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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PPARD

Z-value: 0.64

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Transcription factors associated with PPARD

Gene Symbol Gene ID Gene Info
PPARD
ENSG00000112033.9 peroxisome proliferator activated receptor delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PPARDhg19_v2_chr6_+_35310391_35310410-0.483.4e-01Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_159593418 1.16 ENST00000507475.1
ENST00000307738.5
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr5_+_172484377 0.87 ENST00000523161.1
CREBRF
CREB3 regulatory factor
chr7_-_34978980 0.67 ENST00000428054.1
DPY19L1
dpy-19-like 1 (C. elegans)
chr19_+_10197463 0.66 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr15_+_82555169 0.56 ENST00000565432.1
ENST00000427381.2
FAM154B
family with sequence similarity 154, member B
chr9_-_33402506 0.52 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr14_+_32546145 0.51 ENST00000556611.1
ENST00000539826.2
ARHGAP5
Rho GTPase activating protein 5
chr7_+_7222233 0.51 ENST00000436587.2
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr11_+_17281900 0.46 ENST00000530527.1
NUCB2
nucleobindin 2
chr15_+_43885252 0.45 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr2_+_228190066 0.44 ENST00000436237.1
ENST00000443428.2
ENST00000418961.1
MFF
mitochondrial fission factor
chr2_-_219433014 0.41 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
USP37
ubiquitin specific peptidase 37
chr11_+_111169565 0.38 ENST00000528846.1
COLCA2
colorectal cancer associated 2
chr6_-_135424186 0.38 ENST00000529882.1
HBS1L
HBS1-like (S. cerevisiae)
chr12_-_95467267 0.35 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2, group C, member 1
chr15_+_82555125 0.34 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000566861.1
FAM154B
family with sequence similarity 154, member B
chr14_+_32546274 0.33 ENST00000396582.2
ARHGAP5
Rho GTPase activating protein 5
chr17_+_9745786 0.32 ENST00000304773.5
GLP2R
glucagon-like peptide 2 receptor
chr2_-_28113217 0.32 ENST00000444339.2
RBKS
ribokinase
chr6_+_142468361 0.29 ENST00000367630.4
VTA1
vesicle (multivesicular body) trafficking 1
chr4_+_174089904 0.27 ENST00000265000.4
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr6_+_88299833 0.27 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
ORC3
origin recognition complex, subunit 3
chr17_-_7123021 0.24 ENST00000399510.2
DLG4
discs, large homolog 4 (Drosophila)
chr19_+_10196981 0.24 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chrX_-_108868390 0.23 ENST00000372101.2
KCNE1L
KCNE1-like
chr9_+_34458771 0.23 ENST00000437363.1
ENST00000242317.4
DNAI1
dynein, axonemal, intermediate chain 1
chr1_-_11107280 0.22 ENST00000400897.3
ENST00000400898.3
MASP2
mannan-binding lectin serine peptidase 2
chr20_-_44485835 0.21 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8
acyl-CoA thioesterase 8
chr21_-_27107198 0.21 ENST00000400094.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr21_+_27107672 0.20 ENST00000400075.3
GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr6_-_88299678 0.20 ENST00000369536.5
RARS2
arginyl-tRNA synthetase 2, mitochondrial
chr2_+_219283815 0.20 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr3_-_53878644 0.20 ENST00000481668.1
ENST00000467802.1
CHDH
choline dehydrogenase
chr6_+_142468383 0.19 ENST00000367621.1
ENST00000452973.2
VTA1
vesicle (multivesicular body) trafficking 1
chr7_+_112090483 0.19 ENST00000403825.3
ENST00000429071.1
IFRD1
interferon-related developmental regulator 1
chr19_+_49867181 0.19 ENST00000597546.1
DKKL1
dickkopf-like 1
chr11_-_47470703 0.18 ENST00000298854.2
RAPSN
receptor-associated protein of the synapse
chr9_+_34458851 0.18 ENST00000545019.1
DNAI1
dynein, axonemal, intermediate chain 1
chr21_-_27107344 0.18 ENST00000457143.2
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr9_+_115142217 0.17 ENST00000398805.3
ENST00000398803.1
ENST00000262542.7
ENST00000539114.1
HSDL2
hydroxysteroid dehydrogenase like 2
chr10_+_94050913 0.17 ENST00000358935.2
MARCH5
membrane-associated ring finger (C3HC4) 5
chr3_+_48507210 0.17 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
TREX1
three prime repair exonuclease 1
chr2_+_198365095 0.17 ENST00000409468.1
HSPE1
heat shock 10kDa protein 1
chr1_-_156675564 0.17 ENST00000368220.1
CRABP2
cellular retinoic acid binding protein 2
chr21_-_27107283 0.16 ENST00000284971.3
ENST00000400099.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr2_-_178257401 0.16 ENST00000464747.1
NFE2L2
nuclear factor, erythroid 2-like 2
chr6_+_143999072 0.16 ENST00000440869.2
ENST00000367582.3
ENST00000451827.2
PHACTR2
phosphatase and actin regulator 2
chr2_+_198365122 0.16 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr11_-_47470591 0.15 ENST00000524487.1
RAPSN
receptor-associated protein of the synapse
chr6_+_32006159 0.15 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr8_-_80942139 0.15 ENST00000521434.1
ENST00000519120.1
ENST00000520946.1
MRPS28
mitochondrial ribosomal protein S28
chr6_+_43265992 0.15 ENST00000449231.1
ENST00000372589.3
ENST00000372585.5
SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr3_-_125094093 0.15 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
ZNF148
zinc finger protein 148
chr1_-_161102421 0.14 ENST00000490843.2
ENST00000368006.3
ENST00000392188.1
ENST00000545495.1
DEDD
death effector domain containing
chr5_-_143550159 0.14 ENST00000448443.2
ENST00000513112.1
ENST00000519064.1
ENST00000274496.5
YIPF5
Yip1 domain family, member 5
chr1_+_244998602 0.14 ENST00000411948.2
COX20
COX20 cytochrome C oxidase assembly factor
chr15_+_43985084 0.13 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr3_-_49203744 0.13 ENST00000321895.6
CCDC71
coiled-coil domain containing 71
chr17_-_4464081 0.13 ENST00000574154.1
GGT6
gamma-glutamyltransferase 6
chr3_-_126236588 0.13 ENST00000383579.3
UROC1
urocanate hydratase 1
chr5_-_143550241 0.12 ENST00000522203.1
YIPF5
Yip1 domain family, member 5
chr12_-_56727676 0.12 ENST00000547572.1
ENST00000257931.5
ENST00000440411.3
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr6_+_31637944 0.11 ENST00000375864.4
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr17_+_37894179 0.11 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7
growth factor receptor-bound protein 7
chr11_-_47470682 0.11 ENST00000529341.1
ENST00000352508.3
RAPSN
receptor-associated protein of the synapse
chr1_+_6511651 0.11 ENST00000434576.1
ESPN
espin
chr1_-_109968973 0.11 ENST00000271308.4
ENST00000538610.1
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr3_-_126236605 0.11 ENST00000290868.2
UROC1
urocanate hydratase 1
chr22_+_30163340 0.11 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr1_-_160832642 0.11 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr1_-_160832490 0.10 ENST00000322302.7
ENST00000368033.3
CD244
CD244 molecule, natural killer cell receptor 2B4
chr9_+_126773880 0.10 ENST00000373615.4
LHX2
LIM homeobox 2
chr2_+_178257372 0.10 ENST00000264167.4
ENST00000409888.1
AGPS
alkylglycerone phosphate synthase
chr2_-_207024134 0.10 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr17_+_48610042 0.10 ENST00000503246.1
EPN3
epsin 3
chr15_+_76030311 0.09 ENST00000543887.1
AC019294.1
AC019294.1
chr2_+_28113583 0.09 ENST00000344773.2
ENST00000379624.1
ENST00000342045.2
ENST00000379632.2
ENST00000361704.2
BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr1_+_55107449 0.09 ENST00000421030.2
ENST00000545244.1
ENST00000339553.5
ENST00000409996.1
ENST00000454855.2
MROH7
maestro heat-like repeat family member 7
chr8_-_80942061 0.09 ENST00000519386.1
MRPS28
mitochondrial ribosomal protein S28
chr19_+_4153598 0.09 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3-like 3
chr3_-_49314640 0.09 ENST00000436325.1
C3orf62
chromosome 3 open reading frame 62
chr21_-_27107881 0.08 ENST00000400090.3
ENST00000400087.3
ENST00000400093.3
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr6_+_30594619 0.08 ENST00000318999.7
ENST00000376485.4
ENST00000376478.2
ENST00000319027.5
ENST00000376483.4
ENST00000329992.8
ENST00000330083.5
ATAT1
alpha tubulin acetyltransferase 1
chr5_+_34757309 0.07 ENST00000397449.1
RAI14
retinoic acid induced 14
chr6_+_43266063 0.07 ENST00000372574.3
SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr11_+_111169976 0.07 ENST00000398035.2
COLCA2
colorectal cancer associated 2
chr4_+_140586922 0.07 ENST00000265498.1
ENST00000506797.1
MGST2
microsomal glutathione S-transferase 2
chr19_-_3062465 0.07 ENST00000327141.4
AES
amino-terminal enhancer of split
chr1_-_161102367 0.06 ENST00000464113.1
DEDD
death effector domain containing
chrX_+_2746818 0.06 ENST00000398806.3
GYG2
glycogenin 2
chr5_+_14664762 0.06 ENST00000284274.4
FAM105B
family with sequence similarity 105, member B
chr1_+_55107489 0.06 ENST00000395690.2
MROH7
maestro heat-like repeat family member 7
chrX_+_2746850 0.06 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
GYG2
glycogenin 2
chr2_-_198364581 0.06 ENST00000428204.1
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr10_-_74714533 0.05 ENST00000373032.3
PLA2G12B
phospholipase A2, group XIIB
chr3_-_48936272 0.05 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr12_+_121163602 0.05 ENST00000411593.2
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr1_+_156123318 0.05 ENST00000368285.3
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr7_-_87342564 0.05 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr11_-_61658853 0.04 ENST00000525588.1
ENST00000540820.1
FADS3
fatty acid desaturase 3
chr10_-_49459800 0.03 ENST00000305531.3
FRMPD2
FERM and PDZ domain containing 2
chr6_+_33172407 0.03 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr1_+_145727681 0.02 ENST00000417171.1
ENST00000451928.2
PDZK1
PDZ domain containing 1
chr17_+_4853442 0.02 ENST00000522301.1
ENO3
enolase 3 (beta, muscle)
chr15_+_78441663 0.02 ENST00000299518.2
ENST00000558554.1
ENST00000557826.1
ENST00000561279.1
ENST00000559186.1
ENST00000560770.1
ENST00000559881.1
ENST00000559205.1
ENST00000441490.2
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr19_+_29493486 0.02 ENST00000589821.1
CTD-2081K17.2
CTD-2081K17.2
chr6_+_32006042 0.02 ENST00000418967.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr1_-_160253998 0.01 ENST00000392220.2
PEX19
peroxisomal biogenesis factor 19
chr20_+_46130601 0.01 ENST00000341724.6
NCOA3
nuclear receptor coactivator 3
chr1_-_161039456 0.00 ENST00000368016.3
ARHGAP30
Rho GTPase activating protein 30
chr4_-_7069760 0.00 ENST00000264954.4
GRPEL1
GrpE-like 1, mitochondrial (E. coli)

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 0.4 GO:1900075 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
0.1 0.5 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.1 0.3 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.4 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.1 0.2 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.1 0.5 GO:0015793 glycerol transport(GO:0015793)
0.1 0.3 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 0.7 GO:0018317 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.2 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.7 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.2 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.4 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.5 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.2 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 0.2 GO:2000821 regulation of grooming behavior(GO:2000821)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.6 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.2 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.1 GO:0006844 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.0 0.2 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.0 0.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.1 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.7 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.0 0.4 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.9 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.1 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.5 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.5 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.1 0.3 GO:0004967 glucagon receptor activity(GO:0004967)
0.1 0.2 GO:0001855 complement component C4b binding(GO:0001855)
0.1 0.2 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.4 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.7 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0015227 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.6 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)