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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PAX1_PAX9

Z-value: 0.40

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.9 paired box 1
PAX9
ENSG00000198807.8 paired box 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX9hg19_v2_chr14_+_37131058_37131139-0.739.6e-02Click!
PAX1hg19_v2_chr20_+_21686290_21686311-0.157.8e-01Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_121824374 0.42 ENST00000517992.1
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr19_-_409134 0.33 ENST00000332235.6
C2CD4C
C2 calcium-dependent domain containing 4C
chr18_-_47814032 0.22 ENST00000589548.1
ENST00000591474.1
CXXC1
CXXC finger protein 1
chr19_-_18995029 0.18 ENST00000596048.1
CERS1
ceramide synthase 1
chr9_+_33750515 0.13 ENST00000361005.5
PRSS3
protease, serine, 3
chr17_-_3461092 0.13 ENST00000301365.4
ENST00000572519.1
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr8_-_23282820 0.12 ENST00000520871.1
LOXL2
lysyl oxidase-like 2
chr6_-_170893268 0.11 ENST00000538195.1
PDCD2
programmed cell death 2
chr9_+_33750667 0.10 ENST00000457896.1
ENST00000342836.4
ENST00000429677.3
PRSS3
protease, serine, 3
chr19_+_14184370 0.10 ENST00000590772.1
hsa-mir-1199
hsa-mir-1199
chr14_-_69261310 0.09 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr8_-_23282797 0.09 ENST00000524144.1
LOXL2
lysyl oxidase-like 2
chr20_-_17641097 0.09 ENST00000246043.4
RRBP1
ribosome binding protein 1
chr1_-_204165610 0.09 ENST00000367194.4
KISS1
KiSS-1 metastasis-suppressor
chr18_-_47813940 0.09 ENST00000586837.1
ENST00000412036.2
ENST00000589940.1
CXXC1
CXXC finger protein 1
chr1_+_26759295 0.07 ENST00000430232.1
DHDDS
dehydrodolichyl diphosphate synthase
chr11_-_67397371 0.07 ENST00000376693.2
ENST00000301490.4
NUDT8
nudix (nucleoside diphosphate linked moiety X)-type motif 8
chr22_-_41940404 0.06 ENST00000355209.4
ENST00000337566.5
ENST00000396504.2
ENST00000407461.1
POLR3H
polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
chr6_+_34857019 0.06 ENST00000360359.3
ENST00000535627.1
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr8_-_23261589 0.06 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
LOXL2
lysyl oxidase-like 2
chrX_-_153707545 0.05 ENST00000357360.4
LAGE3
L antigen family, member 3
chr9_+_6716478 0.05 ENST00000452643.1
RP11-390F4.3
RP11-390F4.3
chr19_-_40791211 0.05 ENST00000579047.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr2_-_162931052 0.05 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr5_+_133842243 0.05 ENST00000515627.2
AC005355.2
AC005355.2
chr17_-_7137582 0.04 ENST00000575756.1
ENST00000575458.1
DVL2
dishevelled segment polarity protein 2
chr2_+_234160340 0.04 ENST00000417017.1
ENST00000392020.4
ENST00000392018.1
ATG16L1
autophagy related 16-like 1 (S. cerevisiae)
chr9_+_33795533 0.04 ENST00000379405.3
PRSS3
protease, serine, 3
chr14_+_102196739 0.04 ENST00000556973.1
RP11-796G6.2
Uncharacterized protein
chr22_+_39745930 0.04 ENST00000318801.4
ENST00000216155.7
ENST00000406293.3
ENST00000328933.5
SYNGR1
synaptogyrin 1
chr17_+_39968926 0.03 ENST00000585664.1
ENST00000585922.1
ENST00000429461.1
FKBP10
FK506 binding protein 10, 65 kDa
chr3_-_57113281 0.03 ENST00000468466.1
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr17_+_15848231 0.03 ENST00000304222.2
ADORA2B
adenosine A2b receptor
chr2_+_234160217 0.03 ENST00000392017.4
ENST00000347464.5
ENST00000444735.1
ENST00000373525.5
ENST00000419681.1
ATG16L1
autophagy related 16-like 1 (S. cerevisiae)
chr7_-_22234381 0.03 ENST00000458533.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr2_-_207629997 0.03 ENST00000454776.2
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr17_+_76374714 0.02 ENST00000262764.6
ENST00000589689.1
ENST00000329897.7
ENST00000592043.1
ENST00000587356.1
PGS1
phosphatidylglycerophosphate synthase 1
chr17_+_37356528 0.02 ENST00000225430.4
RPL19
ribosomal protein L19
chr17_+_37356586 0.02 ENST00000579260.1
ENST00000582193.1
RPL19
ribosomal protein L19
chr8_-_101965104 0.02 ENST00000437293.1
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr17_-_39968406 0.02 ENST00000393928.1
LEPREL4
leprecan-like 4
chr2_+_119699864 0.02 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr9_-_131418944 0.02 ENST00000419989.1
ENST00000451652.1
ENST00000372715.2
WDR34
WD repeat domain 34
chr5_-_133747589 0.02 ENST00000458198.2
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr10_-_43904608 0.02 ENST00000337970.3
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr17_+_37356555 0.02 ENST00000579374.1
RPL19
ribosomal protein L19
chr19_-_40791302 0.02 ENST00000392038.2
ENST00000578123.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr17_+_39969183 0.01 ENST00000321562.4
FKBP10
FK506 binding protein 10, 65 kDa
chr11_-_126138808 0.01 ENST00000332118.6
ENST00000532259.1
SRPR
signal recognition particle receptor (docking protein)
chr16_+_67197288 0.01 ENST00000264009.8
ENST00000421453.1
HSF4
heat shock transcription factor 4
chr3_+_127771212 0.01 ENST00000243253.3
ENST00000481210.1
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr11_+_6947720 0.01 ENST00000414517.2
ZNF215
zinc finger protein 215
chr8_-_125384927 0.01 ENST00000297632.6
TMEM65
transmembrane protein 65
chr17_-_39968855 0.01 ENST00000355468.3
ENST00000590496.1
LEPREL4
leprecan-like 4
chr1_-_213031418 0.01 ENST00000356684.3
ENST00000426161.1
ENST00000424044.1
FLVCR1-AS1
FLVCR1 antisense RNA 1 (head to head)
chr11_+_6947647 0.01 ENST00000278319.5
ZNF215
zinc finger protein 215
chr10_-_99393208 0.01 ENST00000307450.6
MORN4
MORN repeat containing 4
chr14_+_64854958 0.01 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr9_-_21142144 0.01 ENST00000380229.2
IFNW1
interferon, omega 1
chr7_+_36429409 0.01 ENST00000265748.2
ANLN
anillin, actin binding protein
chr5_-_133747551 0.01 ENST00000395009.3
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr6_-_170893669 0.01 ENST00000392090.2
ENST00000542896.1
ENST00000453163.2
ENST00000537445.1
PDCD2
programmed cell death 2
chr4_-_163085141 0.01 ENST00000427802.2
ENST00000306100.5
FSTL5
follistatin-like 5
chr4_+_75230853 0.01 ENST00000244869.2
EREG
epiregulin
chr11_+_61522844 0.01 ENST00000265460.5
MYRF
myelin regulatory factor
chr2_-_207630033 0.01 ENST00000449792.1
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr9_+_96793076 0.00 ENST00000375360.3
PTPDC1
protein tyrosine phosphatase domain containing 1
chrX_-_132091284 0.00 ENST00000370833.2
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr6_+_74104471 0.00 ENST00000370336.4
DDX43
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
chr1_+_26758790 0.00 ENST00000427245.2
ENST00000525682.2
ENST00000236342.7
ENST00000526219.1
ENST00000374185.3
ENST00000360009.2
DHDDS
dehydrodolichyl diphosphate synthase
chr6_+_3118926 0.00 ENST00000380379.5
BPHL
biphenyl hydrolase-like (serine hydrolase)
chr18_+_39766626 0.00 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
LINC00907
long intergenic non-protein coding RNA 907
chr21_-_33104367 0.00 ENST00000286835.7
ENST00000399804.1
SCAF4
SR-related CTD-associated factor 4

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0018277 protein deamination(GO:0018277)
0.1 0.2 GO:0072720 cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720)
0.0 0.1 GO:1901545 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.1 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.0 0.1 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.0 0.0 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.0 0.1 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.0 0.0 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.0 0.1 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0 0.0 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.1 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)