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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-4

Z-value: 1.03

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Transcription factors associated with NKX2-4

Gene Symbol Gene ID Gene Info
ENSG00000125816.4 NK2 homeobox 4

Activity profile of NKX2-4 motif

Sorted Z-values of NKX2-4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_155533787 0.80 ENST00000407946.1
ENST00000405164.1
ENST00000336098.3
ENST00000393846.2
ENST00000404648.3
ENST00000443553.1
fibrinogen gamma chain
chr2_+_38177575 0.76 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
regulator of microtubule dynamics 2
chr2_+_109065634 0.68 ENST00000409821.1
GRIP and coiled-coil domain containing 2
chr20_-_23402028 0.67 ENST00000398425.3
ENST00000432543.2
ENST00000377026.4
N-ethylmaleimide-sensitive factor attachment protein, beta
chr1_-_89458287 0.67 ENST00000370485.2
cysteine conjugate-beta lyase 2
chr2_+_172309634 0.65 ENST00000339506.3
DDB1 and CUL4 associated factor 17
chr11_+_34642656 0.65 ENST00000257831.3
ENST00000450654.2
ets homologous factor
chr1_+_222886694 0.62 ENST00000426638.1
ENST00000537020.1
ENST00000539697.1
BRO1 domain and CAAX motif containing
chr1_-_197744763 0.60 ENST00000422998.1
DENN/MADD domain containing 1B
chr4_+_86748898 0.60 ENST00000509300.1
Rho GTPase activating protein 24
chr15_+_34394257 0.57 ENST00000397766.2
piggyBac transposable element derived 4
chr6_-_56492816 0.57 ENST00000522360.1
dystonin
chr4_+_86749045 0.56 ENST00000514229.1
Rho GTPase activating protein 24
chr4_+_130017268 0.56 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
chromosome 4 open reading frame 33
chr10_-_18944123 0.53 ENST00000606425.1
Uncharacterized protein
chr16_-_12062333 0.53 ENST00000597717.1
Uncharacterized protein
chr19_+_4769117 0.52 ENST00000540211.1
ENST00000317292.3
ENST00000586721.1
ENST00000592709.1
ENST00000588711.1
ENST00000589639.1
ENST00000591008.1
ENST00000592663.1
ENST00000588758.1
MIR7-3 host gene (non-protein coding)
chr4_+_90033968 0.51 ENST00000317005.2
tigger transposable element derived 2
chr11_-_64856497 0.51 ENST00000524632.1
ENST00000530719.1
transmembrane protein 262
chr1_-_89591749 0.50 ENST00000370466.3
guanylate binding protein 2, interferon-inducible
chr13_-_96705624 0.49 ENST00000376747.3
ENST00000376712.4
ENST00000397618.3
ENST00000376714.3
UDP-glucose glycoprotein glucosyltransferase 2
chr12_-_48500085 0.49 ENST00000549518.1
SUMO1/sentrin specific peptidase 1
chr2_-_179315786 0.48 ENST00000457633.1
ENST00000438687.3
ENST00000325748.4
protein kinase, interferon-inducible double stranded RNA dependent activator
chrX_-_138914394 0.48 ENST00000327569.3
ENST00000361648.2
ENST00000370543.1
ENST00000359686.2
ATPase, class VI, type 11C
chr11_-_14521349 0.47 ENST00000534234.1
coatomer protein complex, subunit beta 1
chr2_+_161993465 0.47 ENST00000457476.1
TRAF family member-associated NFKB activator
chr2_+_161993412 0.46 ENST00000259075.2
ENST00000432002.1
TRAF family member-associated NFKB activator
chr1_-_222886526 0.46 ENST00000541237.1
axin interactor, dorsalization associated
chr19_-_55669093 0.45 ENST00000344887.5
troponin I type 3 (cardiac)
chr9_-_3469181 0.45 ENST00000366116.2
Uncharacterized protein
chr3_-_88108192 0.45 ENST00000309534.6
CGG triplet repeat binding protein 1
chr2_-_188419078 0.44 ENST00000437725.1
ENST00000409676.1
ENST00000339091.4
ENST00000420747.1
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr7_-_93519471 0.44 ENST00000451238.1
tissue factor pathway inhibitor 2
chr7_+_106810165 0.43 ENST00000468401.1
ENST00000497535.1
ENST00000485846.1
HMG-box transcription factor 1
chr2_-_219925189 0.43 ENST00000295731.6
indian hedgehog
chr4_+_26578293 0.43 ENST00000512840.1
TBC1 domain family, member 19
chr2_-_188419200 0.43 ENST00000233156.3
ENST00000426055.1
ENST00000453013.1
ENST00000417013.1
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr5_-_78808617 0.43 ENST00000282260.6
ENST00000508576.1
ENST00000535690.1
homer homolog 1 (Drosophila)
chr10_+_98592674 0.42 ENST00000356016.3
ENST00000371097.4
ligand dependent nuclear receptor corepressor
chrX_+_49020882 0.40 ENST00000454342.1
MAGI family member, X-linked
chr21_-_16374688 0.40 ENST00000411932.1
nuclear receptor interacting protein 1
chr1_-_85040090 0.39 ENST00000370630.5
chitobiase, di-N-acetyl-
chr11_-_85780853 0.39 ENST00000531930.1
ENST00000528398.1
phosphatidylinositol binding clathrin assembly protein
chr5_+_159436120 0.39 ENST00000522793.1
ENST00000231238.5
tetratricopeptide repeat domain 1
chr4_+_102734967 0.37 ENST00000444316.2
B-cell scaffold protein with ankyrin repeats 1
chr18_+_9136758 0.37 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ankyrin repeat domain 12
chr7_+_133812052 0.37 ENST00000285928.2
leucine-rich repeats and guanylate kinase domain containing
chr14_+_96829886 0.36 ENST00000556095.1
GSK3B interacting protein
chr17_+_57297807 0.36 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
glycerophosphodiester phosphodiesterase domain containing 1
chr15_+_44719996 0.36 ENST00000559793.1
ENST00000558968.1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr12_-_104532062 0.35 ENST00000240055.3
nuclear transcription factor Y, beta
chr11_+_33037652 0.35 ENST00000311388.3
DEP domain containing 7
chr10_-_94301107 0.35 ENST00000436178.1
insulin-degrading enzyme
chr1_+_196788887 0.35 ENST00000320493.5
ENST00000367424.4
ENST00000367421.3
complement factor H-related 1
complement factor H-related 2
chr13_-_108870623 0.34 ENST00000405925.1
ligase IV, DNA, ATP-dependent
chr8_-_74206673 0.34 ENST00000396465.1
ribosomal protein L7
chr11_-_105892937 0.34 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr15_-_43398274 0.34 ENST00000382177.2
ENST00000290650.4
ubiquitin protein ligase E3 component n-recognin 1
chr5_-_39270725 0.34 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr7_-_54826869 0.34 ENST00000450622.1
Sec61 gamma subunit
chr9_-_86432547 0.34 ENST00000376365.3
ENST00000376371.2
G kinase anchoring protein 1
chr13_-_108867846 0.33 ENST00000442234.1
ligase IV, DNA, ATP-dependent
chr12_-_102591604 0.33 ENST00000329406.4
pro-melanin-concentrating hormone
chr3_+_108015382 0.33 ENST00000463019.3
ENST00000491820.1
ENST00000467562.1
ENST00000482430.1
ENST00000462629.1
HERV-H LTR-associating 2
chr11_+_107992518 0.32 ENST00000527942.1
acetyl-CoA acetyltransferase 1
chr2_+_201677390 0.32 ENST00000447069.1
basic leucine zipper and W2 domains 1
chr7_-_99332719 0.31 ENST00000336374.2
cytochrome P450, family 3, subfamily A, polypeptide 7
chr4_-_103747011 0.31 ENST00000350435.7
ubiquitin-conjugating enzyme E2D 3
chr2_-_225434538 0.31 ENST00000409096.1
cullin 3
chr15_-_34394008 0.31 ENST00000527822.1
ENST00000528949.1
ER membrane protein complex subunit 7
chr4_+_75480629 0.29 ENST00000380846.3
amphiregulin B
chr4_+_111397216 0.29 ENST00000265162.5
glutamyl aminopeptidase (aminopeptidase A)
chr18_-_29340827 0.29 ENST00000269205.5
solute carrier family 25, member 52
chr2_-_55920952 0.28 ENST00000447944.2
polyribonucleotide nucleotidyltransferase 1
chr10_+_35484053 0.28 ENST00000487763.1
ENST00000473940.1
ENST00000488328.1
ENST00000356917.5
cAMP responsive element modulator
chr13_-_52026730 0.28 ENST00000420668.2
integrator complex subunit 6
chr14_+_62229075 0.27 ENST00000216294.4
small nuclear RNA activating complex, polypeptide 1, 43kDa
chr6_+_27925019 0.27 ENST00000244623.1
olfactory receptor, family 2, subfamily B, member 6
chr13_+_33160553 0.27 ENST00000315596.10
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr4_+_155484155 0.27 ENST00000509493.1
fibrinogen beta chain
chr14_+_56078695 0.26 ENST00000416613.1
kinectin 1 (kinesin receptor)
chr4_-_68411275 0.26 ENST00000273853.6
centromere protein C
chr1_-_70671216 0.26 ENST00000370952.3
leucine rich repeat containing 40
chr4_-_103746683 0.26 ENST00000504211.1
ENST00000508476.1
ubiquitin-conjugating enzyme E2D 3
chr1_+_61869748 0.26 ENST00000357977.5
nuclear factor I/A
chr19_-_6670128 0.25 ENST00000245912.3
tumor necrosis factor (ligand) superfamily, member 14
chr11_-_14521379 0.25 ENST00000249923.3
ENST00000529866.1
ENST00000439561.2
ENST00000534771.1
coatomer protein complex, subunit beta 1
chr11_+_19138670 0.25 ENST00000446113.2
ENST00000399351.3
zinc finger, DHHC-type containing 13
chr14_+_39703084 0.25 ENST00000553728.1
cTAGE family member 5 isoform 4
chr10_+_60094735 0.25 ENST00000373910.4
ubiquitin-conjugating enzyme E2D 1
chr12_+_10658201 0.25 ENST00000322446.3
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr3_-_107777208 0.24 ENST00000398258.3
CD47 molecule
chr12_+_113416340 0.24 ENST00000552756.1
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr17_+_66244071 0.24 ENST00000580548.1
ENST00000580753.1
ENST00000392720.2
ENST00000359783.4
ENST00000584837.1
ENST00000579724.1
ENST00000584494.1
ENST00000580837.1
archaelysin family metallopeptidase 2
chr7_-_17980091 0.24 ENST00000409389.1
ENST00000409604.1
ENST00000428135.3
sorting nexin 13
chr5_-_98262240 0.24 ENST00000284049.3
chromodomain helicase DNA binding protein 1
chr11_-_85780086 0.24 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
phosphatidylinositol binding clathrin assembly protein
chr6_-_30043539 0.24 ENST00000376751.3
ENST00000244360.6
ring finger protein 39
chr12_+_123011776 0.24 ENST00000450485.2
ENST00000333479.7
kinetochore associated 1
chr2_+_183982238 0.23 ENST00000442895.2
ENST00000446612.1
ENST00000409798.1
nucleoporin 35kDa
chr17_-_38574169 0.23 ENST00000423485.1
topoisomerase (DNA) II alpha 170kDa
chr16_-_82045049 0.23 ENST00000532128.1
ENST00000328945.5
short chain dehydrogenase/reductase family 42E, member 1
chr1_-_242612726 0.23 ENST00000459864.1
phospholipase D family, member 5
chr8_-_33455268 0.23 ENST00000522982.1
dual specificity phosphatase 26 (putative)
chr9_+_131445928 0.23 ENST00000372692.4
SET nuclear oncogene
chr8_+_42396712 0.23 ENST00000518574.1
ENST00000417410.2
ENST00000414154.2
small integral membrane protein 19
chr10_-_65225641 0.23 ENST00000399262.2
jumonji domain containing 1C
chr4_+_39699664 0.22 ENST00000261427.5
ENST00000510934.1
ENST00000295963.6
ubiquitin-conjugating enzyme E2K
chr2_+_37571845 0.22 ENST00000537448.1
glutaminyl-peptide cyclotransferase
chr1_-_85870177 0.22 ENST00000542148.1
dimethylarginine dimethylaminohydrolase 1
chr2_+_162016916 0.22 ENST00000405852.1
TRAF family member-associated NFKB activator
chr1_+_204485571 0.22 ENST00000454264.2
ENST00000367183.3
Mdm4 p53 binding protein homolog (mouse)
chr12_-_122710514 0.22 ENST00000540535.1
ENST00000541656.1
diablo, IAP-binding mitochondrial protein
chr15_+_42694573 0.22 ENST00000397200.4
ENST00000569827.1
calpain 3, (p94)
chr4_-_682769 0.22 ENST00000507165.1
major facilitator superfamily domain containing 7
chr14_-_34420259 0.22 ENST00000250457.3
ENST00000547327.2
egl-9 family hypoxia-inducible factor 3
chr17_+_26684604 0.21 ENST00000292114.3
ENST00000509083.1
transmembrane protein 199
chr6_-_149969829 0.21 ENST00000367411.2
katanin p60 (ATPase containing) subunit A 1
chr1_-_243349684 0.21 ENST00000522895.1
centrosomal protein 170kDa
chr18_+_56338618 0.21 ENST00000348428.3
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr1_+_156308403 0.21 ENST00000481479.1
ENST00000368252.1
ENST00000466306.1
ENST00000368251.1
TSSK6 activating co-chaperone
chr15_+_63354769 0.21 ENST00000558910.1
tropomyosin 1 (alpha)
chr7_+_120629653 0.21 ENST00000450913.2
ENST00000340646.5
cadherin-like and PC-esterase domain containing 1
chr12_+_21590549 0.21 ENST00000545178.1
ENST00000240651.9
pyridine nucleotide-disulphide oxidoreductase domain 1
chr3_-_69249863 0.21 ENST00000478263.1
ENST00000462512.1
FERM domain containing 4B
chr2_-_37544209 0.21 ENST00000234179.2
protein kinase D3
chr11_-_10715287 0.21 ENST00000423302.2
murine retrovirus integration site 1 homolog
chr4_-_103746924 0.21 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
ubiquitin-conjugating enzyme E2D 3
chr17_-_63822563 0.21 ENST00000317442.8
centrosomal protein 112kDa
chr1_-_115301235 0.20 ENST00000525878.1
cold shock domain containing E1, RNA-binding
chr2_+_103378472 0.20 ENST00000412401.2
transmembrane protein 182
chr5_+_118788433 0.20 ENST00000414835.2
hydroxysteroid (17-beta) dehydrogenase 4
chr17_-_29641104 0.20 ENST00000577894.1
ENST00000330927.4
ecotropic viral integration site 2B
chr12_-_123011536 0.20 ENST00000331738.7
ENST00000354654.2
arginine/serine-rich coiled-coil 2
chr7_+_36450169 0.20 ENST00000428612.1
anillin, actin binding protein
chr10_+_6821545 0.20 ENST00000436383.1
long intergenic non-protein coding RNA 707
chr3_+_148847371 0.20 ENST00000296051.2
ENST00000460120.1
Hermansky-Pudlak syndrome 3
chr1_+_56046710 0.20 ENST00000422374.1
RP11-466L17.1
chr12_-_53601055 0.20 ENST00000552972.1
ENST00000422257.3
ENST00000267082.5
integrin, beta 7
chr6_-_149969871 0.20 ENST00000335643.8
ENST00000444282.1
katanin p60 (ATPase containing) subunit A 1
chr1_+_70671363 0.19 ENST00000370951.1
ENST00000370950.3
ENST00000405432.1
ENST00000454435.2
serine/arginine-rich splicing factor 11
chr17_-_19062424 0.19 ENST00000399083.1
Uncharacterized protein
chr13_-_36944307 0.19 ENST00000355182.4
spastic paraplegia 20 (Troyer syndrome)
chr7_-_92463210 0.19 ENST00000265734.4
cyclin-dependent kinase 6
chr1_-_62190793 0.19 ENST00000371177.2
ENST00000606498.1
TM2 domain containing 1
chr5_+_64064748 0.19 ENST00000381070.3
ENST00000508024.1
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr12_-_54778244 0.19 ENST00000549937.1
zinc finger protein 385A
chr2_+_105953972 0.19 ENST00000410049.1
chromosome 2 open reading frame 49
chr5_-_34919094 0.19 ENST00000341754.4
RAD1 homolog (S. pombe)
chr2_-_118943930 0.19 ENST00000449075.1
ENST00000414886.1
ENST00000449819.1
AC093901.1
chr7_-_14028488 0.19 ENST00000405358.4
ets variant 1
chr11_-_102651343 0.19 ENST00000279441.4
ENST00000539681.1
matrix metallopeptidase 10 (stromelysin 2)
chr13_-_41240717 0.19 ENST00000379561.5
forkhead box O1
chr10_-_65225722 0.18 ENST00000399251.1
jumonji domain containing 1C
chr3_+_32737027 0.18 ENST00000454516.2
CCR4-NOT transcription complex, subunit 10
chr21_-_34863693 0.18 ENST00000314399.3
DnaJ (Hsp40) homolog, subfamily C, member 28
chr10_+_22605374 0.18 ENST00000448361.1
COMM domain containing 3
chr3_+_137906154 0.18 ENST00000466749.1
ENST00000358441.2
ENST00000489213.1
armadillo repeat containing 8
chr12_-_12503156 0.18 ENST00000543314.1
ENST00000396349.3
MANSC domain containing 1
chr4_-_175443943 0.18 ENST00000296522.6
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr8_+_42396936 0.18 ENST00000416469.2
small integral membrane protein 19
chr11_+_76813886 0.17 ENST00000529803.1
olfactory marker protein
chr6_-_136610911 0.17 ENST00000530767.1
ENST00000527759.1
ENST00000527536.1
ENST00000529826.1
ENST00000531224.1
ENST00000353331.4
BCL2-associated transcription factor 1
chr15_-_63448973 0.17 ENST00000462430.1
ribosomal protein S27-like
chr7_-_152373216 0.17 ENST00000359321.1
X-ray repair complementing defective repair in Chinese hamster cells 2
chr12_-_39837192 0.16 ENST00000361961.3
ENST00000395670.3
kinesin family member 21A
chr4_-_130692631 0.16 ENST00000500092.2
ENST00000509105.1
RP11-519M16.1
chr11_-_4719072 0.16 ENST00000396950.3
ENST00000532598.1
olfactory receptor, family 51, subfamily E, member 2
chr7_+_151038850 0.16 ENST00000355851.4
ENST00000566856.1
ENST00000470229.1
negative regulator of ubiquitin-like proteins 1
chr11_-_10715502 0.16 ENST00000547195.1
murine retrovirus integration site 1 homolog
chr14_-_88459182 0.16 ENST00000544807.2
galactosylceramidase
chr16_+_4606347 0.16 ENST00000444310.4
chromosome 16 open reading frame 96
chr11_-_82746587 0.16 ENST00000528379.1
ENST00000534103.1
RAB30, member RAS oncogene family
chr12_+_27863706 0.16 ENST00000081029.3
ENST00000538315.1
ENST00000542791.1
mitochondrial ribosomal protein S35
chr3_+_11314072 0.16 ENST00000444619.1
autophagy related 7
chr14_-_71067360 0.16 ENST00000554963.1
ENST00000430055.2
ENST00000440435.2
ENST00000256379.5
mediator complex subunit 6
chr10_+_69869237 0.16 ENST00000373675.3
myopalladin
chr10_-_91102410 0.16 ENST00000282673.4
lipase A, lysosomal acid, cholesterol esterase
chr11_-_85779971 0.16 ENST00000393346.3
phosphatidylinositol binding clathrin assembly protein
chr8_+_26247878 0.16 ENST00000518611.1
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr18_-_28622699 0.16 ENST00000360428.4
desmocollin 3
chr7_-_105221898 0.16 ENST00000486180.1
ENST00000485614.1
ENST00000480514.1
EF-hand calcium binding domain 10
chr3_+_141596371 0.15 ENST00000495216.1
ATPase, Na+/K+ transporting, beta 3 polypeptide
chr3_-_69402828 0.15 ENST00000460709.1
FERM domain containing 4B
chr1_-_100643765 0.15 ENST00000370137.1
ENST00000370138.1
ENST00000342895.3
leucine rich repeat containing 39
chr1_+_95583479 0.15 ENST00000455656.1
ENST00000604534.1
transmembrane protein 56
TMEM56-RWDD3 readthrough
chr5_+_139505520 0.15 ENST00000333305.3
IgA-inducing protein
chr11_+_61717816 0.15 ENST00000435278.2
bestrophin 1
chr7_+_29234375 0.15 ENST00000409350.1
ENST00000495789.2
ENST00000539389.1
chimerin 2
chr10_+_116524547 0.15 ENST00000436932.1
RP11-106M7.1
chr14_+_24702073 0.15 ENST00000399440.2
guanosine monophosphate reductase 2
chr10_+_21823079 0.14 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr1_+_218683438 0.14 ENST00000443836.1
chromosome 1 open reading frame 143
chr3_+_137906109 0.14 ENST00000481646.1
ENST00000469044.1
ENST00000491704.1
ENST00000461600.1
armadillo repeat containing 8
chr19_+_38308119 0.14 ENST00000592103.1
CTD-2554C21.2
chr3_+_32433154 0.14 ENST00000334983.5
ENST00000349718.4
CKLF-like MARVEL transmembrane domain containing 7
chr6_-_39282221 0.14 ENST00000453413.2
potassium channel, subfamily K, member 17
chr3_+_190105909 0.14 ENST00000456423.1
claudin 16
chr3_+_159706537 0.14 ENST00000305579.2
ENST00000480787.1
ENST00000466512.1
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr15_+_80364901 0.14 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
zinc finger, AN1-type domain 6

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.2 0.7 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.2 0.5 GO:0097359 UDP-glucosylation(GO:0097359)
0.1 1.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.4 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 0.4 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.4 GO:0001543 ovarian follicle rupture(GO:0001543)
0.1 0.9 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.8 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 0.3 GO:0046356 acetyl-CoA catabolic process(GO:0046356)
0.1 0.5 GO:0001923 B-1 B cell differentiation(GO:0001923)
0.1 0.3 GO:2000627 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.1 0.3 GO:1901143 insulin catabolic process(GO:1901143)
0.1 0.7 GO:0035494 SNARE complex disassembly(GO:0035494)
0.1 0.2 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.3 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.1 0.2 GO:0031106 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.1 0.3 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.1 0.2 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.1 0.2 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.2 GO:0039521 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521)
0.1 0.3 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.2 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.0 0.2 GO:0051598 meiotic recombination checkpoint(GO:0051598)
0.0 0.3 GO:0002005 angiotensin catabolic process in blood(GO:0002005)
0.0 0.2 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.2 GO:1900111 positive regulation of histone H3-K9 dimethylation(GO:1900111)
0.0 0.3 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 0.5 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.4 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.2 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.0 0.1 GO:0003095 pressure natriuresis(GO:0003095)
0.0 0.4 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.0 0.2 GO:1902617 response to fluoride(GO:1902617)
0.0 1.1 GO:0034116 positive regulation of heterotypic cell-cell adhesion(GO:0034116)
0.0 0.6 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.1 GO:1902714 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) negative regulation of interferon-gamma secretion(GO:1902714) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.0 0.2 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.0 0.5 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.3 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.2 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.0 0.2 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:2000437 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.0 0.2 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.5 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262)
0.0 0.6 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.1 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.4 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.3 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:0003274 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) endocardial cushion fusion(GO:0003274)
0.0 0.2 GO:0018377 protein myristoylation(GO:0018377)
0.0 0.2 GO:2001300 lipoxin metabolic process(GO:2001300)
0.0 0.2 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.2 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.1 GO:2000508 regulation of dendritic cell chemotaxis(GO:2000508) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0 0.2 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.0 0.1 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.0 GO:0043318 regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318)
0.0 0.2 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.1 GO:0007388 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.0 0.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.4 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.2 GO:1904627 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.1 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:0003335 corneocyte development(GO:0003335)
0.0 1.0 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.0 0.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.2 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.1 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.2 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.3 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0 0.1 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.0 0.2 GO:0008228 opsonization(GO:0008228)
0.0 0.2 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.1 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.1 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.4 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.1 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.0 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.2 GO:0006527 arginine catabolic process(GO:0006527) negative regulation of cellular response to hypoxia(GO:1900038)
0.0 0.2 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.4 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.0 0.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.2 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.0 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.7 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1 0.6 GO:0031673 H zone(GO:0031673)
0.1 0.2 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 1.1 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.4 GO:1902560 GMP reductase complex(GO:1902560)
0.1 0.2 GO:1990423 RZZ complex(GO:1990423)
0.0 0.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 1.1 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.4 GO:0002177 manchette(GO:0002177)
0.0 0.2 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.2 GO:0032449 CBM complex(GO:0032449)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.3 GO:0005827 polar microtubule(GO:0005827)
0.0 0.5 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.3 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 0.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0031906 late endosome lumen(GO:0031906)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.2 0.5 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.1 1.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.3 GO:0031626 beta-endorphin binding(GO:0031626)
0.1 0.5 GO:0030172 troponin C binding(GO:0030172)
0.1 0.2 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.2 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.2 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 0.3 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.1 0.4 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.3 GO:0031208 POZ domain binding(GO:0031208)
0.1 0.5 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.2 GO:0019778 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.1 0.7 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.0 0.5 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 0.3 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.1 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.0 0.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.0 0.2 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.0 0.5 GO:0005113 patched binding(GO:0005113)
0.0 0.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.0 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.4 GO:0004568 chitinase activity(GO:0004568)
0.0 0.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.3 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.2 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0004145 diamine N-acetyltransferase activity(GO:0004145) polyamine binding(GO:0019808)
0.0 0.4 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.0 GO:0009384 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.0 0.0 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.4 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.0 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.7 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 1.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.8 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.1 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels