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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-3

Z-value: 0.89

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Transcription factors associated with NKX2-3

Gene Symbol Gene ID Gene Info
NKX2-3
ENSG00000119919.9 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-3hg19_v2_chr10_+_101292684_1012927060.473.5e-01Click!

Activity profile of NKX2-3 motif

Sorted Z-values of NKX2-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_150404904 1.11 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr4_-_140201333 0.76 ENST00000398955.1
MGARP
mitochondria-localized glutamic acid-rich protein
chr15_+_74509530 0.66 ENST00000321288.5
CCDC33
coiled-coil domain containing 33
chr11_+_62379194 0.60 ENST00000525801.1
ENST00000534093.1
ROM1
retinal outer segment membrane protein 1
chr6_+_8652370 0.52 ENST00000503668.1
HULC
hepatocellular carcinoma up-regulated long non-coding RNA
chr6_-_150212029 0.51 ENST00000529948.1
ENST00000357183.4
ENST00000367363.3
RAET1E
retinoic acid early transcript 1E
chr10_-_5227096 0.51 ENST00000488756.1
ENST00000334314.3
AKR1CL1
aldo-keto reductase family 1, member C-like 1
chr18_-_53735601 0.50 ENST00000589754.1
CTD-2008L17.2
CTD-2008L17.2
chr4_+_76439649 0.49 ENST00000507557.1
THAP6
THAP domain containing 6
chr6_-_32160622 0.46 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr4_+_80584903 0.44 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr9_-_4859260 0.41 ENST00000599351.1
AL158147.2
HCG2011465; Uncharacterized protein
chr14_+_45366518 0.40 ENST00000557112.1
C14orf28
chromosome 14 open reading frame 28
chr22_+_45714361 0.39 ENST00000452238.1
FAM118A
family with sequence similarity 118, member A
chr17_-_8059638 0.39 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
PER1
period circadian clock 1
chr22_+_45714672 0.38 ENST00000424557.1
FAM118A
family with sequence similarity 118, member A
chr6_+_149539053 0.38 ENST00000451095.1
RP1-111D6.3
RP1-111D6.3
chr12_+_116985896 0.34 ENST00000547114.1
RP11-809C9.2
RP11-809C9.2
chr20_+_32782375 0.34 ENST00000568305.1
ASIP
agouti signaling protein
chrX_+_109602039 0.33 ENST00000520821.1
RGAG1
retrotransposon gag domain containing 1
chr2_+_191045173 0.33 ENST00000409870.1
C2orf88
chromosome 2 open reading frame 88
chrX_-_49121165 0.32 ENST00000376207.4
ENST00000376199.2
FOXP3
forkhead box P3
chr4_-_109541539 0.31 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr3_+_98482175 0.31 ENST00000485391.1
ENST00000492254.1
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr1_-_89488510 0.30 ENST00000564665.1
ENST00000370481.4
GBP3
guanylate binding protein 3
chr11_+_35211511 0.30 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr19_+_53761545 0.30 ENST00000341702.3
VN1R2
vomeronasal 1 receptor 2
chr13_-_45048386 0.29 ENST00000472477.1
TSC22D1
TSC22 domain family, member 1
chr1_-_26633480 0.26 ENST00000450041.1
UBXN11
UBX domain protein 11
chr1_+_54359854 0.26 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
DIO1
deiodinase, iodothyronine, type I
chr2_+_114163945 0.26 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr12_-_104531945 0.25 ENST00000551446.1
NFYB
nuclear transcription factor Y, beta
chr1_-_240775447 0.25 ENST00000318160.4
GREM2
gremlin 2, DAN family BMP antagonist
chr13_-_44735393 0.25 ENST00000400419.1
SMIM2
small integral membrane protein 2
chr6_+_32121789 0.25 ENST00000437001.2
ENST00000375137.2
PPT2
palmitoyl-protein thioesterase 2
chr17_-_39023462 0.24 ENST00000251643.4
KRT12
keratin 12
chr16_+_75690093 0.24 ENST00000564671.2
TERF2IP
telomeric repeat binding factor 2, interacting protein
chr5_-_132200477 0.24 ENST00000296875.2
GDF9
growth differentiation factor 9
chr10_+_99332529 0.24 ENST00000455090.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr3_+_145782358 0.24 ENST00000422482.1
AC107021.1
HCG1786590; PRO2533; Uncharacterized protein
chr19_-_17622684 0.23 ENST00000596643.1
CTD-3131K8.2
CTD-3131K8.2
chr10_-_97200772 0.23 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
SORBS1
sorbin and SH3 domain containing 1
chr5_-_110848253 0.23 ENST00000505803.1
ENST00000502322.1
STARD4
StAR-related lipid transfer (START) domain containing 4
chr5_+_140213815 0.23 ENST00000525929.1
ENST00000378125.3
PCDHA7
protocadherin alpha 7
chr3_+_149192475 0.23 ENST00000465758.1
TM4SF4
transmembrane 4 L six family member 4
chr10_+_99332198 0.22 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr22_+_45714301 0.22 ENST00000427777.1
FAM118A
family with sequence similarity 118, member A
chr6_+_131958436 0.22 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr7_+_7196565 0.22 ENST00000429911.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr4_-_39034542 0.22 ENST00000344606.6
TMEM156
transmembrane protein 156
chr12_-_42878101 0.21 ENST00000552108.1
PRICKLE1
prickle homolog 1 (Drosophila)
chr22_+_25202232 0.21 ENST00000400358.4
ENST00000400359.4
SGSM1
small G protein signaling modulator 1
chr6_+_32121218 0.21 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
PPT2
palmitoyl-protein thioesterase 2
chr11_+_10326612 0.21 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
ADM
adrenomedullin
chr3_-_114790179 0.21 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr6_-_111927062 0.21 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr16_-_2031464 0.21 ENST00000356120.4
ENST00000354249.4
NOXO1
NADPH oxidase organizer 1
chr11_+_33563618 0.21 ENST00000526400.1
KIAA1549L
KIAA1549-like
chr1_-_26633067 0.21 ENST00000421827.2
ENST00000374215.1
ENST00000374223.1
ENST00000357089.4
ENST00000535108.1
ENST00000314675.7
ENST00000436301.2
ENST00000423664.1
ENST00000374221.3
UBXN11
UBX domain protein 11
chr13_-_46679144 0.21 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr19_+_50148087 0.20 ENST00000601038.1
ENST00000595242.1
SCAF1
SR-related CTD-associated factor 1
chrX_+_78003204 0.20 ENST00000435339.3
ENST00000514744.1
LPAR4
lysophosphatidic acid receptor 4
chr19_+_18485509 0.20 ENST00000597765.1
GDF15
growth differentiation factor 15
chr12_-_52604607 0.20 ENST00000551894.1
ENST00000553017.1
C12orf80
chromosome 12 open reading frame 80
chr18_-_60985914 0.19 ENST00000589955.1
BCL2
B-cell CLL/lymphoma 2
chr16_+_31225337 0.19 ENST00000322122.3
TRIM72
tripartite motif containing 72
chr19_+_56653064 0.18 ENST00000593100.1
ZNF444
zinc finger protein 444
chr17_+_48823896 0.17 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr10_+_129785536 0.17 ENST00000419012.2
PTPRE
protein tyrosine phosphatase, receptor type, E
chrX_-_115085422 0.17 ENST00000430756.2
RP11-761E20.1
RP11-761E20.1
chr8_+_32579271 0.17 ENST00000518084.1
NRG1
neuregulin 1
chr6_-_11382478 0.17 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr19_-_38743878 0.17 ENST00000587515.1
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr5_-_152069089 0.17 ENST00000506723.2
AC091969.1
AC091969.1
chrX_+_71354000 0.17 ENST00000510661.1
ENST00000535692.1
NHSL2
NHS-like 2
chr13_+_23993097 0.17 ENST00000443092.1
SACS-AS1
SACS antisense RNA 1
chr10_-_49813090 0.16 ENST00000249601.4
ARHGAP22
Rho GTPase activating protein 22
chr13_-_50018241 0.16 ENST00000409308.1
CAB39L
calcium binding protein 39-like
chr21_+_33671160 0.16 ENST00000303645.5
MRAP
melanocortin 2 receptor accessory protein
chr3_+_113775594 0.16 ENST00000479882.1
ENST00000493014.1
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr4_-_100212132 0.15 ENST00000209668.2
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr16_-_3450963 0.15 ENST00000573327.1
ENST00000571906.1
ENST00000573830.1
ENST00000439568.2
ENST00000422427.2
ENST00000304926.3
ENST00000396852.4
ZSCAN32
zinc finger and SCAN domain containing 32
chr4_+_81118647 0.15 ENST00000415738.2
PRDM8
PR domain containing 8
chr7_-_29186008 0.15 ENST00000396276.3
ENST00000265394.5
CPVL
carboxypeptidase, vitellogenic-like
chr3_+_124223586 0.15 ENST00000393496.1
KALRN
kalirin, RhoGEF kinase
chr9_-_117267717 0.15 ENST00000374057.3
DFNB31
deafness, autosomal recessive 31
chr19_-_15575369 0.15 ENST00000343625.7
RASAL3
RAS protein activator like 3
chrX_+_71353499 0.15 ENST00000373677.1
NHSL2
NHS-like 2
chr4_-_52883786 0.15 ENST00000343457.3
LRRC66
leucine rich repeat containing 66
chr15_+_58702742 0.14 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr3_-_122134882 0.14 ENST00000330689.4
WDR5B
WD repeat domain 5B
chr14_+_102276192 0.14 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr3_-_131753830 0.14 ENST00000429747.1
CPNE4
copine IV
chr15_-_78369994 0.14 ENST00000300584.3
ENST00000409931.3
TBC1D2B
TBC1 domain family, member 2B
chr3_+_190105909 0.14 ENST00000456423.1
CLDN16
claudin 16
chr11_+_94038759 0.14 ENST00000440961.2
ENST00000328458.4
FOLR4
folate receptor 4, delta (putative)
chr8_-_99955042 0.14 ENST00000519420.1
STK3
serine/threonine kinase 3
chr14_+_39703112 0.14 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr2_+_191002486 0.13 ENST00000396974.2
C2orf88
chromosome 2 open reading frame 88
chr5_-_114631958 0.13 ENST00000395557.4
CCDC112
coiled-coil domain containing 112
chr10_+_135207623 0.13 ENST00000317502.6
ENST00000432508.3
MTG1
mitochondrial ribosome-associated GTPase 1
chr1_+_158901329 0.13 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr7_-_84569561 0.13 ENST00000439105.1
AC074183.4
AC074183.4
chr5_-_180688105 0.13 ENST00000327767.4
TRIM52
tripartite motif containing 52
chr4_+_139230865 0.13 ENST00000502757.1
ENST00000507145.1
ENST00000515282.1
ENST00000510736.1
LINC00499
long intergenic non-protein coding RNA 499
chr19_-_44174330 0.13 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr20_-_43729750 0.12 ENST00000537075.1
ENST00000306117.1
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr1_+_32666188 0.12 ENST00000421922.2
CCDC28B
coiled-coil domain containing 28B
chr20_+_60962143 0.12 ENST00000343986.4
RPS21
ribosomal protein S21
chr15_+_85147127 0.12 ENST00000541040.1
ENST00000538076.1
ENST00000485222.2
ZSCAN2
zinc finger and SCAN domain containing 2
chr12_-_104532062 0.12 ENST00000240055.3
NFYB
nuclear transcription factor Y, beta
chr3_-_49757101 0.12 ENST00000320431.7
AMIGO3
adhesion molecule with Ig-like domain 3
chr6_-_32634425 0.12 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr19_-_39368887 0.12 ENST00000340740.3
ENST00000591812.1
RINL
Ras and Rab interactor-like
chr11_+_94277017 0.12 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr18_-_67624160 0.11 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr9_+_36036430 0.11 ENST00000377966.3
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr10_+_135207598 0.11 ENST00000477902.2
MTG1
mitochondrial ribosome-associated GTPase 1
chr13_+_50018402 0.11 ENST00000354234.4
SETDB2
SET domain, bifurcated 2
chr1_-_114696472 0.11 ENST00000393296.1
ENST00000369547.1
ENST00000610222.1
SYT6
synaptotagmin VI
chr10_-_36813162 0.11 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr6_-_33285505 0.11 ENST00000431845.2
ZBTB22
zinc finger and BTB domain containing 22
chr1_+_202317855 0.11 ENST00000356764.2
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr11_+_64950801 0.11 ENST00000526468.1
CAPN1
calpain 1, (mu/I) large subunit
chrX_-_108976449 0.11 ENST00000469857.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr2_+_204103663 0.11 ENST00000356079.4
ENST00000429815.2
CYP20A1
cytochrome P450, family 20, subfamily A, polypeptide 1
chr3_-_47950745 0.11 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr4_+_76439665 0.11 ENST00000508105.1
ENST00000311638.3
ENST00000380837.3
ENST00000507556.1
ENST00000504190.1
ENST00000507885.1
ENST00000502620.1
ENST00000514480.1
THAP6
THAP domain containing 6
chr16_-_69166031 0.11 ENST00000398235.2
ENST00000520529.1
CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr3_+_98482159 0.11 ENST00000468553.1
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr12_-_122296755 0.11 ENST00000289004.4
HPD
4-hydroxyphenylpyruvate dioxygenase
chr3_-_49058479 0.11 ENST00000440857.1
DALRD3
DALR anticodon binding domain containing 3
chr6_-_112081113 0.11 ENST00000517419.1
FYN
FYN oncogene related to SRC, FGR, YES
chr22_+_38453207 0.11 ENST00000404072.3
ENST00000424694.1
PICK1
protein interacting with PRKCA 1
chr18_+_61445007 0.11 ENST00000447428.1
ENST00000546027.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr6_-_26027480 0.11 ENST00000377364.3
HIST1H4B
histone cluster 1, H4b
chr3_+_149191723 0.11 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr19_+_36142147 0.10 ENST00000590618.1
COX6B1
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
chr3_+_186743261 0.10 ENST00000423451.1
ENST00000446170.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr20_-_31071309 0.10 ENST00000326071.4
C20orf112
chromosome 20 open reading frame 112
chr18_-_51750948 0.10 ENST00000583046.1
ENST00000398398.2
MBD2
methyl-CpG binding domain protein 2
chr10_-_104262426 0.10 ENST00000487599.1
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr4_-_104020968 0.10 ENST00000504285.1
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr16_+_56969284 0.10 ENST00000568358.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr14_+_36295638 0.10 ENST00000543183.1
BRMS1L
breast cancer metastasis-suppressor 1-like
chr15_-_50558223 0.10 ENST00000267845.3
HDC
histidine decarboxylase
chr1_-_85870177 0.10 ENST00000542148.1
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr19_+_3178736 0.09 ENST00000246115.3
S1PR4
sphingosine-1-phosphate receptor 4
chr6_+_131148538 0.09 ENST00000541421.2
SMLR1
small leucine-rich protein 1
chr12_-_131478468 0.09 ENST00000536673.1
ENST00000542980.1
RP11-76C10.5
RP11-76C10.5
chr19_-_3772209 0.09 ENST00000555978.1
ENST00000555633.1
RAX2
retina and anterior neural fold homeobox 2
chr20_+_48884002 0.09 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3
RP11-290F20.3
chr10_+_17794251 0.09 ENST00000377495.1
ENST00000338221.5
TMEM236
transmembrane protein 236
chr1_+_156561533 0.09 ENST00000368234.3
ENST00000368235.3
ENST00000368233.3
APOA1BP
apolipoprotein A-I binding protein
chr10_-_104262460 0.09 ENST00000446605.2
ENST00000369905.4
ENST00000545684.1
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr9_+_125376948 0.09 ENST00000297913.2
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr10_+_27793197 0.09 ENST00000356940.6
ENST00000535776.1
RAB18
RAB18, member RAS oncogene family
chr6_+_36562132 0.09 ENST00000373715.6
ENST00000339436.7
SRSF3
serine/arginine-rich splicing factor 3
chr7_+_1609765 0.09 ENST00000437964.1
ENST00000533935.1
ENST00000532358.1
ENST00000524978.1
PSMG3-AS1
PSMG3 antisense RNA 1 (head to head)
chr17_-_80797886 0.08 ENST00000572562.1
ZNF750
zinc finger protein 750
chr17_+_12569306 0.08 ENST00000425538.1
MYOCD
myocardin
chr17_-_36348610 0.08 ENST00000339023.4
ENST00000354664.4
TBC1D3
TBC1 domain family, member 3
chr5_+_49961727 0.08 ENST00000505697.2
ENST00000503750.2
ENST00000514342.2
PARP8
poly (ADP-ribose) polymerase family, member 8
chr19_+_14492247 0.08 ENST00000357355.3
ENST00000592261.2
ENST00000242786.5
CD97
CD97 molecule
chr16_+_23765948 0.08 ENST00000300113.2
CHP2
calcineurin-like EF-hand protein 2
chr14_+_36295504 0.08 ENST00000216807.7
BRMS1L
breast cancer metastasis-suppressor 1-like
chr15_+_57891609 0.08 ENST00000569089.1
MYZAP
myocardial zonula adherens protein
chr3_-_101039402 0.08 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chr19_-_42746714 0.08 ENST00000222330.3
GSK3A
glycogen synthase kinase 3 alpha
chr10_+_101419187 0.08 ENST00000370489.4
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr22_-_37584321 0.08 ENST00000397110.2
ENST00000337843.2
C1QTNF6
C1q and tumor necrosis factor related protein 6
chr5_+_140227048 0.08 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr12_-_120632505 0.08 ENST00000300648.6
GCN1L1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr6_-_33239612 0.08 ENST00000482399.1
ENST00000445902.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr13_-_46679185 0.08 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr1_+_230193521 0.08 ENST00000543760.1
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr18_-_64271363 0.08 ENST00000262150.2
CDH19
cadherin 19, type 2
chr16_-_66952742 0.08 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
CDH16
cadherin 16, KSP-cadherin
chr3_+_30648066 0.08 ENST00000359013.4
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr20_-_33539655 0.08 ENST00000451957.2
GSS
glutathione synthetase
chr11_+_118889142 0.07 ENST00000533632.1
TRAPPC4
trafficking protein particle complex 4
chr7_-_105221898 0.07 ENST00000486180.1
ENST00000485614.1
ENST00000480514.1
EFCAB10
EF-hand calcium binding domain 10
chr17_+_26662679 0.07 ENST00000578158.1
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr7_-_150974494 0.07 ENST00000392811.2
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr20_+_57464200 0.07 ENST00000604005.1
GNAS
GNAS complex locus
chr11_-_62607036 0.07 ENST00000311713.7
ENST00000278856.4
WDR74
WD repeat domain 74
chr15_-_101142362 0.07 ENST00000559577.1
ENST00000561308.1
ENST00000560133.1
ENST00000560941.1
ENST00000559736.1
ENST00000560272.1
LINS
lines homolog (Drosophila)
chr14_+_94547675 0.07 ENST00000393115.3
ENST00000554166.1
ENST00000556381.1
ENST00000553664.1
ENST00000555341.1
ENST00000557218.1
ENST00000554544.1
ENST00000557066.1
IFI27L1
interferon, alpha-inducible protein 27-like 1
chr19_-_18433910 0.07 ENST00000594828.3
ENST00000593829.1
LSM4
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr19_+_41882466 0.07 ENST00000436170.2
TMEM91
transmembrane protein 91
chr9_+_118950325 0.07 ENST00000534838.1
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr18_+_43684310 0.07 ENST00000592471.1
ENST00000585518.1
HAUS1
HAUS augmin-like complex, subunit 1
chr11_-_64536521 0.07 ENST00000486867.1
SF1
splicing factor 1
chr10_+_1120312 0.07 ENST00000436154.1
WDR37
WD repeat domain 37
chr17_+_36283971 0.07 ENST00000327454.6
ENST00000378174.5
TBC1D3F
TBC1 domain family, member 3F
chr11_+_57435219 0.07 ENST00000527985.1
ENST00000287169.3
ZDHHC5
zinc finger, DHHC-type containing 5
chr4_+_102734967 0.07 ENST00000444316.2
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr5_-_77072085 0.07 ENST00000518338.2
ENST00000520039.1
ENST00000306388.6
ENST00000520361.1
TBCA
tubulin folding cofactor A
chr20_-_31071239 0.07 ENST00000359676.5
C20orf112
chromosome 20 open reading frame 112
chr13_-_30880979 0.06 ENST00000414289.1
KATNAL1
katanin p60 subunit A-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.2 0.8 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 0.3 GO:0002669 regulation of tolerance induction dependent upon immune response(GO:0002652) positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.1 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.2 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.3 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.2 GO:0010877 lipid transport involved in lipid storage(GO:0010877)
0.1 0.5 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.1 0.2 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.1 0.3 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.3 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:0042701 progesterone secretion(GO:0042701)
0.0 0.2 GO:2000691 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.0 0.2 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0 0.3 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.1 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.0 0.1 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.0 0.1 GO:0001694 histamine biosynthetic process(GO:0001694)
0.0 0.5 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.5 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.6 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.1 GO:0071879 UDP-glucose catabolic process(GO:0006258) positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0 0.5 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.1 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.1 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 0.2 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.0 0.2 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 0.3 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.1 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.2 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.2 GO:0060263 regulation of respiratory burst(GO:0060263)
0.0 0.1 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.1 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.1 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.1 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.0 0.1 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.0 0.1 GO:0033384 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.0 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.1 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.5 GO:0097503 sialylation(GO:0097503)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.4 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.1 1.4 GO:0008430 selenium binding(GO:0008430)
0.1 0.2 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.0 0.2 GO:0035529 phosphodiesterase I activity(GO:0004528) NADH pyrophosphatase activity(GO:0035529)
0.0 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.5 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.1 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.3 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.3 GO:0036122 BMP binding(GO:0036122)
0.0 0.1 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.0 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.1 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.0 GO:0048257 3'-flap endonuclease activity(GO:0048257)
0.0 0.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0003696 satellite DNA binding(GO:0003696)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones