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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU6F1

Z-value: 0.66

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
POU6F1
ENSG00000184271.11 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg19_v2_chr12_-_51611477_51611612-0.473.5e-01Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_26746951 0.41 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chr19_+_52076425 0.35 ENST00000436511.2
ZNF175
zinc finger protein 175
chr12_+_102514019 0.31 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chrX_-_122756660 0.30 ENST00000441692.1
THOC2
THO complex 2
chr1_-_197115818 0.29 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr6_+_26183958 0.28 ENST00000356530.3
HIST1H2BE
histone cluster 1, H2be
chr13_-_52027134 0.28 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr12_+_102513950 0.27 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr18_+_52495426 0.27 ENST00000262094.5
RAB27B
RAB27B, member RAS oncogene family
chr1_+_225140372 0.26 ENST00000366848.1
ENST00000439375.2
DNAH14
dynein, axonemal, heavy chain 14
chr11_+_85339623 0.26 ENST00000358867.6
ENST00000534341.1
ENST00000393375.1
ENST00000531274.1
TMEM126B
transmembrane protein 126B
chr20_+_5987890 0.25 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr22_-_28490123 0.25 ENST00000442232.1
TTC28
tetratricopeptide repeat domain 28
chr6_-_111804905 0.24 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr2_+_207220463 0.23 ENST00000598562.1
AC017081.1
Uncharacterized protein
chr5_+_67586465 0.23 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chrY_+_14958970 0.22 ENST00000453031.1
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr7_-_83824449 0.22 ENST00000420047.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr17_-_25568687 0.20 ENST00000581944.1
RP11-663N22.1
RP11-663N22.1
chr6_-_47009996 0.20 ENST00000371243.2
GPR110
G protein-coupled receptor 110
chr1_+_225117350 0.20 ENST00000413949.2
ENST00000430092.1
ENST00000366850.3
ENST00000400952.3
ENST00000366849.1
DNAH14
dynein, axonemal, heavy chain 14
chr15_-_85259384 0.18 ENST00000455959.3
SEC11A
SEC11 homolog A (S. cerevisiae)
chr2_+_242289502 0.18 ENST00000451310.1
SEPT2
septin 2
chr4_+_78829479 0.17 ENST00000504901.1
MRPL1
mitochondrial ribosomal protein L1
chr2_+_191045562 0.17 ENST00000340623.4
C2orf88
chromosome 2 open reading frame 88
chr15_+_80351977 0.17 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chr13_+_98612446 0.17 ENST00000496368.1
ENST00000421861.2
ENST00000357602.3
IPO5
importin 5
chr5_+_162864575 0.16 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
CCNG1
cyclin G1
chr20_-_50418947 0.15 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr4_-_169401628 0.15 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chrX_+_119737806 0.14 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr10_-_94257512 0.14 ENST00000371581.5
IDE
insulin-degrading enzyme
chr5_+_115177178 0.13 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr15_-_85259294 0.13 ENST00000558217.1
ENST00000558196.1
ENST00000558134.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr14_+_39944025 0.13 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
RP11-111A21.1
chr4_-_130692631 0.12 ENST00000500092.2
ENST00000509105.1
RP11-519M16.1
RP11-519M16.1
chr14_+_24970800 0.12 ENST00000555109.1
RP11-80A15.1
Uncharacterized protein
chr6_-_110501126 0.12 ENST00000368938.1
WASF1
WAS protein family, member 1
chr3_-_108248169 0.12 ENST00000273353.3
MYH15
myosin, heavy chain 15
chr13_+_107028897 0.12 ENST00000439790.1
ENST00000435024.1
LINC00460
long intergenic non-protein coding RNA 460
chr22_+_31518938 0.11 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr3_-_114343768 0.11 ENST00000393785.2
ZBTB20
zinc finger and BTB domain containing 20
chr2_+_128403720 0.11 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr1_-_153538292 0.11 ENST00000497140.1
ENST00000368708.3
S100A2
S100 calcium binding protein A2
chrX_+_102024075 0.11 ENST00000431616.1
ENST00000440496.1
ENST00000420471.1
ENST00000435966.1
LINC00630
long intergenic non-protein coding RNA 630
chr13_+_49551020 0.10 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr11_+_12302492 0.10 ENST00000533534.1
MICALCL
MICAL C-terminal like
chr15_+_80351910 0.10 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr7_-_83824169 0.09 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr6_-_111136299 0.09 ENST00000457688.1
CDK19
cyclin-dependent kinase 19
chr12_-_95397442 0.09 ENST00000547157.1
ENST00000547986.1
ENST00000327772.2
NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr6_+_110501344 0.08 ENST00000368932.1
CDC40
cell division cycle 40
chr6_+_110501621 0.08 ENST00000368930.1
ENST00000307731.1
CDC40
cell division cycle 40
chr7_-_77427676 0.08 ENST00000257663.3
TMEM60
transmembrane protein 60
chr2_+_102721023 0.08 ENST00000409589.1
ENST00000409329.1
IL1R1
interleukin 1 receptor, type I
chr4_-_83812157 0.08 ENST00000513323.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr15_-_85259330 0.07 ENST00000560266.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr11_+_118398178 0.07 ENST00000302783.4
ENST00000539546.1
TTC36
tetratricopeptide repeat domain 36
chr4_+_123161120 0.07 ENST00000446180.1
KIAA1109
KIAA1109
chr12_-_57443886 0.07 ENST00000300119.3
MYO1A
myosin IA
chr4_-_76912070 0.07 ENST00000395711.4
ENST00000356260.5
SDAD1
SDA1 domain containing 1
chr2_+_128403439 0.07 ENST00000544369.1
GPR17
G protein-coupled receptor 17
chr19_+_10959043 0.06 ENST00000397820.4
C19orf38
chromosome 19 open reading frame 38
chr11_-_107729287 0.06 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr9_+_128509624 0.06 ENST00000342287.5
ENST00000373487.4
PBX3
pre-B-cell leukemia homeobox 3
chr1_-_106161540 0.05 ENST00000420901.1
ENST00000610126.1
ENST00000435253.2
RP11-251P6.1
RP11-251P6.1
chr11_-_107729504 0.05 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr15_-_31283618 0.05 ENST00000563714.1
MTMR10
myotubularin related protein 10
chr20_+_58515417 0.05 ENST00000360816.3
FAM217B
family with sequence similarity 217, member B
chr6_-_74231444 0.04 ENST00000331523.2
ENST00000356303.2
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr9_+_103790991 0.04 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr4_+_130692778 0.04 ENST00000513875.1
ENST00000508724.1
RP11-422J15.1
RP11-422J15.1
chr12_-_91546926 0.04 ENST00000550758.1
DCN
decorin
chr10_+_97803151 0.03 ENST00000403870.3
ENST00000265992.5
ENST00000465148.2
ENST00000534974.1
CCNJ
cyclin J
chr9_-_4666337 0.03 ENST00000381890.5
SPATA6L
spermatogenesis associated 6-like
chr12_+_49297887 0.03 ENST00000266984.5
CCDC65
coiled-coil domain containing 65
chr16_+_19421803 0.03 ENST00000541464.1
TMC5
transmembrane channel-like 5
chr15_-_44828838 0.03 ENST00000560750.1
EIF3J-AS1
EIF3J antisense RNA 1 (head to head)
chrX_+_43515467 0.03 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr8_-_10512569 0.03 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr1_+_113010056 0.03 ENST00000369686.5
WNT2B
wingless-type MMTV integration site family, member 2B
chr11_+_2323349 0.03 ENST00000381121.3
TSPAN32
tetraspanin 32
chr15_-_85259360 0.03 ENST00000559729.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr11_-_93583697 0.02 ENST00000409977.1
VSTM5
V-set and transmembrane domain containing 5
chr6_-_111136513 0.02 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr12_+_10460417 0.02 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr17_-_39677971 0.02 ENST00000393976.2
KRT15
keratin 15
chr2_+_202937972 0.02 ENST00000541917.1
ENST00000295844.3
AC079354.1
uncharacterized protein KIAA2012
chr20_+_58203664 0.02 ENST00000541461.1
PHACTR3
phosphatase and actin regulator 3
chr11_+_2323236 0.02 ENST00000182290.4
TSPAN32
tetraspanin 32
chr12_+_54892550 0.01 ENST00000545638.2
NCKAP1L
NCK-associated protein 1-like
chr15_+_45028753 0.01 ENST00000338264.4
TRIM69
tripartite motif containing 69
chr19_-_3786354 0.01 ENST00000395040.2
ENST00000310132.6
MATK
megakaryocyte-associated tyrosine kinase
chr9_-_13165457 0.01 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr15_+_45028520 0.01 ENST00000329464.4
TRIM69
tripartite motif containing 69
chr10_+_18041218 0.01 ENST00000480516.1
ENST00000457860.1
TMEM236
TMEM236
chr20_-_58515344 0.00 ENST00000370996.3
PPP1R3D
protein phosphatase 1, regulatory subunit 3D
chr20_-_50418972 0.00 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr16_+_19422035 0.00 ENST00000381414.4
ENST00000396229.2
TMC5
transmembrane channel-like 5
chr8_+_39792474 0.00 ENST00000502986.2
IDO2
indoleamine 2,3-dioxygenase 2
chr19_-_3786253 0.00 ENST00000585778.1
MATK
megakaryocyte-associated tyrosine kinase
chr9_-_89562104 0.00 ENST00000298743.7
GAS1
growth arrest-specific 1

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.3 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.2 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.2 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.3 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.1 GO:0007388 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.0 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0 0.0 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0 0.3 GO:0071985 multivesicular body sorting pathway(GO:0071985)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.3 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.3 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.2 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030572 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.1 GO:0031626 beta-endorphin binding(GO:0031626)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.5 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors