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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PRRX1_ALX4_PHOX2A

Z-value: 0.74

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Transcription factors associated with PRRX1_ALX4_PHOX2A

Gene Symbol Gene ID Gene Info
PRRX1
ENSG00000116132.7 paired related homeobox 1
ALX4
ENSG00000052850.5 ALX homeobox 4
PHOX2A
ENSG00000165462.5 paired like homeobox 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRRX1hg19_v2_chr1_+_170632250_1706322770.805.4e-02Click!
ALX4hg19_v2_chr11_-_44331679_443317160.187.4e-01Click!

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_86999516 1.98 ENST00000521564.1
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr17_+_61151306 1.89 ENST00000580068.1
ENST00000580466.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr3_-_12587055 0.89 ENST00000564146.3
C3orf83
chromosome 3 open reading frame 83
chr6_+_12007897 0.85 ENST00000437559.1
RP11-456H18.2
RP11-456H18.2
chr2_+_29001711 0.79 ENST00000418910.1
PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr7_+_30589829 0.65 ENST00000579437.1
RP4-777O23.1
RP4-777O23.1
chr12_+_14369524 0.59 ENST00000538329.1
RP11-134N1.2
RP11-134N1.2
chr14_-_57197224 0.54 ENST00000554597.1
ENST00000556696.1
RP11-1085N6.3
Uncharacterized protein
chr1_+_50459990 0.53 ENST00000448346.1
AL645730.2
AL645730.2
chr12_-_91546926 0.51 ENST00000550758.1
DCN
decorin
chr1_-_234667504 0.50 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr6_+_12007963 0.50 ENST00000607445.1
RP11-456H18.2
RP11-456H18.2
chr12_-_118796910 0.49 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr7_-_111032971 0.49 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr6_+_26087646 0.46 ENST00000309234.6
HFE
hemochromatosis
chr2_-_145275228 0.44 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
ZEB2
zinc finger E-box binding homeobox 2
chr17_-_39023462 0.41 ENST00000251643.4
KRT12
keratin 12
chr2_-_145275828 0.40 ENST00000392861.2
ENST00000409211.1
ZEB2
zinc finger E-box binding homeobox 2
chr6_-_137314371 0.39 ENST00000432330.1
ENST00000418699.1
RP11-55K22.5
RP11-55K22.5
chr1_-_151148442 0.38 ENST00000441701.1
ENST00000416280.2
TMOD4
tropomodulin 4 (muscle)
chr17_-_39150385 0.36 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr12_+_116985896 0.35 ENST00000547114.1
RP11-809C9.2
RP11-809C9.2
chr14_-_95236551 0.34 ENST00000238558.3
GSC
goosecoid homeobox
chr6_+_3259122 0.33 ENST00000438998.2
ENST00000380305.4
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr8_+_86851932 0.32 ENST00000517368.1
CTA-392E5.1
CTA-392E5.1
chr2_-_114461655 0.32 ENST00000424612.1
AC017074.2
AC017074.2
chr1_+_170632250 0.32 ENST00000367760.3
PRRX1
paired related homeobox 1
chr18_+_20714525 0.30 ENST00000400473.2
CABLES1
Cdk5 and Abl enzyme substrate 1
chr18_+_616672 0.29 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr6_-_110679475 0.29 ENST00000338882.4
METTL24
methyltransferase like 24
chr2_-_145188137 0.29 ENST00000440875.1
ZEB2
zinc finger E-box binding homeobox 2
chrX_+_107288239 0.28 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr12_-_75784669 0.28 ENST00000552497.1
ENST00000551829.1
ENST00000436898.1
ENST00000442339.2
CAPS2
calcyphosine 2
chr2_-_172967621 0.28 ENST00000234198.4
ENST00000466293.2
DLX2
distal-less homeobox 2
chr3_-_27764190 0.28 ENST00000537516.1
EOMES
eomesodermin
chr10_+_97709725 0.27 ENST00000472454.2
RP11-248J23.6
Protein LOC100652732
chr15_-_76304731 0.26 ENST00000394907.3
NRG4
neuregulin 4
chr13_-_81801115 0.26 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chrX_+_107288197 0.25 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr10_+_67330096 0.25 ENST00000433152.4
ENST00000601979.1
ENST00000599409.1
ENST00000608678.1
RP11-222A11.1
RP11-222A11.1
chr8_+_67039131 0.25 ENST00000315962.4
ENST00000353317.5
TRIM55
tripartite motif containing 55
chr16_+_53412368 0.25 ENST00000565189.1
RP11-44F14.2
RP11-44F14.2
chr12_-_25150373 0.24 ENST00000549828.1
C12orf77
chromosome 12 open reading frame 77
chr4_-_87028478 0.23 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr15_+_51669513 0.22 ENST00000558426.1
GLDN
gliomedin
chr18_+_61445205 0.22 ENST00000431370.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr18_+_616711 0.22 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr4_+_76649753 0.22 ENST00000603759.1
USO1
USO1 vesicle transport factor
chr4_-_70653673 0.21 ENST00000512870.1
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr1_+_15668240 0.20 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr11_+_18433840 0.20 ENST00000541669.1
ENST00000280704.4
LDHC
lactate dehydrogenase C
chr6_+_3259148 0.20 ENST00000419065.2
ENST00000473000.2
ENST00000451246.2
ENST00000454610.2
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr19_+_13842559 0.20 ENST00000586600.1
CCDC130
coiled-coil domain containing 130
chr12_+_122688090 0.19 ENST00000324189.4
ENST00000546192.1
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr16_+_89334512 0.19 ENST00000602042.1
AC137932.1
AC137932.1
chr1_+_244214577 0.18 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr12_-_118628315 0.18 ENST00000540561.1
TAOK3
TAO kinase 3
chr2_-_214013353 0.18 ENST00000451136.2
ENST00000421754.2
ENST00000374327.4
ENST00000413091.3
IKZF2
IKAROS family zinc finger 2 (Helios)
chr12_-_49581152 0.17 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr2_+_196313239 0.16 ENST00000413290.1
AC064834.1
AC064834.1
chr11_-_96076334 0.16 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr18_-_52989217 0.16 ENST00000570287.2
TCF4
transcription factor 4
chrX_-_124097620 0.16 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr10_-_75226166 0.15 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr2_+_74685413 0.15 ENST00000233615.2
WBP1
WW domain binding protein 1
chr6_-_32908792 0.15 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_-_154751629 0.15 ENST00000424998.1
CNKSR3
CNKSR family member 3
chr13_-_47471155 0.15 ENST00000543956.1
ENST00000542664.1
HTR2A
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
chr8_+_107738343 0.15 ENST00000521592.1
OXR1
oxidation resistance 1
chr1_+_206557366 0.15 ENST00000414007.1
ENST00000419187.2
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr12_+_28605426 0.15 ENST00000542801.1
CCDC91
coiled-coil domain containing 91
chr7_-_55620433 0.15 ENST00000418904.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr1_-_151148492 0.15 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr2_-_145277882 0.14 ENST00000465070.1
ENST00000444559.1
ZEB2
zinc finger E-box binding homeobox 2
chr9_-_95298254 0.14 ENST00000444490.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr11_+_1295809 0.14 ENST00000598274.1
AC136297.1
Uncharacterized protein
chr4_+_88571429 0.14 ENST00000339673.6
ENST00000282479.7
DMP1
dentin matrix acidic phosphoprotein 1
chr12_+_59989918 0.14 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr12_-_28125638 0.14 ENST00000545234.1
PTHLH
parathyroid hormone-like hormone
chr11_-_82708435 0.13 ENST00000525117.1
ENST00000532548.1
RAB30
RAB30, member RAS oncogene family
chr19_-_11456722 0.13 ENST00000354882.5
TMEM205
transmembrane protein 205
chr5_+_133562095 0.13 ENST00000602919.1
CTD-2410N18.3
CTD-2410N18.3
chr12_-_25150409 0.13 ENST00000549262.1
C12orf77
chromosome 12 open reading frame 77
chr8_-_57123815 0.13 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr8_+_87111059 0.13 ENST00000285393.3
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr14_+_85994943 0.13 ENST00000553678.1
RP11-497E19.2
Uncharacterized protein
chr20_-_43133491 0.12 ENST00000411544.1
SERINC3
serine incorporator 3
chr3_-_27763803 0.12 ENST00000449599.1
EOMES
eomesodermin
chr11_+_66276550 0.12 ENST00000419755.3
CTD-3074O7.11
Bardet-Biedl syndrome 1 protein
chrX_+_39868501 0.12 ENST00000447651.1
AC092198.1
AC092198.1
chr14_+_65453432 0.12 ENST00000246166.2
FNTB
farnesyltransferase, CAAX box, beta
chr12_-_91573132 0.12 ENST00000550563.1
ENST00000546370.1
DCN
decorin
chr3_-_186262166 0.12 ENST00000307944.5
CRYGS
crystallin, gamma S
chr5_-_54468974 0.12 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
CDC20B
cell division cycle 20B
chr5_-_54529415 0.11 ENST00000282572.4
CCNO
cyclin O
chr17_-_39623681 0.11 ENST00000225899.3
KRT32
keratin 32
chr3_-_157824292 0.11 ENST00000483851.2
SHOX2
short stature homeobox 2
chr12_-_118796971 0.11 ENST00000542902.1
TAOK3
TAO kinase 3
chr6_+_34204642 0.11 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr6_-_138833630 0.11 ENST00000533765.1
NHSL1
NHS-like 1
chr12_+_26348246 0.10 ENST00000422622.2
SSPN
sarcospan
chr4_-_23735183 0.10 ENST00000507666.1
RP11-380P13.2
RP11-380P13.2
chr10_+_52094298 0.10 ENST00000595931.1
AC069547.1
HCG1745369; PRO3073; Uncharacterized protein
chr10_+_97803151 0.10 ENST00000403870.3
ENST00000265992.5
ENST00000465148.2
ENST00000534974.1
CCNJ
cyclin J
chr10_+_24544249 0.09 ENST00000430453.2
KIAA1217
KIAA1217
chr7_-_35013217 0.09 ENST00000446375.1
DPY19L1
dpy-19-like 1 (C. elegans)
chrX_+_18725758 0.09 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
PPEF1
protein phosphatase, EF-hand calcium binding domain 1
chrX_-_68385354 0.09 ENST00000361478.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr2_-_69180012 0.09 ENST00000481498.1
GKN2
gastrokine 2
chr7_-_27169801 0.09 ENST00000511914.1
HOXA4
homeobox A4
chr2_+_176994408 0.09 ENST00000429017.1
ENST00000313173.4
ENST00000544999.1
HOXD8
homeobox D8
chr8_+_107738240 0.09 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr4_-_89951028 0.09 ENST00000506913.1
FAM13A
family with sequence similarity 13, member A
chr1_+_154401791 0.09 ENST00000476006.1
IL6R
interleukin 6 receptor
chr6_+_88106840 0.09 ENST00000369570.4
C6orf164
chromosome 6 open reading frame 164
chr12_+_58003935 0.09 ENST00000333972.7
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr12_+_49621658 0.09 ENST00000541364.1
TUBA1C
tubulin, alpha 1c
chr3_-_101039402 0.09 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chr5_-_111312622 0.09 ENST00000395634.3
NREP
neuronal regeneration related protein
chrX_+_48687283 0.09 ENST00000338270.1
ERAS
ES cell expressed Ras
chr1_+_44679159 0.09 ENST00000315913.5
ENST00000372289.2
DMAP1
DNA methyltransferase 1 associated protein 1
chr3_+_111393659 0.08 ENST00000477665.1
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr17_+_74463650 0.08 ENST00000392492.3
AANAT
aralkylamine N-acetyltransferase
chr3_-_164914640 0.08 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr3_-_45838011 0.08 ENST00000358525.4
ENST00000413781.1
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr16_+_1728257 0.08 ENST00000248098.3
ENST00000562684.1
ENST00000561516.1
ENST00000382711.5
ENST00000566742.1
HN1L
hematological and neurological expressed 1-like
chr17_+_71228843 0.08 ENST00000582391.1
C17orf80
chromosome 17 open reading frame 80
chr1_+_109756523 0.08 ENST00000234677.2
ENST00000369923.4
SARS
seryl-tRNA synthetase
chr1_+_104615595 0.08 ENST00000418362.1
RP11-364B6.1
RP11-364B6.1
chr19_-_11456905 0.08 ENST00000588560.1
ENST00000592952.1
TMEM205
transmembrane protein 205
chr5_-_160279207 0.08 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr5_-_87516448 0.08 ENST00000511218.1
TMEM161B
transmembrane protein 161B
chr12_+_72080253 0.07 ENST00000549735.1
TMEM19
transmembrane protein 19
chr1_+_145525015 0.07 ENST00000539363.1
ENST00000538811.1
ITGA10
integrin, alpha 10
chr22_-_30642728 0.07 ENST00000403987.3
LIF
leukemia inhibitory factor
chr3_-_45837959 0.07 ENST00000353278.4
ENST00000456124.2
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr1_+_67632083 0.07 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr14_-_75536182 0.07 ENST00000555463.1
ACYP1
acylphosphatase 1, erythrocyte (common) type
chr9_-_123639600 0.07 ENST00000373896.3
PHF19
PHD finger protein 19
chr9_+_99449322 0.07 ENST00000423924.1
RP11-535M15.1
RP11-535M15.1
chr21_+_43619796 0.07 ENST00000398457.2
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr6_-_133055896 0.07 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
VNN3
vanin 3
chr15_-_52970820 0.07 ENST00000261844.7
ENST00000399202.4
ENST00000562135.1
FAM214A
family with sequence similarity 214, member A
chr7_-_122840015 0.07 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr19_+_42580274 0.07 ENST00000359044.4
ZNF574
zinc finger protein 574
chr9_-_123639445 0.07 ENST00000312189.6
PHF19
PHD finger protein 19
chr8_-_102803163 0.06 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr5_+_98109322 0.06 ENST00000513185.1
RGMB
repulsive guidance molecule family member b
chr3_+_111393501 0.06 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr9_-_123639304 0.06 ENST00000436309.1
PHF19
PHD finger protein 19
chr12_+_26348429 0.06 ENST00000242729.2
SSPN
sarcospan
chr1_+_44679113 0.06 ENST00000361745.6
ENST00000446292.1
ENST00000440641.1
ENST00000436069.1
ENST00000437511.1
DMAP1
DNA methyltransferase 1 associated protein 1
chr6_+_15401075 0.06 ENST00000541660.1
JARID2
jumonji, AT rich interactive domain 2
chr4_+_183370146 0.06 ENST00000510504.1
TENM3
teneurin transmembrane protein 3
chr15_+_80733570 0.06 ENST00000533983.1
ENST00000527771.1
ENST00000525103.1
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr21_-_43346790 0.06 ENST00000329623.7
C2CD2
C2 calcium-dependent domain containing 2
chr14_-_81425828 0.06 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr10_+_57358750 0.06 ENST00000512524.2
MTRNR2L5
MT-RNR2-like 5
chr19_-_38183201 0.06 ENST00000590008.1
ENST00000358582.4
ZNF781
zinc finger protein 781
chr3_+_149192475 0.06 ENST00000465758.1
TM4SF4
transmembrane 4 L six family member 4
chr2_+_54683419 0.06 ENST00000356805.4
SPTBN1
spectrin, beta, non-erythrocytic 1
chr5_+_59783540 0.06 ENST00000515734.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr6_+_76330355 0.06 ENST00000483859.2
SENP6
SUMO1/sentrin specific peptidase 6
chr7_+_90338712 0.06 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chr8_-_61880248 0.06 ENST00000525556.1
AC022182.3
AC022182.3
chr2_+_162272605 0.06 ENST00000389554.3
TBR1
T-box, brain, 1
chr19_+_36630454 0.06 ENST00000246533.3
CAPNS1
calpain, small subunit 1
chr17_-_46690839 0.06 ENST00000498634.2
HOXB8
homeobox B8
chrX_-_15332665 0.06 ENST00000537676.1
ENST00000344384.4
ASB11
ankyrin repeat and SOCS box containing 11
chr5_+_137722255 0.06 ENST00000542866.1
KDM3B
lysine (K)-specific demethylase 3B
chr2_+_128458514 0.06 ENST00000310981.4
SFT2D3
SFT2 domain containing 3
chr15_-_34331243 0.06 ENST00000306730.3
AVEN
apoptosis, caspase activation inhibitor
chrX_+_100224676 0.06 ENST00000450049.2
ARL13A
ADP-ribosylation factor-like 13A
chr12_+_12878829 0.06 ENST00000326765.6
APOLD1
apolipoprotein L domain containing 1
chr15_+_101417919 0.06 ENST00000561338.1
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr3_-_48956818 0.06 ENST00000408959.2
ARIH2OS
ariadne homolog 2 opposite strand
chr6_+_44187242 0.06 ENST00000393844.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr6_-_134639042 0.06 ENST00000461976.2
SGK1
serum/glucocorticoid regulated kinase 1
chr16_-_67517716 0.06 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr2_-_69180083 0.06 ENST00000328895.4
GKN2
gastrokine 2
chr4_-_69083720 0.06 ENST00000432593.3
TMPRSS11BNL
TMPRSS11B N-terminal like
chr5_+_59783941 0.06 ENST00000506884.1
ENST00000504876.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr21_-_35899113 0.05 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr6_-_133055815 0.05 ENST00000509351.1
ENST00000417437.2
ENST00000414302.2
ENST00000423615.2
ENST00000427187.2
ENST00000275223.3
ENST00000519686.2
VNN3
vanin 3
chr12_-_107380846 0.05 ENST00000548101.1
ENST00000550496.1
ENST00000552029.1
MTERFD3
MTERF domain containing 3
chr1_-_50889155 0.05 ENST00000404795.3
DMRTA2
DMRT-like family A2
chr1_-_94147385 0.05 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr22_-_22337204 0.05 ENST00000430142.1
ENST00000357179.5
TOP3B
topoisomerase (DNA) III beta
chr10_+_89420706 0.05 ENST00000427144.2
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr5_+_140514782 0.05 ENST00000231134.5
PCDHB5
protocadherin beta 5
chr6_-_152639479 0.05 ENST00000356820.4
SYNE1
spectrin repeat containing, nuclear envelope 1
chr19_-_11456935 0.05 ENST00000590788.1
ENST00000586590.1
ENST00000589555.1
ENST00000586956.1
ENST00000593256.2
ENST00000447337.1
ENST00000591677.1
ENST00000586701.1
ENST00000589655.1
TMEM205
RAB3D
transmembrane protein 205
RAB3D, member RAS oncogene family
chr9_-_71869642 0.05 ENST00000600472.1
AL358113.1
Tight junction protein 2 (Zona occludens 2) isoform 1 variant; Uncharacterized protein
chr17_+_41150290 0.05 ENST00000589037.1
ENST00000253788.5
RPL27
ribosomal protein L27
chr18_-_13915530 0.05 ENST00000327606.3
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chrX_-_48858667 0.05 ENST00000376423.4
ENST00000376441.1
GRIPAP1
GRIP1 associated protein 1
chrX_-_68385274 0.05 ENST00000374584.3
ENST00000590146.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr5_+_140227048 0.05 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr4_+_118955500 0.05 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr17_+_7155819 0.05 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
ELP5
elongator acetyltransferase complex subunit 5

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0061300 cerebellum vasculature development(GO:0061300)
0.2 0.5 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
0.1 1.3 GO:1902748 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.3 GO:0061075 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 0.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.2 GO:0019516 lactate oxidation(GO:0019516)
0.1 0.4 GO:0060809 mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.1 2.1 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.5 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.8 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.3 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.2 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.1 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.1 GO:0021816 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.0 0.1 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.1 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.1 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.1 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.0 0.1 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.1 GO:0090402 senescence-associated heterochromatin focus assembly(GO:0035986) oncogene-induced cell senescence(GO:0090402)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.3 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.0 0.1 GO:0060166 olfactory pit development(GO:0060166)
0.0 0.1 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 0.2 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.1 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915) locomotion involved in locomotory behavior(GO:0031987)
0.0 0.0 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.0 0.1 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.0 0.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.2 GO:0015816 glycine transport(GO:0015816)
0.0 0.1 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 2.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.6 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.5 GO:1990357 terminal web(GO:1990357)
0.1 0.8 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.1 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 0.1 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 0.8 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.1 0.5 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.2 GO:0070052 collagen V binding(GO:0070052)
0.0 0.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.1 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.0 0.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.1 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.0 0.1 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.1 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.0 1.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.0 0.1 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.0 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.1 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.0 0.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.0 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters