ISMARA results: PATZ1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PATZ1_KLF4

Z-value: 3.92

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Transcription factors associated with PATZ1_KLF4

Gene Symbol	Gene ID	Gene Info
PATZ1 Ensembl NCBI GeneCards UniProt	ENSG00000100105.13	POZ/BTB and AT hook containing zinc finger 1
KLF4 Ensembl NCBI GeneCards UniProt	ENSG00000136826.10	Kruppel like factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PATZ1	hg19_v2_chr22_-_31742218_31742350	0.96	2.1e-03	Click!
KLF4	hg19_v2_chr9_-_110251836_110251927	0.54	2.7e-01	Click!

Activity profile of PATZ1_KLF4 motif

Sorted Z-values of PATZ1_KLF4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_220252603 Show fit	7.23	ENST00000322176.7 ENST00000273075.4	DNPEP Ensembl NCBI GeneCards UniProt Show fit	aspartyl aminopeptidase
chr2_+_74212073 Show fit	6.80	ENST00000441217.1	AC073046.25 Ensembl NCBI GeneCards UniProt Show fit	AC073046.25
chrX_-_1331527 Show fit	6.27	ENST00000381567.3 ENST00000381566.1 ENST00000400841.2	CRLF2 Ensembl NCBI GeneCards UniProt Show fit	cytokine receptor-like factor 2
chr2_-_220252530 Show fit	5.64	ENST00000521459.1	DNPEP Ensembl NCBI GeneCards UniProt Show fit	aspartyl aminopeptidase
chr19_-_38878632 Show fit	5.11	ENST00000586599.1 ENST00000334928.6 ENST00000587676.1	GGN Ensembl NCBI GeneCards UniProt Show fit	gametogenetin
chr7_+_97910962 Show fit	4.90	ENST00000539286.1	BRI3 Ensembl NCBI GeneCards UniProt Show fit	brain protein I3
chr2_+_20866424 Show fit	4.63	ENST00000272224.3	GDF7 Ensembl NCBI GeneCards UniProt Show fit	growth differentiation factor 7
chr9_+_139971921 Show fit	4.60	ENST00000409858.3	UAP1L1 Ensembl NCBI GeneCards UniProt Show fit	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr12_+_132379160 Show fit	4.16	ENST00000321867.4	ULK1 Ensembl NCBI GeneCards UniProt Show fit	unc-51 like autophagy activating kinase 1
chr1_+_11333546 Show fit	4.15	ENST00000376804.2	UBIAD1 Ensembl NCBI GeneCards UniProt Show fit	UbiA prenyltransferase domain containing 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PATZ1_KLF4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	13.0	GO:0007257	activation of JUN kinase activity(GO:0007257)
0.4	12.9	GO:0031581	hemidesmosome assembly(GO:0031581)
0.2	11.9	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.2	10.6	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.4	10.5	GO:0030220	platelet formation(GO:0030220)
0.3	9.8	GO:0032011	ARF protein signal transduction(GO:0032011)
0.7	9.7	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1	8.8	GO:0006414	translational elongation(GO:0006414)
0.4	8.6	GO:0070586	cell-cell adhesion involved in gastrulation(GO:0070586)
0.1	8.6	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)

Showing 1 to 10 of 1,601 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	49.0	GO:0016021	integral component of membrane(GO:0016021)
0.1	36.6	GO:0005925	focal adhesion(GO:0005925)
0.2	31.7	GO:0042641	actomyosin(GO:0042641)
0.2	28.2	GO:0043202	lysosomal lumen(GO:0043202)
0.0	24.6	GO:0005759	mitochondrial matrix(GO:0005759)
0.2	21.5	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1	19.0	GO:0060076	excitatory synapse(GO:0060076)
0.3	18.5	GO:0043034	costamere(GO:0043034)
0.0	17.7	GO:0031012	extracellular matrix(GO:0031012)
0.1	15.0	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Showing 1 to 10 of 484 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	52.6	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1	35.3	GO:0017137	Rab GTPase binding(GO:0017137)
0.1	24.2	GO:0005096	GTPase activator activity(GO:0005096)
0.2	19.5	GO:0008307	structural constituent of muscle(GO:0008307)
0.7	15.6	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.6	15.3	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.2	12.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.1	12.0	GO:0003714	transcription corepressor activity(GO:0003714)
0.1	11.2	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.3	10.9	GO:0017166	vinculin binding(GO:0017166)

Showing 1 to 10 of 901 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	30.1	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.2	20.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	19.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	19.2	ST GAQ PATHWAY	G alpha q Pathway
0.4	18.8	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	16.0	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	14.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	14.2	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.5	13.8	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2	13.6	PID AR TF PATHWAY	Regulation of Androgen receptor activity

Showing 1 to 10 of 131 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	21.5	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	21.0	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.2	18.8	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.2	17.7	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4	15.9	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.3	15.5	REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	Genes involved in Glucagon signaling in metabolic regulation
0.4	15.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	13.3	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	13.1	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	12.4	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex

Showing 1 to 10 of 188 entries

Results for PATZ1_KLF4

Z-value: 3.92

Motif logo

Transcription factors associated with PATZ1_KLF4

Activity-expression correlation:

Activity profile of PATZ1_KLF4 motif

Sorted Z-values of PATZ1_KLF4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PATZ1_KLF4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: