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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX1-2_RAX

Z-value: 0.38

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Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
ENSG00000229544.6 NK1 homeobox 2
ENSG00000134438.9 retina and anterior neural fold homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX1-2hg19_v2_chr10_-_126138622_1261387530.937.2e-03Click!
RAXhg19_v2_chr18_-_56940611_569406600.493.2e-01Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_8740061 0.23 ENST00000593792.1
CTD-2586B10.1
chr4_-_89442940 0.18 ENST00000527353.1
phosphatidylinositol glycan anchor biosynthesis, class Y
chr6_+_130339710 0.17 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr17_+_57233087 0.16 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
proline rich 11
chr1_-_159832438 0.16 ENST00000368100.1
V-set and immunoglobulin domain containing 8
chr13_+_78315295 0.15 ENST00000351546.3
SLAIN motif family, member 1
chr11_-_63376013 0.15 ENST00000540943.1
phospholipase A2, group XVI
chr4_+_80584903 0.14 ENST00000506460.1
RP11-452C8.1
chr17_+_1666108 0.13 ENST00000570731.1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_-_62521614 0.12 ENST00000527994.1
ENST00000394807.3
zinc finger and BTB domain containing 3
chr16_-_28608364 0.12 ENST00000533150.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr13_+_78315348 0.12 ENST00000441784.1
SLAIN motif family, member 1
chr3_+_28390637 0.11 ENST00000420223.1
ENST00000383768.2
zinc finger, CW type with PWWP domain 2
chr11_+_29181503 0.11 ENST00000530960.1
RP11-466I1.1
chr2_+_13677795 0.11 ENST00000434509.1
AC092635.1
chr9_-_5339873 0.10 ENST00000223862.1
ENST00000223858.4
relaxin 1
chr12_-_10022735 0.10 ENST00000228438.2
C-type lectin domain family 2, member B
chr19_-_6424783 0.10 ENST00000398148.3
KH-type splicing regulatory protein
chr14_+_32798547 0.09 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr17_+_59489112 0.09 ENST00000335108.2
chromosome 17 open reading frame 82
chr12_+_7014126 0.09 ENST00000415834.1
ENST00000436789.1
leucine rich repeat containing 23
chr12_-_74686314 0.08 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
chr4_+_26324474 0.08 ENST00000514675.1
recombination signal binding protein for immunoglobulin kappa J region
chr8_-_102803163 0.08 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
neurocalcin delta
chr19_+_48949087 0.08 ENST00000598711.1
glutamate-rich WD repeat containing 1
chr4_+_66536248 0.08 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
chr10_+_35894338 0.08 ENST00000321660.1
gap junction protein, delta 4, 40.1kDa
chr9_+_125133315 0.08 ENST00000223423.4
ENST00000362012.2
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_+_160370344 0.07 ENST00000368061.2
VANGL planar cell polarity protein 2
chr9_+_125132803 0.07 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_+_47293795 0.07 ENST00000422579.1
MAP-kinase activating death domain
chr14_+_103851712 0.07 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MAP/microtubule affinity-regulating kinase 3
chr9_+_34646624 0.07 ENST00000450095.2
ENST00000556278.1
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr17_-_39216344 0.07 ENST00000391418.2
keratin associated protein 2-3
chr3_+_51851612 0.07 ENST00000456080.1
IQ motif containing F3
chr1_-_211307404 0.06 ENST00000367007.4
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr3_-_11685345 0.06 ENST00000430365.2
vestigial like 4 (Drosophila)
chr4_-_74486347 0.06 ENST00000342081.3
Ras association (RalGDS/AF-6) domain family member 6
chr17_-_40337470 0.05 ENST00000293330.1
hypocretin (orexin) neuropeptide precursor
chr7_-_99716914 0.05 ENST00000431404.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_-_17766198 0.05 ENST00000375436.4
regulator of chromosome condensation 2
chr11_-_13011081 0.05 ENST00000532541.1
ENST00000526388.1
ENST00000534477.1
ENST00000531402.1
ENST00000527945.1
ENST00000504230.2
long intergenic non-protein coding RNA 958
chr12_-_12837423 0.05 ENST00000540510.1
G protein-coupled receptor 19
chr20_-_50722183 0.05 ENST00000371523.4
ZFP64 zinc finger protein
chr2_+_105050794 0.05 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
long intergenic non-protein coding RNA 1102
chr3_+_158519654 0.05 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
major facilitator superfamily domain containing 1
chr17_-_41466555 0.05 ENST00000586231.1
long intergenic non-protein coding RNA 910
chr4_-_74486109 0.05 ENST00000395777.2
Ras association (RalGDS/AF-6) domain family member 6
chr3_+_195447738 0.05 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
mucin 20, cell surface associated
chr6_+_34204642 0.05 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
high mobility group AT-hook 1
chr16_-_28608424 0.05 ENST00000335715.4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr10_-_105845674 0.04 ENST00000353479.5
ENST00000369733.3
collagen, type XVII, alpha 1
chr1_-_224624730 0.04 ENST00000445239.1
WD repeat domain 26
chr15_+_64680003 0.04 ENST00000261884.3
thyroid hormone receptor interactor 4
chr10_-_92681033 0.04 ENST00000371697.3
ankyrin repeat domain 1 (cardiac muscle)
chr7_+_138145076 0.04 ENST00000343526.4
tripartite motif containing 24
chr2_-_74618964 0.04 ENST00000417090.1
ENST00000409868.1
dynactin 1
chr3_-_114790179 0.04 ENST00000462705.1
zinc finger and BTB domain containing 20
chr6_+_26402517 0.04 ENST00000414912.2
butyrophilin, subfamily 3, member A1
chr2_-_74619152 0.04 ENST00000440727.1
ENST00000409240.1
dynactin 1
chr6_-_111927449 0.03 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3 interacting protein 2
chr2_+_187371440 0.03 ENST00000445547.1
zinc finger CCCH-type containing 15
chr16_-_48281444 0.03 ENST00000537808.1
ENST00000569991.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr8_-_135522425 0.03 ENST00000521673.1
zinc finger and AT hook domain containing
chr1_+_100818009 0.03 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
cell division cycle 14A
chr7_-_99716940 0.03 ENST00000440225.1
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr17_-_27418537 0.03 ENST00000408971.2
TGFB1-induced anti-apoptotic factor 1
chr3_-_105587879 0.03 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr6_+_52442083 0.03 ENST00000606714.1
TRAM2 antisense RNA 1 (head to head)
chr3_+_45986511 0.03 ENST00000458629.1
ENST00000457814.1
chemokine (C-X-C motif) receptor 6
chr4_-_103749179 0.03 ENST00000502690.1
ubiquitin-conjugating enzyme E2D 3
chr6_-_33663474 0.03 ENST00000594414.1
SBP1; Uncharacterized protein
chr17_-_4938712 0.03 ENST00000254853.5
ENST00000424747.1
solute carrier family 52 (riboflavin transporter), member 1
chr9_-_3469181 0.03 ENST00000366116.2
Uncharacterized protein
chr19_+_11071546 0.03 ENST00000358026.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr11_-_3859089 0.03 ENST00000396979.1
ras homolog family member G
chr10_+_6779326 0.03 ENST00000417112.1
RP11-554I8.2
chr6_-_111927062 0.03 ENST00000359831.4
TRAF3 interacting protein 2
chr20_+_43990576 0.03 ENST00000372727.1
ENST00000414310.1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr4_-_103749205 0.03 ENST00000508249.1
ubiquitin-conjugating enzyme E2D 3
chr17_+_39346139 0.02 ENST00000398470.1
ENST00000318329.5
keratin associated protein 9-1
chr11_-_102651343 0.02 ENST00000279441.4
ENST00000539681.1
matrix metallopeptidase 10 (stromelysin 2)
chr1_+_201979645 0.02 ENST00000367284.5
ENST00000367283.3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr19_+_48949030 0.02 ENST00000253237.5
glutamate-rich WD repeat containing 1
chr2_+_166095898 0.02 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
sodium channel, voltage-gated, type II, alpha subunit
chrX_-_13835147 0.02 ENST00000493677.1
ENST00000355135.2
glycoprotein M6B
chr19_+_54641444 0.02 ENST00000221232.5
ENST00000358389.3
CCR4-NOT transcription complex, subunit 3
chr9_-_21368075 0.02 ENST00000449498.1
interferon, alpha 13
chr7_-_37488547 0.02 ENST00000453399.1
engulfment and cell motility 1
chr19_-_46285736 0.02 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
dystrophia myotonica-protein kinase
chr8_-_101571964 0.02 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ankyrin repeat domain 46
chr14_-_53258314 0.02 ENST00000216410.3
ENST00000557604.1
glucosamine-phosphate N-acetyltransferase 1
chr17_-_39341594 0.02 ENST00000398472.1
keratin associated protein 4-1
chr2_-_220264703 0.02 ENST00000519905.1
ENST00000523282.1
ENST00000434339.1
ENST00000457935.1
aspartyl aminopeptidase
chr1_+_100818156 0.02 ENST00000336454.3
cell division cycle 14A
chr9_+_125133467 0.02 ENST00000426608.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_-_16253112 0.02 ENST00000380683.1
chromosome 9 open reading frame 92
chrX_-_77225135 0.02 ENST00000458128.1
phosphoglycerate mutase family member 4
chr19_+_36239576 0.02 ENST00000587751.1
lin-37 homolog (C. elegans)
chr15_+_51669513 0.02 ENST00000558426.1
gliomedin
chr5_+_150226085 0.02 ENST00000522154.1
immunity-related GTPase family, M
chr2_+_217524323 0.02 ENST00000456764.1
insulin-like growth factor binding protein 2, 36kDa
chr21_-_19858196 0.02 ENST00000422787.1
transmembrane protease, serine 15
chr1_-_28969517 0.02 ENST00000263974.4
ENST00000373824.4
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr6_+_26501449 0.02 ENST00000244513.6
butyrophilin, subfamily 1, member A1
chr7_-_7575477 0.02 ENST00000399429.3
collagen, type XXVIII, alpha 1
chr8_-_30670384 0.02 ENST00000221138.4
ENST00000518243.1
protein phosphatase 2, catalytic subunit, beta isozyme
chr11_+_118398178 0.02 ENST00000302783.4
ENST00000539546.1
tetratricopeptide repeat domain 36
chr14_+_67831576 0.02 ENST00000555876.1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_+_210517895 0.02 ENST00000447185.1
microtubule-associated protein 2
chr10_+_18549645 0.02 ENST00000396576.2
calcium channel, voltage-dependent, beta 2 subunit
chr6_+_26402465 0.01 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
butyrophilin, subfamily 3, member A1
chr6_+_30687978 0.01 ENST00000327892.8
ENST00000435534.1
tubulin, beta class I
chr1_-_201140673 0.01 ENST00000367333.2
transmembrane protein 9
chrX_+_19362011 0.01 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
pyruvate dehydrogenase (lipoamide) alpha 1
chr7_-_99716952 0.01 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr10_-_114206649 0.01 ENST00000369404.3
ENST00000369405.3
zinc finger, DHHC-type containing 6
chr7_-_86849883 0.01 ENST00000433078.1
transmembrane protein 243, mitochondrial
chr2_+_191221240 0.01 ENST00000409027.1
ENST00000458193.1
inositol polyphosphate-1-phosphatase
chr19_-_3557570 0.01 ENST00000355415.2
major facilitator superfamily domain containing 12
chr8_-_101571933 0.01 ENST00000520311.1
ankyrin repeat domain 46
chr10_+_99205894 0.01 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
zinc finger, DHHC-type containing 16
chr20_-_1447467 0.01 ENST00000353088.2
ENST00000350991.4
NSFL1 (p97) cofactor (p47)
chr14_+_74034310 0.01 ENST00000538782.1
acyl-CoA thioesterase 2
chr2_-_169887827 0.01 ENST00000263817.6
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr19_-_3985455 0.01 ENST00000309311.6
eukaryotic translation elongation factor 2
chr9_+_34646651 0.01 ENST00000378842.3
galactose-1-phosphate uridylyltransferase
chr10_-_4285923 0.01 ENST00000418372.1
ENST00000608792.1
long intergenic non-protein coding RNA 702
chr11_+_33061543 0.01 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
t-complex 11, testis-specific-like 1
chr9_+_109685630 0.01 ENST00000451160.2
Uncharacterized protein
chr2_+_27008865 0.01 ENST00000335756.4
ENST00000233505.8
centromere protein A
chr10_-_99205607 0.01 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
exosome component 1
chr3_+_186353756 0.01 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
fetuin B
chr4_-_103748880 0.01 ENST00000453744.2
ENST00000349311.8
ubiquitin-conjugating enzyme E2D 3
chr6_-_94129244 0.01 ENST00000369303.4
ENST00000369297.1
EPH receptor A7
chr7_+_120628731 0.01 ENST00000310396.5
cadherin-like and PC-esterase domain containing 1
chr15_+_93447675 0.01 ENST00000536619.1
chromodomain helicase DNA binding protein 2
chr2_+_149402989 0.01 ENST00000397424.2
enhancer of polycomb homolog 2 (Drosophila)
chr12_+_8309630 0.01 ENST00000396570.3
zinc finger protein 705A
chr19_-_36001113 0.01 ENST00000434389.1
dermokine
chr4_-_74486217 0.01 ENST00000335049.5
ENST00000307439.5
Ras association (RalGDS/AF-6) domain family member 6
chr14_-_72458326 0.01 ENST00000542853.1
AC005477.1
chr1_+_43148059 0.01 ENST00000321358.7
ENST00000332220.6
Y box binding protein 1
chr10_+_99205959 0.01 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
zinc finger, DHHC-type containing 16
chr17_-_45266542 0.01 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
cell division cycle 27
chr14_+_55494323 0.01 ENST00000339298.2
suppressor of cytokine signaling 4
chr8_+_107738343 0.01 ENST00000521592.1
oxidation resistance 1
chr10_+_114206956 0.01 ENST00000432306.1
ENST00000393077.2
vesicle transport through interaction with t-SNAREs 1A
chr4_-_25865159 0.01 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr11_+_112047087 0.00 ENST00000526088.1
ENST00000532593.1
ENST00000531169.1
beta-carotene oxygenase 2
chr16_-_48281305 0.00 ENST00000356608.2
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr4_-_103749105 0.00 ENST00000394801.4
ENST00000394804.2
ubiquitin-conjugating enzyme E2D 3
chr7_+_100770328 0.00 ENST00000223095.4
ENST00000445463.2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr14_+_55493920 0.00 ENST00000395472.2
ENST00000555846.1
suppressor of cytokine signaling 4
chr10_+_124913930 0.00 ENST00000368858.5
BUB3 mitotic checkpoint protein
chr16_-_28937027 0.00 ENST00000358201.4
rabaptin, RAB GTPase binding effector protein 2
chr16_+_3333443 0.00 ENST00000572748.1
ENST00000573578.1
ENST00000574253.1
zinc finger protein 263
chr14_-_71276211 0.00 ENST00000381250.4
ENST00000555993.2
mitogen-activated protein kinase kinase kinase 9
chr8_+_107738240 0.00 ENST00000449762.2
ENST00000297447.6
oxidation resistance 1
chr10_-_105845536 0.00 ENST00000393211.3
collagen, type XVII, alpha 1
chr17_-_71258491 0.00 ENST00000397671.1
cleavage and polyadenylation specific factor 4-like
chr7_+_21582638 0.00 ENST00000409508.3
ENST00000328843.6
dynein, axonemal, heavy chain 11
chr18_+_63273310 0.00 ENST00000579862.1
RP11-775G23.1
chr1_-_190446759 0.00 ENST00000367462.3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr11_-_65625678 0.00 ENST00000308162.5
cofilin 1 (non-muscle)
chr5_-_102898465 0.00 ENST00000507423.1
ENST00000230792.2
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr6_+_53964336 0.00 ENST00000447836.2
ENST00000511678.1
muscular LMNA-interacting protein
chr2_+_74682150 0.00 ENST00000233331.7
ENST00000431187.1
ENST00000409917.1
ENST00000409493.2
INO80 complex subunit B
chr12_+_16500599 0.00 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
microsomal glutathione S-transferase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.0 0.1 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.1 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.0 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS