_-_57960545 0.12 ENST00000526336.1
ENST00000216445.3
C14orf105
chromosome 14 open reading frame 105
chr4_-_170897045 0.12 ENST00000508313.1
RP11-205M3.3
RP11-205M3.3
chr5_+_89770696 0.12 ENST00000504930.1
ENST00000514483.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr1_-_101360374 0.12 ENST00000535414.1
EXTL2
exostosin-like glycosyltransferase 2
chr7_-_151217166 0.12 ENST00000496004.1
RHEB
Ras homolog enriched in brain
chr5_+_89770664 0.12 ENST00000503973.1
ENST00000399107.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr2_+_200472779 0.12 ENST00000427045.1
ENST00000419243.1
AC093590.1
AC093590.1
chr2_-_180871780 0.12 ENST00000410053.3
ENST00000295749.6
ENST00000404136.2
CWC22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr4_+_119809984 0.12 ENST00000307142.4
ENST00000448416.2
ENST00000429713.2
SYNPO2
synaptopodin 2
chr4_+_26323764 0.12 ENST00000514730.1
ENST00000507574.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr16_-_66864806 0.11 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chr12_-_110937351 0.11 ENST00000552130.2
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr1_+_101003687 0.11 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr8_-_17533838 0.11 ENST00000400046.1
MTUS1
microtubule associated tumor suppressor 1
chr5_-_56778635 0.11 ENST00000423391.1
ACTBL2
actin, beta-like 2
chr4_+_66536248 0.11 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr3_-_33686743 0.11 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr12_-_89746264 0.11 ENST00000548755.1
DUSP6
dual specificity phosphatase 6
chr6_-_76203454 0.11 ENST00000237172.7
FILIP1
filamin A interacting protein 1
chr10_+_126630692 0.11 ENST00000359653.4
ZRANB1
zinc finger, RAN-binding domain containing 1
chr20_+_5987890 0.11 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr11_-_327537 0.11 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr4_+_158493642 0.11 ENST00000507108.1
ENST00000455598.1
ENST00000509450.1
RP11-364P22.1
RP11-364P22.1
chr17_-_64225508 0.11 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_+_76649797 0.11 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr11_-_111649015 0.11 ENST00000529841.1
RP11-108O10.2
RP11-108O10.2
chr13_-_44735393 0.11 ENST00000400419.1
SMIM2
small integral membrane protein 2
chr12_+_104337515 0.11 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr5_-_87516448 0.11 ENST00000511218.1
TMEM161B
transmembrane protein 161B
chr1_-_150738261 0.10 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr2_-_44550441 0.10 ENST00000420756.1
ENST00000444696.1
PREPL
prolyl endopeptidase-like
chr7_-_120497178 0.10 ENST00000441017.1
ENST00000424710.1
ENST00000433758.1
TSPAN12
tetraspanin 12
chr12_+_32832203 0.10 ENST00000553257.1
ENST00000549701.1
ENST00000358214.5
ENST00000266481.6
ENST00000551476.1
ENST00000550154.1
ENST00000547312.1
ENST00000414834.2
ENST00000381000.4
ENST00000548750.1
DNM1L
dynamin 1-like
chr8_-_124279627 0.10 ENST00000357082.4
ZHX1-C8ORF76
ZHX1-C8ORF76 readthrough
chr1_+_204494618 0.10 ENST00000367180.1
ENST00000391947.2
MDM4
Mdm4 p53 binding protein homolog (mouse)
chr14_-_92413727 0.10 ENST00000267620.10
FBLN5
fibulin 5
chr1_-_28384598 0.10 ENST00000373864.1
EYA3
eyes absent homolog 3 (Drosophila)
chr17_-_40337470 0.10 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr14_-_92413353 0.10 ENST00000556154.1
FBLN5
fibulin 5
chr4_+_174089904 0.10 ENST00000265000.4
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr7_+_1272522 0.10 ENST00000316333.8
UNCX
UNC homeobox
chr2_+_234637754 0.10 ENST00000482026.1
ENST00000609767.1
UGT1A3
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr18_+_3247779 0.10 ENST00000578611.1
ENST00000583449.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr14_-_57960456 0.10 ENST00000534126.1
ENST00000422976.2
C14orf105
chromosome 14 open reading frame 105
chr6_+_149887377 0.10 ENST00000367419.5
GINM1
glycoprotein integral membrane 1
chr4_+_155484103 0.09 ENST00000302068.4
FGB
fibrinogen beta chain
chr10_-_52008313 0.09 ENST00000329428.6
ENST00000395526.4
ENST00000447815.1
ASAH2
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
chr12_+_72058130 0.09 ENST00000547843.1
THAP2
THAP domain containing, apoptosis associated protein 2
chr12_+_16500599 0.09 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
MGST1
microsomal glutathione S-transferase 1
chr12_+_20963632 0.09 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr17_-_39203519 0.09 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr6_+_47666275 0.09 ENST00000327753.3
ENST00000283303.2
GPR115
G protein-coupled receptor 115
chr17_-_62499334 0.09 ENST00000579996.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr19_+_52800410 0.09 ENST00000595962.1
ENST00000598016.1
ENST00000334564.7
ENST00000490272.1
ZNF480
zinc finger protein 480
chr7_-_77427676 0.09 ENST00000257663.3
TMEM60
transmembrane protein 60
chr10_+_17686193 0.09 ENST00000377500.1
STAM
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
chr16_-_53737722 0.09 ENST00000569716.1
ENST00000562588.1
ENST00000562230.1
ENST00000379925.3
ENST00000563746.1
ENST00000568653.3
RPGRIP1L
RPGRIP1-like
chr10_+_69865866 0.09 ENST00000354393.2
MYPN
myopalladin
chr11_+_17316870 0.09 ENST00000458064.2
NUCB2
nucleobindin 2
chr7_+_142829162 0.09 ENST00000291009.3
PIP
prolactin-induced protein
chr11_+_112041253 0.09 ENST00000532612.1
AP002884.3
AP002884.3
chr10_+_94594351 0.09 ENST00000371552.4
EXOC6
exocyst complex component 6
chr22_+_18632666 0.09 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr12_-_74686314 0.09 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr3_+_138340049 0.09 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule

Network of associatons between targets according to the STRING database.

First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0060005 vestibular reflex(GO:0060005)
0.1 1.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.2 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.5 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.2 GO:0007113 endomitotic cell cycle(GO:0007113)
0.1 1.0 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.4 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.1 0.2 GO:0070101 positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.1 0.2 GO:0033025 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.0 0.2 GO:0035425 autocrine signaling(GO:0035425)
0.0 0.1 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.1 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.0 0.3 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.2 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.2 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.3 GO:1905068 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.2 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.1 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) T-helper 1 cell activation(GO:0035711) negative regulation of apoptotic cell clearance(GO:2000426)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.4 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:0045766 positive regulation of angiogenesis(GO:0045766)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.1 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 0.3 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.2 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.3 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.0 0.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.1 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.0 0.2 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.0 0.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.6 GO:0034116 positive regulation of heterotypic cell-cell adhesion(GO:0034116)
0.0 0.1 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
0.0 0.1 GO:0061010 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.0 0.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) strand invasion(GO:0042148)
0.0 1.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.0 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0 0.1 GO:0006789 bilirubin conjugation(GO:0006789)
0.0 0.1 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.0 0.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.2 GO:1903961 positive regulation of anion transmembrane transport(GO:1903961)
0.0 0.1 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0 0.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.1 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.0 0.1 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.0 0.2 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0 0.2 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:1903551 regulation of extracellular exosome assembly(GO:1903551)
0.0 0.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0009820 alkaloid metabolic process(GO:0009820)
0.0 0.1 GO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.2 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.1 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.0 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.1 GO:0086053 AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.0 0.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.0 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 0.1 GO:0045209 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.1 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.0 0.1 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 0.0 GO:0008057 eye pigment granule organization(GO:0008057)
0.0 0.2 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.1 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.0 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.0 0.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.0 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.0 GO:0051795 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.0 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.3 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.0 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) astrocyte end-foot(GO:0097450) glial limiting end-foot(GO:0097451)
0.1 0.7 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0031673 H zone(GO:0031673)
0.0 0.1 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 1.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0033565 ESCRT-0 complex(GO:0033565)
0.0 0.2 GO:0071953 elastic fiber(GO:0071953)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.4 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.1 GO:0070069 cytochrome complex(GO:0070069)
0.0 0.1 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.1 GO:0097422 tubular endosome(GO:0097422)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.1 0.4 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.1 0.3 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.1 0.3 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0031862 prostanoid receptor binding(GO:0031862)
0.0 0.2 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0030572 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 2.0 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.2 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.1 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.0 0.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.1 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.5 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.0 0.1 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.0 0.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.1 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.0 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.0 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532) copper-dependent protein binding(GO:0032767)
0.0 0.0 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.0 0.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.0 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing