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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MSX2

Z-value: 0.58

Motif logo

Transcription factors associated with MSX2

Gene Symbol Gene ID Gene Info
ENSG00000120149.7 msh homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSX2hg19_v2_chr5_+_174151536_1741516100.325.4e-01Click!

Activity profile of MSX2 motif

Sorted Z-values of MSX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_1922789 0.72 ENST00000521498.1
RP11-439C15.4
chr7_-_99716914 0.48 ENST00000431404.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr4_-_171012844 0.43 ENST00000502392.1
aminoadipate aminotransferase
chr14_-_88200641 0.42 ENST00000556168.1
RP11-1152H15.1
chr1_-_36916011 0.40 ENST00000356637.5
ENST00000354267.3
ENST00000235532.5
organic solute carrier partner 1
chr3_-_112127981 0.39 ENST00000486726.2
RP11-231E6.1
chr17_-_46716647 0.39 ENST00000608940.1
RP11-357H14.17
chr18_+_63273310 0.37 ENST00000579862.1
RP11-775G23.1
chr19_+_11485333 0.33 ENST00000312423.2
SWIM-type zinc finger 7 associated protein 1
chr1_+_81001398 0.31 ENST00000418041.1
ENST00000443104.1
RP5-887A10.1
chr2_-_8715616 0.30 ENST00000418358.1
AC011747.3
chr4_-_19458597 0.30 ENST00000505347.1
RP11-3J1.1
chr1_-_232651312 0.28 ENST00000262861.4
signal-induced proliferation-associated 1 like 2
chr17_+_12569472 0.26 ENST00000343344.4
myocardin
chr17_+_44679808 0.24 ENST00000571172.1
N-ethylmaleimide-sensitive factor
chr7_-_2883928 0.22 ENST00000275364.3
guanine nucleotide binding protein (G protein) alpha 12
chr17_+_74261277 0.22 ENST00000327490.6
UBA-like domain containing 2
chr7_-_2883650 0.22 ENST00000544127.1
guanine nucleotide binding protein (G protein) alpha 12
chrX_-_21676442 0.21 ENST00000379499.2
kelch-like family member 34
chr1_+_27158505 0.20 ENST00000534643.1
zinc finger, DHHC-type containing 18
chr16_+_69345243 0.20 ENST00000254950.11
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chrX_-_15332665 0.19 ENST00000537676.1
ENST00000344384.4
ankyrin repeat and SOCS box containing 11
chr1_-_151762943 0.18 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
tudor and KH domain containing
chr3_+_113251143 0.17 ENST00000264852.4
ENST00000393830.3
SID1 transmembrane family, member 1
chr20_+_56964169 0.17 ENST00000475243.1
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr12_+_64798826 0.17 ENST00000540203.1
exportin, tRNA
chr6_+_25652501 0.16 ENST00000334979.6
secretagogin, EF-hand calcium binding protein
chr20_-_50418947 0.16 ENST00000371539.3
spalt-like transcription factor 4
chr1_-_36916066 0.16 ENST00000315643.9
organic solute carrier partner 1
chr1_-_68698197 0.15 ENST00000370973.2
ENST00000370971.1
wntless Wnt ligand secretion mediator
chr17_-_9929581 0.14 ENST00000437099.2
ENST00000396115.2
growth arrest-specific 7
chr17_-_12920907 0.14 ENST00000609757.1
ENST00000581499.2
ENST00000580504.1
elaC ribonuclease Z 2
chr10_-_28571015 0.14 ENST00000375719.3
ENST00000375732.1
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr10_+_99205894 0.14 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
zinc finger, DHHC-type containing 16
chr7_-_99717463 0.14 ENST00000437822.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr7_-_99716940 0.14 ENST00000440225.1
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_-_21377383 0.14 ENST00000374935.3
eukaryotic translation initiation factor 4 gamma, 3
chr7_-_99716952 0.13 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_-_8877692 0.13 ENST00000400908.2
arginine-glutamic acid dipeptide (RE) repeats
chr1_-_151431674 0.13 ENST00000531094.1
pogo transposable element with ZNF domain
