ISMARA results: RCOR1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RCOR1_MTA3

Z-value: 3.05

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Transcription factors associated with RCOR1_MTA3

Gene Symbol	Gene ID	Gene Info
RCOR1 Ensembl NCBI GeneCards UniProt	ENSG00000089902.8	REST corepressor 1
MTA3 Ensembl NCBI GeneCards UniProt	ENSG00000057935.9	metastasis associated 1 family member 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MTA3	hg19_v2_chr2_+_42795745_42795824	0.63	1.8e-01	Click!
RCOR1	hg19_v2_chr14_+_103058948_103059005	-0.08	8.7e-01	Click!

Activity profile of RCOR1_MTA3 motif

Sorted Z-values of RCOR1_MTA3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_948803 Show fit	7.89	ENST00000379389.4	ISG15 Ensembl NCBI GeneCards UniProt Show fit	ISG15 ubiquitin-like modifier
chr11_-_615570 Show fit	7.38	ENST00000525445.1 ENST00000348655.6 ENST00000397566.1	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr11_-_615942 Show fit	6.37	ENST00000397562.3 ENST00000330243.5 ENST00000397570.1 ENST00000397574.2	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr17_-_72968837 Show fit	5.86	ENST00000581676.1	HID1 Ensembl NCBI GeneCards UniProt Show fit	HID1 domain containing
chr19_+_15783879 Show fit	5.63	ENST00000551607.1	CYP4F12 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450, family 4, subfamily F, polypeptide 12
chr12_+_112451222 Show fit	4.98	ENST00000552052.1	ERP29 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum protein 29
chr21_+_38338737 Show fit	4.84	ENST00000430068.1	AP000704.5 Ensembl NCBI GeneCards UniProt Show fit	AP000704.5
chr4_+_89299994 Show fit	4.81	ENST00000264346.7	HERC6 Ensembl NCBI GeneCards UniProt Show fit	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr6_+_80714332 Show fit	4.65	ENST00000502580.1 ENST00000511260.1	TTK Ensembl NCBI GeneCards UniProt Show fit	TTK protein kinase
chr9_+_96717821 Show fit	4.65	ENST00000454594.1	RP11-231K24.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-231K24.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RCOR1_MTA3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	18.2	GO:0060337	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.3	17.1	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
1.4	16.6	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.3	15.6	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
1.3	14.8	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.3	14.5	GO:0045494	photoreceptor cell maintenance(GO:0045494)
0.5	14.3	GO:0035455	response to interferon-alpha(GO:0035455)
0.1	14.0	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.4	13.8	GO:0008334	histone mRNA metabolic process(GO:0008334)
4.6	13.7	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)

Showing 1 to 10 of 1,588 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	32.1	GO:0005730	nucleolus(GO:0005730)
0.1	31.7	GO:0005635	nuclear envelope(GO:0005635)
0.0	19.9	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	14.3	GO:0005813	centrosome(GO:0005813)
0.1	12.5	GO:0000776	kinetochore(GO:0000776)
0.1	12.2	GO:0072562	blood microparticle(GO:0072562)
0.4	11.9	GO:0030992	intraciliary transport particle B(GO:0030992)
0.1	11.6	GO:0044309	neuron spine(GO:0044309)
0.1	11.5	GO:0034705	potassium channel complex(GO:0034705)
0.1	11.4	GO:0016605	PML body(GO:0016605)

Showing 1 to 10 of 517 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	25.3	GO:0061659	ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
1.5	17.8	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.2	16.6	GO:0019003	GDP binding(GO:0019003)
0.5	15.6	GO:0042609	CD4 receptor binding(GO:0042609)
0.1	15.2	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.4	15.0	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1	14.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	12.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.0	12.6	GO:0031386	protein tag(GO:0031386)
0.1	11.9	GO:0019208	phosphatase regulator activity(GO:0019208)

Showing 1 to 10 of 892 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	23.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	22.8	PID PLK1 PATHWAY	PLK1 signaling events
0.3	16.2	PID BARD1 PATHWAY	BARD1 signaling events
0.1	14.2	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.2	13.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	12.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	11.0	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.3	10.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	9.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	9.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation

Showing 1 to 10 of 110 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	68.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	36.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	29.2	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	22.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3	16.0	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	15.0	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.4	14.7	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
1.0	14.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2	13.4	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.2	13.3	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes

Showing 1 to 10 of 209 entries

Results for RCOR1_MTA3

Z-value: 3.05

Motif logo

Transcription factors associated with RCOR1_MTA3

Activity-expression correlation:

Activity profile of RCOR1_MTA3 motif

Sorted Z-values of RCOR1_MTA3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RCOR1_MTA3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: