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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU4F2

Z-value: 0.50

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
POU4F2
ENSG00000151615.3 POU class 4 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F2hg19_v2_chr4_+_147560042_1475600460.325.3e-01Click!

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_51027838 0.34 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr4_+_141264597 0.30 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr19_-_7698599 0.30 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr6_-_111136299 0.28 ENST00000457688.1
CDK19
cyclin-dependent kinase 19
chr9_-_37384431 0.28 ENST00000452923.1
RP11-397D12.4
RP11-397D12.4
chr5_-_87516448 0.22 ENST00000511218.1
TMEM161B
transmembrane protein 161B
chr17_+_61151306 0.20 ENST00000580068.1
ENST00000580466.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr12_-_118796910 0.19 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr18_-_73967160 0.17 ENST00000579714.1
RP11-94B19.7
RP11-94B19.7
chr13_-_34250861 0.16 ENST00000445227.1
ENST00000454681.2
RP11-141M1.3
RP11-141M1.3
chrX_+_139791917 0.16 ENST00000607004.1
ENST00000370535.3
LINC00632
long intergenic non-protein coding RNA 632
chr6_+_130339710 0.14 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr6_-_111136513 0.14 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr11_-_125550764 0.13 ENST00000527795.1
ACRV1
acrosomal vesicle protein 1
chr20_+_5987890 0.12 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr11_-_125550726 0.12 ENST00000315608.3
ENST00000530048.1
ACRV1
acrosomal vesicle protein 1
chr2_+_191792376 0.12 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr8_-_18541603 0.12 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3
chr15_+_45544426 0.11 ENST00000347644.3
ENST00000560438.1
SLC28A2
solute carrier family 28 (concentrative nucleoside transporter), member 2
chr1_-_193028632 0.11 ENST00000421683.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr11_+_31531291 0.11 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr19_-_7697857 0.10 ENST00000598935.1
PCP2
Purkinje cell protein 2
chr2_+_44502597 0.10 ENST00000260649.6
ENST00000409387.1
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr14_+_55221541 0.10 ENST00000555192.1
SAMD4A
sterile alpha motif domain containing 4A
chr8_-_131399110 0.09 ENST00000521426.1
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr2_+_172309634 0.09 ENST00000339506.3
DCAF17
DDB1 and CUL4 associated factor 17
chr17_+_48243352 0.09 ENST00000344627.6
ENST00000262018.3
ENST00000543315.1
ENST00000451235.2
ENST00000511303.1
SGCA
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
chr4_-_36245561 0.09 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_-_169401628 0.09 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr1_-_193028426 0.08 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr4_+_169013666 0.08 ENST00000359299.3
ANXA10
annexin A10
chr9_+_125132803 0.08 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr15_-_37393406 0.08 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr4_+_76481258 0.08 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr1_-_193028621 0.07 ENST00000367455.4
ENST00000367454.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr16_-_69390209 0.07 ENST00000563634.1
RP11-343C2.9
Uncharacterized protein
chr12_-_89746173 0.07 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr15_+_101402041 0.07 ENST00000558475.1
ENST00000558641.1
ENST00000559673.1
RP11-66B24.1
RP11-66B24.1
chr21_+_17443521 0.07 ENST00000456342.1
LINC00478
long intergenic non-protein coding RNA 478
chr1_+_193028552 0.06 ENST00000400968.2
ENST00000432079.1
TROVE2
TROVE domain family, member 2
chr6_+_12717892 0.06 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr17_-_64225508 0.06 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chrX_+_133930798 0.06 ENST00000414371.2
FAM122C
family with sequence similarity 122C
chr20_-_50418972 0.05 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr17_+_68100989 0.05 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr9_+_125133315 0.05 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_-_107729287 0.05 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr7_+_142982023 0.05 ENST00000359333.3
ENST00000409244.1
ENST00000409541.1
ENST00000410004.1
TMEM139
transmembrane protein 139
chr1_+_160370344 0.05 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chrX_+_68835911 0.05 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chr12_-_130529501 0.05 ENST00000561864.1
ENST00000567788.1
RP11-474D1.4
RP11-474D1.3
RP11-474D1.4
RP11-474D1.3
chr10_-_73848086 0.05 ENST00000536168.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr11_-_96076334 0.05 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr13_+_46039037 0.04 ENST00000349995.5
COG3
component of oligomeric golgi complex 3
chr12_-_52779433 0.04 ENST00000257951.3
KRT84
keratin 84
chr11_-_31531121 0.04 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMMP1L
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr10_-_73848531 0.04 ENST00000373109.2
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr10_-_116444371 0.04 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr2_+_44502630 0.04 ENST00000410056.3
ENST00000409741.1
ENST00000409229.3
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr13_-_74993252 0.04 ENST00000325811.1
AL355390.1
Uncharacterized protein
chr6_+_4087664 0.04 ENST00000430835.2
C6orf201
chromosome 6 open reading frame 201
chr9_-_79520989 0.04 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
PRUNE2
prune homolog 2 (Drosophila)
chr6_+_151042224 0.03 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr1_+_198608146 0.03 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_193028717 0.03 ENST00000415442.2
ENST00000506303.1
TROVE2
TROVE domain family, member 2
chr19_+_1269324 0.02 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP
cold inducible RNA binding protein
chr2_-_122262593 0.02 ENST00000418989.1
CLASP1
cytoplasmic linker associated protein 1
chr9_-_5830768 0.02 ENST00000381506.3
ERMP1
endoplasmic reticulum metallopeptidase 1
chr2_-_158300556 0.02 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr21_+_17442799 0.02 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
LINC00478
long intergenic non-protein coding RNA 478
chr3_+_147657764 0.02 ENST00000467198.1
ENST00000485006.1
RP11-71N10.1
RP11-71N10.1
chr1_+_66820058 0.02 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr20_+_56136136 0.02 ENST00000319441.4
ENST00000543666.1
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr12_-_118797475 0.02 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr3_+_50230105 0.02 ENST00000440836.1
GNAT1
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
chr9_+_125133467 0.02 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_-_36304201 0.02 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr18_-_71959159 0.02 ENST00000494131.2
ENST00000397914.4
ENST00000340533.4
CYB5A
cytochrome b5 type A (microsomal)
chr6_+_39760129 0.02 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr5_-_58295712 0.01 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr16_+_19422035 0.01 ENST00000381414.4
ENST00000396229.2
TMC5
transmembrane channel-like 5
chrX_-_133931164 0.01 ENST00000370790.1
ENST00000298090.6
FAM122B
family with sequence similarity 122B
chr10_+_95372289 0.01 ENST00000371447.3
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr12_-_89746264 0.01 ENST00000548755.1
DUSP6
dual specificity phosphatase 6
chr12_+_109577202 0.00 ENST00000377848.3
ENST00000377854.5
ACACB
acetyl-CoA carboxylase beta
chr11_-_115127611 0.00 ENST00000545094.1
CADM1
cell adhesion molecule 1
chr12_-_6233828 0.00 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr17_-_33390667 0.00 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr5_+_154393260 0.00 ENST00000435029.4
KIF4B
kinesin family member 4B
chr10_-_99205607 0.00 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr18_+_32455201 0.00 ENST00000590831.2
DTNA
dystrobrevin, alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0015811 L-cystine transport(GO:0015811)
0.0 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.0 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.1 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.1 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.0 0.3 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.1 GO:0043249 erythrocyte maturation(GO:0043249)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.0 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0031597 cytosolic proteasome complex(GO:0031597)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.1 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.0 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)