chr12_+_52695617 0.13 ENST00000293525.5
keratin 86
chr1_-_151762900 0.13 ENST00000440583.2
tudor and KH domain containing
chr14_-_95236551 0.13 ENST00000238558.3
goosecoid homeobox
chr5_-_31532160 0.13 ENST00000511367.2
ENST00000513349.1
drosha, ribonuclease type III
chr1_-_36915880 0.13 ENST00000445843.3
organic solute carrier partner 1
chr1_+_27158483 0.12 ENST00000374141.2
zinc finger, DHHC-type containing 18
chr11_+_33061543 0.12 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
t-complex 11, testis-specific-like 1
chr9_+_124329336 0.12 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2 interacting protein
chr11_-_71823796 0.12 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
anaphase promoting complex subunit 15
chr10_+_99205959 0.11 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
zinc finger, DHHC-type containing 16
chr6_+_25652432 0.11 ENST00000377961.2
secretagogin, EF-hand calcium binding protein
chr1_-_151431647 0.11 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
pogo transposable element with ZNF domain
chr22_-_30960876 0.11 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
galactose-3-O-sulfotransferase 1
chr7_-_56174161 0.11 ENST00000395422.3
coiled-coil-helix-coiled-coil-helix domain containing 2
chr7_+_99717230 0.10 ENST00000262932.3
canopy FGF signaling regulator 4
chr5_+_140557371 0.10 ENST00000239444.2
protocadherin beta 8
chr5_+_95997885 0.10 ENST00000511097.2
calpastatin
chr2_-_200335983 0.10 ENST00000457245.1
SATB homeobox 2
chr14_+_32798547 0.10 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr1_-_94050668 0.10 ENST00000539242.1
breast cancer anti-estrogen resistance 3
chr6_-_116833500 0.10 ENST00000356128.4
trafficking protein particle complex 3-like
chr10_-_72142345 0.10 ENST00000373224.1
ENST00000446961.1
ENST00000358141.2
ENST00000357631.2
leucine rich repeat containing 20
chr12_+_53662110 0.09 ENST00000552462.1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr3_-_120400960 0.09 ENST00000476082.2
homogentisate 1,2-dioxygenase
chr19_+_17378159 0.09 ENST00000598188.1
ENST00000359435.4
ENST00000599474.1
ENST00000599057.1
ENST00000601043.1
ENST00000447614.2
BRISC and BRCA1 A complex member 1
chr1_+_202317815 0.09 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
protein phosphatase 1, regulatory subunit 12B
chr12_-_120315074 0.09 ENST00000261833.7
ENST00000392521.2
citron (rho-interacting, serine/threonine kinase 21)
chr10_+_85954377 0.09 ENST00000332904.3
ENST00000372117.3
cadherin-related family member 1
chr21_-_22175341 0.08 ENST00000416768.1
ENST00000452561.1
ENST00000419299.1
ENST00000437238.1
long intergenic non-protein coding RNA 320
chr11_-_71823715 0.08 ENST00000545944.1
ENST00000502597.2
anaphase promoting complex subunit 15
chr1_-_151431909 0.08 ENST00000361398.3
ENST00000271715.2
pogo transposable element with ZNF domain
chr14_+_32798462 0.08 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr12_-_57039739 0.08 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr7_-_100183742 0.08 ENST00000310300.6
leucine-rich repeats and calponin homology (CH) domain containing 4
chr1_+_202317855 0.08 ENST00000356764.2
protein phosphatase 1, regulatory subunit 12B
chr20_-_54967187 0.08 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
aurora kinase A
chr20_+_49126881 0.08 ENST00000371621.3
ENST00000541713.1
protein tyrosine phosphatase, non-receptor type 1
chr19_+_42817527 0.08 ENST00000598766.1
transmembrane protein 145
chr19_-_46088068 0.08 ENST00000263275.4
ENST00000323060.3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr17_-_43045439 0.08 ENST00000253407.3
complement component 1, q subcomponent-like 1
chr9_+_74729511 0.08 ENST00000545168.1
guanine deaminase
chr2_-_73460334 0.07 ENST00000258083.2
protease-associated domain containing 1
chr19_+_17378278 0.07 ENST00000596335.1
ENST00000601436.1
ENST00000595632.1
BRISC and BRCA1 A complex member 1
chr5_+_95998070 0.07 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
calpastatin
chr11_-_71823266 0.07 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
anaphase promoting complex subunit 15
chr12_-_9102224 0.07 ENST00000543845.1
ENST00000544245.1
mannose-6-phosphate receptor (cation dependent)
chr8_+_9413410 0.06 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr12_-_9102549 0.06 ENST00000000412.3
mannose-6-phosphate receptor (cation dependent)
chr11_+_17298342 0.06 ENST00000530964.1
nucleobindin 2
chr16_-_29934558 0.05 ENST00000568995.1
ENST00000566413.1
potassium channel tetramerization domain containing 13
chr6_+_30687978 0.05 ENST00000327892.8
ENST00000435534.1
tubulin, beta class I
chr3_-_180397256 0.05 ENST00000442201.2
coiled-coil domain containing 39
chr5_+_150639360 0.05 ENST00000523004.1
GM2 ganglioside activator
chr17_+_74261413 0.05 ENST00000587913.1
UBA-like domain containing 2
chr16_+_58783542 0.05 ENST00000500117.1
ENST00000565722.1
RP11-410D17.2
chr1_+_151735431 0.05 ENST00000321531.5
ENST00000315067.8
ornithine decarboxylase antizyme 3
chrX_-_48931648 0.04 ENST00000376386.3
ENST00000376390.4
PRA1 domain family, member 2
chr12_+_54718904 0.04 ENST00000262061.2
ENST00000549043.1
ENST00000552218.1
ENST00000553231.1
ENST00000552362.1
ENST00000455864.2
ENST00000416254.2
ENST00000549116.1
ENST00000551779.1
coatomer protein complex, subunit zeta 1
chr14_-_23504432 0.04 ENST00000425762.2
proteasome (prosome, macropain) subunit, beta type, 5
chr20_+_56964253 0.04 ENST00000395802.3
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr11_+_67250490 0.04 ENST00000528641.2
ENST00000279146.3
aryl hydrocarbon receptor interacting protein
chr12_+_53662073 0.04 ENST00000553219.1
ENST00000257934.4
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr1_-_68698222 0.04 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
wntless Wnt ligand secretion mediator
chr6_-_31830655 0.04 ENST00000375631.4
sialidase 1 (lysosomal sialidase)
chr18_-_48346298 0.04 ENST00000398439.3
maestro
chr2_-_98280383 0.03 ENST00000289228.5
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr15_-_98417780 0.03 ENST00000503874.3
long intergenic non-protein coding RNA 923
chr4_-_88449771 0.03 ENST00000535835.1
SPARC-like 1 (hevin)
chr4_-_109684120 0.03 ENST00000512646.1
ENST00000411864.2
ENST00000296486.3
ENST00000510706.1
ethanolamine-phosphate phospho-lyase
chr4_-_69434245 0.03 ENST00000317746.2
UDP glucuronosyltransferase 2 family, polypeptide B17
chr6_+_34204642 0.03 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
high mobility group AT-hook 1
chr17_-_48785216 0.03 ENST00000285243.6
ankyrin repeat domain 40
chr7_+_100210133 0.03 ENST00000393950.2
ENST00000424091.2
motile sperm domain containing 3
chr19_-_10121144 0.03 ENST00000264828.3
collagen, type V, alpha 3
chr19_+_4007644 0.03 ENST00000262971.2
protein inhibitor of activated STAT, 4
chr18_+_39535239 0.03 ENST00000585528.1
phosphatidylinositol 3-kinase, catalytic subunit type 3
chr15_+_41245160 0.02 ENST00000444189.2
ENST00000446533.3
ChaC, cation transport regulator homolog 1 (E. coli)
chr20_-_50419055 0.02 ENST00000217086.4
spalt-like transcription factor 4
chr11_+_108535752 0.02 ENST00000322536.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr22_+_17956618 0.02 ENST00000262608.8
cat eye syndrome chromosome region, candidate 2
chr13_-_103389159 0.02 ENST00000322527.2
coiled-coil domain containing 168
chr9_+_34646651 0.02 ENST00000378842.3
galactose-1-phosphate uridylyltransferase
chr15_-_37393406 0.02 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
Meis homeobox 2
chr20_+_30467600 0.02 ENST00000375934.4
ENST00000375922.4
tubulin tyrosine ligase-like family, member 9
chr5_+_95997918 0.02 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
calpastatin
chr7_+_48211048 0.02 ENST00000435803.1
ATP-binding cassette, sub-family A (ABC1), member 13
chr7_+_100209979 0.01 ENST00000493970.1
ENST00000379527.2
motile sperm domain containing 3
chr17_-_80250663 0.01 ENST00000581489.1
RP13-516M14.4
chr5_+_140797296 0.01 ENST00000398594.2
protocadherin gamma subfamily B, 7
chr1_+_244515930 0.01 ENST00000366537.1
ENST00000308105.4
chromosome 1 open reading frame 100
chr18_+_39535152 0.01 ENST00000262039.4
ENST00000398870.3
ENST00000586545.1
phosphatidylinositol 3-kinase, catalytic subunit type 3
chr6_-_167040731 0.01 ENST00000265678.4
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr10_-_15762124 0.01 ENST00000378076.3
integrin, alpha 8
chr11_-_124981475 0.01 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
transmembrane protein 218
chr14_-_23504337 0.01 ENST00000361611.6
proteasome (prosome, macropain) subunit, beta type, 5
chr7_+_100183927 0.01 ENST00000241071.6
ENST00000360609.2
F-box protein 24
chr17_+_42264556 0.00 ENST00000319511.6
ENST00000589785.1
ENST00000592825.1
ENST00000589184.1
transmembrane and ubiquitin-like domain containing 2
chr19_+_46236509 0.00 ENST00000457052.2
Uncharacterized protein
chrX_+_77154935 0.00 ENST00000481445.1
cytochrome c oxidase subunit VIIb
chrX_+_70752945 0.00 ENST00000373701.3
O-linked N-acetylglucosamine (GlcNAc) transferase
chr1_-_23694794 0.00 ENST00000374608.3
zinc finger protein 436
chr10_-_99447024 0.00 ENST00000370626.3
arginine vasopressin-induced 1

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512) L-kynurenine metabolic process(GO:0097052)
0.1 0.2 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.1 GO:0072684 mitochondrial tRNA 3'-trailer cleavage, endonucleolytic(GO:0072684)
0.0 0.2 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.4 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.2 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.1 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.0 0.1 GO:0099558 maintenance of synapse structure(GO:0099558)
0.0 0.1 GO:0006147 guanine catabolic process(GO:0006147)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.3 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.1 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.2 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.3 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097196 Shu complex(GO:0097196)
0.1 0.3 GO:0071547 piP-body(GO:0071547)
0.0 0.2 GO:0044301 climbing fiber(GO:0044301)
0.0 0.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0047536 2-aminoadipate transaminase activity(GO:0047536)
0.1 0.4 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 0.2 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.0 0.2 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.1 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 0.1 GO:0008892 guanine deaminase activity(GO:0008892)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.2 GO:0031628 opioid receptor binding(GO:0031628) mu-type opioid receptor binding(GO:0031852)
0.0 0.1 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.0 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID S1P S1P4 PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening