Project

A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation
Downloads

Results for NKX1-1

Z-value: 0.53

Motif logo

logo of

Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
NKX1-1
ENSG00000235608.1 NK1 homeobox 1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_159832438 0.37 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr18_+_63273310 0.33 ENST00000579862.1
RP11-775G23.1
RP11-775G23.1
chr17_+_1666108 0.30 ENST00000570731.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_-_4629367 0.29 ENST00000533021.1
TRIM68
tripartite motif containing 68
chr4_-_87515202 0.25 ENST00000502302.1
ENST00000513186.1
MAPK10
mitogen-activated protein kinase 10
chr19_+_39930212 0.24 ENST00000396843.1
AC011500.1
Interleukin-like; Uncharacterized protein
chr6_-_85473073 0.24 ENST00000606621.1
TBX18
T-box 18
chr3_-_105587879 0.19 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr3_-_52567792 0.18 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
NT5DC2
5'-nucleotidase domain containing 2
chr3_-_105588231 0.17 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr14_+_32798547 0.17 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr1_-_159915386 0.14 ENST00000361509.3
ENST00000368094.1
IGSF9
immunoglobulin superfamily, member 9
chr11_+_72983246 0.14 ENST00000393590.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr5_+_66300464 0.12 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr2_+_8822113 0.12 ENST00000396290.1
ENST00000331129.3
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr17_+_45286706 0.11 ENST00000393450.1
ENST00000572303.1
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr11_-_4629388 0.11 ENST00000526337.1
ENST00000300747.5
TRIM68
tripartite motif containing 68
chr10_+_120789223 0.11 ENST00000425699.1
NANOS1
nanos homolog 1 (Drosophila)
chrX_-_153363188 0.11 ENST00000303391.6
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr17_-_61777459 0.10 ENST00000578993.1
ENST00000583211.1
ENST00000259006.3
LIMD2
LIM domain containing 2
chr2_+_105050794 0.10 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr13_+_78315295 0.10 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr1_+_174843548 0.10 ENST00000478442.1
ENST00000465412.1
RABGAP1L
RAB GTPase activating protein 1-like
chr7_+_2559399 0.09 ENST00000222725.5
ENST00000359574.3
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr19_+_41256764 0.09 ENST00000243563.3
ENST00000601253.1
ENST00000597353.1
ENST00000599362.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr11_+_72983450 0.09 ENST00000536225.1
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr12_+_7013897 0.08 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr6_-_80247105 0.08 ENST00000369846.4
LCA5
Leber congenital amaurosis 5
chr19_+_36249044 0.08 ENST00000444637.2
ENST00000396908.4
ENST00000544099.1
C19orf55
chromosome 19 open reading frame 55
chr7_-_86849883 0.08 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr1_+_161691353 0.08 ENST00000367948.2
FCRLB
Fc receptor-like B
chr6_+_26501449 0.07 ENST00000244513.6
BTN1A1
butyrophilin, subfamily 1, member A1
chr9_+_116225999 0.07 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr1_+_222910625 0.07 ENST00000360827.2
FAM177B
family with sequence similarity 177, member B
chr3_+_158519654 0.07 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr12_+_7014064 0.06 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr11_-_47198380 0.06 ENST00000419701.2
ENST00000526342.1
ENST00000528444.1
ENST00000530596.1
ENST00000525398.1
ENST00000319543.6
ENST00000426335.2
ENST00000527927.1
ENST00000525314.1
ARFGAP2
ADP-ribosylation factor GTPase activating protein 2
chr9_+_139780942 0.06 ENST00000247668.2
ENST00000359662.3
TRAF2
TNF receptor-associated factor 2
chrX_-_47509994 0.06 ENST00000343894.4
ELK1
ELK1, member of ETS oncogene family
chr10_-_1095050 0.06 ENST00000381344.3
IDI1
isopentenyl-diphosphate delta isomerase 1
chr5_-_22853429 0.06 ENST00000504376.2
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr12_-_50790267 0.06 ENST00000327337.5
ENST00000543111.1
FAM186A
family with sequence similarity 186, member A
chr11_-_62521614 0.06 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr10_+_1095416 0.06 ENST00000358220.1
WDR37
WD repeat domain 37
chr17_-_8113886 0.05 ENST00000577833.1
ENST00000534871.1
ENST00000583915.1
ENST00000316199.6
ENST00000581511.1
ENST00000585124.1
AURKB
aurora kinase B
chr3_+_186560476 0.05 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr12_+_6961279 0.05 ENST00000229268.8
ENST00000389231.5
ENST00000542087.1
USP5
ubiquitin specific peptidase 5 (isopeptidase T)
chr12_+_64798826 0.05 ENST00000540203.1
XPOT
exportin, tRNA
chr10_-_99205607 0.05 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr4_-_103682145 0.05 ENST00000226578.4
MANBA
mannosidase, beta A, lysosomal
chr5_+_150226085 0.05 ENST00000522154.1
IRGM
immunity-related GTPase family, M
chr17_+_45286387 0.05 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr3_-_59035673 0.05 ENST00000491845.1
ENST00000472469.1
ENST00000471288.1
ENST00000295966.7
C3orf67
chromosome 3 open reading frame 67
chrX_+_55026763 0.05 ENST00000374987.3
APEX2
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr14_-_24711764 0.04 ENST00000557921.1
ENST00000558476.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr14_+_32798462 0.04 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr4_-_54232144 0.04 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
SCFD2
sec1 family domain containing 2
chr1_-_151762943 0.04 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
TDRKH
tudor and KH domain containing
chrX_+_72783026 0.04 ENST00000373504.6
ENST00000373502.5
CHIC1
cysteine-rich hydrophobic domain 1
chr11_-_71823715 0.04 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr17_+_59489112 0.04 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr11_+_134201768 0.04 ENST00000535456.2
ENST00000339772.7
GLB1L2
galactosidase, beta 1-like 2
chr13_+_36050881 0.04 ENST00000537702.1
NBEA
neurobeachin
chr8_+_94929273 0.03 ENST00000518573.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr14_-_24711470 0.03 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr7_+_99647411 0.03 ENST00000438937.1
ZSCAN21
zinc finger and SCAN domain containing 21
chr1_-_221915418 0.03 ENST00000323825.3
ENST00000366899.3
DUSP10
dual specificity phosphatase 10
chr22_+_41601209 0.03 ENST00000216237.5
L3MBTL2
l(3)mbt-like 2 (Drosophila)
chr2_+_217524323 0.03 ENST00000456764.1
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr16_-_2318373 0.03 ENST00000566458.1
ENST00000320225.5
RNPS1
RNA binding protein S1, serine-rich domain
chr2_-_167232484 0.03 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr4_-_89442940 0.03 ENST00000527353.1
PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chr12_-_6961050 0.03 ENST00000538862.2
CDCA3
cell division cycle associated 3
chr4_-_66536196 0.02 ENST00000511294.1
EPHA5
EPH receptor A5
chr11_-_65625678 0.02 ENST00000308162.5
CFL1
cofilin 1 (non-muscle)
chr7_-_27239703 0.02 ENST00000222753.4
HOXA13
homeobox A13
chr12_+_16500571 0.02 ENST00000543076.1
ENST00000396210.3
MGST1
microsomal glutathione S-transferase 1
chr3_+_57261743 0.02 ENST00000288266.3
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chrX_-_153363125 0.02 ENST00000407218.1
ENST00000453960.2
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr15_+_64386261 0.02 ENST00000560829.1
SNX1
sorting nexin 1
chr7_+_99717230 0.02 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr17_-_44657017 0.02 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ARL17A
ADP-ribosylation factor-like 17A
chr3_+_186560462 0.02 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr4_-_8873531 0.02 ENST00000400677.3
HMX1
H6 family homeobox 1
chrX_-_47509887 0.01 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
ELK1
ELK1, member of ETS oncogene family
chr7_+_70597109 0.01 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr1_+_240255166 0.01 ENST00000319653.9
FMN2
formin 2
chr4_-_66536057 0.01 ENST00000273854.3
EPHA5
EPH receptor A5
chr22_-_39151463 0.01 ENST00000405510.1
ENST00000433561.1
SUN2
Sad1 and UNC84 domain containing 2
chr11_-_71823796 0.01 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr19_-_8070474 0.01 ENST00000407627.2
ENST00000593807.1
ELAVL1
ELAV like RNA binding protein 1
chr1_-_21620877 0.01 ENST00000527991.1
ECE1
endothelin converting enzyme 1
chr22_+_17956618 0.01 ENST00000262608.8
CECR2
cat eye syndrome chromosome region, candidate 2
chr5_+_66300446 0.01 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr5_-_115890554 0.01 ENST00000509665.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chrX_+_19362011 0.01 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr7_-_122339162 0.01 ENST00000340112.2
RNF133
ring finger protein 133
chr1_+_155278539 0.01 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr12_+_16500599 0.01 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
MGST1
microsomal glutathione S-transferase 1
chr6_+_34204642 0.01 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr11_-_124981475 0.01 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr1_-_197115818 0.01 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr16_-_2318055 0.01 ENST00000561518.1
ENST00000561718.1
ENST00000567147.1
ENST00000562690.1
ENST00000569598.2
RNPS1
RNA binding protein S1, serine-rich domain
chr8_+_94929077 0.00 ENST00000297598.4
ENST00000520614.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr7_+_144052381 0.00 ENST00000498580.1
ENST00000056217.5
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr8_+_94929110 0.00 ENST00000520728.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr8_+_26371763 0.00 ENST00000521913.1
DPYSL2
dihydropyrimidinase-like 2
chr13_+_78315348 0.00 ENST00000441784.1
SLAIN1
SLAIN motif family, member 1
chr1_-_231004220 0.00 ENST00000366663.5
C1orf198
chromosome 1 open reading frame 198
chr15_-_78526855 0.00 ENST00000541759.1
ENST00000558130.1
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr7_-_99717463 0.00 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr10_+_99205894 0.00 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr19_-_6424783 0.00 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr7_-_99716940 0.00 ENST00000440225.1
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0060829 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.0 0.3 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:2000532 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.4 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.0 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.3 GO:0043203 axon hillock(GO:0043203)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0010385 double-stranded methylated DNA binding(GO:0010385)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors