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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PKNOX2

Z-value: 0.33

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Transcription factors associated with PKNOX2

Gene Symbol Gene ID Gene Info
PKNOX2
ENSG00000165495.11 PBX/knotted 1 homeobox 2

Activity profile of PKNOX2 motif

Sorted Z-values of PKNOX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_52719888 0.33 ENST00000458294.1
PBRM1
polybromo 1
chr19_+_57050317 0.28 ENST00000301318.3
ENST00000591844.1
ZFP28
ZFP28 zinc finger protein
chr10_+_94608245 0.25 ENST00000443748.2
ENST00000260762.6
EXOC6
exocyst complex component 6
chr4_-_83483094 0.24 ENST00000508701.1
ENST00000454948.3
TMEM150C
transmembrane protein 150C
chr8_-_99837856 0.24 ENST00000518165.1
ENST00000419617.2
STK3
serine/threonine kinase 3
chr2_-_61765315 0.23 ENST00000406957.1
ENST00000401558.2
XPO1
exportin 1 (CRM1 homolog, yeast)
chr13_-_48575376 0.21 ENST00000434484.1
SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit
chr12_+_62654155 0.20 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
USP15
ubiquitin specific peptidase 15
chr18_-_54318353 0.18 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr2_+_196440692 0.17 ENST00000458054.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr6_-_101329191 0.16 ENST00000324723.6
ENST00000369162.2
ENST00000522650.1
ASCC3
activating signal cointegrator 1 complex subunit 3
chr18_-_54305658 0.16 ENST00000586262.1
ENST00000217515.6
TXNL1
thioredoxin-like 1
chr3_-_52719912 0.16 ENST00000420148.1
PBRM1
polybromo 1
chrX_-_80377118 0.16 ENST00000373250.3
HMGN5
high mobility group nucleosome binding domain 5
chr13_+_33160553 0.16 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr20_-_31124186 0.16 ENST00000375678.3
C20orf112
chromosome 20 open reading frame 112
chrX_-_80377162 0.16 ENST00000430960.1
ENST00000447319.1
HMGN5
high mobility group nucleosome binding domain 5
chr5_+_118407053 0.15 ENST00000311085.8
ENST00000539542.1
DMXL1
Dmx-like 1
chr6_-_101329157 0.15 ENST00000369143.2
ASCC3
activating signal cointegrator 1 complex subunit 3
chr14_+_24600484 0.14 ENST00000267426.5
FITM1
fat storage-inducing transmembrane protein 1
chr2_-_242842587 0.14 ENST00000404031.1
AC131097.4
Protein LOC285095
chr1_-_100598444 0.14 ENST00000535161.1
ENST00000287482.5
SASS6
spindle assembly 6 homolog (C. elegans)
chr6_+_17600576 0.13 ENST00000259963.3
FAM8A1
family with sequence similarity 8, member A1
chr5_+_118406796 0.13 ENST00000503802.1
DMXL1
Dmx-like 1
chr10_+_49514698 0.13 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
MAPK8
mitogen-activated protein kinase 8
chrX_+_16804544 0.12 ENST00000380122.5
ENST00000398155.4
TXLNG
taxilin gamma
chr18_-_52626622 0.12 ENST00000591504.1
CCDC68
coiled-coil domain containing 68
chr5_-_132073111 0.12 ENST00000403231.1
KIF3A
kinesin family member 3A
chr4_+_140222609 0.12 ENST00000296543.5
ENST00000398947.1
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr4_-_157892055 0.12 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr6_+_111195973 0.12 ENST00000368885.3
ENST00000368882.3
ENST00000451850.2
ENST00000368877.5
AMD1
adenosylmethionine decarboxylase 1
chr3_+_186692745 0.12 ENST00000438590.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr17_-_42452063 0.11 ENST00000588098.1
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr22_+_17082732 0.11 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1
transmembrane phosphatase with tensin homology pseudogene 1
chr8_+_57124245 0.11 ENST00000521831.1
ENST00000355315.3
ENST00000303759.3
ENST00000517636.1
ENST00000517933.1
ENST00000518801.1
ENST00000523975.1
ENST00000396723.5
ENST00000523061.1
ENST00000521524.1
CHCHD7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr4_-_157892498 0.11 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr12_+_69201923 0.11 ENST00000462284.1
ENST00000258149.5
ENST00000356290.4
ENST00000540827.1
ENST00000428863.2
ENST00000393412.3
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr5_-_94620239 0.11 ENST00000515393.1
MCTP1
multiple C2 domains, transmembrane 1
chr6_+_24126350 0.11 ENST00000378491.4
ENST00000378478.1
ENST00000378477.2
NRSN1
neurensin 1
chr2_+_202316392 0.10 ENST00000194530.3
ENST00000392249.2
STRADB
STE20-related kinase adaptor beta
chr6_+_150070831 0.10 ENST00000367380.5
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr1_+_66258846 0.10 ENST00000341517.4
PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_-_149867122 0.10 ENST00000253329.2
PPIL4
peptidylprolyl isomerase (cyclophilin)-like 4
chr6_+_155334780 0.09 ENST00000538270.1
ENST00000535231.1
TIAM2
T-cell lymphoma invasion and metastasis 2
chr12_+_62654119 0.09 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr4_+_128703295 0.09 ENST00000296464.4
ENST00000508549.1
HSPA4L
heat shock 70kDa protein 4-like
chr2_-_61765732 0.09 ENST00000443240.1
ENST00000436018.1
XPO1
exportin 1 (CRM1 homolog, yeast)
chr5_-_52405564 0.09 ENST00000510818.2
ENST00000396954.3
ENST00000508922.1
ENST00000361377.4
ENST00000582677.1
ENST00000584946.1
ENST00000450852.3
MOCS2
molybdenum cofactor synthesis 2
chr3_+_113667354 0.08 ENST00000491556.1
ZDHHC23
zinc finger, DHHC-type containing 23
chr18_-_67872891 0.08 ENST00000454359.1
ENST00000437017.1
RTTN
rotatin
chr12_-_62653903 0.08 ENST00000552075.1
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr5_-_58882219 0.08 ENST00000505453.1
ENST00000360047.5
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_100253993 0.08 ENST00000461605.1
ENST00000160382.5
ACTL6B
actin-like 6B
chr9_-_99637820 0.08 ENST00000289032.8
ENST00000535338.1
ZNF782
zinc finger protein 782
chr9_+_98637954 0.07 ENST00000288985.7
ERCC6L2
excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2
chr8_-_57123815 0.07 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr11_-_119247004 0.07 ENST00000531070.1
USP2
ubiquitin specific peptidase 2
chr16_+_2880296 0.07 ENST00000571723.1
ZG16B
zymogen granule protein 16B
chr11_-_111741994 0.07 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr6_-_84418841 0.07 ENST00000369694.2
ENST00000195649.6
SNAP91
synaptosomal-associated protein, 91kDa
chr10_+_70661014 0.07 ENST00000373585.3
DDX50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr11_+_74660278 0.07 ENST00000263672.6
ENST00000530257.1
ENST00000526361.1
ENST00000532972.1
SPCS2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr6_+_150070857 0.06 ENST00000544496.1
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr5_-_81046904 0.06 ENST00000515395.1
SSBP2
single-stranded DNA binding protein 2
chr3_+_32147997 0.06 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr10_-_101945771 0.06 ENST00000370408.2
ENST00000407654.3
ERLIN1
ER lipid raft associated 1
chr14_+_61995722 0.06 ENST00000556347.1
RP11-47I22.4
RP11-47I22.4
chr17_+_8316442 0.06 ENST00000582812.1
NDEL1
nudE neurodevelopment protein 1-like 1
chr6_-_84418738 0.06 ENST00000519779.1
SNAP91
synaptosomal-associated protein, 91kDa
chr6_-_84418860 0.06 ENST00000521743.1
SNAP91
synaptosomal-associated protein, 91kDa
chr3_-_33481835 0.05 ENST00000283629.3
UBP1
upstream binding protein 1 (LBP-1a)
chr3_-_3221358 0.05 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN
cereblon
chr6_+_26124373 0.05 ENST00000377791.2
ENST00000602637.1
HIST1H2AC
histone cluster 1, H2ac
chr5_-_81046841 0.05 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
SSBP2
single-stranded DNA binding protein 2
chr16_+_2880369 0.05 ENST00000572863.1
ZG16B
zymogen granule protein 16B
chr2_+_233271546 0.05 ENST00000295453.3
ALPPL2
alkaline phosphatase, placental-like 2
chr19_+_41281282 0.05 ENST00000263369.3
MIA
melanoma inhibitory activity
chr5_-_81046922 0.04 ENST00000514493.1
ENST00000320672.4
SSBP2
single-stranded DNA binding protein 2
chr16_+_50776021 0.04 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chr1_-_201081579 0.04 ENST00000367338.3
ENST00000362061.3
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr8_+_72755367 0.04 ENST00000537896.1
RP11-383H13.1
Protein LOC100132891; cDNA FLJ53548
chr7_+_1272522 0.04 ENST00000316333.8
UNCX
UNC homeobox
chr13_+_20268547 0.04 ENST00000601204.1
AL354808.2
AL354808.2
chr14_-_21492113 0.04 ENST00000554094.1
NDRG2
NDRG family member 2
chr9_-_140142181 0.04 ENST00000484720.1
FAM166A
family with sequence similarity 166, member A
chr1_+_161736072 0.04 ENST00000367942.3
ATF6
activating transcription factor 6
chr2_-_190446738 0.04 ENST00000427419.1
ENST00000455320.1
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr4_-_157892167 0.03 ENST00000541126.1
PDGFC
platelet derived growth factor C
chr9_-_33447584 0.03 ENST00000297991.4
AQP3
aquaporin 3 (Gill blood group)
chr3_+_52828805 0.03 ENST00000416872.2
ENST00000449956.2
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr1_-_247171347 0.03 ENST00000339986.7
ENST00000487338.2
ZNF695
zinc finger protein 695
chr22_+_20905286 0.03 ENST00000428629.1
MED15
mediator complex subunit 15
chr12_+_113495492 0.03 ENST00000257600.3
DTX1
deltex homolog 1 (Drosophila)
chr2_-_202316260 0.03 ENST00000332624.3
TRAK2
trafficking protein, kinesin binding 2
chr3_+_52719936 0.03 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr11_-_46867780 0.03 ENST00000529230.1
ENST00000415402.1
ENST00000312055.5
CKAP5
cytoskeleton associated protein 5
chr6_-_37225391 0.03 ENST00000356757.2
TMEM217
transmembrane protein 217
chr16_-_1275257 0.03 ENST00000234798.4
TPSG1
tryptase gamma 1
chr6_-_84418432 0.03 ENST00000519825.1
ENST00000523484.2
SNAP91
synaptosomal-associated protein, 91kDa
chr4_-_100871506 0.03 ENST00000296417.5
H2AFZ
H2A histone family, member Z
chr2_+_202937972 0.03 ENST00000541917.1
ENST00000295844.3
AC079354.1
uncharacterized protein KIAA2012
chr3_-_101395936 0.03 ENST00000461821.1
ZBTB11
zinc finger and BTB domain containing 11
chr14_-_21994337 0.02 ENST00000537235.1
ENST00000450879.2
SALL2
spalt-like transcription factor 2
chr2_+_64681219 0.02 ENST00000238875.5
LGALSL
lectin, galactoside-binding-like
chr11_-_19262486 0.02 ENST00000250024.4
E2F8
E2F transcription factor 8
chr5_+_78985673 0.02 ENST00000446378.2
CMYA5
cardiomyopathy associated 5
chr8_-_20161466 0.02 ENST00000381569.1
LZTS1
leucine zipper, putative tumor suppressor 1
chr2_+_219081817 0.02 ENST00000315717.5
ENST00000420104.1
ENST00000295685.10
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr15_+_68346501 0.02 ENST00000249636.6
PIAS1
protein inhibitor of activated STAT, 1
chr2_+_128848740 0.02 ENST00000375990.3
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr7_-_104909435 0.02 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr10_+_51565188 0.02 ENST00000430396.2
ENST00000374087.4
ENST00000414907.2
NCOA4
nuclear receptor coactivator 4
chr8_+_133787586 0.02 ENST00000395379.1
ENST00000395386.2
ENST00000337920.4
PHF20L1
PHD finger protein 20-like 1
chr17_-_40337470 0.02 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr17_+_68071389 0.02 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr19_-_38743878 0.02 ENST00000587515.1
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr7_-_148580563 0.02 ENST00000476773.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr2_-_202316169 0.01 ENST00000430254.1
TRAK2
trafficking protein, kinesin binding 2
chr9_+_87285539 0.01 ENST00000359847.3
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr1_+_145549203 0.01 ENST00000355594.4
ENST00000544626.1
ANKRD35
ankyrin repeat domain 35
chr15_+_33010175 0.01 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1
gremlin 1, DAN family BMP antagonist
chr9_+_6758109 0.01 ENST00000536108.1
KDM4C
lysine (K)-specific demethylase 4C
chr5_+_125758865 0.01 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr10_+_94608218 0.01 ENST00000371543.1
EXOC6
exocyst complex component 6
chr20_+_43514320 0.01 ENST00000372839.3
ENST00000428262.1
ENST00000445830.1
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr17_+_39868577 0.01 ENST00000329402.3
GAST
gastrin
chr2_+_128848881 0.01 ENST00000259253.6
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr6_+_138188551 0.01 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr22_+_20905422 0.01 ENST00000424287.1
ENST00000423862.1
MED15
mediator complex subunit 15
chr2_-_179672142 0.01 ENST00000342992.6
ENST00000360870.5
ENST00000460472.2
ENST00000589042.1
ENST00000591111.1
ENST00000342175.6
ENST00000359218.5
TTN
titin
chr19_+_36142147 0.01 ENST00000590618.1
COX6B1
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
chr11_-_64013288 0.01 ENST00000542235.1
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr4_-_175750364 0.01 ENST00000340217.5
ENST00000274093.3
GLRA3
glycine receptor, alpha 3
chr1_-_234667504 0.01 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr17_+_68071458 0.01 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr1_+_154966058 0.01 ENST00000392487.1
LENEP
lens epithelial protein
chr11_+_120207787 0.00 ENST00000397843.2
ENST00000356641.3
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr2_+_113033164 0.00 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr3_+_23244780 0.00 ENST00000396703.1
UBE2E2
ubiquitin-conjugating enzyme E2E 2
chr1_-_179112173 0.00 ENST00000408940.3
ENST00000504405.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr9_+_6758024 0.00 ENST00000442236.2
KDM4C
lysine (K)-specific demethylase 4C
chr1_-_179112189 0.00 ENST00000512653.1
ENST00000344730.3
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.2 GO:0006781 succinyl-CoA pathway(GO:0006781)
0.0 0.1 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.0 0.2 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.0 0.3 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.0 GO:0098939 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.0 0.0 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.2 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.0 GO:1903988 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.0 0.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.0 GO:0097359 UDP-glucosylation(GO:0097359)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0043291 RAVE complex(GO:0043291)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.5 GO:0090544 BAF-type complex(GO:0090544)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.2 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0019808 polyamine binding(GO:0019808)
0.0 0.1 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.0 0.3 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.1 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 0.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.0 GO:0097689 iron channel activity(GO:0097689)
0.0 0.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.0 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions