Project

A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation
Downloads

Results for REST

Z-value: 0.47

Motif logo

logo of

Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 RE1 silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.928.9e-03Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_93389425 0.46 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr10_+_99609996 0.38 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr2_-_27531313 0.37 ENST00000296099.2
UCN
urocortin
chr22_+_31199037 0.35 ENST00000424224.1
OSBP2
oxysterol binding protein 2
chrX_-_49056635 0.31 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
SYP
synaptophysin
chr15_-_32162833 0.28 ENST00000560598.1
OTUD7A
OTU domain containing 7A
chr3_+_193853927 0.27 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr16_+_3019309 0.23 ENST00000576565.1
PAQR4
progestin and adipoQ receptor family member IV
chr7_+_150748288 0.20 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr11_-_75141206 0.20 ENST00000376292.4
KLHL35
kelch-like family member 35
chrX_-_153141302 0.19 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1CAM
L1 cell adhesion molecule
chr19_-_11639910 0.18 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr16_+_3019246 0.18 ENST00000318782.8
ENST00000293978.8
PAQR4
progestin and adipoQ receptor family member IV
chr11_-_72492878 0.18 ENST00000535054.1
ENST00000545082.1
STARD10
StAR-related lipid transfer (START) domain containing 10
chr12_-_24737089 0.17 ENST00000483544.1
LINC00477
long intergenic non-protein coding RNA 477
chr3_-_48700310 0.16 ENST00000164024.4
ENST00000544264.1
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3
chr17_+_72667239 0.16 ENST00000402449.4
RAB37
RAB37, member RAS oncogene family
chr20_-_62284766 0.15 ENST00000370053.1
STMN3
stathmin-like 3
chrX_+_153238220 0.15 ENST00000425274.1
TMEM187
transmembrane protein 187
chr11_+_64808675 0.14 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr19_-_11639931 0.14 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr17_+_30813576 0.14 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr19_-_3971050 0.14 ENST00000545797.2
ENST00000596311.1
DAPK3
death-associated protein kinase 3
chr19_+_39759154 0.13 ENST00000331982.5
IFNL2
interferon, lambda 2
chr7_-_65113280 0.13 ENST00000593865.1
AC104057.1
Protein LOC100996407
chr10_+_102790980 0.12 ENST00000393459.1
ENST00000224807.5
SFXN3
sideroflexin 3
chrX_-_153141434 0.12 ENST00000407935.2
ENST00000439496.1
L1CAM
L1 cell adhesion molecule
chrX_-_153237258 0.12 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr12_+_52695617 0.12 ENST00000293525.5
KRT86
keratin 86
chr16_+_335680 0.11 ENST00000435833.1
PDIA2
protein disulfide isomerase family A, member 2
chr5_+_175298487 0.11 ENST00000393745.3
CPLX2
complexin 2
chr8_-_145752390 0.11 ENST00000529415.2
ENST00000533758.1
LRRC24
leucine rich repeat containing 24
chr19_-_45927622 0.10 ENST00000300853.3
ENST00000589165.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr14_-_51562037 0.10 ENST00000338969.5
TRIM9
tripartite motif containing 9
chr5_+_175298674 0.10 ENST00000514150.1
CPLX2
complexin 2
chr19_+_9203855 0.10 ENST00000429566.3
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr20_+_36012051 0.10 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr5_-_176037105 0.10 ENST00000303991.4
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr1_+_171750776 0.09 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chr15_+_75287861 0.09 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
SCAMP5
secretory carrier membrane protein 5
chr11_+_45907177 0.09 ENST00000241014.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr5_+_175298573 0.08 ENST00000512824.1
CPLX2
complexin 2
chr10_+_60936921 0.08 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr1_-_40105617 0.08 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr6_+_43603552 0.07 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr5_-_135701164 0.07 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr4_+_96012585 0.07 ENST00000502683.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr1_+_154540246 0.07 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr12_+_113796347 0.07 ENST00000545182.2
ENST00000280800.3
PLBD2
phospholipase B domain containing 2
chr1_+_212606219 0.07 ENST00000366988.3
NENF
neudesin neurotrophic factor
chr18_-_40857493 0.07 ENST00000255224.3
SYT4
synaptotagmin IV
chr3_-_8686479 0.07 ENST00000544814.1
ENST00000427408.1
SSUH2
ssu-2 homolog (C. elegans)
chr11_-_66115032 0.07 ENST00000311181.4
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr3_+_9745487 0.06 ENST00000383832.3
CPNE9
copine family member IX
chr2_+_46524537 0.06 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr19_-_45927097 0.06 ENST00000340192.7
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr2_+_226265364 0.05 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr19_-_40724246 0.05 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr12_+_113229337 0.05 ENST00000552667.1
RPH3A
rabphilin 3A homolog (mouse)
chr12_+_113229737 0.05 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr17_-_7218403 0.05 ENST00000570780.1
GPS2
G protein pathway suppressor 2
chr20_+_30555805 0.05 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr5_+_167956121 0.05 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr12_+_113229725 0.04 ENST00000551198.1
RPH3A
rabphilin 3A homolog (mouse)
chr12_-_12837423 0.04 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr10_-_79398127 0.04 ENST00000372443.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr6_+_25652501 0.04 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr12_+_113229708 0.04 ENST00000550901.1
RPH3A
rabphilin 3A homolog (mouse)
chr19_-_45926739 0.04 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr15_-_72612470 0.03 ENST00000287202.5
CELF6
CUGBP, Elav-like family member 6
chr20_+_62327996 0.03 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr19_-_51845378 0.03 ENST00000335624.4
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr19_-_55691614 0.03 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr12_-_99288986 0.03 ENST00000552407.1
ENST00000551613.1
ENST00000548447.1
ENST00000546364.3
ENST00000552748.1
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr8_-_91095099 0.02 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr3_-_131753830 0.02 ENST00000429747.1
CPNE4
copine IV
chr20_+_44657807 0.02 ENST00000372315.1
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr12_+_113229452 0.02 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chrX_-_47479246 0.02 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr18_-_40857447 0.01 ENST00000590752.1
ENST00000596867.1
SYT4
synaptotagmin IV
chr10_+_89419370 0.01 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr3_+_9745510 0.01 ENST00000383831.3
CPNE9
copine family member IX
chr6_+_25652432 0.01 ENST00000377961.2
SCGN
secretagogin, EF-hand calcium binding protein
chr14_-_74892805 0.00 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr2_-_51259641 0.00 ENST00000406316.2
ENST00000405581.1
NRXN1
neurexin 1
chr12_-_57443886 0.00 ENST00000300119.3
MYO1A
myosin IA
chr10_-_79398250 0.00 ENST00000286627.5
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr6_+_158957431 0.00 ENST00000367090.3
TMEM181
transmembrane protein 181
chr14_-_51561784 0.00 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr2_+_131513864 0.00 ENST00000458606.1
ENST00000423981.1
AMER3
APC membrane recruitment protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1900738 dense core granule biogenesis(GO:0061110) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.4 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 0.3 GO:0060164 negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of mechanoreceptor differentiation(GO:0045632) regulation of timing of neuron differentiation(GO:0060164) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.0 0.1 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.0 0.2 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.0 0.3 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.2 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.0 0.1 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.0 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.2 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.0 0.1 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.0 GO:0000494 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.2 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 0.3 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0043196 varicosity(GO:0043196)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.3 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.5 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.1 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.2 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.0 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)