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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX6-3

Z-value: 0.42

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Transcription factors associated with NKX6-3

Gene Symbol Gene ID Gene Info
NKX6-3
ENSG00000165066.11 NK6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX6-3hg19_v2_chr8_-_41508855_41508855-0.602.1e-01Click!

Activity profile of NKX6-3 motif

Sorted Z-values of NKX6-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_130339710 0.23 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr14_-_51027838 0.21 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr12_-_94673956 0.18 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr4_+_80584903 0.16 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr2_-_44550441 0.14 ENST00000420756.1
ENST00000444696.1
PREPL
prolyl endopeptidase-like
chr1_+_160370344 0.13 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr4_+_76481258 0.11 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr18_+_20494078 0.10 ENST00000579124.1
ENST00000577588.1
ENST00000582354.1
ENST00000581819.1
RBBP8
retinoblastoma binding protein 8
chr1_+_66820058 0.09 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr4_+_26324474 0.07 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr14_+_67831576 0.07 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr9_+_125132803 0.06 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr14_+_88852059 0.06 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr19_+_4402659 0.06 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr20_-_33735070 0.06 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chrX_+_150565038 0.06 ENST00000370361.1
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chrX_+_43515467 0.06 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr5_-_139726181 0.06 ENST00000507104.1
ENST00000230990.6
HBEGF
heparin-binding EGF-like growth factor
chr12_-_52761262 0.05 ENST00000257901.3
KRT85
keratin 85
chr8_-_90769422 0.05 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
RP11-37B2.1
chr17_+_4692230 0.05 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr9_-_215744 0.05 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr3_+_136649311 0.05 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr15_+_90735145 0.04 ENST00000559792.1
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr1_-_232651312 0.04 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr1_-_151431647 0.04 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr17_-_64225508 0.04 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chrX_+_47696337 0.04 ENST00000334937.4
ENST00000376950.4
ZNF81
zinc finger protein 81
chr10_+_18549645 0.03 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr5_-_142780280 0.03 ENST00000424646.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr16_-_67517716 0.03 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr20_-_7921090 0.03 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_-_9933500 0.03 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr14_+_88851874 0.03 ENST00000393545.4
ENST00000356583.5
ENST00000555401.1
ENST00000553885.1
SPATA7
spermatogenesis associated 7
chr1_-_151431674 0.03 ENST00000531094.1
POGZ
pogo transposable element with ZNF domain
chr15_+_93443419 0.03 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr9_+_125133467 0.02 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_+_50016610 0.02 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_-_58295712 0.02 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_151431909 0.02 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr10_-_27529486 0.01 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr8_+_77593474 0.01 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr13_-_81801115 0.00 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr11_+_22689648 0.00 ENST00000278187.3
GAS2
growth arrest-specific 2

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.1 GO:0001835 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.1 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.0 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.1 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) astrocyte end-foot(GO:0097450) glial limiting end-foot(GO:0097451)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)